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WO2002012499A3 - Haplotypes of the ntf3 gene - Google Patents

Haplotypes of the ntf3 gene Download PDF

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Publication number
WO2002012499A3
WO2002012499A3 PCT/US2001/024665 US0124665W WO0212499A3 WO 2002012499 A3 WO2002012499 A3 WO 2002012499A3 US 0124665 W US0124665 W US 0124665W WO 0212499 A3 WO0212499 A3 WO 0212499A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
ntf3
gene
disclosed
ntf3 gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/024665
Other languages
French (fr)
Other versions
WO2002012499A2 (en
Inventor
Stefanie E Kliem
Beena Koshy
Elizabeth M Lanz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2001294513A priority Critical patent/AU2001294513A1/en
Publication of WO2002012499A2 publication Critical patent/WO2002012499A2/en
Anticipated expiration legal-status Critical
Publication of WO2002012499A3 publication Critical patent/WO2002012499A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel genetic variants of the Neurotrophin 3 (NTF3) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the NTF3 gene. Compositions and methods for haplotyping and/or genotyping the NTF3 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/024665 2000-08-04 2001-08-06 Haplotypes of the ntf3 gene Ceased WO2002012499A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001294513A AU2001294513A1 (en) 2000-08-04 2001-08-06 Haplotypes of the ntf3 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22320800P 2000-08-04 2000-08-04
US60/223,208 2000-08-04

Publications (2)

Publication Number Publication Date
WO2002012499A2 WO2002012499A2 (en) 2002-02-14
WO2002012499A3 true WO2002012499A3 (en) 2003-08-28

Family

ID=22835526

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024665 Ceased WO2002012499A2 (en) 2000-08-04 2001-08-06 Haplotypes of the ntf3 gene

Country Status (2)

Country Link
AU (1) AU2001294513A1 (en)
WO (1) WO2002012499A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103374628B (en) * 2012-04-27 2016-08-17 中国科学院上海生命科学研究院 Associated Gene of Congenital Heart Disease FAM71A and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005783A1 (en) * 1991-09-20 1993-04-01 The General Hospital Corporation Diagnosis and therapy for parkinson's disease
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
WO2000058519A2 (en) * 1999-03-31 2000-10-05 Whitehead Institute For Biomedical Research Charaterization of single nucleotide polymorphisms in coding regions of human genes
WO2001080156A1 (en) * 2000-04-18 2001-10-25 Genaissance Pharmaceuticals, Inc. Method and system for determining haplotypes from a collection of polymorphisms

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993005783A1 (en) * 1991-09-20 1993-04-01 The General Hospital Corporation Diagnosis and therapy for parkinson's disease
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
WO2000058519A2 (en) * 1999-03-31 2000-10-05 Whitehead Institute For Biomedical Research Charaterization of single nucleotide polymorphisms in coding regions of human genes
WO2001080156A1 (en) * 2000-04-18 2001-10-25 Genaissance Pharmaceuticals, Inc. Method and system for determining haplotypes from a collection of polymorphisms

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
CARGILL M ET AL: "Characterization of single-nucleotide polymorphisms in coding regions of human genes", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 22, July 1999 (1999-07-01), pages 231 - 238, XP002121300, ISSN: 1061-4036 *
CLAIBORNE STEPHENS J: "SINGLE-NUCLEOTIDE POLYMORPHISMS, HAPLOTYPES AND THEIR RELEVANCE TO PHARMACOGENTICS", MOLECULAR DIAGNOSIS, NAPERVILLE, IL, US, vol. 4, no. 4, 1999, pages 309 - 317, XP002937520, ISSN: 1084-8592 *
CLARK A G ET AL: "HAPLOTYPE STRUCTURE AND POPULATION GENETIC INFERENCES FROM NUCLEOTIDE- SEQUENCE VARIATION IN HUMAN LIPOPROTEIN LIPASE", AMERICAN JOURNAL OF HUMAN GENETICS, UNIVERSITY OF CHICAGO PRESS, CHICAGO,, US, vol. 63, 1998, pages 595 - 612, XP002937239, ISSN: 0002-9297 *
DRYSDALE C M ET AL: "COMPLEX PROMOTER AND CODING REGION BETA2-ADRENERGIC RECEPTOR HAPLOTYPES ALTER RECEPTOR EXPRESSION AND PREDICT IN VIVO RESPONSIVENESS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 19, 12 September 2000 (2000-09-12), pages 10483 - 10488, XP002940094, ISSN: 0027-8424 *
EMILIEN G ET AL: "IMPACT OF GENOMICS ON DRUG DISCOVERY AND CLINICAL MEDICINE", QUARTERLY JOURNAL OF MEDICINE, CLARENDON PRESS, OXFORD, GB, vol. 93, no. 7, June 2000 (2000-06-01), pages 391 - 423, XP000941207, ISSN: 0033-5622 *
HATTORI M ET AL: "Association of neurotrophin-3 gene variant with severe forms of schizophrenia.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. UNITED STATES 17 APR 1995, vol. 209, no. 2, 17 April 1995 (1995-04-17), pages 513 - 518, XP001055072, ISSN: 0006-291X *
JONES K R ET AL: "Molecular cloning of a human gene that is a member of the nerve growth factor family.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES OCT 1990, vol. 87, no. 20, October 1990 (1990-10-01), pages 8060 - 8064, XP000159841, ISSN: 0027-8424 *
JUDSON R ET AL: "THE PREDICTIVE POWER OF HAPLOTYPES IN CLINICAL RESPONSE", PHARMACOGENOMICS, ASHLEY PUBLICATIONS, GB, vol. 1, no. 1, February 2000 (2000-02-01), pages 15 - 26, XP001113104, ISSN: 1462-2416 *
LU ANTONY Y H: "Drug-metabolism research challenges in the new millennium: Individual variability in drug therapy and drug safety.", DRUG METABOLISM AND DISPOSITION, vol. 26, no. 12, December 1998 (1998-12-01), pages 1217 - 1222, XP002223866, ISSN: 0090-9556 *
MAREZ D ET AL: "Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution", PHARMACOGENETICS, CHAPMAN & HALL, LONDON, GB, vol. 7, no. 3, 1997, pages 193 - 202, XP002955538, ISSN: 0960-314X *
ROSENTHAL A ET AL: "PRIMARY STRUCTURE AND BIOLOGICAL ACTIVITY OF A NOVEL HUMAN NEUROTROPHIC FACTOR", NEURON, CAMBRIDGE, MA, US, vol. 4, 1 May 1990 (1990-05-01), pages 767 - 773, XP000386322 *
RUANO G ET AL: "GENOTYPING AND HAPLOTYPING OF POLYMORPHISMS DIRECTLY FROM GENOMIC DNA VIA COUPLED AMPLIFICATION AND SEQUENCING (CAS)", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 19, no. 24, 1991, pages 6877 - 6882, XP000197814, ISSN: 0305-1048 *
RUANO: "Genaissance awarded broad patent on methods for collecting genes for variation analysis across populations", GENAISSANCE PRESS RELEASE, 8 November 1999 (1999-11-08), XP002229209, Retrieved from the Internet <URL:www.biomedicine.ch/publications/genaissance/g111199.html> [retrieved on 20030129] *
ULBRECHT M ET AL: "Assoziation of beta 2-adrenoreceptor variants with bronchial hyperresponsiveness", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 161, no. 2, February 2000 (2000-02-01), pages 469 - 474, XP002188594, ISSN: 1073-449X *

Also Published As

Publication number Publication date
AU2001294513A1 (en) 2002-02-18
WO2002012499A2 (en) 2002-02-14

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