[go: up one dir, main page]

WO2001090122A3 - Haplotypes of the ctla4 gene - Google Patents

Haplotypes of the ctla4 gene Download PDF

Info

Publication number
WO2001090122A3
WO2001090122A3 PCT/US2001/016905 US0116905W WO0190122A3 WO 2001090122 A3 WO2001090122 A3 WO 2001090122A3 US 0116905 W US0116905 W US 0116905W WO 0190122 A3 WO0190122 A3 WO 0190122A3
Authority
WO
WIPO (PCT)
Prior art keywords
haplotypes
ctla4
gene
disclosed
ctla4 gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/016905
Other languages
French (fr)
Other versions
WO2001090122A2 (en
Inventor
Anne Chew
Julie Y Choi
Chad Messer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2001264936A priority Critical patent/AU2001264936A1/en
Publication of WO2001090122A2 publication Critical patent/WO2001090122A2/en
Publication of WO2001090122A3 publication Critical patent/WO2001090122A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Novel genetic variants of the Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the CTLA4 gene. Compositions and methods for haplotyping and/or genotyping the CTLA4 gene in an individual are also disclosed. Polynucleotides defined by the sequence the haplotypes disclosed herein are also described.
PCT/US2001/016905 2000-05-23 2001-05-23 Haplotypes of the ctla4 gene Ceased WO2001090122A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001264936A AU2001264936A1 (en) 2000-05-23 2001-05-23 Haplotypes of the ctla4 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20635300P 2000-05-23 2000-05-23
US60/206,353 2000-05-23

Publications (2)

Publication Number Publication Date
WO2001090122A2 WO2001090122A2 (en) 2001-11-29
WO2001090122A3 true WO2001090122A3 (en) 2002-03-28

Family

ID=22765983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016905 Ceased WO2001090122A2 (en) 2000-05-23 2001-05-23 Haplotypes of the ctla4 gene

Country Status (2)

Country Link
AU (1) AU2001264936A1 (en)
WO (1) WO2001090122A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887471B1 (en) 1991-06-27 2005-05-03 Bristol-Myers Squibb Company Method to inhibit T cell interactions with soluble B7
US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
IL153593A0 (en) 2000-07-03 2003-07-06 Bristol Myers Squibb Co A pharmaceutical composition containing a soluble ctla4 mutant molecule
US20040091897A1 (en) * 2001-03-19 2004-05-13 John Todd Disease associated polymorphism in the ctla-4 locus
CZ305380B6 (en) 2001-05-23 2015-08-26 Bristol-Myers Squibb Company Medicament for inhibiting rejection of transplanted cells of pancreas islets
AU2003259093A1 (en) * 2003-07-09 2005-02-25 Cambridge University Technical Services Limited Novel splice variant of ctla-4
WO2007056466A2 (en) * 2005-11-08 2007-05-18 Avi Biopharma, Inc. Immunosuppression compound and treatment method
US8501704B2 (en) 2005-11-08 2013-08-06 Sarepta Therapeutics, Inc. Immunosuppression compound and treatment method

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE SNP [online] NATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION, NATIONAL LIBRARY OF MEDICINE, NIH (BETHESDA, MD, USA); 29 January 2001 (2001-01-29), XP002906081, accession no. NCBI Database accession no. CTLA4 *
DONNER ET AL.: "Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 82, no. 12, 1997, pages 4130 - 4132, XP002906076 *
LING ET AL.: "Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders", GENOMICS, vol. 60, 1999, pages 341 - 355, XP002906077 *

Also Published As

Publication number Publication date
AU2001264936A1 (en) 2001-12-03
WO2001090122A2 (en) 2001-11-29

Similar Documents

Publication Publication Date Title
WO2001090122A3 (en) Haplotypes of the ctla4 gene
WO2002050098A3 (en) Haplotypes of the prlr gene
WO2001087909A3 (en) Haplotypes of the aanat gene
WO2002012562A3 (en) Haplotypes of the pla2g1b gene
WO2001092278A3 (en) Haplotypes of the rlbp1 gene
WO2002002580A3 (en) Haplotypes of the etfb gene
WO2001090127A3 (en) Haplotypes of the hoxd3 gene
WO2001090118A3 (en) Haplotypes of the edn2 gene
WO2001090126A3 (en) Haplotypes of the snap29 gene
WO2002090378A3 (en) Haplotypes of the ces2 gene
WO2002032926A3 (en) Haplotypes of the ccbp2 gene
WO2002016399A3 (en) Haplotypes of the tacr1 gene
WO2002038587A3 (en) Haplotypes of the grm8 gene
WO2002012499A3 (en) Haplotypes of the ntf3 gene
WO2001087904A3 (en) Haplotypes of the gpr4 gene
WO2001087907A3 (en) Haplotypes of the osm gene
WO2001094362A3 (en) Haplotypes of the acp2 gene
WO2002094850A3 (en) Haplotypes of the gnrh2 gene
WO2002032924A3 (en) Haplotypes of the chrm5 gene
WO2002026766A3 (en) Haplotypes of the sstr4 gene
WO2001090128A3 (en) Haplotypes of the gpr3 gene
WO2002036609A3 (en) Haplotypes of the chrm4 gene
WO2002026765A3 (en) Haplotypes of the muc1 gene
WO2002042320A3 (en) Haplotypes of the gsr gene
WO2002020556A3 (en) Haplotypes of the gpr68 gene

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP