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WO2002032924A3 - Haplotypes of the chrm5 gene - Google Patents

Haplotypes of the chrm5 gene Download PDF

Info

Publication number
WO2002032924A3
WO2002032924A3 PCT/US2001/032022 US0132022W WO0232924A3 WO 2002032924 A3 WO2002032924 A3 WO 2002032924A3 US 0132022 W US0132022 W US 0132022W WO 0232924 A3 WO0232924 A3 WO 0232924A3
Authority
WO
WIPO (PCT)
Prior art keywords
chrm5
gene
haplotypes
disclosed
haplotyping
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/032022
Other languages
French (fr)
Other versions
WO2002032924A2 (en
Inventor
Karyn M Bieglecki
Anne Chew
Julie Y Choi
R Rex Denton
Krishnan Nandabalan
Elizabeth Ann Sausker
J Claiborne Stephens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2000/029071 external-priority patent/WO2001028995A2/en
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2002213185A priority Critical patent/AU2002213185A1/en
Publication of WO2002032924A2 publication Critical patent/WO2002032924A2/en
Publication of WO2002032924A3 publication Critical patent/WO2002032924A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Novel genetic variants of the Cholinergic Receptor, Muscarinic 5 (CHRM5) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the CHRM5 gene. Compositions and methods for haplotyping and/or genotyping the CHRM5 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/032022 2000-10-19 2001-10-11 Haplotypes of the chrm5 gene Ceased WO2002032924A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002213185A AU2002213185A1 (en) 2000-10-19 2001-10-11 Haplotypes of the chrm5 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2000/029071 WO2001028995A2 (en) 1999-10-21 2000-10-19 Drug target isogenes: polymorphisms in the cholinergic receptor, muscarinic 5 gene
USPCT/US00/29071 2000-10-19

Publications (2)

Publication Number Publication Date
WO2002032924A2 WO2002032924A2 (en) 2002-04-25
WO2002032924A3 true WO2002032924A3 (en) 2002-08-01

Family

ID=21741914

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/032022 Ceased WO2002032924A2 (en) 2000-10-19 2001-10-11 Haplotypes of the chrm5 gene

Country Status (2)

Country Link
AU (1) AU2002213185A1 (en)
WO (1) WO2002032924A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1306037C (en) * 2004-10-19 2007-03-21 哈尔滨医科大学 Novel use of cardiocyte M3 receptor and IkM3 in screening medicament for treating arrhythmia

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BONNER ET AL.: "Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes", NEURON, vol. 1, no. 5, July 1988 (1988-07-01), pages 403 - 410, XP002916494 *
BROOKES ET AL.: "HGBASE: a database of SNPs and other variations in and around human genes", NUCLEIC ACIDS RESEARCH, vol. 28, no. 1, 2000, pages 356 - 360, XP002946185 *
MCCARTHY ET AL.: "The use of single-nucleotide polymorphism maps in pharmacogenomics", NATURE BIOTECHNOLOGY, vol. 18, May 2000 (2000-05-01), pages 505 - 508, XP000941628 *
STEPHENS: "Single-nucleotide polymorphisms, haplotypes and their relevance to pharmacogenetics", MOLECULAR DIAGNOSTICS, vol. 4, no. 4, 1999, pages 309 - 317, XP002937520 *

Also Published As

Publication number Publication date
WO2002032924A2 (en) 2002-04-25
AU2002213185A1 (en) 2002-04-29

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