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WO2001079224A3 - Haplotypes of the cyp8b1 gene - Google Patents

Haplotypes of the cyp8b1 gene Download PDF

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Publication number
WO2001079224A3
WO2001079224A3 PCT/US2001/011946 US0111946W WO0179224A3 WO 2001079224 A3 WO2001079224 A3 WO 2001079224A3 US 0111946 W US0111946 W US 0111946W WO 0179224 A3 WO0179224 A3 WO 0179224A3
Authority
WO
WIPO (PCT)
Prior art keywords
cyp8b1
gene
haplotypes
disclosed
cyp8b1 gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/011946
Other languages
French (fr)
Other versions
WO2001079224A2 (en
Inventor
Steven C Bentivegna
Anne Chew
Julie Y Choi
Beena Koshy
J Claiborne Stephens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2001257021A priority Critical patent/AU2001257021A1/en
Publication of WO2001079224A2 publication Critical patent/WO2001079224A2/en
Publication of WO2001079224A3 publication Critical patent/WO2001079224A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Novel single nucleotide polymorphisms in the human cytochrome P450 subfamily VIIIB (CYP8B1) gene are described. In addition, various genotypes, haplotypes and haplotype pairs for the CYP8B1 gene that exist in the population are described. Compositions and methods for haplotyping and/or genotyping the CYP8B1 gene in an individual are also disclosed. Polynucleotides containing one or more of the CYP8B1 polymorphisms disclosed herein are also described.
PCT/US2001/011946 2000-04-12 2001-04-12 Haplotypes of the cyp8b1 gene Ceased WO2001079224A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001257021A AU2001257021A1 (en) 2000-04-12 2001-04-12 Haplotypes of the cyp8b1 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19640800P 2000-04-12 2000-04-12
US60/196,408 2000-04-12

Publications (2)

Publication Number Publication Date
WO2001079224A2 WO2001079224A2 (en) 2001-10-25
WO2001079224A3 true WO2001079224A3 (en) 2002-02-28

Family

ID=22725282

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/011946 Ceased WO2001079224A2 (en) 2000-04-12 2001-04-12 Haplotypes of the cyp8b1 gene

Country Status (2)

Country Link
AU (1) AU2001257021A1 (en)
WO (1) WO2001079224A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04012560A (en) * 2002-06-13 2005-10-19 Wyeth Corp Inhibitors of inflammatory gene activity and cholesterol biosynthesis.
KR100921793B1 (en) 2007-05-31 2009-10-16 대한민국 Haplotype Analysis Kits of Genes encoding CPP2C19
WO2014018375A1 (en) 2012-07-23 2014-01-30 Xenon Pharmaceuticals Inc. Cyp8b1 and uses thereof in therapeutic and diagnostic methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GAFVELS M. ET AL.: "Structure and chromosomal assignment of sterol 12.alpha.-hydroxylase gene (CYP8B1) in human and mouse: Eukaryotic cytochrome P-450 gene devoid of introns", GENOMICS, vol. 56, 1999, pages 184 - 196, XP002949131 *

Also Published As

Publication number Publication date
WO2001079224A2 (en) 2001-10-25
AU2001257021A1 (en) 2001-10-30

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