MA27066A1 - 6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES CONTRôLANT LES CYTOKINES INFLAMMATOIRES. - Google Patents
6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES CONTRôLANT LES CYTOKINES INFLAMMATOIRES.Info
- Publication number
- MA27066A1 MA27066A1 MA27569A MA27569A MA27066A1 MA 27066 A1 MA27066 A1 MA 27066A1 MA 27569 A MA27569 A MA 27569A MA 27569 A MA27569 A MA 27569A MA 27066 A1 MA27066 A1 MA 27066A1
- Authority
- MA
- Morocco
- Prior art keywords
- inflammatory cytokines
- taken together
- hydrogen
- pyrazolo
- pyrazol
- Prior art date
Links
- 102000004127 Cytokines Human genes 0.000 title abstract 3
- 108090000695 Cytokines Proteins 0.000 title abstract 3
- 230000002757 inflammatory effect Effects 0.000 title abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES QUI CONTROLENT LES CYTOKINES INFLAMMATOIRES THE PROCTER & GAMBLE COMPANY Invention de: CLARK Michael Philip LAUFER-SWEILER Matthew John DJUNG Jane Fra-Jine NATCHUS Michael George DE Biswanath Priorité: demande de brevet déposée aux Etats-Unis le 20 septembre 2002 sous le no. 60/323,625 La présente invention concerne des composés qui sont à même d'empêcher la libération extracellulaire de cytokines inflammatoires; lesdits composés comprenant toutes les formes énantiomères et diastéréomères et leurs sels acceptables au plan pharmaceutique ont la formule (I) dans laquelle R comprend des éthers ou des aminés; R1 est a) un groupe aryle substitué ou non substitué; ou b) un groupe hétéroaryle substitué ou non substitué; chaque unité R2 est choisie indépendamment dans le groupe constitué des suivants : a) l'hydrogène; b) -(CH2)jO(CH2)nR8; c) -(CH2)jNR9aR9b; d) -(CH2)jCO2R10; e) -(CH2)jOCO2R10; f) -(CH2)jCON(R10)2; g) -(CH2)jOCON(R10)2; h) deux unités R2 peuvent être prises conjointement pour former une unité carbonyle; i) et leurs mélanges; R8, R9a, R9b et R10 sont chacun indépendamment l'hydrogène, un groupe alkyle en C1-C4 et leurs mélanges; R9a et R9b peuvent être pris conjointement pour former un cycle carbocyclique ou hétérocyclique comprenant 3 à 7 atomes; deux unités R10 peuvent être pris conjointement pour former un cycle carbocyclique ou hétérocyclique comprenant 3 à 7 atomes; j est un indice de 0 à 5, n est un indice de 0 à 5; Z est O, S, NR11 ou NOR11; R11 est l'hydrogène ou un groupe alkyle en C1-C4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32362501P | 2001-09-20 | 2001-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA27066A1 true MA27066A1 (fr) | 2004-12-20 |
Family
ID=23259997
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA27569A MA27066A1 (fr) | 2001-09-20 | 2004-03-10 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES CONTRôLANT LES CYTOKINES INFLAMMATOIRES. |
| MA27568A MA27065A1 (fr) | 2001-09-20 | 2004-03-10 | Composes inhibant la liberation des cytokines inflammatoires. |
| MA27567A MA27064A1 (fr) | 2001-09-20 | 2004-03-10 | 6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones spirocycliques regulant les cytokines inflammatoires. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA27568A MA27065A1 (fr) | 2001-09-20 | 2004-03-10 | Composes inhibant la liberation des cytokines inflammatoires. |
| MA27567A MA27064A1 (fr) | 2001-09-20 | 2004-03-10 | 6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones spirocycliques regulant les cytokines inflammatoires. |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US6566357B1 (fr) |
| EP (3) | EP1427727B1 (fr) |
| JP (3) | JP2005504083A (fr) |
| KR (4) | KR20060036125A (fr) |
| CN (3) | CN1250551C (fr) |
| AR (3) | AR037145A1 (fr) |
| AT (3) | ATE356126T1 (fr) |
| AU (2) | AU2002334641B2 (fr) |
| BR (3) | BR0212716A (fr) |
| CA (3) | CA2461071A1 (fr) |
| CO (3) | CO5560590A2 (fr) |
| CY (1) | CY1106398T1 (fr) |
| CZ (3) | CZ2004345A3 (fr) |
| DE (3) | DE60218704T2 (fr) |
| DK (2) | DK1427732T3 (fr) |
| EG (2) | EG24413A (fr) |
| ES (3) | ES2237691T3 (fr) |
| HU (3) | HUP0402500A3 (fr) |
| IL (3) | IL160682A0 (fr) |
| MA (3) | MA27066A1 (fr) |
| MX (3) | MXPA04002570A (fr) |
| MY (2) | MY129329A (fr) |
| NO (2) | NO20041594L (fr) |
| NZ (3) | NZ531063A (fr) |
| PE (3) | PE20030474A1 (fr) |
| PL (3) | PL370415A1 (fr) |
| PT (3) | PT1427732E (fr) |
| RU (3) | RU2299885C2 (fr) |
| SA (1) | SA03230529B1 (fr) |
| SK (3) | SK1492004A3 (fr) |
| WO (3) | WO2003024971A1 (fr) |
| ZA (3) | ZA200401260B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6849627B2 (en) | 2001-09-20 | 2005-02-01 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
| US7087615B2 (en) | 2001-09-20 | 2006-08-08 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia |
| US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
| US7473695B2 (en) * | 2001-10-22 | 2009-01-06 | Mitsubishi Tanabe Pharma Corporation | 4-imidazolin-2-one compounds |
| US6677337B2 (en) * | 2002-03-19 | 2004-01-13 | The Procter & Gamble Company | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines |
| PL379544A1 (pl) * | 2002-09-09 | 2006-10-02 | Amgen Inc. | 1,4,5-podstawione pochodne 1,2-dihydro-pirazol-3-onu i 3-alkoksy 1H-pirazolu jako środki obniżające poziom TNF-alfa oraz interleukin do leczenia stanów zapalnych |
| WO2004087696A1 (fr) * | 2003-04-03 | 2004-10-14 | Merck Patent Gmbh | Derives de l'acide pyrazolidine-1,2-dicarboxylique-1-(phenylamide)-2-(phenylamide) comme inhibiteurs du facteur de coagulation xa dans le traitement de thromboses |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| US7482356B2 (en) * | 2003-11-10 | 2009-01-27 | The Procter & Gamble Company | Bicyclic pyrazolone cytokine inhibitors |
| CN101426498A (zh) * | 2006-04-18 | 2009-05-06 | 艾博特公司 | 香草素受体亚型1（vr1）的拮抗剂及其用途 |
| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| PE20120325A1 (es) * | 2009-05-19 | 2012-04-12 | Dow Agrosciences Llc | Aminopirimidinas sustituidas con arilo como agentes fungicidas |
| WO2016205284A1 (fr) | 2015-06-15 | 2016-12-22 | Cummins Inc. | Dispositif d'élasticité pour chambre de combustion |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| CN107033090B (zh) * | 2017-05-16 | 2019-05-07 | 无锡捷化医药科技有限公司 | 一种1,2,3,4-四氢噌啉的制备方法 |
| RU2721684C1 (ru) * | 2019-09-06 | 2020-05-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" | Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты |
| EP4422621A4 (fr) * | 2021-10-27 | 2025-08-27 | Merck Sharp & Dohme Llc | Inhibiteurs de ripk1 spirotricycliques et leurs procédés d'utilisation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1054291A (fr) | 1963-02-26 | |||
| GB1124982A (en) * | 1965-02-09 | 1968-08-21 | Lepetit Spa | Diazabicyclo octanes and derivatives thereof |
| CH529154A (fr) | 1969-10-27 | 1972-10-15 | Lepetit Spa | Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones |
| US5358924A (en) * | 1991-03-21 | 1994-10-25 | Bayer Aktiengesellschaft | 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use |
| HU223663B1 (hu) * | 1992-05-15 | 2004-11-29 | Merrel Dow Pharmaceuticals Inc. | Enkefalináz és ACE gátló hatású 9-[(2-acetil-tio-3-fenil)-propanoil-amino]-piridazo[1,2-a][1,2]diazepin-származékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények |
| GB9303993D0 (en) * | 1993-02-26 | 1993-04-14 | Fujisawa Pharmaceutical Co | New heterocyclic derivatives |
| WO2001017972A2 (fr) * | 1999-09-07 | 2001-03-15 | Syngenta Participations Ag | Nouveaux herbicides |
| US6730668B2 (en) * | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
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2002
- 2002-09-18 US US10/246,499 patent/US6566357B1/en not_active Expired - Fee Related
- 2002-09-18 US US10/245,927 patent/US6821971B2/en not_active Expired - Fee Related
- 2002-09-20 NZ NZ531063A patent/NZ531063A/en not_active IP Right Cessation
- 2002-09-20 CA CA002461071A patent/CA2461071A1/fr not_active Abandoned
- 2002-09-20 CZ CZ2004345A patent/CZ2004345A3/cs unknown
- 2002-09-20 KR KR1020067006983A patent/KR20060036125A/ko not_active Ceased
- 2002-09-20 PT PT02799017T patent/PT1427732E/pt unknown
- 2002-09-20 CN CNB028182294A patent/CN1250551C/zh not_active Expired - Fee Related
- 2002-09-20 DE DE60218704T patent/DE60218704T2/de not_active Expired - Lifetime
- 2002-09-20 PE PE2002000925A patent/PE20030474A1/es not_active Application Discontinuation
- 2002-09-20 DK DK02799017T patent/DK1427732T3/da active
- 2002-09-20 AU AU2002334641A patent/AU2002334641B2/en not_active Expired - Fee Related
- 2002-09-20 RU RU2004111803/04A patent/RU2299885C2/ru active
- 2002-09-20 CZ CZ2004358A patent/CZ2004358A3/cs unknown
- 2002-09-20 CA CA002461073A patent/CA2461073A1/fr not_active Abandoned
- 2002-09-20 NZ NZ531123A patent/NZ531123A/en not_active IP Right Cessation
- 2002-09-20 AU AU2002327690A patent/AU2002327690B2/en not_active Ceased
- 2002-09-20 AR ARP020103548A patent/AR037145A1/es unknown
- 2002-09-20 EP EP02763692A patent/EP1427727B1/fr not_active Expired - Lifetime
- 2002-09-20 SK SK149-2004A patent/SK1492004A3/sk unknown
- 2002-09-20 RU RU2004111805/04A patent/RU2278864C2/ru active
- 2002-09-20 JP JP2003528820A patent/JP2005504083A/ja active Pending
- 2002-09-20 ES ES02763692T patent/ES2237691T3/es not_active Expired - Lifetime
- 2002-09-20 AT AT02763693T patent/ATE356126T1/de not_active IP Right Cessation
- 2002-09-20 JP JP2003528818A patent/JP2005504082A/ja active Pending
- 2002-09-20 PL PL02370415A patent/PL370415A1/xx not_active Application Discontinuation
- 2002-09-20 MY MYPI20023518A patent/MY129329A/en unknown
- 2002-09-20 AR ARP020103549A patent/AR037502A1/es not_active Application Discontinuation
- 2002-09-20 BR BR0212716-4A patent/BR0212716A/pt not_active IP Right Cessation
- 2002-09-20 EP EP02799017A patent/EP1427732B1/fr not_active Expired - Lifetime
- 2002-09-20 EP EP02763693A patent/EP1427728B1/fr not_active Expired - Lifetime
- 2002-09-20 CN CNB028182286A patent/CN1257905C/zh not_active Expired - Fee Related
- 2002-09-20 RU RU2004111806/04A patent/RU2272040C2/ru not_active IP Right Cessation
- 2002-09-20 AT AT02799017T patent/ATE332901T1/de not_active IP Right Cessation
- 2002-09-20 HU HU0402500A patent/HUP0402500A3/hu unknown
- 2002-09-20 BR BR0212905-1A patent/BR0212905A/pt not_active IP Right Cessation
- 2002-09-20 ES ES02763693T patent/ES2282459T3/es not_active Expired - Lifetime
- 2002-09-20 PT PT02763693T patent/PT1427728E/pt unknown
- 2002-09-20 AT AT02763692T patent/ATE287887T1/de not_active IP Right Cessation
- 2002-09-20 CZ CZ2004361A patent/CZ2004361A3/cs unknown
- 2002-09-20 MY MYPI20023502A patent/MY129069A/en unknown
- 2002-09-20 PL PL02370351A patent/PL370351A1/xx not_active Application Discontinuation
- 2002-09-20 NZ NZ531122A patent/NZ531122A/en unknown
- 2002-09-20 IL IL16068202A patent/IL160682A0/xx unknown
- 2002-09-20 HU HU0500752A patent/HUP0500752A2/hu unknown
- 2002-09-20 WO PCT/US2002/030135 patent/WO2003024971A1/fr not_active Ceased
- 2002-09-20 MX MXPA04002570A patent/MXPA04002570A/es active IP Right Grant
- 2002-09-20 SK SK150-2004A patent/SK1502004A3/sk unknown
- 2002-09-20 WO PCT/US2002/030134 patent/WO2003024970A1/fr not_active Ceased
- 2002-09-20 KR KR1020047004045A patent/KR100623879B1/ko not_active Expired - Fee Related
- 2002-09-20 JP JP2003528817A patent/JP2005504081A/ja active Pending
- 2002-09-20 WO PCT/US2002/030133 patent/WO2003024973A1/fr not_active Ceased
- 2002-09-20 MX MXPA04002574A patent/MXPA04002574A/es active IP Right Grant
- 2002-09-20 DE DE60213108T patent/DE60213108T2/de not_active Expired - Fee Related
- 2002-09-20 IL IL16074202A patent/IL160742A0/xx unknown
- 2002-09-20 DE DE60202782T patent/DE60202782T2/de not_active Expired - Lifetime
- 2002-09-20 KR KR1020047004043A patent/KR100656126B1/ko not_active Expired - Fee Related
- 2002-09-20 PE PE2002000924A patent/PE20030446A1/es not_active Application Discontinuation
- 2002-09-20 PE PE2002000923A patent/PE20030430A1/es not_active Application Discontinuation
- 2002-09-20 CA CA002461072A patent/CA2461072A1/fr not_active Abandoned
- 2002-09-20 CN CNB028183800A patent/CN1249066C/zh not_active Expired - Fee Related
- 2002-09-20 PL PL02370362A patent/PL370362A1/xx not_active Application Discontinuation
- 2002-09-20 IL IL16074102A patent/IL160741A0/xx unknown
- 2002-09-20 SK SK148-2004A patent/SK1482004A3/sk unknown
- 2002-09-20 KR KR10-2004-7004046A patent/KR20040035837A/ko not_active Ceased
- 2002-09-20 BR BR0212673-7A patent/BR0212673A/pt not_active IP Right Cessation
- 2002-09-20 ES ES02799017T patent/ES2268154T3/es not_active Expired - Lifetime
- 2002-09-20 PT PT02763692T patent/PT1427727E/pt unknown
- 2002-09-20 MX MXPA04002569A patent/MXPA04002569A/es active IP Right Grant
- 2002-09-20 HU HU0402378A patent/HUP0402378A3/hu unknown
- 2002-09-20 DK DK02763693T patent/DK1427728T3/da active
- 2002-09-20 AR ARP020103550A patent/AR037237A1/es not_active Application Discontinuation
- 2002-09-21 EG EG2002091039A patent/EG24413A/xx active
- 2002-09-21 EG EG2002091037A patent/EG24363A/xx active
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2003
- 2003-01-26 SA SA3230529A patent/SA03230529B1/ar unknown
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2004
- 2004-02-17 ZA ZA200401260A patent/ZA200401260B/en unknown
- 2004-02-20 ZA ZA200401402A patent/ZA200401402B/en unknown
- 2004-02-20 ZA ZA200401403A patent/ZA200401403B/en unknown
- 2004-03-09 CO CO04021425A patent/CO5560590A2/es not_active Application Discontinuation
- 2004-03-09 CO CO04021424A patent/CO5560589A2/es not_active Application Discontinuation
- 2004-03-10 MA MA27569A patent/MA27066A1/fr unknown
- 2004-03-10 MA MA27568A patent/MA27065A1/fr unknown
- 2004-03-10 MA MA27567A patent/MA27064A1/fr unknown
- 2004-03-12 CO CO04023010A patent/CO5560579A2/es not_active Application Discontinuation
- 2004-04-19 NO NO20041594A patent/NO20041594L/no not_active Application Discontinuation
- 2004-04-20 NO NO20041605A patent/NO20041605L/no not_active Application Discontinuation
-
2007
- 2007-03-20 CY CY20071100383T patent/CY1106398T1/el unknown
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