DK0458387T3 - Isochromanderivater - Google Patents
IsochromanderivaterInfo
- Publication number
- DK0458387T3 DK0458387T3 DK91201119.4T DK91201119T DK0458387T3 DK 0458387 T3 DK0458387 T3 DK 0458387T3 DK 91201119 T DK91201119 T DK 91201119T DK 0458387 T3 DK0458387 T3 DK 0458387T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- hydrogen
- group
- alkoxy
- hydroxy
- Prior art date
Links
- HEBMCVBCEDMUOF-UHFFFAOYSA-N isochromane Chemical compound C1=CC=C2COCCC2=C1 HEBMCVBCEDMUOF-UHFFFAOYSA-N 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- -1 methylenedioxy group Chemical group 0.000 abstract 3
- 125000001118 alkylidene group Chemical group 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000031229 Cardiomyopathies Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 206010042434 Sudden death Diseases 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000003384 isochromanyl group Chemical class C1(OCCC2=CC=CC=C12)* 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP90401407 | 1990-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0458387T3 true DK0458387T3 (da) | 1996-10-21 |
Family
ID=8205714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91201119.4T DK0458387T3 (da) | 1990-05-25 | 1991-05-10 | Isochromanderivater |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0458387B1 (da) |
| JP (1) | JPH04253970A (da) |
| KR (1) | KR910020004A (da) |
| AT (1) | ATE140001T1 (da) |
| AU (1) | AU643277B2 (da) |
| CA (1) | CA2042861A1 (da) |
| DE (1) | DE69120603T2 (da) |
| DK (1) | DK0458387T3 (da) |
| ES (1) | ES2091283T3 (da) |
| FI (1) | FI912400L (da) |
| GR (1) | GR3021084T3 (da) |
| IE (1) | IE73232B1 (da) |
| NZ (1) | NZ238243A (da) |
| PT (1) | PT97766B (da) |
| ZA (1) | ZA913691B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2176722A1 (en) * | 1993-12-28 | 1995-07-06 | Ruth E. Ten Brink | Heterocyclic compounds for the treatment of cns and cardiovascular disorders |
| US6951862B2 (en) | 1998-06-30 | 2005-10-04 | Neuromed Technologies, Inc. | Calcium channel blockers comprising two benzhydril moieties |
| US6943168B2 (en) | 1998-06-30 | 2005-09-13 | Neuromed Technologies Inc. | Calcium channel inhibitors comprising benzhydril spaced from piperazine |
| US6310059B1 (en) | 1998-06-30 | 2001-10-30 | Neuromed Technologies, Inc. | Fused ring calcium channel blockers |
| US6492375B2 (en) | 1998-06-30 | 2002-12-10 | Neuromed Technologies, Inc. | Partially saturated calcium channel blockers |
| US7186726B2 (en) | 1998-06-30 | 2007-03-06 | Neuromed Pharmaceuticals Ltd. | Preferentially substituted calcium channel blockers |
| US6011035A (en) | 1998-06-30 | 2000-01-04 | Neuromed Technologies Inc. | Calcium channel blockers |
| US6387897B1 (en) | 1998-06-30 | 2002-05-14 | Neuromed Technologies, Inc. | Preferentially substituted calcium channel blockers |
| EP2964611B1 (en) | 2013-03-08 | 2022-10-19 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Potent and selective inhibitors of monoamine transporters; method of making; and use thereof |
| EA201791804A1 (ru) * | 2015-02-11 | 2018-02-28 | Суновион Фармасьютикалз Инк. | Соединения 1-гетероциклил изохроманила и аналоги для лечения расстройств цнс |
| WO2019094856A1 (en) | 2017-11-13 | 2019-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Atypical inhibitors of monoamine transporters; method of making; and use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1552004A (en) * | 1976-05-26 | 1979-09-05 | Takeda Chemical Industries Ltd | Isochroman derivatives |
| EP0450689A1 (en) * | 1990-04-02 | 1991-10-09 | Akzo Nobel N.V. | New isochromane derivatives |
-
1991
- 1991-05-09 IE IE158991A patent/IE73232B1/en not_active IP Right Cessation
- 1991-05-10 DK DK91201119.4T patent/DK0458387T3/da active
- 1991-05-10 AT AT91201119T patent/ATE140001T1/de not_active IP Right Cessation
- 1991-05-10 EP EP91201119A patent/EP0458387B1/en not_active Expired - Lifetime
- 1991-05-10 DE DE69120603T patent/DE69120603T2/de not_active Expired - Fee Related
- 1991-05-10 ES ES91201119T patent/ES2091283T3/es not_active Expired - Lifetime
- 1991-05-15 ZA ZA913691A patent/ZA913691B/xx unknown
- 1991-05-17 FI FI912400A patent/FI912400L/fi not_active Application Discontinuation
- 1991-05-17 CA CA002042861A patent/CA2042861A1/en not_active Abandoned
- 1991-05-23 NZ NZ238243A patent/NZ238243A/en unknown
- 1991-05-24 PT PT97766A patent/PT97766B/pt not_active IP Right Cessation
- 1991-05-24 KR KR1019910008399A patent/KR910020004A/ko not_active Ceased
- 1991-05-24 JP JP3222510A patent/JPH04253970A/ja active Pending
- 1991-05-24 AU AU77334/91A patent/AU643277B2/en not_active Ceased
-
1996
- 1996-09-19 GR GR960402440T patent/GR3021084T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE911589A1 (en) | 1991-12-04 |
| CA2042861A1 (en) | 1991-11-26 |
| DE69120603D1 (de) | 1996-08-08 |
| PT97766B (pt) | 1998-10-30 |
| AU7733491A (en) | 1991-11-28 |
| GR3021084T3 (en) | 1996-12-31 |
| EP0458387A1 (en) | 1991-11-27 |
| NZ238243A (en) | 1992-12-23 |
| FI912400A7 (fi) | 1991-11-26 |
| ATE140001T1 (de) | 1996-07-15 |
| AU643277B2 (en) | 1993-11-11 |
| JPH04253970A (ja) | 1992-09-09 |
| ES2091283T3 (es) | 1996-11-01 |
| FI912400L (fi) | 1991-11-26 |
| DE69120603T2 (de) | 1997-01-02 |
| PT97766A (pt) | 1992-03-31 |
| IE73232B1 (en) | 1997-05-21 |
| EP0458387B1 (en) | 1996-07-03 |
| KR910020004A (ko) | 1991-12-19 |
| FI912400A0 (fi) | 1991-05-17 |
| ZA913691B (en) | 1992-02-26 |
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