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WO2002063044A3 - Haplotypes of the il15 gene - Google Patents

Haplotypes of the il15 gene Download PDF

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Publication number
WO2002063044A3
WO2002063044A3 PCT/US2001/025470 US0125470W WO02063044A3 WO 2002063044 A3 WO2002063044 A3 WO 2002063044A3 US 0125470 W US0125470 W US 0125470W WO 02063044 A3 WO02063044 A3 WO 02063044A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
haplotypes
disclosed
haplotyping
genotyping
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/025470
Other languages
French (fr)
Other versions
WO2002063044A2 (en
Inventor
Alison E Anastasio
Anne Chew
R Rex Denton
Krishnan Nandabalan
J Claiborne Stephens
Charles Tirrell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/004130 external-priority patent/WO2001058914A2/en
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Publication of WO2002063044A2 publication Critical patent/WO2002063044A2/en
Anticipated expiration legal-status Critical
Publication of WO2002063044A3 publication Critical patent/WO2002063044A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Novel genetic variants of the Peroxisome Proliferator-Activated Receptor, Delta (IL15) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the IL15 gene. Compositions and methods for haplotyping and/or genotyping the IL15 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/025470 2001-02-08 2001-08-15 Haplotypes of the il15 gene Ceased WO2002063044A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2001/004130 WO2001058914A2 (en) 2000-02-08 2001-02-08 Haplotypes of the interleukin 15 gene
USPCT/US01/04130 2001-02-08

Publications (2)

Publication Number Publication Date
WO2002063044A2 WO2002063044A2 (en) 2002-08-15
WO2002063044A3 true WO2002063044A3 (en) 2004-02-26

Family

ID=21742326

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/025470 Ceased WO2002063044A2 (en) 2001-02-08 2001-08-15 Haplotypes of the il15 gene

Country Status (1)

Country Link
WO (1) WO2002063044A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1648931T3 (en) 2003-07-21 2011-03-07 Transgene Sa Multifunctional cytokines

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
WO2001058914A2 (en) * 2000-02-08 2001-08-16 Genaissance Pharmaceuticals, Inc. Haplotypes of the interleukin 15 gene
WO2001080156A1 (en) * 2000-04-18 2001-10-25 Genaissance Pharmaceuticals, Inc. Method and system for determining haplotypes from a collection of polymorphisms

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972614A (en) * 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
WO2001058914A2 (en) * 2000-02-08 2001-08-16 Genaissance Pharmaceuticals, Inc. Haplotypes of the interleukin 15 gene
WO2001080156A1 (en) * 2000-04-18 2001-10-25 Genaissance Pharmaceuticals, Inc. Method and system for determining haplotypes from a collection of polymorphisms

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
[online] "SNP", XP002229429, retrieved from DBSNP/NCBI Database accession no. rs1493012 *
[online] "SNP", XP002229430, retrieved from DBSNP/NCBI Database accession no. rs1493013 *
[online] 12 September 2000 (2000-09-12), BENNETT AND COWSERT: ""Antisense inhibition of interleukin-15 expression", XP002213638, retrieved from EBI Database accession no. AR087016 *
BADER J S: "THE RELATIVE POWER OF SNPS AND HAPLOTYPE AS GENETIC MARKERS FOR ASSOCIATION TESTS", PHARMACOGENOMICS, ASHLEY PUBLICATIONS, GB, vol. 2, no. 1, February 2001 (2001-02-01), pages 11 - 24, XP009002043, ISSN: 1462-2416 *
BIDWELL J L ET AL: "HUMAN CYTOKINE GENE NUCLEOTIDE SEQUENCE ALIGNMENTS, 1998", EUROPEAN JOURNAL OF IMMUNOGENETICS, OXFORD, GB, vol. 2/3, no. 25, April 1998 (1998-04-01), pages 83 - 265, XP001094797, ISSN: 0960-7420 *
CLAIBORNE STEPHENS J: "SINGLE-NUCLEOTIDE POLYMORPHISMS, HAPLOTYPES AND THEIR RELEVANCE TO PHARMACOGENTICS", MOLECULAR DIAGNOSIS, NAPERVILLE, IL, US, vol. 4, no. 4, 1999, pages 309 - 317, XP002937520, ISSN: 1084-8592 *
CLARK A G ET AL: "HAPLOTYPE STRUCTURE AND POPULATION GENETIC INFERENCES FROM NUCLEOTIDE- SEQUENCE VARIATION IN HUMAN LIPOPROTEIN LIPASE", AMERICAN JOURNAL OF HUMAN GENETICS, UNIVERSITY OF CHICAGO PRESS, CHICAGO,, US, vol. 63, 1998, pages 595 - 612, XP002937239, ISSN: 0002-9297 *
DRYSDALE C M ET AL: "Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 12 SEP 2000, vol. 97, no. 19, 12 September 2000 (2000-09-12), pages 10483 - 10488, XP002213210, ISSN: 0027-8424 *
JUDSON R ET AL: "NOTES FROM THE SNP VS. HAPLOTYPE FRONT", PHARMACOGENOMICS, ASHLEY PUBLICATIONS, GB, vol. 2, no. 1, 2001, pages 1 - 7, XP008009453, ISSN: 1462-2416 *
JUDSON R ET AL: "The predictive power of haplotypes in clinical response.", PHARMACOGENOMICS. ENGLAND FEB 2000, vol. 1, no. 1, February 2000 (2000-02-01), pages 15 - 26, XP002213209, ISSN: 1462-2416 *
KRAUSE H ET AL: "GENOMIC STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN INTERLEUKIN 15 GENE (IL-15)", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, vol. 8, no. 9, September 1996 (1996-09-01), pages 667 - 674, XP002946159, ISSN: 1043-4666 *
OESTREICHER P: "4th Annual Pharmacogenomics and Medicine Lectures.", PHARMACOGENOMICS. ENGLAND AUG 2001, vol. 2, no. 3, April 2001 (2001-04-01), pages 291 - 296, XP002229261, ISSN: 1462-2416 *
RUANO G ET AL: "GENOTYPING AND HAPLOTYPING OF POLYMORPHISMS DIRECTLY FROM GENOMIC DNA VIA COUPLED AMPLIFICATION AND SEQUENCING (CAS)", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 19, no. 24, 1991, pages 6877 - 6882, XP000197814, ISSN: 0305-1048 *
RUANO: "Genaissance Awarded Broad Patent On Methods For Collecting Genes For Variation Analysis Across Populations", GENAISSANCE PRESS RELEASE, 8 November 1999 (1999-11-08), XP002229209, Retrieved from the Internet <URL:WWW.biomedicine.ch/publications/genaissance/g111199.html> [retrieved on 20030226] *
STEPHENS J C ET AL: "Haplotype variation and linkage disequilibrium in 313 human genes.", SCIENCE. UNITED STATES 20 JUL 2001, vol. 293, no. 5529, 20 July 2001 (2001-07-20), pages 489 - 493, XP002229260, ISSN: 0036-8075 *
ULBRECHT M ET AL: "Assoziation of beta 2-adrenoreceptor variants with bronchial hyperresponsiveness", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 161, no. 2, February 2000 (2000-02-01), pages 469 - 474, XP002188594, ISSN: 1073-449X *

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Publication number Publication date
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