PE20030474A1 - Compuesto que inhibe la liberacion de citoquinas inflamatorias - Google Patents
Compuesto que inhibe la liberacion de citoquinas inflamatoriasInfo
- Publication number
- PE20030474A1 PE20030474A1 PE2002000925A PE2002000925A PE20030474A1 PE 20030474 A1 PE20030474 A1 PE 20030474A1 PE 2002000925 A PE2002000925 A PE 2002000925A PE 2002000925 A PE2002000925 A PE 2002000925A PE 20030474 A1 PE20030474 A1 PE 20030474A1
- Authority
- PE
- Peru
- Prior art keywords
- aryl
- alkyl
- pyrimidin
- fluorophenyl
- heteroaryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000004127 Cytokines Human genes 0.000 title abstract 2
- 108090000695 Cytokines Proteins 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- -1 4-FLUOROPHENYL Chemical class 0.000 abstract 4
- RQEUFEKYXDPUSK-UHFFFAOYSA-N 1-phenylethylamine Chemical compound CC(N)C1=CC=CC=C1 RQEUFEKYXDPUSK-UHFFFAOYSA-N 0.000 abstract 1
- 229940051880 analgesics and antipyretics pyrazolones Drugs 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE REFIERE A PIRIMIDIN-PIRAZOLONAS CONDENSADAS DE FORMULA I DONDE R ES H, O[CH2]kR3, NR4aR4b; R3 ES ALQUILO, HIDROCARBILO CICLICO, HETEROCICLILO, ARILO, HETEROARILO; k ES 0-5; R4a Y R4b SON H, -[C(R5aR5b)]xR6, R5a Y R5b SON H, OR7, N(R7)2, CO2R7, CON(R7)2, ALQUILO; R6 ES OR7, N(R7)2, CO2R7, CON(R7)2, ARILO, HETEROARILO; R7 ES H, ALQUILO, ARILO; x ES 0-5; R1 ES ARILO, HETEROARILO; R2a, R2b SON H, O(CH2)jR8, (CH2)jNR9aNR9b, (CH2)jCO2R10, (CH2)jOCO2R10, ENTRE OTROS, R8, R9a, R9b, R10 SON H, ALQUILO; R9a, R9b JUNTOS FORMAN UN ANILLO CARBOCICLICO, HETEROCICLICO DE 3 A 7 ATOMOS, O DOS R10 FORMAN JUNTOS UN ANILLO CARBOCICLICO, HETEROCICLICO; j ES 0-5; m Y n SON 1-5, m+n ES 0-6. SON COMPUESTOS PREFERIDOS ESTER METILICO DEL ACIDO 2-(4-FLUOROFENIL)-3-(2-METILSULFANIL-PIRIMIDIN-4-IL)-3-OXO-PROPIONICO; 2-(4-FLUOROFENIL)-3-[2(S)-(1-FENILETILAMINO)-PIRIMIDIN-4-IL]-5,10-DIHIDROPIRAZOLO[1,2-b]FTALAZIN-1-ONA; 2-(4-FLUOROFENIL)-3-[2-(1-FENILETILAMINO)-PIRIMIDIN-4-IL]-5,8-DIHIDROPIRAZOLO[1,2-a]PIRIDAZIN-1-ONA. LOS COMPUESTOS INIHIBEN LA LIBERACION EXTRACELULAR DE CITOQUINAS INFLAMATORIAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32362501P | 2001-09-20 | 2001-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030474A1 true PE20030474A1 (es) | 2003-07-22 |
Family
ID=23259997
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000923A PE20030430A1 (es) | 2001-09-20 | 2002-09-20 | 6,7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONAS QUE CONTROLAN CITOQUINAS INFLAMATORIAS |
| PE2002000925A PE20030474A1 (es) | 2001-09-20 | 2002-09-20 | Compuesto que inhibe la liberacion de citoquinas inflamatorias |
| PE2002000924A PE20030446A1 (es) | 2001-09-20 | 2002-09-20 | 6-7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONAS ESPIROCICLICAS QUE CONTROLAN CITOQUINAS INFLAMATORIAS |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000923A PE20030430A1 (es) | 2001-09-20 | 2002-09-20 | 6,7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONAS QUE CONTROLAN CITOQUINAS INFLAMATORIAS |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000924A PE20030446A1 (es) | 2001-09-20 | 2002-09-20 | 6-7-DIHIDRO-5H-PIRAZOLO[1,2-a]PIRAZOL-1-ONAS ESPIROCICLICAS QUE CONTROLAN CITOQUINAS INFLAMATORIAS |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US6566357B1 (es) |
