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WO2002038586A3 - Haplotypes of the il6 gene - Google Patents

Haplotypes of the il6 gene Download PDF

Info

Publication number
WO2002038586A3
WO2002038586A3 PCT/US2001/047077 US0147077W WO0238586A3 WO 2002038586 A3 WO2002038586 A3 WO 2002038586A3 US 0147077 W US0147077 W US 0147077W WO 0238586 A3 WO0238586 A3 WO 0238586A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
haplotypes
disclosed
haplotyping
genotyping
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/047077
Other languages
French (fr)
Other versions
WO2002038586A2 (en
Inventor
Steven C Bentivegna
Karyn M Bieglecki
Anne Chew
R Rex Denton
Michael Lachowicz
Krishnan Nandabalan
Katie E Parks
Elizabeth Ann Sausker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2002228871A priority Critical patent/AU2002228871A1/en
Publication of WO2002038586A2 publication Critical patent/WO2002038586A2/en
Publication of WO2002038586A3 publication Critical patent/WO2002038586A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Novel genetic variants of the Interleukin-6 (IL6) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the IL6 gene. Compositions and methods for haplotyping and/or genotyping the IL6 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/047077 2000-11-09 2001-11-09 Haplotypes of the il6 gene Ceased WO2002038586A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002228871A AU2002228871A1 (en) 2000-11-09 2001-11-09 Haplotypes of the il6 gene

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24757800P 2000-11-09 2000-11-09
US60/247,578 2000-11-09
US31396301P 2001-08-21 2001-08-21
US60/313,963 2001-08-21

Publications (2)

Publication Number Publication Date
WO2002038586A2 WO2002038586A2 (en) 2002-05-16
WO2002038586A3 true WO2002038586A3 (en) 2002-11-07

Family

ID=26938770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047077 Ceased WO2002038586A2 (en) 2000-11-09 2001-11-09 Haplotypes of the il6 gene

Country Status (2)

Country Link
AU (1) AU2002228871A1 (en)
WO (1) WO2002038586A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005041896A2 (en) 2003-11-03 2005-05-12 Duke University Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521301A (en) * 1988-12-12 1996-05-28 City Of Hope Genotyping of multiple allele systems
US5851762A (en) * 1990-07-11 1998-12-22 Gene Type Ag Genomic mapping method by direct haplotyping using intron sequence analysis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521301A (en) * 1988-12-12 1996-05-28 City Of Hope Genotyping of multiple allele systems
US5851762A (en) * 1990-07-11 1998-12-22 Gene Type Ag Genomic mapping method by direct haplotyping using intron sequence analysis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BOWCOCK ET AL.: "The human 'interferon beta2/hepatocyte stimulating factor/interleukin 6' gene: DNA polymorphism studies and localization to chromosome 7p21", GENOMICS, vol. 3, 1988, pages 8 - 16, XP002950928 *
TERRY ET AL.: "Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation", J. BIOL. CHEM., vol. 275, no. 24, 16 June 2000 (2000-06-16), pages 18138 - 18144, XP002950929 *
YASUKAWA ET AL.: "Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene", EMBO J., vol. 6, no. 10, 1987, pages 2939 - 2945, XP002950930 *

Also Published As

Publication number Publication date
WO2002038586A2 (en) 2002-05-16
AU2002228871A1 (en) 2002-05-21

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