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WO2002030951A3 - Haplotypes of the cyp1b1 gene - Google Patents

Haplotypes of the cyp1b1 gene Download PDF

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Publication number
WO2002030951A3
WO2002030951A3 PCT/US2001/042726 US0142726W WO0230951A3 WO 2002030951 A3 WO2002030951 A3 WO 2002030951A3 US 0142726 W US0142726 W US 0142726W WO 0230951 A3 WO0230951 A3 WO 0230951A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
cyp1b1
gene
disclosed
cyp1b1 gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/042726
Other languages
French (fr)
Other versions
WO2002030951A2 (en
Inventor
Jin-Hua Han
Stefanie E Kliem
Angela Sanchis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU1192102A priority Critical patent/AU1192102A/en
Publication of WO2002030951A2 publication Critical patent/WO2002030951A2/en
Publication of WO2002030951A3 publication Critical patent/WO2002030951A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Novel genetic variants of the Cytochrome P450, Subfamily I (Dioxin-Inducible), Polypeptide 1 (Glaucoma 3, Primary Infantile) (CYP1B1) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the CYP1B1 gene. Compositions and methods for haplotyping and/or genotyping the CYP1B1 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/042726 2000-10-13 2001-10-15 Haplotypes of the cyp1b1 gene Ceased WO2002030951A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU1192102A AU1192102A (en) 2000-10-13 2001-10-15 Haplotypes of the cyp1b1 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24021100P 2000-10-13 2000-10-13
US60/240,211 2000-10-13

Publications (2)

Publication Number Publication Date
WO2002030951A2 WO2002030951A2 (en) 2002-04-18
WO2002030951A3 true WO2002030951A3 (en) 2002-07-04

Family

ID=22905591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/042726 Ceased WO2002030951A2 (en) 2000-10-13 2001-10-15 Haplotypes of the cyp1b1 gene

Country Status (2)

Country Link
AU (1) AU1192102A (en)
WO (1) WO2002030951A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004683A2 (en) * 2000-07-11 2002-01-17 Vanderbilt University Method of detecting an increased susceptibility to breast cancer
WO2006137751A2 (en) * 2005-06-23 2006-12-28 Pomeranian Academy Of Medicine Methods, uses and compositions for detection of increased or decreased predisposition to various cancers by identification of specific genotypes of cyp1b1 gene
US20100280084A1 (en) * 2005-09-12 2010-11-04 Government of the US, as represented by the Secret ary, Department of Health and Human Services Cyp1B1 Genotype
PL2134876T3 (en) * 2006-06-22 2014-10-31 Pomorski Univ Medyczny Determining a predisposition to breast cancer by identification of genotype combinations of specific variants of the genes cyp1b1, brca2 and chek2
GB0803071D0 (en) 2008-02-20 2008-03-26 Care Technologies Inc Cancer detection methods and techniques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SUTTER T.R. ET AL.: "Complete cDNA sequence of a human dioxin-induble mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, May 1994 (1994-05-01), pages 13092 - 13099, XP000652286 *
TANG Y.M. ET AL.: "Isolation and characterization of the human cytochrome P450 CYP1B1 gene", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, November 1996 (1996-11-01), pages 28324 - 28330, XP002068982 *

Also Published As

Publication number Publication date
WO2002030951A2 (en) 2002-04-18
AU1192102A (en) 2002-04-22

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