PE20020610A1 - Compuestos hidroxietilamina tripeptidos mimeticos como inhibidores de la aspartil proteasa de vih - Google Patents
Compuestos hidroxietilamina tripeptidos mimeticos como inhibidores de la aspartil proteasa de vihInfo
- Publication number
- PE20020610A1 PE20020610A1 PE2001001170A PE2001001170A PE20020610A1 PE 20020610 A1 PE20020610 A1 PE 20020610A1 PE 2001001170 A PE2001001170 A PE 2001001170A PE 2001001170 A PE2001001170 A PE 2001001170A PE 20020610 A1 PE20020610 A1 PE 20020610A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- aspartile
- tripeptide
- mimetic
- hiv
- Prior art date
Links
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical class NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 title abstract 2
- 108091005804 Peptidases Proteins 0.000 title abstract 2
- 239000004365 Protease Substances 0.000 title abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- ZRALMJNLWLKCOK-SMOXQLQSSA-N (3S,4aS)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxamide Chemical compound C1N[C@@H](C[C@@H]2CCCCC12)C(=O)N ZRALMJNLWLKCOK-SMOXQLQSSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229950003188 isovaleryl diethylamide Drugs 0.000 abstract 2
- JTRIUPVSQUCCHH-UHFFFAOYSA-N $l^{1}-oxidanylsulfinylmethane Chemical class C[S](=O)=O JTRIUPVSQUCCHH-UHFFFAOYSA-N 0.000 abstract 1
- 101100294102 Caenorhabditis elegans nhr-2 gene Proteins 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 150000002485 inorganic esters Chemical group 0.000 abstract 1
- 150000002895 organic esters Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS HIDROXIETILAMINA TRIPEPTIDOS MIMETICOS DE FORMULA I DONDE R1 ES H, OH, NHR2 DONDE R2 ES H, ALQUILO, ALQUENILO, ALQUINILO, ARILALQUILO, HETEROCICLILALQUILO, CICLOALQUIL ALQUIL CARBONILO, ENTRE OTROS; R3 Y R4 SON ALQUILO O JUNTO AL CARBONO AL QUE ESTAN UNIDOS FORMAN UN CARBOCICLO; R5 ES ALQUIL, ARIL ALQUILO HETEROCICLIL ALQUILO; R4 Y R5 JUNTO A C Y S AL QUE ESTAN UNIDOS FORMAN UN HETEROCICLO; R6 ES ALQUILO, ARIL ALQUILO, HETEROCICLIL ALQUILO, ENTRE OTROS; R13 ES UN ESTER INORGANICO U ORGANICO; R15 ES ARILO. SON COMPUESTOS PREFERIDOS 2-[3(S)-[[N-BENZOIL-3-(METANOSULFONIL)-L-VALIL]-AMINO]-2(R)-HIDROXI-4-FENILBUTIL]-N-BENCIL-1,2,3,4,4a(S),5,6,7,8,8a(S)-DECAHIDRO-3(S)-ISOQUINOLINA-CARBOXAMIDA, N-TERC-BUTIL-2-[3(S)-[[N-[(9-FLUORFENI)-METOXI-CARBONIL]-3-(METANO-SULFONIL)-L-VALIL]-AMINO]-2(R)-HIDROXI-4-FENILBUTIL]-1,2,3,4,4a(S),5,6,7,8,8a(S)-DECAHIDRO-3(S)-ISOQUINOLINA-CARBOXAMIDA. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA ASPARTIL PROTEASA DE VIH.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0028483.6A GB0028483D0 (en) | 2000-11-22 | 2000-11-22 | Hydroxyethylamine HIV protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020610A1 true PE20020610A1 (es) | 2002-07-13 |
Family
ID=9903670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001001170A PE20020610A1 (es) | 2000-11-22 | 2001-11-22 | Compuestos hidroxietilamina tripeptidos mimeticos como inhibidores de la aspartil proteasa de vih |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6472404B1 (es) |
| EP (1) | EP1339692A1 (es) |
| JP (1) | JP2004520283A (es) |
| KR (1) | KR20030060953A (es) |
| CN (1) | CN1476436A (es) |
| AR (1) | AR031763A1 (es) |
| AU (2) | AU2954602A (es) |
| BG (1) | BG107839A (es) |
| BR (1) | BR0115566A (es) |
| CA (1) | CA2428459A1 (es) |
| CZ (1) | CZ20031667A3 (es) |
| EC (1) | ECSP034618A (es) |
| GB (1) | GB0028483D0 (es) |
| GT (1) | GT200100233A (es) |
| HU (1) | HUP0303007A2 (es) |
| IL (1) | IL155573A0 (es) |
| MA (1) | MA26966A1 (es) |
| MX (1) | MXPA03004534A (es) |
| NO (1) | NO20032290D0 (es) |
| NZ (1) | NZ525550A (es) |
| PA (1) | PA8533401A1 (es) |
| PE (1) | PE20020610A1 (es) |
| PL (1) | PL366704A1 (es) |
| RU (1) | RU2265016C2 (es) |
| SK (1) | SK7602003A3 (es) |
| UY (1) | UY27033A1 (es) |
| WO (1) | WO2002042277A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4953297B2 (ja) * | 2004-09-15 | 2012-06-13 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体 |
| UA87884C2 (uk) * | 2004-12-03 | 2009-08-25 | Мерк Энд Ко., Инк. | Безводна кристалічна калієва сіль інгібітора віл-інтегрази |
| BRPI0913986A2 (pt) * | 2008-03-26 | 2015-10-20 | Daiichi Sankyo Co Ltd | composto, composição farmacêutica, e, uso de um composto |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8927913D0 (en) | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| MX9308016A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
-
2000
- 2000-11-22 GB GBGB0028483.6A patent/GB0028483D0/en not_active Ceased
-
2001
- 2001-11-12 WO PCT/EP2001/013068 patent/WO2002042277A1/en not_active Ceased
- 2001-11-12 AU AU2954602A patent/AU2954602A/xx active Pending
- 2001-11-12 RU RU2003117468/04A patent/RU2265016C2/ru not_active IP Right Cessation
- 2001-11-12 NZ NZ525550A patent/NZ525550A/en unknown
- 2001-11-12 PL PL01366704A patent/PL366704A1/xx not_active Application Discontinuation
- 2001-11-12 KR KR10-2003-7006907A patent/KR20030060953A/ko not_active Ceased
- 2001-11-12 CZ CZ20031667A patent/CZ20031667A3/cs unknown
- 2001-11-12 IL IL15557301A patent/IL155573A0/xx unknown
- 2001-11-12 MX MXPA03004534A patent/MXPA03004534A/es active IP Right Grant
- 2001-11-12 EP EP01990405A patent/EP1339692A1/en not_active Withdrawn
- 2001-11-12 HU HU0303007A patent/HUP0303007A2/hu unknown
- 2001-11-12 AU AU2002229546A patent/AU2002229546B2/en not_active Ceased
- 2001-11-12 BR BR0115566-0A patent/BR0115566A/pt not_active IP Right Cessation
- 2001-11-12 JP JP2002544412A patent/JP2004520283A/ja active Pending
- 2001-11-12 SK SK760-2003A patent/SK7602003A3/sk unknown
- 2001-11-12 CA CA002428459A patent/CA2428459A1/en not_active Abandoned
- 2001-11-12 CN CNA018192890A patent/CN1476436A/zh active Pending
- 2001-11-20 US US09/999,082 patent/US6472404B1/en not_active Expired - Fee Related
- 2001-11-21 PA PA20018533401A patent/PA8533401A1/es unknown
- 2001-11-21 GT GT200100233A patent/GT200100233A/es unknown
- 2001-11-21 UY UY27033A patent/UY27033A1/es not_active Application Discontinuation
- 2001-11-21 AR ARP010105431A patent/AR031763A1/es unknown
- 2001-11-22 PE PE2001001170A patent/PE20020610A1/es not_active Application Discontinuation
-
2003
- 2003-05-21 EC EC2003004618A patent/ECSP034618A/es unknown
- 2003-05-21 NO NO20032290A patent/NO20032290D0/no unknown
- 2003-05-22 MA MA27172A patent/MA26966A1/fr unknown
- 2003-05-22 BG BG107839A patent/BG107839A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK7602003A3 (en) | 2004-01-08 |
| UY27033A1 (es) | 2002-06-20 |
| NZ525550A (en) | 2004-11-26 |
| WO2002042277A1 (en) | 2002-05-30 |
| BR0115566A (pt) | 2003-09-30 |
| AU2002229546B2 (en) | 2006-05-04 |
| JP2004520283A (ja) | 2004-07-08 |
