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WO2001077124A3 - Haplotypes of the apoa4 gene - Google Patents

Haplotypes of the apoa4 gene Download PDF

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Publication number
WO2001077124A3
WO2001077124A3 PCT/US2001/010670 US0110670W WO0177124A3 WO 2001077124 A3 WO2001077124 A3 WO 2001077124A3 US 0110670 W US0110670 W US 0110670W WO 0177124 A3 WO0177124 A3 WO 0177124A3
Authority
WO
WIPO (PCT)
Prior art keywords
apoa4
gene
haplotypes
disclosed
apoa4 gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/010670
Other languages
French (fr)
Other versions
WO2001077124A2 (en
Inventor
Steven C Bentivegna
Julie Y Choi
Stefanie E Kliem
Beena Koshy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2001251245A priority Critical patent/AU2001251245A1/en
Publication of WO2001077124A2 publication Critical patent/WO2001077124A2/en
Publication of WO2001077124A3 publication Critical patent/WO2001077124A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel single nucleotide polymorphisms in the human apolipoprotein A-IV (APOA4) gene are described. In addition, various genotypes, haplotypes and haplotype pairs for the APOA4 gene that exist in the population are described. Compositions and methods for haplotyping and/or genotyping the APOA4 gene in an individual are also disclosed. Polynucleotides containing one or more of the APOA4 polymorphisms disclosed herein are also described.
PCT/US2001/010670 2000-04-05 2001-04-03 Haplotypes of the apoa4 gene Ceased WO2001077124A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001251245A AU2001251245A1 (en) 2000-04-05 2001-04-03 Haplotypes of the apoa4 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19436200P 2000-04-05 2000-04-05
US60/194,362 2000-04-05

Publications (2)

Publication Number Publication Date
WO2001077124A2 WO2001077124A2 (en) 2001-10-18
WO2001077124A3 true WO2001077124A3 (en) 2002-10-03

Family

ID=22717288

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010670 Ceased WO2001077124A2 (en) 2000-04-05 2001-04-03 Haplotypes of the apoa4 gene

Country Status (2)

Country Link
AU (1) AU2001251245A1 (en)
WO (1) WO2001077124A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3979099A (en) 1998-05-11 1999-11-29 Philadelphia Health & Education Corporation (mct-1), a human oncogene
US20030113808A1 (en) * 2001-12-13 2003-06-19 George Jackowski Apolipoprotein biopolymer markers predictive of alzheimers disease
US20040005566A1 (en) * 2002-07-02 2004-01-08 Genelink, Inc. Kits and methods for assessing cardiovascular health
FR2893136A1 (en) * 2005-11-10 2007-05-11 Sanofi Aventis Sa METHODS OF DIAGNOSING HEPATIC DISEASES AND SCREENING MOLECULES FOR THE TREATMENT OF THESE DISEASES
KR20140071272A (en) * 2011-01-19 2014-06-11 유니버시티 오브 신시내티 Apolipoprotein aiv as an antidiabetic peptide

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CENARRO ET AL.: "Polymorphisms in the human apolipoproteins aiv gene detected by PCR and SSCP/heteroduplex analysis", MOLECULAR AND CELLULAR PROBES, vol. 12, 1998, pages 117 - 120, XP002949655 *
DATABASE GENBANK [online] 11 April 1996 (1996-04-11), XP002949654, Database accession no. J02758 *
DEEB ET AL.: "Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity", HUMAN MUTATION, vol. 8, 1996, pages 319 - 325, XP002949659 *
ELSHOURBAGY ET AL.: "Structure and expression of the human apolipoprotein A-IV gene", J. OF BIOL. CHEM., vol. 262, no. 17, 15 June 1987 (1987-06-15), pages 7973 - 7981, XP002949653 *
LOHSE ET AL.: "Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene", J. OF BIOL. CHEMISTRY, vol. 265, no. 17, 15 June 1990 (1990-06-15), pages 10061 - 10064, XP002949658 *
TENKANEN ET AL.: "A novel polymorphisms of apolipoprotein A-IV is the results of an asparagine to serine substitution at residue 127", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1138, 1992, pages 27 - 33, XP002949657 *
VON ECKARDSTEIN ET AL.: "Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-1 containing lipoproteins in a normal population", AMERICAN J. HUMAN GENETICS, vol. 50, 1992, pages 1115 - 1128, XP002949656 *

Also Published As

Publication number Publication date
WO2001077124A2 (en) 2001-10-18
AU2001251245A1 (en) 2001-10-23

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