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WO2002036608A3 - Haplotypes of the cyp1a2 gene - Google Patents

Haplotypes of the cyp1a2 gene Download PDF

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Publication number
WO2002036608A3
WO2002036608A3 PCT/US2001/042637 US0142637W WO0236608A3 WO 2002036608 A3 WO2002036608 A3 WO 2002036608A3 US 0142637 W US0142637 W US 0142637W WO 0236608 A3 WO0236608 A3 WO 0236608A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
cyp1a2
gene
disclosed
cyp1a2 gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/042637
Other languages
French (fr)
Other versions
WO2002036608A2 (en
Inventor
Steven C Bentivegna
Amir Kazemi
Beena Koshy
Katie E Parks
Eileen Rounds
Elizabeth Ann Sausker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2002230402A priority Critical patent/AU2002230402A1/en
Publication of WO2002036608A2 publication Critical patent/WO2002036608A2/en
Anticipated expiration legal-status Critical
Publication of WO2002036608A3 publication Critical patent/WO2002036608A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Novel genetic variants of the Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2 (CYP1A2) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the CYP1A2 gene. Compositions and methods for haplotyping and/or genotyping the CYP1A2 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/042637 2000-10-11 2001-10-11 Haplotypes of the cyp1a2 gene Ceased WO2002036608A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002230402A AU2002230402A1 (en) 2000-10-11 2001-10-11 Haplotypes of the cyp1a2 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23974000P 2000-10-11 2000-10-11
US60/239,740 2000-10-11

Publications (2)

Publication Number Publication Date
WO2002036608A2 WO2002036608A2 (en) 2002-05-10
WO2002036608A3 true WO2002036608A3 (en) 2003-12-11

Family

ID=22903513

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/042637 Ceased WO2002036608A2 (en) 2000-10-11 2001-10-11 Haplotypes of the cyp1a2 gene

Country Status (2)

Country Link
AU (1) AU2002230402A1 (en)
WO (1) WO2002036608A2 (en)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] CHEVALIER ET AL.: "Mutation and polymorphism report", XP002959386, Database accession no. (AH002667) *
HUMAN MUTATION. REPORT #233 ONLINE, April 2001 (2001-04-01) *
IKEYA ET AL.: "Human CYP1A2: Sequence, gene structure, comparison with the mouse and rat orthologous gene and differences in liver 1A2 mRNA expression", MOL. ENDOCRINOLOGY, vol. 3, no. 9, 1989, pages 1399 - 1408, XP002959388 *
RALLAN ET AL.: "Identification of novel polymorphisms within the cytochrome P450 1A2 (CYP1A2) gene", J. MEDICAL GENETICS, vol. 36, no. 591, SUPPL. 1, September 1999 (1999-09-01), pages S91, XP002959387 *

Also Published As

Publication number Publication date
WO2002036608A2 (en) 2002-05-10
AU2002230402A1 (en) 2002-05-15

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Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
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