| EP (3) | EP1427728B1 (es) |
| JP (3) | JP2005504083A (es) |
| KR (4) | KR100656126B1 (es) |
| CN (3) | CN1250551C (es) |
| AR (3) | AR037237A1 (es) |
| AT (3) | ATE287887T1 (es) |
| AU (2) | AU2002334641B2 (es) |
| BR (3) | BR0212905A (es) |
| CA (3) | CA2461071A1 (es) |
| CO (3) | CO5560590A2 (es) |
| CY (1) | CY1106398T1 (es) |
| CZ (3) | CZ2004361A3 (es) |
| DE (3) | DE60202782T2 (es) |
| DK (2) | DK1427732T3 (es) |
| EG (2) | EG24363A (es) |
| ES (3) | ES2282459T3 (es) |
| HU (3) | HUP0500752A2 (es) |
| IL (3) | IL160742A0 (es) |
| MA (3) | MA27066A1 (es) |
| MX (3) | MXPA04002569A (es) |
| MY (2) | MY129069A (es) |
| NO (2) | NO20041594L (es) |
| NZ (3) | NZ531123A (es) |
| PE (3) | PE20030430A1 (es) |
| PL (3) | PL370362A1 (es) |
| PT (3) | PT1427732E (es) |
| RU (3) | RU2278864C2 (es) |
| SA (1) | SA03230529B1 (es) |
| SK (3) | SK1492004A3 (es) |
| WO (3) | WO2003024970A1 (es) |
| ZA (3) | ZA200401260B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6849627B2 (en) | 2001-09-20 | 2005-02-01 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
| US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
| US7087615B2 (en) | 2001-09-20 | 2006-08-08 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia |
| US7473695B2 (en) * | 2001-10-22 | 2009-01-06 | Mitsubishi Tanabe Pharma Corporation | 4-imidazolin-2-one compounds |
| US6677337B2 (en) * | 2002-03-19 | 2004-01-13 | The Procter & Gamble Company | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines |
| AU2003273295B2 (en) * | 2002-09-09 | 2007-03-22 | Amgen Inc. | 1, 4, 5-substituted 1, 2-dihydro-pyrazol-3-one derivatives as TNF-alpha and interleukin lowering agents for the treatment of inflammation |
| WO2004087696A1 (de) * | 2003-04-03 | 2004-10-14 | Merck Patent Gmbh | Pirazolidin-1,2-dicarbonsaüre-1-((phenyl)-amid)-2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen |
| GB0308466D0 (en) * | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| US7482356B2 (en) * | 2003-11-10 | 2009-01-27 | The Procter & Gamble Company | Bicyclic pyrazolone cytokine inhibitors |
| KR20080111144A (ko) * | 2006-04-18 | 2008-12-22 | 아보트 러보러터리즈 | 바닐로이드 수용체 서브타입 １(ｖｒ１)의 길항제 및 이의 용도 |
| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| PT2432767E (pt) * | 2009-05-19 | 2013-07-25 | Dow Agrosciences Llc | Compostos e métodos para controlo de fungos |
| EP3308059B1 (en) | 2015-06-15 | 2021-05-26 | Cummins, Inc. | Combustion chamber elasticity device |
| WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
| CN107033090B (zh) * | 2017-05-16 | 2019-05-07 | 无锡捷化医药科技有限公司 | 一种1,2,3,4-四氢噌啉的制备方法 |
| RU2721684C1 (ru) * | 2019-09-06 | 2020-05-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" | Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты |
| EP4422621A4 (en) * | 2021-10-27 | 2025-08-27 | Merck Sharp & Dohme Llc | SPIROTRICYCLIC RIPK1 INHIBITORS AND METHODS OF USE THEREOF |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1054291A (es) | 1963-02-26 | |||
| GB1124982A (en) * | 1965-02-09 | 1968-08-21 | Lepetit Spa | Diazabicyclo octanes and derivatives thereof |
| CH529153A (fr) | 1969-10-27 | 1972-10-15 | Lepetit Spa | Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones |
| US5358924A (en) * | 1991-03-21 | 1994-10-25 | Bayer Aktiengesellschaft | 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use |
| WO1993023403A1 (en) * | 1992-05-15 | 1993-11-25 | Merrell Dow Pharmaceuticals Inc. | NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE |
| GB9303993D0 (en) * | 1993-02-26 | 1993-04-14 | Fujisawa Pharmaceutical Co | New heterocyclic derivatives |
| ES2259425T3 (es) * | 1999-09-07 | 2006-10-01 | Syngenta Participations Ag | Nuevos herbicidas. |
| US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
-
2002
- 2002-09-18 US US10/246,499 patent/US6566357B1/en not_active Expired - Fee Related
- 2002-09-18 US US10/245,927 patent/US6821971B2/en not_active Expired - Fee Related
- 2002-09-20 EP EP02763693A patent/EP1427728B1/en not_active Expired - Lifetime
- 2002-09-20 KR KR1020047004043A patent/KR100656126B1/ko not_active Expired - Fee Related
- 2002-09-20 AU AU2002334641A patent/AU2002334641B2/en not_active Expired - Fee Related
- 2002-09-20 PE PE2002000923A patent/PE20030430A1/es not_active Application Discontinuation
- 2002-09-20 DE DE60202782T patent/DE60202782T2/de not_active Expired - Lifetime
- 2002-09-20 ES ES02763693T patent/ES2282459T3/es not_active Expired - Lifetime
- 2002-09-20 IL IL16074202A patent/IL160742A0/xx unknown
- 2002-09-20 KR KR1020067006983A patent/KR20060036125A/ko not_active Ceased
- 2002-09-20 MY MYPI20023502A patent/MY129069A/en unknown
- 2002-09-20 HU HU0500752A patent/HUP0500752A2/hu unknown
- 2002-09-20 CZ CZ2004361A patent/CZ2004361A3/cs unknown
- 2002-09-20 DE DE60213108T patent/DE60213108T2/de not_active Expired - Fee Related
- 2002-09-20 IL IL16068202A patent/IL160682A0/xx unknown
- 2002-09-20 WO PCT/US2002/030134 patent/WO2003024970A1/en not_active Ceased
- 2002-09-20 WO PCT/US2002/030133 patent/WO2003024973A1/en not_active Ceased
- 2002-09-20 PE PE2002000925A patent/PE20030474A1/es not_active Application Discontinuation
- 2002-09-20 RU RU2004111805/04A patent/RU2278864C2/ru active
- 2002-09-20 DE DE60218704T patent/DE60218704T2/de not_active Expired - Lifetime
- 2002-09-20 SK SK149-2004A patent/SK1492004A3/sk unknown
- 2002-09-20 MX MXPA04002569A patent/MXPA04002569A/es active IP Right Grant
- 2002-09-20 DK DK02799017T patent/DK1427732T3/da active
- 2002-09-20 NZ NZ531123A patent/NZ531123A/en not_active IP Right Cessation
- 2002-09-20 CA CA002461071A patent/CA2461071A1/en not_active Abandoned
- 2002-09-20 SK SK150-2004A patent/SK1502004A3/sk unknown
- 2002-09-20 AT AT02763692T patent/ATE287887T1/de not_active IP Right Cessation
- 2002-09-20 JP JP2003528820A patent/JP2005504083A/ja active Pending
- 2002-09-20 PT PT02799017T patent/PT1427732E/pt unknown
- 2002-09-20 NZ NZ531063A patent/NZ531063A/en not_active IP Right Cessation
- 2002-09-20 MX MXPA04002570A patent/MXPA04002570A/es active IP Right Grant
- 2002-09-20 NZ NZ531122A patent/NZ531122A/en unknown
- 2002-09-20 DK DK02763693T patent/DK1427728T3/da active
- 2002-09-20 AR ARP020103550A patent/AR037237A1/es not_active Application Discontinuation
- 2002-09-20 AT AT02799017T patent/ATE332901T1/de not_active IP Right Cessation
- 2002-09-20 IL IL16074102A patent/IL160741A0/xx unknown
- 2002-09-20 ES ES02763692T patent/ES2237691T3/es not_active Expired - Lifetime
- 2002-09-20 BR BR0212905-1A patent/BR0212905A/pt not_active IP Right Cessation
- 2002-09-20 CN CNB028182294A patent/CN1250551C/zh not_active Expired - Fee Related
- 2002-09-20 PT PT02763693T patent/PT1427728E/pt unknown
- 2002-09-20 CA CA002461073A patent/CA2461073A1/en not_active Abandoned
- 2002-09-20 PL PL02370362A patent/PL370362A1/xx not_active Application Discontinuation
- 2002-09-20 BR BR0212716-4A patent/BR0212716A/pt not_active IP Right Cessation
- 2002-09-20 BR BR0212673-7A patent/BR0212673A/pt not_active IP Right Cessation
- 2002-09-20 HU HU0402378A patent/HUP0402378A3/hu unknown
- 2002-09-20 JP JP2003528817A patent/JP2005504081A/ja active Pending
- 2002-09-20 EP EP02799017A patent/EP1427732B1/en not_active Expired - Lifetime
- 2002-09-20 RU RU2004111803/04A patent/RU2299885C2/ru active
- 2002-09-20 AT AT02763693T patent/ATE356126T1/de not_active IP Right Cessation
- 2002-09-20 KR KR10-2004-7004046A patent/KR20040035837A/ko not_active Ceased
- 2002-09-20 CN CNB028182286A patent/CN1257905C/zh not_active Expired - Fee Related
- 2002-09-20 RU RU2004111806/04A patent/RU2272040C2/ru not_active IP Right Cessation
- 2002-09-20 EP EP02763692A patent/EP1427727B1/en not_active Expired - Lifetime
- 2002-09-20 ES ES02799017T patent/ES2268154T3/es not_active Expired - Lifetime
- 2002-09-20 PL PL02370415A patent/PL370415A1/xx not_active Application Discontinuation
- 2002-09-20 MY MYPI20023518A patent/MY129329A/en unknown
- 2002-09-20 CN CNB028183800A patent/CN1249066C/zh not_active Expired - Fee Related
- 2002-09-20 HU HU0402500A patent/HUP0402500A3/hu unknown
- 2002-09-20 PE PE2002000924A patent/PE20030446A1/es not_active Application Discontinuation
- 2002-09-20 JP JP2003528818A patent/JP2005504082A/ja active Pending
- 2002-09-20 WO PCT/US2002/030135 patent/WO2003024971A1/en not_active Ceased
- 2002-09-20 CA CA002461072A patent/CA2461072A1/en not_active Abandoned
- 2002-09-20 AR ARP020103548A patent/AR037145A1/es unknown
- 2002-09-20 SK SK148-2004A patent/SK1482004A3/sk unknown
- 2002-09-20 AU AU2002327690A patent/AU2002327690B2/en not_active Ceased
- 2002-09-20 AR ARP020103549A patent/AR037502A1/es not_active Application Discontinuation
- 2002-09-20 CZ CZ2004358A patent/CZ2004358A3/cs unknown
- 2002-09-20 CZ CZ2004345A patent/CZ2004345A3/cs unknown
- 2002-09-20 PT PT02763692T patent/PT1427727E/pt unknown
- 2002-09-20 MX MXPA04002574A patent/MXPA04002574A/es active IP Right Grant
- 2002-09-20 PL PL02370351A patent/PL370351A1/xx not_active Application Discontinuation
- 2002-09-20 KR KR1020047004045A patent/KR100623879B1/ko not_active Expired - Fee Related
- 2002-09-21 EG EG2002091037A patent/EG24363A/xx active
- 2002-09-21 EG EG2002091039A patent/EG24413A/xx active
-
2003
- 2003-01-26 SA SA3230529A patent/SA03230529B1/ar unknown
-
2004
- 2004-02-17 ZA ZA200401260A patent/ZA200401260B/en unknown
- 2004-02-20 ZA ZA200401402A patent/ZA200401402B/en unknown
