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WO2001079234A3 - Haplotypes of the apoe gene - Google Patents

Haplotypes of the apoe gene Download PDF

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Publication number
WO2001079234A3
WO2001079234A3 PCT/US2001/012303 US0112303W WO0179234A3 WO 2001079234 A3 WO2001079234 A3 WO 2001079234A3 US 0112303 W US0112303 W US 0112303W WO 0179234 A3 WO0179234 A3 WO 0179234A3
Authority
WO
WIPO (PCT)
Prior art keywords
apoe
haplotypes
gene
apoe gene
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/012303
Other languages
French (fr)
Other versions
WO2001079234A2 (en
Inventor
Julie Y Choi
Stephanie E Kliem
Beena Koshy
Helen H Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2001255403A priority Critical patent/AU2001255403A1/en
Publication of WO2001079234A2 publication Critical patent/WO2001079234A2/en
Publication of WO2001079234A3 publication Critical patent/WO2001079234A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Novel single nucleotide polymorphisms in the human apolipoprotein E (APOE) gene are described. In addition, various genotypes, haplotypes and haplotype pairs for the APOE gene that exist in the population are described. Compositions and methods for haplotyping and/or genotyping the APOE gene in an individual are also disclosed. Polynucleotides containing one or more of the APOE polymorphisms disclosed herein are also described.
PCT/US2001/012303 2000-04-14 2001-04-16 Haplotypes of the apoe gene Ceased WO2001079234A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001255403A AU2001255403A1 (en) 2000-04-14 2001-04-16 Haplotypes of the apoe gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19718800P 2000-04-14 2000-04-14
US60/197,188 2000-04-14

Publications (2)

Publication Number Publication Date
WO2001079234A2 WO2001079234A2 (en) 2001-10-25
WO2001079234A3 true WO2001079234A3 (en) 2002-01-24

Family

ID=22728397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/012303 Ceased WO2001079234A2 (en) 2000-04-14 2001-04-16 Haplotypes of the apoe gene

Country Status (2)

Country Link
AU (1) AU2001255403A1 (en)
WO (1) WO2001079234A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435541B2 (en) 2000-05-23 2008-10-14 Sequenom, Inc. Restriction enzyme genotyping
EP1364046B1 (en) * 2000-05-23 2011-11-30 Variagenics, Inc. Methods for genetic analysis of dna to detect sequence variances
EP1465998A2 (en) * 2002-01-08 2004-10-13 Bayer HealthCare AG Single nucleotide polymorphisms predicting cardiovascular disease and medication efficacy
JP4143756B2 (en) * 2002-06-21 2008-09-03 財団法人名古屋産業科学研究所 Risk diagnosis method for myocardial infarction
US20050277129A1 (en) * 2004-01-22 2005-12-15 Genaissance Pharmaceuticals APOE genetic markers associated with age of onset of Alzheimer's disease
WO2007092380A2 (en) * 2006-02-06 2007-08-16 Berkeley Heartlab, Inc. Apolipoprotein e genotyping and accompanying internet-based health management system

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARTIGA ET AL.: "Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene", FEBS LETTERS, vol. 421, no. 2, January 1998 (1998-01-01), pages 105 - 108, XP002947338 *
NICKERSON ET AL.: "Sequence diversity and large-scale typing of SNPs in the human apoliprotein E gene", GENOME RESEARCH, vol. 10, no. 10, October 2000 (2000-10-01), pages 1532 - 1545, XP002947337 *
PAIK ET AL.: "Nucleotide sequence and structure of the human apolipoprotein E gene", PROC. NATL. ACAD. SCI. USA, vol. 82, May 1985 (1985-05-01), pages 3445 - 3449, XP002947336 *
SAMBROOK ET AL.: "Molecular cloning: a laboratory manual", 1989, COLD SPRING HARBOR LABORATORY PRESS, COLD SPRING HARBOR, XP002947335 *

Also Published As

Publication number Publication date
AU2001255403A1 (en) 2001-10-30
WO2001079234A2 (en) 2001-10-25

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