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WO2001075065A3 - Haplotypes of the gp1ba gene - Google Patents

Haplotypes of the gp1ba gene Download PDF

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Publication number
WO2001075065A3
WO2001075065A3 PCT/US2001/010671 US0110671W WO0175065A3 WO 2001075065 A3 WO2001075065 A3 WO 2001075065A3 US 0110671 W US0110671 W US 0110671W WO 0175065 A3 WO0175065 A3 WO 0175065A3
Authority
WO
WIPO (PCT)
Prior art keywords
gp1ba
gene
haplotypes
disclosed
gp1ba gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/010671
Other languages
French (fr)
Other versions
WO2001075065A2 (en
Inventor
Steven C Bentivegna
Julie Y Choi
Stephanie E Kliem
Beena Koshy
Katie E Parks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2001253091A priority Critical patent/AU2001253091A1/en
Publication of WO2001075065A2 publication Critical patent/WO2001075065A2/en
Publication of WO2001075065A3 publication Critical patent/WO2001075065A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Novel single nucleotide polymorphisms in the human glycoprotein Ib (platelet), alpha polypeptide (GP1BA) gene are described. In addition, various genotypes, haplotypes and haplotype pairs for the GP1BA gene that exist in the population are described. Compositions and methods for haplotyping and/or genotyping the GP1BA gene in an individual are also disclosed. Polynucleotides containing one or more of the GP1BA polymorphisms disclosed herein are also described.
PCT/US2001/010671 2000-04-03 2001-04-03 Haplotypes of the gp1ba gene Ceased WO2001075065A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001253091A AU2001253091A1 (en) 2000-04-03 2001-04-03 Haplotypes of the gp1ba gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19434100P 2000-04-03 2000-04-03
US60/194,341 2000-04-03

Publications (2)

Publication Number Publication Date
WO2001075065A2 WO2001075065A2 (en) 2001-10-11
WO2001075065A3 true WO2001075065A3 (en) 2002-03-21

Family

ID=22717212

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010671 Ceased WO2001075065A2 (en) 2000-04-03 2001-04-03 Haplotypes of the gp1ba gene

Country Status (2)

Country Link
AU (1) AU2001253091A1 (en)
WO (1) WO2001075065A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4140329B2 (en) 2002-09-25 2008-08-27 財団法人名古屋産業科学研究所 Hypertension risk diagnosis method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192659A (en) * 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192659A (en) * 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE SNP [online] NATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION, NATIONAL LIBRARY OF MEDICINE, NIH (BETHESDA, MD, USA); July 1999 (1999-07-01), XP002949583, accession no. NCBI, Assay ID (ss#) 7682, References SNP ID (rs#) *
DATABASE SNP [online] NATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION, NATIONAL LIBRARY OF MEDICINE, NIH (BETHESDA, MD, USA); July 1999 (1999-07-01), XP002949584, accession no. NCBI Assay ID (ss#) 7685, References SNP ID (rs#) *
DATABASE SNP [online] NATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION, NATIONAL LIBRARY OF MEDICINE, NIH (BETHESDA, MD, USA); July 1999 (1999-07-01), XP002949585, accession no. NCBI, Assay ID (ss#) 7683, Reference SNP ID (rs#) *
DATABASE SNP [online] NATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION, NATIONAL LIBRARY OF MEDICINE, NIH (BETHESDA, MD, USA); XP002949586, accession no. NCBI, Assay ID (ss#) 7684, References SNP ID (rs#) *
KASKI ET AL.: "Systematic screening for genetic polymorphism in human platelet glycoprotein Ibalpha", IMMUNOGENETICS, vol. 44, 1996, pages 170 - 176, XP002949515 *
KENNY ET AL.: "Naturally occurring mutations in glycoprotein Ibalpha that result in defective ligand binding and synthesis of a truncated protein", BLOOD, vol. 92, no. 1, 1 July 1998 (1998-07-01), pages 175 - 183, XP002949514 *
LI ET AL.: "Threonine-145/methionine-145 variants of baculovirus produced recombinant ligand binding domain of GPIbalpha express HPA-2 epitopes and show equal binding of von Willebrand factor", BLOOD, vol. 95, no. 1, 1 January 2000 (2000-01-01), pages 205 - 211, XP002949513 *

Also Published As

Publication number Publication date
AU2001253091A1 (en) 2001-10-15
WO2001075065A2 (en) 2001-10-11

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