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WO2002040502A3 - Haplotypes of the lipe gene - Google Patents

Haplotypes of the lipe gene Download PDF

Info

Publication number
WO2002040502A3
WO2002040502A3 PCT/US2001/043518 US0143518W WO0240502A3 WO 2002040502 A3 WO2002040502 A3 WO 2002040502A3 US 0143518 W US0143518 W US 0143518W WO 0240502 A3 WO0240502 A3 WO 0240502A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
lipe
gene
disclosed
lipe gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/043518
Other languages
French (fr)
Other versions
WO2002040502A2 (en
Inventor
Alison E Anastasio
Steven C Bentivegna
Anne Chew
Beena Koshy
Eileen Rounds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2002228618A priority Critical patent/AU2002228618A1/en
Publication of WO2002040502A2 publication Critical patent/WO2002040502A2/en
Publication of WO2002040502A3 publication Critical patent/WO2002040502A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Novel genetic variants of the Lipase, Hormone-Sensitive (LIPE) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the LIPE gene. Compositions and methods for haplotyping and/or genotyping the LIPE gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/043518 2000-11-16 2001-11-16 Haplotypes of the lipe gene Ceased WO2002040502A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002228618A AU2002228618A1 (en) 2000-11-16 2001-11-16 Haplotypes of the lipe gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24930200P 2000-11-16 2000-11-16
US60/249,302 2000-11-16

Publications (2)

Publication Number Publication Date
WO2002040502A2 WO2002040502A2 (en) 2002-05-23
WO2002040502A3 true WO2002040502A3 (en) 2003-01-30

Family

ID=22942887

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/043518 Ceased WO2002040502A2 (en) 2000-11-16 2001-11-16 Haplotypes of the lipe gene

Country Status (2)

Country Link
AU (1) AU2002228618A1 (en)
WO (1) WO2002040502A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030096771A1 (en) * 2001-07-26 2003-05-22 Butler Madeline M. Antisense modulation of hormone-sensitive lipase expression
IT202200009500A1 (en) * 2022-05-09 2023-11-09 Fondazione St Italiano Tecnologia TDP-43-binding single-stranded aptamers and their uses

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALEMAN-GOMEZ ET AL.: "Relationship of human pancreatic cholesterol esterase gene structure with phenotypes", LIFE SCIENCES, vol. 64, no. 25, 1999, pages 2419 - 2427, XP002952518 *
DATABASE GENBANK [online] DOE JOINT GENOME INSTITUTE; 30 June 2000 (2000-06-30), "Homo sapiens chromosome 19 clone CTB-50E14, complete sequence", XP002952522, accession no. NCBI Database accession no. (AC011497.6 *
LANGIN ET AL.: "Gene organization and primary structure of human hormone-sensitive lipase: Possible significance of a sequence homology with a lipase of Moraxella TA144, an antartic bacterium", PROC. NATL. ACAD. SCI. USA, vol. 90, June 1993 (1993-06-01), pages 4897 - 4901, XP002952519 *
PAJUKANTA ET AL.: "No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families", ARTERIOSCLEROSIS, THROMBOSIS AND VASCULAR BIOLOGY, vol. 17, no. 5, May 1997 (1997-05-01), pages 841 - 850, XP002952517 *

Also Published As

Publication number Publication date
AU2002228618A1 (en) 2002-05-27
WO2002040502A2 (en) 2002-05-23

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