- 2004-02-20 ZA ZA200401403A patent/ZA200401403B/en unknown
- 2004-03-09 CO CO04021425A patent/CO5560590A2/es not_active Application Discontinuation
- 2004-03-09 CO CO04021424A patent/CO5560589A2/es not_active Application Discontinuation
- 2004-03-10 MA MA27569A patent/MA27066A1/fr unknown
- 2004-03-10 MA MA27568A patent/MA27065A1/fr unknown
- 2004-03-10 MA MA27567A patent/MA27064A1/fr unknown
- 2004-03-12 CO CO04023010A patent/CO5560579A2/es not_active Application Discontinuation
- 2004-04-19 NO NO20041594A patent/NO20041594L/no not_active Application Discontinuation
- 2004-04-20 NO NO20041605A patent/NO20041605L/no not_active Application Discontinuation
-
2007
- 2007-03-20 CY CY20071100383T patent/CY1106398T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20030474A1 (es) | Compuesto que inhibe la liberacion de citoquinas inflamatorias | |
| AR011502A1 (es) | Un compuesto substituido de acido 4-hidroxi-fenilalcanoico con actividad agonista a ppar-gamma, un metodo para prepararlo una composicion farmaceutica que lo contiene y uso del compuesto para la fabricacion de un medicamento | |
| AR066528A1 (es) | Peptidos inhibidores de la replicacion del virus de la hepatitis c | |
| MEP61208A (en) | Novel compounds having inhibitory activity against sodium-dependant transporter | |
| ATE69224T1 (de) | Mit einer phenylgruppe und einer heterobicyclischen gruppe disubstituierte acetylene mit retinoidaehnlicher wirkung. | |
| DE60103697D1 (de) | Langwelligabsorbierende Bacteriochlorin-Alkyl-Aether- Analoge | |
| ES2038678T3 (es) | Procedimiento para la preparacion de n-(2-alquil-3-mercapto-glutaril)-alfamino-acidos. | |
| PE20020524A1 (es) | 7-oxo-piridopirimidinas como inhibidores de quinasas | |
| YU12992A (sh) | 2-amino-1,2,3,4,-tetrahidronaftaleni supstituisani u prstenu | |
| IS1726B (is) | Hliðstæðar aðferðir til framleiðslu á andróstenónafleiðu og milliefni notuð í aðferðunum | |
| DK0458387T3 (da) | Isochromanderivater | |
| ES2066266T3 (es) | Compuestos biciclicos. | |
| DK148804C (da) | Fremgangsmaade til fremstilling af 1,2,3,4-tetrahydroquinolin-4-oner | |
| NO305989B1 (no) | Kondenserte heterocykliske glutaminsyrederivater | |
| MX221794B (es) | Analogos de la vitamina d3 y proceso de preparacion de los mismos. | |
| ES2096628T3 (es) | Derivados heterociclicos. | |
| DK0481742T3 (da) | Piperazinderivater | |
| AU4219897A (en) | Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers | |
| EP0386778B1 (en) | Biphenyl derivatives | |
| ES2273619T1 (es) | Procedimiento de preparacion de derivados de feniltetrazol. | |
| YU48255B (sh) | Racemski ili optički aktivni izohinolin derivati, postupak za njihovo dobivanje i postupak za dobivanje farmaceutskih preparata koji ih sadrže | |
| ES552486A0 (es) | Un procedimiento para la obtencion de compuestos de 1-oxa-1-dertia cefalosporina. | |
| PE20020610A1 (es) | Compuestos hidroxietilamina tripeptidos mimeticos como inhibidores de la aspartil proteasa de vih | |
| DE69011714D1 (de) | Kalziumantagonisten. | |
| DK248287A (da) | Fremgangsmaade til fremstilling af chephalosporinderivater |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |