NO20041594L - Spirysyklisk-6,7-dihydro-5H-pyrazolo[1,2 a]pyrazol-1-oner som styrer inflammatoriske cytokiner - Google Patents

Spirysyklisk-6,7-dihydro-5H-pyrazolo[1,2 a]pyrazol-1-oner som styrer inflammatoriske cytokiner

Info

Publication number: NO20041594L
Authority: NO; Norway
Prior art keywords: spirycyclic; pyrazolo; pyrazol; dihydro; inflammatory cytokines
Prior art date: 2001-09-20

Application number

NO20041594A

Other languages

English (en)

Inventor

Adam Golebiowski

Biswanath De

Matthew John Laufersweiler

Michael Phillip Clark

Jane Far-Jine Djung

Todd Andrew Brugel

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-20

Filing date

2004-04-19

Publication date

2004-06-21

2004-04-19 Application filed by Procter & Gamble filed Critical Procter & Gamble

2004-06-21 Publication of NO20041594L publication Critical patent/NO20041594L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO20041594A 2001-09-20 2004-04-19 Spirysyklisk-6,7-dihydro-5H-pyrazolo[1,2 a]pyrazol-1-oner som styrer inflammatoriske cytokiner NO20041594L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32362501P	2001-09-20	2001-09-20
PCT/US2002/030133 WO2003024973A1 (en)	2001-09-20	2002-09-20	Spirocyclic-6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Publications (1)

Publication Number	Publication Date
NO20041594L true NO20041594L (no)	2004-06-21

Family

ID=23259997

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20041594A NO20041594L (no)	2001-09-20	2004-04-19	Spirysyklisk-6,7-dihydro-5H-pyrazolo[1,2 a]pyrazol-1-oner som styrer inflammatoriske cytokiner
NO20041605A NO20041605L (no)	2001-09-20	2004-04-20	6,7-dihydro-5H-pyrazolo[1,2A)pyrazol-1-oner som styrer inflammatoriske cytokiner

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20041605A NO20041605L (no)	2001-09-20	2004-04-20	6,7-dihydro-5H-pyrazolo[1,2A)pyrazol-1-oner som styrer inflammatoriske cytokiner

Country Status (32)

Country	Link
US (2)	US6566357B1 (no)
EP (3)	EP1427727B1 (no)
JP (3)	JP2005504083A (no)
KR (4)	KR20060036125A (no)
CN (3)	CN1250551C (no)
AR (3)	AR037145A1 (no)
AT (3)	ATE356126T1 (no)
AU (2)	AU2002334641B2 (no)
BR (3)	BR0212716A (no)
CA (3)	CA2461071A1 (no)
CO (3)	CO5560590A2 (no)
CY (1)	CY1106398T1 (no)
CZ (3)	CZ2004345A3 (no)
DE (3)	DE60218704T2 (no)
DK (2)	DK1427732T3 (no)
EG (2)	EG24413A (no)
ES (3)	ES2237691T3 (no)
HU (3)	HUP0402500A3 (no)
IL (3)	IL160682A0 (no)
MA (3)	MA27066A1 (no)
MX (3)	MXPA04002570A (no)
MY (2)	MY129329A (no)
NO (2)	NO20041594L (no)
NZ (3)	NZ531063A (no)
PE (3)	PE20030474A1 (no)
PL (3)	PL370415A1 (no)
PT (3)	PT1427732E (no)
RU (3)	RU2299885C2 (no)
SA (1)	SA03230529B1 (no)
SK (3)	SK1492004A3 (no)
WO (3)	WO2003024971A1 (no)
ZA (3)	ZA200401260B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6849627B2 (en)	2001-09-20	2005-02-01	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7087615B2 (en)	2001-09-20	2006-08-08	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US6730668B2 (en) *	2001-09-20	2004-05-04	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7473695B2 (en) *	2001-10-22	2009-01-06	Mitsubishi Tanabe Pharma Corporation	4-imidazolin-2-one compounds
US6677337B2 (en) *	2002-03-19	2004-01-13	The Procter & Gamble Company	1,2-dihydropyrazol-3-ones which controls inflammatory cytokines
PL379544A1 (pl) *	2002-09-09	2006-10-02	Amgen Inc.	1,4,5-podstawione pochodne 1,2-dihydro-pirazol-3-onu i 3-alkoksy 1H-pirazolu jako środki obniżające poziom TNF-alfa oraz interleukin do leczenia stanów zapalnych
WO2004087696A1 (de) *	2003-04-03	2004-10-14	Merck Patent Gmbh	Pirazolidin-1,2-dicarbonsaüre-1-((phenyl)-amid)-2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen
GB0308466D0 (en)	2003-04-11	2003-05-21	Novartis Ag	Organic compounds
US7482356B2 (en) *	2003-11-10	2009-01-27	The Procter & Gamble Company	Bicyclic pyrazolone cytokine inhibitors
CN101426498A (zh) *	2006-04-18	2009-05-06	艾博特公司	香草素受体亚型1（vr1）的拮抗剂及其用途
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
PE20120325A1 (es) *	2009-05-19	2012-04-12	Dow Agrosciences Llc	Aminopirimidinas sustituidas con arilo como agentes fungicidas
WO2016205284A1 (en)	2015-06-15	2016-12-22	Cummins Inc.	Combustion chamber elasticity device
US20190060286A1 (en)	2016-02-29	2019-02-28	University Of Florida Research Foundation, Incorpo	Chemotherapeutic Methods
CN107033090B (zh) *	2017-05-16	2019-05-07	无锡捷化医药科技有限公司	一种1,2,3,4-四氢噌啉的制备方法
RU2721684C1 (ru) *	2019-09-06	2020-05-21	Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет"	Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты
EP4422621A4 (en) *	2021-10-27	2025-08-27	Merck Sharp & Dohme Llc	SPIROTRICYCLIC RIPK1 INHIBITORS AND METHODS OF USE THEREOF

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1054291A (no)	1963-02-26
GB1124982A (en) *	1965-02-09	1968-08-21	Lepetit Spa	Diazabicyclo octanes and derivatives thereof
CH529154A (fr)	1969-10-27	1972-10-15	Lepetit Spa	Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones
US5358924A (en) *	1991-03-21	1994-10-25	Bayer Aktiengesellschaft	3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use
HU223663B1 (hu) *	1992-05-15	2004-11-29	Merrel Dow Pharmaceuticals Inc.	Enkefalináz és ACE gátló hatású 9-[(2-acetil-tio-3-fenil)-propanoil-amino]-piridazo[1,2-a][1,2]diazepin-származékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
GB9303993D0 (en) *	1993-02-26	1993-04-14	Fujisawa Pharmaceutical Co	New heterocyclic derivatives
WO2001017972A2 (de) *	1999-09-07	2001-03-15	Syngenta Participations Ag	Neue herbizide
US6730668B2 (en) *	2001-09-20	2004-05-04	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

2002
- 2002-09-18 US US10/246,499 patent/US6566357B1/en not_active Expired - Fee Related
- 2002-09-18 US US10/245,927 patent/US6821971B2/en not_active Expired - Fee Related
- 2002-09-20 NZ NZ531063A patent/NZ531063A/en not_active IP Right Cessation
- 2002-09-20 CA CA002461071A patent/CA2461071A1/en not_active Abandoned
- 2002-09-20 CZ CZ2004345A patent/CZ2004345A3/cs unknown
- 2002-09-20 KR KR1020067006983A patent/KR20060036125A/ko not_active Ceased
- 2002-09-20 PT PT02799017T patent/PT1427732E/pt unknown
- 2002-09-20 CN CNB028182294A patent/CN1250551C/zh not_active Expired - Fee Related
- 2002-09-20 DE DE60218704T patent/DE60218704T2/de not_active Expired - Lifetime
- 2002-09-20 PE PE2002000925A patent/PE20030474A1/es not_active Application Discontinuation
- 2002-09-20 DK DK02799017T patent/DK1427732T3/da active
- 2002-09-20 AU AU2002334641A patent/AU2002334641B2/en not_active Expired - Fee Related
- 2002-09-20 RU RU2004111803/04A patent/RU2299885C2/ru active
- 2002-09-20 CZ CZ2004358A patent/CZ2004358A3/cs unknown
- 2002-09-20 CA CA002461073A patent/CA2461073A1/en not_active Abandoned
- 2002-09-20 NZ NZ531123A patent/NZ531123A/en not_active IP Right Cessation
- 2002-09-20 AU AU2002327690A patent/AU2002327690B2/en not_active Ceased
- 2002-09-20 AR ARP020103548A patent/AR037145A1/es unknown
- 2002-09-20 EP EP02763692A patent/EP1427727B1/en not_active Expired - Lifetime
- 2002-09-20 SK SK149-2004A patent/SK1492004A3/sk unknown
- 2002-09-20 RU RU2004111805/04A patent/RU2278864C2/ru active
- 2002-09-20 JP JP2003528820A patent/JP2005504083A/ja active Pending
- 2002-09-20 ES ES02763692T patent/ES2237691T3/es not_active Expired - Lifetime
- 2002-09-20 AT AT02763693T patent/ATE356126T1/de not_active IP Right Cessation
- 2002-09-20 JP JP2003528818A patent/JP2005504082A/ja active Pending
- 2002-09-20 PL PL02370415A patent/PL370415A1/xx not_active Application Discontinuation
- 2002-09-20 MY MYPI20023518A patent/MY129329A/en unknown
- 2002-09-20 AR ARP020103549A patent/AR037502A1/es not_active Application Discontinuation
- 2002-09-20 BR BR0212716-4A patent/BR0212716A/pt not_active IP Right Cessation
- 2002-09-20 EP EP02799017A patent/EP1427732B1/en not_active Expired - Lifetime
- 2002-09-20 EP EP02763693A patent/EP1427728B1/en not_active Expired - Lifetime
- 2002-09-20 CN CNB028182286A patent/CN1257905C/zh not_active Expired - Fee Related
- 2002-09-20 RU RU2004111806/04A patent/RU2272040C2/ru not_active IP Right Cessation
- 2002-09-20 AT AT02799017T patent/ATE332901T1/de not_active IP Right Cessation
- 2002-09-20 HU HU0402500A patent/HUP0402500A3/hu unknown
- 2002-09-20 BR BR0212905-1A patent/BR0212905A/pt not_active IP Right Cessation
- 2002-09-20 ES ES02763693T patent/ES2282459T3/es not_active Expired - Lifetime
- 2002-09-20 PT PT02763693T patent/PT1427728E/pt unknown
- 2002-09-20 AT AT02763692T patent/ATE287887T1/de not_active IP Right Cessation
- 2002-09-20 CZ CZ2004361A patent/CZ2004361A3/cs unknown
- 2002-09-20 MY MYPI20023502A patent/MY129069A/en unknown
- 2002-09-20 PL PL02370351A patent/PL370351A1/xx not_active Application Discontinuation
- 2002-09-20 NZ NZ531122A patent/NZ531122A/en unknown
- 2002-09-20 IL IL16068202A patent/IL160682A0/xx unknown
- 2002-09-20 HU HU0500752A patent/HUP0500752A2/hu unknown
- 2002-09-20 WO PCT/US2002/030135 patent/WO2003024971A1/en not_active Ceased
- 2002-09-20 MX MXPA04002570A patent/MXPA04002570A/es active IP Right Grant
- 2002-09-20 SK SK150-2004A patent/SK1502004A3/sk unknown
- 2002-09-20 WO PCT/US2002/030134 patent/WO2003024970A1/en not_active Ceased
- 2002-09-20 KR KR1020047004045A patent/KR100623879B1/ko not_active Expired - Fee Related
- 2002-09-20 JP JP2003528817A patent/JP2005504081A/ja active Pending
- 2002-09-20 WO PCT/US2002/030133 patent/WO2003024973A1/en not_active Ceased
- 2002-09-20 MX MXPA04002574A patent/MXPA04002574A/es active IP Right Grant
- 2002-09-20 DE DE60213108T patent/DE60213108T2/de not_active Expired - Fee Related
- 2002-09-20 IL IL16074202A patent/IL160742A0/xx unknown
- 2002-09-20 DE DE60202782T patent/DE60202782T2/de not_active Expired - Lifetime
- 2002-09-20 KR KR1020047004043A patent/KR100656126B1/ko not_active Expired - Fee Related
- 2002-09-20 PE PE2002000924A patent/PE20030446A1/es not_active Application Discontinuation
- 2002-09-20 PE PE2002000923A patent/PE20030430A1/es not_active Application Discontinuation
- 2002-09-20 CA CA002461072A patent/CA2461072A1/en not_active Abandoned
- 2002-09-20 CN CNB028183800A patent/CN1249066C/zh not_active Expired - Fee Related
- 2002-09-20 PL PL02370362A patent/PL370362A1/xx not_active Application Discontinuation
- 2002-09-20 IL IL16074102A patent/IL160741A0/xx unknown
- 2002-09-20 SK SK148-2004A patent/SK1482004A3/sk unknown
- 2002-09-20 KR KR10-2004-7004046A patent/KR20040035837A/ko not_active Ceased
- 2002-09-20 BR BR0212673-7A patent/BR0212673A/pt not_active IP Right Cessation
- 2002-09-20 ES ES02799017T patent/ES2268154T3/es not_active Expired - Lifetime
- 2002-09-20 PT PT02763692T patent/PT1427727E/pt unknown
- 2002-09-20 MX MXPA04002569A patent/MXPA04002569A/es active IP Right Grant
- 2002-09-20 HU HU0402378A patent/HUP0402378A3/hu unknown
- 2002-09-20 DK DK02763693T patent/DK1427728T3/da active
- 2002-09-20 AR ARP020103550A patent/AR037237A1/es not_active Application Discontinuation
- 2002-09-21 EG EG2002091039A patent/EG24413A/xx active
- 2002-09-21 EG EG2002091037A patent/EG24363A/xx active
2003
- 2003-01-26 SA SA3230529A patent/SA03230529B1/ar unknown
2004
- 2004-02-17 ZA ZA200401260A patent/ZA200401260B/en unknown
- 2004-02-20 ZA ZA200401402A patent/ZA200401402B/en unknown
- 2004-02-20 ZA ZA200401403A patent/ZA200401403B/en unknown
- 2004-03-09 CO CO04021425A patent/CO5560590A2/es not_active Application Discontinuation
- 2004-03-09 CO CO04021424A patent/CO5560589A2/es not_active Application Discontinuation
- 2004-03-10 MA MA27569A patent/MA27066A1/fr unknown
- 2004-03-10 MA MA27568A patent/MA27065A1/fr unknown
- 2004-03-10 MA MA27567A patent/MA27064A1/fr unknown
- 2004-03-12 CO CO04023010A patent/CO5560579A2/es not_active Application Discontinuation
- 2004-04-19 NO NO20041594A patent/NO20041594L/no not_active Application Discontinuation
- 2004-04-20 NO NO20041605A patent/NO20041605L/no not_active Application Discontinuation
2007
- 2007-03-20 CY CY20071100383T patent/CY1106398T1/el unknown

Also Published As

Publication number	Publication date
DK1427732T3 (da)	2006-10-30
DE60202782T2 (de)	2006-01-19
WO2003024970A1 (en)	2003-03-27
ZA200401260B (en)	2004-08-30
CN1555379A (zh)	2004-12-15
CN1249066C (zh)	2006-04-05
DE60213108D1 (de)	2006-08-24
MXPA04002570A (es)	2004-05-31
AR037237A1 (es)	2004-11-03
MA27065A1 (fr)	2004-12-20
NZ531122A (en)	2005-09-30
CN1555375A (zh)	2004-12-15
HUP0402378A3 (en)	2008-10-28
KR20040035837A (ko)	2004-04-29
CZ2004358A3 (cs)	2004-07-14
BR0212905A (pt)	2004-10-13
HUP0500752A2 (en)	2006-01-30
PE20030446A1 (es)	2003-07-21
CA2461072A1 (en)	2003-03-27
EP1427727B1 (en)	2005-01-26
MXPA04002574A (es)	2004-06-18
PT1427732E (pt)	2006-12-29
MY129069A (en)	2007-03-30
PE20030430A1 (es)	2003-06-24
ATE332901T1 (de)	2006-08-15
PT1427728E (pt)	2007-05-31
EG24363A (en)	2009-03-04
WO2003024971A1 (en)	2003-03-27
JP2005504082A (ja)	2005-02-10
MY129329A (en)	2007-03-30
CA2461073A1 (en)	2003-03-27
CO5560579A2 (es)	2005-09-30
IL160741A0 (en)	2004-08-31
EP1427728A1 (en)	2004-06-16
CN1556811A (zh)	2004-12-22
MXPA04002569A (es)	2004-05-31
CY1106398T1 (el)	2011-10-12
JP2005504081A (ja)	2005-02-10
ATE356126T1 (de)	2007-03-15
CZ2004361A3 (cs)	2004-07-14
ES2268154T3 (es)	2007-03-16
EP1427732B1 (en)	2006-07-12
KR20060036125A (ko)	2006-04-27
DE60218704D1 (de)	2007-04-19
ZA200401403B (en)	2004-08-30
RU2278864C2 (ru)	2006-06-27
MA27064A1 (fr)	2004-12-20
HK1071565A1 (en)	2005-07-22
AR037145A1 (es)	2004-10-27
EP1427727A1 (en)	2004-06-16
ZA200401402B (en)	2004-08-27
DE60218704T2 (de)	2007-11-08
RU2004111803A (ru)	2005-10-10
HUP0402500A2 (hu)	2005-03-29
CO5560589A2 (es)	2005-09-30
RU2004111806A (ru)	2005-03-27
HUP0402378A2 (hu)	2005-02-28
AU2002327690B2 (en)	2006-07-20
BR0212673A (pt)	2004-08-24
SK1482004A3 (en)	2004-08-03
ES2282459T3 (es)	2007-10-16
AU2002334641B2 (en)	2007-03-29
NO20041605L (no)	2004-06-21
EG24413A (en)	2009-05-25
PL370362A1 (en)	2005-05-16
US6821971B2 (en)	2004-11-23
CN1250551C (zh)	2006-04-12
CA2461071A1 (en)	2003-03-27
SA03230529B1 (ar)	2008-06-21
CZ2004345A3 (cs)	2004-06-16
KR100656126B1 (ko)	2006-12-12
PE20030474A1 (es)	2003-07-22
NZ531123A (en)	2006-08-31
RU2004111805A (ru)	2005-04-10
ATE287887T1 (de)	2005-02-15
DE60213108T2 (de)	2007-02-08
AR037502A1 (es)	2004-11-17
CO5560590A2 (es)	2005-09-30
US20030105084A1 (en)	2003-06-05
KR20040035835A (ko)	2004-04-29
KR100623879B1 (ko)	2006-09-19
EP1427732A1 (en)	2004-06-16
RU2272040C2 (ru)	2006-03-20
EP1427728B1 (en)	2007-03-07
KR20040035836A (ko)	2004-04-29
HK1071366A1 (en)	2005-07-15
DK1427728T3 (da)	2007-07-09
PL370415A1 (en)	2005-05-30
MA27066A1 (fr)	2004-12-20
IL160742A0 (en)	2004-08-31
SK1502004A3 (en)	2004-09-08
CN1257905C (zh)	2006-05-31
BR0212716A (pt)	2004-08-03
HUP0402500A3 (en)	2008-10-28
ES2237691T3 (es)	2005-08-01
WO2003024973A1 (en)	2003-03-27
JP2005504083A (ja)	2005-02-10
RU2299885C2 (ru)	2007-05-27
NZ531063A (en)	2007-08-31
SK1492004A3 (en)	2004-11-03
IL160682A0 (en)	2004-08-31
PT1427727E (pt)	2005-06-30
PL370351A1 (en)	2005-05-16
US6566357B1 (en)	2003-05-20
DE60202782D1 (de)	2005-03-03

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AU2002327093A1 (en)	2003-06-05	1,2-dihydro-2-oxo-1,8-naphthyridine derivative
IS7131A (is)	2004-01-29	Nýjar 2,4-díamínóþíasól afleiður
ITRM20010007U1 (it)	2002-07-12	Cronotermostato a controllo vocale
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