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WO2001077363A3 - Haplotypes of the impdh2 gene - Google Patents

Haplotypes of the impdh2 gene Download PDF

Info

Publication number
WO2001077363A3
WO2001077363A3 PCT/US2001/011851 US0111851W WO0177363A3 WO 2001077363 A3 WO2001077363 A3 WO 2001077363A3 US 0111851 W US0111851 W US 0111851W WO 0177363 A3 WO0177363 A3 WO 0177363A3
Authority
WO
WIPO (PCT)
Prior art keywords
impdh2
gene
haplotypes
disclosed
impdh2 gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/011851
Other languages
French (fr)
Other versions
WO2001077363A2 (en
Inventor
Anne Chew
Julie Y Choi
Beena Koshy
Helen H Lee
J Claiborne Stephens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2001253386A priority Critical patent/AU2001253386A1/en
Publication of WO2001077363A2 publication Critical patent/WO2001077363A2/en
Publication of WO2001077363A3 publication Critical patent/WO2001077363A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Medical Informatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Novel single nucleotide polymorphisms in the human IMP dehydrogenase 2 (IMPDH2) gene are described. In addition, various genotypes, haplotypes and haplotype pairs for the IMPDH2 gene that exist in the population are described. Compositions and methods for haplotyping and/or genotyping the IMPDH2 gene in an individual are also disclosed. Polynucleotides containing one or more of the IMPDH2 polymorphisms disclosed herein are also described.
PCT/US2001/011851 2000-04-11 2001-04-11 Haplotypes of the impdh2 gene Ceased WO2001077363A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001253386A AU2001253386A1 (en) 2000-04-11 2001-04-11 Haplotypes of the impdh2 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19624800P 2000-04-11 2000-04-11
US60/196,248 2000-04-11

Publications (2)

Publication Number Publication Date
WO2001077363A2 WO2001077363A2 (en) 2001-10-18
WO2001077363A3 true WO2001077363A3 (en) 2002-03-14

Family

ID=22724608

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/011851 Ceased WO2001077363A2 (en) 2000-04-11 2001-04-11 Haplotypes of the impdh2 gene

Country Status (2)

Country Link
AU (1) AU2001253386A1 (en)
WO (1) WO2001077363A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1896614A1 (en) * 2005-06-13 2008-03-12 F. Hoffmann-La Roche Ag MDRl SNP IN ACUTE RETECTION
WO2006133842A1 (en) * 2005-06-13 2006-12-21 F.Hoffmann-La Roche Ag Impdh2 snp associated with acute rejection
WO2006133840A1 (en) * 2005-06-13 2006-12-21 F.Hoffmann-La Roche Ag Il10 snp associated with acute rejection

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GLESNE D.A. ET AL.: "Cloning and sequence of the human type II IMP dehydrogenase gene", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 205, November 1994 (1994-11-01), pages 537 - 544, XP002905466 *
LIGHTFOOT T. ET AL.: "Gene amplification and dual point mutations of mouse IMP dehydrogenase associated with cellular resistance to mycophenolic acid", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1217, 1994, pages 156 - 162, XP002905467 *

Also Published As

Publication number Publication date
WO2001077363A2 (en) 2001-10-18
AU2001253386A1 (en) 2001-10-23

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