[go: up one dir, main page]

WO2002008425A3 - Haplotypes of the adrb3 gene - Google Patents

Haplotypes of the adrb3 gene Download PDF

Info

Publication number
WO2002008425A3
WO2002008425A3 PCT/US2001/023223 US0123223W WO0208425A3 WO 2002008425 A3 WO2002008425 A3 WO 2002008425A3 US 0123223 W US0123223 W US 0123223W WO 0208425 A3 WO0208425 A3 WO 0208425A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
adrb3
gene
disclosed
adrb3 gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/023223
Other languages
French (fr)
Other versions
WO2002008425A2 (en
Inventor
Kevin Finkel
Beena Koshy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2001280727A priority Critical patent/AU2001280727A1/en
Publication of WO2002008425A2 publication Critical patent/WO2002008425A2/en
Anticipated expiration legal-status Critical
Publication of WO2002008425A3 publication Critical patent/WO2002008425A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Novel genetic variants of the Beta-3-Adrenergic Receptor (ADRB3) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the ADRB3 gene. Compositions and methods for haplotyping and/or genotyping the ADRB3 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/023223 2000-07-21 2001-07-23 Haplotypes of the adrb3 gene Ceased WO2002008425A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001280727A AU2001280727A1 (en) 2000-07-21 2001-07-23 Haplotypes of the adrb3 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22008800P 2000-07-21 2000-07-21
US60/220,088 2000-07-21

Publications (2)

Publication Number Publication Date
WO2002008425A2 WO2002008425A2 (en) 2002-01-31
WO2002008425A3 true WO2002008425A3 (en) 2003-09-25

Family

ID=22822002

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/023223 Ceased WO2002008425A2 (en) 2000-07-21 2001-07-23 Haplotypes of the adrb3 gene

Country Status (2)

Country Link
AU (1) AU2001280727A1 (en)
WO (1) WO2002008425A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002086122A2 (en) * 2001-03-14 2002-10-31 Hybrigenics Protein-protein interactions in adipocytes
AU2003276727A1 (en) * 2002-06-14 2003-12-31 Cedars-Sinai Medical Center Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
US8178294B2 (en) 2002-06-14 2012-05-15 Cedars-Sinai Medical Center Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
CN107271675B (en) * 2017-03-24 2020-06-02 郑猛 Anti-human ADRB3 monoclonal antibody and application thereof in disease diagnosis and treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001027312A2 (en) * 1999-10-13 2001-04-19 Genaissance Pharmaceuticals, Inc. Drug target isogenes: polymorphisms in the m1 muscarinic acetylcholine receptor gene
WO2001080156A1 (en) * 2000-04-18 2001-10-25 Genaissance Pharmaceuticals, Inc. Method and system for determining haplotypes from a collection of polymorphisms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001027312A2 (en) * 1999-10-13 2001-04-19 Genaissance Pharmaceuticals, Inc. Drug target isogenes: polymorphisms in the m1 muscarinic acetylcholine receptor gene
WO2001080156A1 (en) * 2000-04-18 2001-10-25 Genaissance Pharmaceuticals, Inc. Method and system for determining haplotypes from a collection of polymorphisms