| NO20032290L (no) | 2003-05-21 |
| ECSP034618A (es) | 2003-06-25 |
| CA2428459A1 (en) | 2002-05-30 |
| GB0028483D0 (en) | 2001-01-10 |
| KR20030060953A (ko) | 2003-07-16 |
| CN1476436A (zh) | 2004-02-18 |
| HUP0303007A2 (hu) | 2003-12-29 |
| PA8533401A1 (es) | 2002-10-31 |
| RU2265016C2 (ru) | 2005-11-27 |
| RU2003117468A (ru) | 2005-01-27 |
| BG107839A (bg) | 2004-06-30 |
| US6472404B1 (en) | 2002-10-29 |
| MXPA03004534A (es) | 2003-09-10 |
| NO20032290D0 (no) | 2003-05-21 |
| GT200100233A (es) | 2002-07-04 |
| EP1339692A1 (en) | 2003-09-03 |
| AU2954602A (en) | 2002-06-03 |
| IL155573A0 (en) | 2003-11-23 |
| PL366704A1 (en) | 2005-02-07 |
| AR031763A1 (es) | 2003-10-01 |
| MA26966A1 (fr) | 2004-12-20 |
| CZ20031667A3 (cs) | 2004-01-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200100755A1 (ru) | 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты | |
| EA200400815A1 (ru) | Контролируемый синтез зипразидона и его композиции | |
| ECSP034660A (es) | Derivados del novedoso carbamato de quinuclidina y las composiciones medicinales que los contienen | |
| EA200100971A1 (ru) | Новые соединения и композиции в качестве ингибиторов протеазы | |
| LU91196I2 (fr) | Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO). | |
| CO4940458A1 (es) | Novedosos inhibidores de urea n-sustituida de transferasa de proteina farnesilo | |
| FI970246A7 (fi) | Dihydrobentsofuraanit | |
| EA200100970A1 (ru) | Аминопроизводные как ингибиторы протеазы | |
| AR016429A1 (es) | Compuesto derivado de acido hidroxamico como inhibidores de metaloproteasa de matriz (mmp), composiciones farmaceuticas y formulaciones veterinarias, usopara la preparacion de composiciones y formulaciones, compuesto intermediario, procedimiento de preparacion del compuesto. | |
| PE20020566A1 (es) | DERIVADOS DE FENILACETAMIDO-PIRAZOLES COMO INHIBIDORES DE LA cdk/CICLINA QUINASA | |
| EA200201071A1 (ru) | Циклопентилзамещенные производные глутарамида в качестве ингибиторов нейтральной эндопептидазы | |
| CO5160347A1 (es) | Derivados de acido carbamico | |
| AR039226A2 (es) | Compuestos utiles como intermediarios de preparacion y procedimientos | |
| ES2213007T3 (es) | Derivados de 4,5-diaril-3(2h)-furanona como inhibidores de la ciclooxigenasa-2. | |
| CO4940477A1 (es) | Inhibidores de proteasa | |
| ES2133504T3 (es) | Derivados peptidicos del acido boronico con una actividad inhibidora de proteasa, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
| CO4950553A1 (es) | Compuestos de 7-tetrahidroisoquinolinas y procedimiento para su preparacion | |
| YU12992A (sh) | 2-amino-1,2,3,4,-tetrahidronaftaleni supstituisani u prstenu | |
| CO4950567A1 (es) | Inhibidores de proteasas dores de proteasas. | |
| PE20021018A1 (es) | DERIVADOS DE ß - CARBOLINA | |
| EA200300044A1 (ru) | Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции | |
| PE20020610A1 (es) | Compuestos hidroxietilamina tripeptidos mimeticos como inhibidores de la aspartil proteasa de vih | |
| ES553058A0 (es) | Procedimiento de preparacion de aminoacidos opticamente activos. | |
| PT97766A (pt) | Processo depreparacao de derivados de isocromano e de composicoes farmaceuticas que os contem | |
| ES2183434T3 (es) | Derivados de cromano sustituidos con carboxilo utiles como agonistas de adrenoreceptores. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |