DK1427728T3 - 6,7 -dihydro-5H-pyrazolo[1,2a]pyrazol-1-oner, som kontrollerer inflammatoriske cytokiner - Google Patents

6,7 -dihydro-5H-pyrazolo[1,2a]pyrazol-1-oner, som kontrollerer inflammatoriske cytokiner

Info

Publication number: DK1427728T3
Authority: DK; Denmark
Prior art keywords: pyrazolo; pyrazol; dihydro; inflammatory cytokines; controlling inflammatory
Prior art date: 2001-09-20

Application number

DK02763693T

Other languages

English (en)

Inventor

Michael Phillip Clark

Matthew John Laufersweiler

Jane Far-Jine Djung

Michael George Natchus

Biswanath De

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-20

Filing date

2002-09-20

Publication date

2007-07-09

2002-09-20 Application filed by Procter & Gamble filed Critical Procter & Gamble

2007-07-09 Application granted granted Critical

2007-07-09 Publication of DK1427728T3 publication Critical patent/DK1427728T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Immunology (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Diabetes (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK02763693T 2001-09-20 2002-09-20 6,7 -dihydro-5H-pyrazolo[1,2a]pyrazol-1-oner, som kontrollerer inflammatoriske cytokiner DK1427728T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32362501P	2001-09-20	2001-09-20
PCT/US2002/030135 WO2003024971A1 (en)	2001-09-20	2002-09-20	6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Publications (1)

Publication Number	Publication Date
DK1427728T3 true DK1427728T3 (da)	2007-07-09

Family

ID=23259997

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK02799017T DK1427732T3 (da)	2001-09-20	2002-09-20	Spirocyclisk-6,7-dihydro-5H-pyrazolo[1,2-a] pyrazol-1-oner som kontrollerer inflammatoriske cytokiner
DK02763693T DK1427728T3 (da)	2001-09-20	2002-09-20	6,7 -dihydro-5H-pyrazolo[1,2a]pyrazol-1-oner, som kontrollerer inflammatoriske cytokiner

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK02799017T DK1427732T3 (da)	2001-09-20	2002-09-20	Spirocyclisk-6,7-dihydro-5H-pyrazolo[1,2-a] pyrazol-1-oner som kontrollerer inflammatoriske cytokiner

Country Status (32)

Country	Link
US (2)	US6821971B2 (da)
EP (3)	EP1427727B1 (da)
JP (3)	JP2005504082A (da)
KR (4)	KR20060036125A (da)
CN (3)	CN1250551C (da)
AR (3)	AR037502A1 (da)
AT (3)	ATE332901T1 (da)
AU (2)	AU2002327690B2 (da)
BR (3)	BR0212716A (da)
CA (3)	CA2461072A1 (da)
CO (3)	CO5560589A2 (da)
CY (1)	CY1106398T1 (da)
CZ (3)	CZ2004345A3 (da)
DE (3)	DE60202782T2 (da)
DK (2)	DK1427732T3 (da)
EG (2)	EG24413A (da)
ES (3)	ES2282459T3 (da)
HU (3)	HUP0402378A3 (da)
IL (3)	IL160682A0 (da)
MA (3)	MA27065A1 (da)
MX (3)	MXPA04002569A (da)
MY (2)	MY129329A (da)
NO (2)	NO20041594L (da)
NZ (3)	NZ531122A (da)
PE (3)	PE20030446A1 (da)
PL (3)	PL370415A1 (da)
PT (3)	PT1427732E (da)
RU (3)	RU2272040C2 (da)
SA (1)	SA03230529B1 (da)
SK (3)	SK1492004A3 (da)
WO (3)	WO2003024973A1 (da)
ZA (3)	ZA200401260B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6849627B2 (en)	2001-09-20	2005-02-01	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7087615B2 (en)	2001-09-20	2006-08-08	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US6730668B2 (en) *	2001-09-20	2004-05-04	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7473695B2 (en) *	2001-10-22	2009-01-06	Mitsubishi Tanabe Pharma Corporation	4-imidazolin-2-one compounds
US6677337B2 (en) *	2002-03-19	2004-01-13	The Procter & Gamble Company	1,2-dihydropyrazol-3-ones which controls inflammatory cytokines
US6967254B2 (en) *	2002-09-09	2005-11-22	Amgen Inc.	Substituted heterocyclic compounds and methods of use
US7557102B2 (en) *	2003-04-03	2009-07-07	Merck Patent Gmbh	Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses
GB0308466D0 (en)	2003-04-11	2003-05-21	Novartis Ag	Organic compounds
US7482356B2 (en) *	2003-11-10	2009-01-27	The Procter & Gamble Company	Bicyclic pyrazolone cytokine inhibitors
BRPI0710507A2 (pt) *	2006-04-18	2011-08-16	Abbott Lab	Antagonistas do receptor vanilóide de subtipo 1 (vr1) e usos destes
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
KR20120016247A (ko) *	2009-05-19	2012-02-23	다우 아그로사이언시즈 엘엘씨	진균 방제를 위한 화합물 및 방법
EP3308059B1 (en)	2015-06-15	2021-05-26	Cummins, Inc.	Combustion chamber elasticity device
WO2017151409A1 (en)	2016-02-29	2017-09-08	University Of Florida Research Foundation, Incorporated	Chemotherapeutic methods
CN107033090B (zh) *	2017-05-16	2019-05-07	无锡捷化医药科技有限公司	一种1,2,3,4-四氢噌啉的制备方法
RU2721684C1 (ru) *	2019-09-06	2020-05-21	Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет"	Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты
WO2023076133A1 (en) *	2021-10-27	2023-05-04	Merck Sharp & Dohme Llc	Spirotricycle ripk1 inhibitors and methods of uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1054291A (da) *	1963-02-26
GB1124982A (en) *	1965-02-09	1968-08-21	Lepetit Spa	Diazabicyclo octanes and derivatives thereof
CH529154A (fr)	1969-10-27	1972-10-15	Lepetit Spa	Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones
US5358924A (en) *	1991-03-21	1994-10-25	Bayer Aktiengesellschaft	3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use
KR100281450B1 (ko) *	1992-05-15	2001-02-01	슈테펜 엘. 네스비트	엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 신규 메르캅토아세틸아미도 피리다조[1,2]피리다진, 피라졸로[1,2]피리다진, 피리다조[1,2-a][1,2]디아제핀 및 피라졸로[1,2-a][1,2]디아제핀 유도체
GB9303993D0 (en) *	1993-02-26	1993-04-14	Fujisawa Pharmaceutical Co	New heterocyclic derivatives
DK1481970T3 (da) *	1999-09-07	2006-07-31	Syngenta Participations Ag	Nye herbicider
US6730668B2 (en) *	2001-09-20	2004-05-04	The Procter & Gamble Company	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

2002
- 2002-09-18 US US10/245,927 patent/US6821971B2/en not_active Expired - Fee Related
- 2002-09-18 US US10/246,499 patent/US6566357B1/en not_active Expired - Fee Related
- 2002-09-20 KR KR1020067006983A patent/KR20060036125A/ko not_active Ceased
- 2002-09-20 ES ES02763693T patent/ES2282459T3/es not_active Expired - Lifetime
- 2002-09-20 RU RU2004111806/04A patent/RU2272040C2/ru not_active IP Right Cessation
- 2002-09-20 MY MYPI20023518A patent/MY129329A/en unknown
- 2002-09-20 CN CNB028182294A patent/CN1250551C/zh not_active Expired - Fee Related
- 2002-09-20 MX MXPA04002569A patent/MXPA04002569A/es active IP Right Grant
- 2002-09-20 CN CNB028182286A patent/CN1257905C/zh not_active Expired - Fee Related
- 2002-09-20 NZ NZ531122A patent/NZ531122A/en unknown
- 2002-09-20 EP EP02763692A patent/EP1427727B1/en not_active Expired - Lifetime
- 2002-09-20 AR ARP020103549A patent/AR037502A1/es not_active Application Discontinuation
- 2002-09-20 IL IL16068202A patent/IL160682A0/xx unknown
- 2002-09-20 EP EP02763693A patent/EP1427728B1/en not_active Expired - Lifetime
- 2002-09-20 RU RU2004111803/04A patent/RU2299885C2/ru active
- 2002-09-20 PT PT02799017T patent/PT1427732E/pt unknown
- 2002-09-20 WO PCT/US2002/030133 patent/WO2003024973A1/en not_active Ceased
- 2002-09-20 PL PL02370415A patent/PL370415A1/xx not_active Application Discontinuation
- 2002-09-20 NZ NZ531063A patent/NZ531063A/en not_active IP Right Cessation
- 2002-09-20 CZ CZ2004345A patent/CZ2004345A3/cs unknown
- 2002-09-20 MY MYPI20023502A patent/MY129069A/en unknown
- 2002-09-20 BR BR0212716-4A patent/BR0212716A/pt not_active IP Right Cessation
- 2002-09-20 PE PE2002000924A patent/PE20030446A1/es not_active Application Discontinuation
- 2002-09-20 ES ES02799017T patent/ES2268154T3/es not_active Expired - Lifetime
- 2002-09-20 SK SK149-2004A patent/SK1492004A3/sk unknown
- 2002-09-20 PL PL02370362A patent/PL370362A1/xx not_active Application Discontinuation
- 2002-09-20 AT AT02799017T patent/ATE332901T1/de not_active IP Right Cessation
- 2002-09-20 DK DK02799017T patent/DK1427732T3/da active
- 2002-09-20 CZ CZ2004361A patent/CZ2004361A3/cs unknown
- 2002-09-20 SK SK148-2004A patent/SK1482004A3/sk unknown
- 2002-09-20 AR ARP020103550A patent/AR037237A1/es not_active Application Discontinuation
- 2002-09-20 CN CNB028183800A patent/CN1249066C/zh not_active Expired - Fee Related
- 2002-09-20 CA CA002461072A patent/CA2461072A1/en not_active Abandoned
- 2002-09-20 DE DE60202782T patent/DE60202782T2/de not_active Expired - Lifetime
- 2002-09-20 HU HU0402378A patent/HUP0402378A3/hu unknown
- 2002-09-20 AU AU2002327690A patent/AU2002327690B2/en not_active Ceased
- 2002-09-20 DE DE60213108T patent/DE60213108T2/de not_active Expired - Fee Related
- 2002-09-20 KR KR1020047004043A patent/KR100656126B1/ko not_active Expired - Fee Related
- 2002-09-20 PT PT02763692T patent/PT1427727E/pt unknown
- 2002-09-20 KR KR1020047004045A patent/KR100623879B1/ko not_active Expired - Fee Related
- 2002-09-20 JP JP2003528818A patent/JP2005504082A/ja active Pending
- 2002-09-20 IL IL16074202A patent/IL160742A0/xx unknown
- 2002-09-20 DK DK02763693T patent/DK1427728T3/da active
- 2002-09-20 AT AT02763693T patent/ATE356126T1/de not_active IP Right Cessation
- 2002-09-20 PE PE2002000923A patent/PE20030430A1/es not_active Application Discontinuation
- 2002-09-20 SK SK150-2004A patent/SK1502004A3/sk unknown
- 2002-09-20 PE PE2002000925A patent/PE20030474A1/es not_active Application Discontinuation
- 2002-09-20 ES ES02763692T patent/ES2237691T3/es not_active Expired - Lifetime
- 2002-09-20 DE DE60218704T patent/DE60218704T2/de not_active Expired - Lifetime
- 2002-09-20 AR ARP020103548A patent/AR037145A1/es unknown
- 2002-09-20 JP JP2003528820A patent/JP2005504083A/ja active Pending
- 2002-09-20 RU RU2004111805/04A patent/RU2278864C2/ru active
- 2002-09-20 IL IL16074102A patent/IL160741A0/xx unknown
- 2002-09-20 AT AT02763692T patent/ATE287887T1/de not_active IP Right Cessation
- 2002-09-20 AU AU2002334641A patent/AU2002334641B2/en not_active Expired - Fee Related
- 2002-09-20 JP JP2003528817A patent/JP2005504081A/ja active Pending
- 2002-09-20 BR BR0212905-1A patent/BR0212905A/pt not_active IP Right Cessation
- 2002-09-20 MX MXPA04002570A patent/MXPA04002570A/es active IP Right Grant
- 2002-09-20 CA CA002461071A patent/CA2461071A1/en not_active Abandoned
- 2002-09-20 HU HU0500752A patent/HUP0500752A2/hu unknown
- 2002-09-20 EP EP02799017A patent/EP1427732B1/en not_active Expired - Lifetime
- 2002-09-20 CA CA002461073A patent/CA2461073A1/en not_active Abandoned
- 2002-09-20 NZ NZ531123A patent/NZ531123A/en not_active IP Right Cessation
- 2002-09-20 BR BR0212673-7A patent/BR0212673A/pt not_active IP Right Cessation
- 2002-09-20 PL PL02370351A patent/PL370351A1/xx not_active Application Discontinuation
- 2002-09-20 HU HU0402500A patent/HUP0402500A3/hu unknown
- 2002-09-20 WO PCT/US2002/030135 patent/WO2003024971A1/en not_active Ceased
- 2002-09-20 PT PT02763693T patent/PT1427728E/pt unknown
- 2002-09-20 MX MXPA04002574A patent/MXPA04002574A/es active IP Right Grant
- 2002-09-20 CZ CZ2004358A patent/CZ2004358A3/cs unknown
- 2002-09-20 WO PCT/US2002/030134 patent/WO2003024970A1/en not_active Ceased
- 2002-09-20 KR KR10-2004-7004046A patent/KR20040035837A/ko not_active Ceased
- 2002-09-21 EG EG2002091039A patent/EG24413A/xx active
- 2002-09-21 EG EG2002091037A patent/EG24363A/xx active
2003
- 2003-01-26 SA SA3230529A patent/SA03230529B1/ar unknown
2004
- 2004-02-17 ZA ZA200401260A patent/ZA200401260B/en unknown
- 2004-02-20 ZA ZA200401403A patent/ZA200401403B/en unknown
- 2004-02-20 ZA ZA200401402A patent/ZA200401402B/en unknown
- 2004-03-09 CO CO04021424A patent/CO5560589A2/es not_active Application Discontinuation
- 2004-03-09 CO CO04021425A patent/CO5560590A2/es not_active Application Discontinuation
- 2004-03-10 MA MA27568A patent/MA27065A1/fr unknown
- 2004-03-10 MA MA27569A patent/MA27066A1/fr unknown
- 2004-03-10 MA MA27567A patent/MA27064A1/fr unknown
- 2004-03-12 CO CO04023010A patent/CO5560579A2/es not_active Application Discontinuation
- 2004-04-19 NO NO20041594A patent/NO20041594L/no not_active Application Discontinuation
- 2004-04-20 NO NO20041605A patent/NO20041605L/no not_active Application Discontinuation
2007
- 2007-03-20 CY CY20071100383T patent/CY1106398T1/el unknown

Also Published As

Publication number	Publication date
PT1427732E (pt)	2006-12-29
ES2268154T3 (es)	2007-03-16
IL160682A0 (en)	2004-08-31
EP1427728A1 (en)	2004-06-16
EP1427732A1 (en)	2004-06-16
NZ531123A (en)	2006-08-31
CA2461073A1 (en)	2003-03-27
PL370351A1 (en)	2005-05-16
CN1555375A (zh)	2004-12-15
CN1249066C (zh)	2006-04-05
BR0212673A (pt)	2004-08-24
NZ531122A (en)	2005-09-30
PL370415A1 (en)	2005-05-30
AU2002334641B2 (en)	2007-03-29
HUP0402378A3 (en)	2008-10-28
ZA200401403B (en)	2004-08-30
CZ2004345A3 (cs)	2004-06-16
PT1427727E (pt)	2005-06-30
EP1427727A1 (en)	2004-06-16
NO20041605L (no)	2004-06-21
ATE356126T1 (de)	2007-03-15
SK1492004A3 (en)	2004-11-03
KR20060036125A (ko)	2006-04-27
PE20030474A1 (es)	2003-07-22
ATE332901T1 (de)	2006-08-15
MY129329A (en)	2007-03-30
PL370362A1 (en)	2005-05-16
BR0212716A (pt)	2004-08-03
HK1071565A1 (en)	2005-07-22
MA27064A1 (fr)	2004-12-20
EG24363A (en)	2009-03-04
ZA200401260B (en)	2004-08-30
KR20040035835A (ko)	2004-04-29
AR037502A1 (es)	2004-11-17
CO5560590A2 (es)	2005-09-30
PT1427728E (pt)	2007-05-31
RU2004111806A (ru)	2005-03-27
RU2299885C2 (ru)	2007-05-27
JP2005504083A (ja)	2005-02-10
US6821971B2 (en)	2004-11-23
CN1257905C (zh)	2006-05-31
AR037237A1 (es)	2004-11-03
CO5560579A2 (es)	2005-09-30
EP1427732B1 (en)	2006-07-12
PE20030430A1 (es)	2003-06-24
DE60218704T2 (de)	2007-11-08
WO2003024973A1 (en)	2003-03-27
ZA200401402B (en)	2004-08-27
EP1427728B1 (en)	2007-03-07
DE60213108T2 (de)	2007-02-08
MXPA04002569A (es)	2004-05-31
KR100656126B1 (ko)	2006-12-12
CN1555379A (zh)	2004-12-15
AR037145A1 (es)	2004-10-27
HUP0402500A2 (hu)	2005-03-29
PE20030446A1 (es)	2003-07-21
NZ531063A (en)	2007-08-31
KR20040035836A (ko)	2004-04-29
CZ2004358A3 (cs)	2004-07-14
CN1556811A (zh)	2004-12-22
WO2003024971A1 (en)	2003-03-27
RU2004111803A (ru)	2005-10-10
JP2005504082A (ja)	2005-02-10
RU2004111805A (ru)	2005-04-10
CA2461072A1 (en)	2003-03-27
MY129069A (en)	2007-03-30
SK1502004A3 (en)	2004-09-08
KR100623879B1 (ko)	2006-09-19
DE60218704D1 (de)	2007-04-19
RU2272040C2 (ru)	2006-03-20
DE60202782D1 (de)	2005-03-03
MA27066A1 (fr)	2004-12-20
KR20040035837A (ko)	2004-04-29
DE60202782T2 (de)	2006-01-19
CY1106398T1 (el)	2011-10-12
ES2237691T3 (es)	2005-08-01
HUP0402500A3 (en)	2008-10-28
EP1427727B1 (en)	2005-01-26
CZ2004361A3 (cs)	2004-07-14
CA2461071A1 (en)	2003-03-27
DE60213108D1 (de)	2006-08-24
WO2003024970A1 (en)	2003-03-27
US20030105084A1 (en)	2003-06-05
EG24413A (en)	2009-05-25
RU2278864C2 (ru)	2006-06-27
US6566357B1 (en)	2003-05-20
HK1071366A1 (en)	2005-07-15
JP2005504081A (ja)	2005-02-10
NO20041594L (no)	2004-06-21
HUP0402378A2 (hu)	2005-02-28
CO5560589A2 (es)	2005-09-30
CN1250551C (zh)	2006-04-12
SA03230529B1 (ar)	2008-06-21
BR0212905A (pt)	2004-10-13
MXPA04002574A (es)	2004-06-18
DK1427732T3 (da)	2006-10-30
SK1482004A3 (en)	2004-08-03
ES2282459T3 (es)	2007-10-16
AU2002327690B2 (en)	2006-07-20
MA27065A1 (fr)	2004-12-20
IL160741A0 (en)	2004-08-31
HUP0500752A2 (en)	2006-01-30
IL160742A0 (en)	2004-08-31
MXPA04002570A (es)	2004-05-31
ATE287887T1 (de)	2005-02-15

Publication	Publication Date	Title
CY20162200002T2 (el)	2017-01-25	Αντιιικοι παραγοντες
DK1427728T3 (da)	2007-07-09	6,7 -dihydro-5H-pyrazolo[1,2a]pyrazol-1-oner, som kontrollerer inflammatoriske cytokiner
AU2002351525A1 (en)	2003-03-03	System-on-a-chip controller
NO20042474L (no)	2004-08-11	Reguleringsventil-stromningsjusteringsanordning.
DK1399355T3 (da)	2013-07-15	Styringsenhed
BR0201807B1 (pt)	2010-06-29	controlador hidráulico.
FI20010885L (fi)	2002-10-28	Menetelmä rullaimen ohjaamiseksi
FI20012004A0 (fi)	2001-10-15	Kaapelointimenetelmä
NO20033189L (no)	2003-09-08	Kontrollmidler
DE60134712D1 (de)	2008-08-21	Regulierventil
AUPR795101A0 (en)	2001-10-18	Central shutter controller
DE50209593D1 (de)	2007-04-12	Antriebsregelung
IS7131A (is)	2004-01-29	Nýjar 2,4-díamínóþíasól afleiður
AU2002327093A1 (en)	2003-06-05	1,2-dihydro-2-oxo-1,8-naphthyridine derivative
FI5315U1 (fi)	2002-04-09	Sähköverkkoa hyväksikäyttävä valvontapuhelinjärjestelmä
AU2002240563A1 (en)	2002-09-12	Flow controller
IS7299A (is)	2004-06-03	3,4-díhýdró-1H-ísókínólóín-2-ýl-afleiður
FI20010181L (fi)	2002-08-01	Virtausohjain
DE50205113D1 (de)	2006-01-05	Regelventil
DK200100112U3 (da)	2001-07-13	Håndbetjening
FI20012524A0 (fi)	2001-12-20	Ohjausventtiili
AUPR513501A0 (en)	2001-06-14	Controller
AU2002244929A1 (en)	2002-11-05	Controller
HK1036705A (en)	2002-01-11	Power controlling network element
ITMI20011661A0 (it)	2001-07-31	Gruppo verniciatura