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CLAIBORNE STEPHENS J: "SINGLE-NUCLEOTIDE POLYMORPHISMS, HAPLOTYPES AND THEIR RELEVANCE TO PHARMACOGENTICS", MOLECULAR DIAGNOSIS, NAPERVILLE, IL, US, vol. 4, no. 4, 1999, pages 309 - 317, XP002937520, ISSN: 1084-8592 *
CLARK A G ET AL: "HAPLOTYPE STRUCTURE AND POPULATION GENETIC INFERENCES FROM NUCLEOTIDE-SEQUENCE VARIATION IN HUMAN LIPOPROTEIN LIPASE", AMERICAN JOURNAL OF HUMAN GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS, CHICAGO, IL, US, vol. 63, 1998, pages 595 - 612, XP002936696, ISSN: 0002-9297 *
DATABASE EMBL [online] 1 April 1993 (1993-04-01), XP002221280, retrieved from EMBL Database accession no. X72861 *
DRYSDALE C M ET AL: "COMPLEX PROMOTER AND CODING REGION BETA2-ADRENERGIC RECEPTOR HAPLOTYPES ALTER RECEPTOR EXPRESSION AND PREDICT IN VIVO RESPONSIVENESS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 19, 12 September 2000 (2000-09-12), pages 10483 - 10488, XP002940094, ISSN: 0027-8424 *
GAUTHIER C ET AL: "beta3-Adrenoceptors in the cardiovascular system", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 21, no. 11, 1 November 2000 (2000-11-01), pages 426 - 431, XP004220561, ISSN: 0165-6147 *
JUDSON RICHARD J: "THE PREDICTIVE POWER OF HAPLOTYPES IN CLINICAL RESPONSE", PHARMOCOGENOMICS, vol. 1, no. 1, February 2000 (2000-02-01), pages 15 - 26, XP002221279 *
MICHALATOS-BELOIN S ET AL: "MOLECULAR HAPLOTYPING OF GENETIC MARKERS 10 KB APART BY ALLELE-SPECIFIC LONG-RANGE PCR", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 24, no. 23, 1996, pages 4841 - 4843, XP002939512, ISSN: 0305-1048 *
SILVER KRISTI ET AL: "Molecular scanning of the beta-3-adrenergic receptor gene in Pima Indians and Caucasians.", DIABETES-METABOLISM RESEARCH AND REVIEWS, vol. 15, no. 3, May 1999 (1999-05-01), pages 175 - 180, XP002221278, ISSN: 1520-7552 *
SPRONSEN VAN A ET AL: "THE PROMOTER AND INTRON/EXON STRUCTURE OF THE HUMAN AND MOUSE SS3-ADRENERGIC-RECEPTOR GENES", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 213, no. 3, X72861, 1993, pages 1117 - 1124, XP000910637, ISSN: 0014-2956, Retrieved from the Internet <URL:EMBL> *
ULBRECHT M ET AL: "Assoziation of beta 2-adrenoreceptor variants with bronchial hyperresponsiveness", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 161, no. 2, February 2000 (2000-02-01), pages 469 - 474, XP002188594, ISSN: 1073-449X *

Also Published As

Publication number Publication date
WO2002008425A2 (en) 2002-01-31
AU2001280727A1 (en) 2002-02-05

Similar Documents

Publication Publication Date Title
WO2002006294A3 (en) Haplotypes of the mmp13 gene
WO2002008425A3 (en) Haplotypes of the adrb3 gene
WO2001079234A3 (en) Haplotypes of the apoe gene
WO2002018414A3 (en) Haplotypes of the bf gene
WO2002026764A3 (en) Haplotypes of the ccr6 gene
WO2002032928A3 (en) Haplotypes of the hrh1 gene
WO2002090512A3 (en) Haplotypes of the nnmt gene
WO2002050098A3 (en) Haplotypes of the prlr gene
WO2001087909A3 (en) Haplotypes of the aanat gene
WO2002040502A3 (en) Haplotypes of the lipe gene
WO2001090127A3 (en) Haplotypes of the hoxd3 gene
WO2002044201A3 (en) Haplotypes of the sah gene
WO2002038587A3 (en) Haplotypes of the grm8 gene
WO2002036610A3 (en) Haplotypes of the adora3 gene
WO2002032924A3 (en) Haplotypes of the chrm5 gene
WO2001096350A3 (en) Haplotypes of the grm3 gene
WO2002038586A3 (en) Haplotypes of the il6 gene
WO2001087904A3 (en) Haplotypes of the gpr4 gene
WO2002016399A3 (en) Haplotypes of the tacr1 gene
WO2001090128A3 (en) Haplotypes of the gpr3 gene
WO2002020556A3 (en) Haplotypes of the gpr68 gene
WO2001077129A3 (en) Haplotypes of the apoc1 gene
WO2002042320A3 (en) Haplotypes of the gsr gene
WO2002090378A3 (en) Haplotypes of the ces2 gene
WO2001085742A3 (en) Haplotypes of the npy1r gene

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP