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ES2149164T3 - Nanoparticulas de farmacos de superficie modificada. - Google Patents

Nanoparticulas de farmacos de superficie modificada.

Info

Publication number
ES2149164T3
ES2149164T3 ES92200153T ES92200153T ES2149164T3 ES 2149164 T3 ES2149164 T3 ES 2149164T3 ES 92200153 T ES92200153 T ES 92200153T ES 92200153 T ES92200153 T ES 92200153T ES 2149164 T3 ES2149164 T3 ES 2149164T3
Authority
ES
Spain
Prior art keywords
pharmaces
nanoparticles
modified surface
particles
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92200153T
Other languages
English (en)
Inventor
Gary Liversidge
Kenneth Cundy
John Bishop
David Czekai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanosystems LLC
Original Assignee
Nanosystems LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24595721&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2149164(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nanosystems LLC filed Critical Nanosystems LLC
Application granted granted Critical
Publication of ES2149164T3 publication Critical patent/ES2149164T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/049—Surface-modified nanoparticles, e.g. immune-nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/0428—Surface-modified nanoparticles, e.g. immuno-nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Helmets And Other Head Coverings (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

PARTICULAS DISPERSABLES QUE CONSTAN ESENCIALMENTE DE UNA SUSTANCIA DROGA CRISTALINA PROVISTA DE UN MODIFICADOR DE SUPERFICIE ABSORBIDA EN LA SUPERFICIE DEL MISMO EN CANTIDAD SUFICIENTE PARA MANTENER UNA PROPORCION EFECTIVA DEL TAMAÑO DE LAS PARTICULAS MENOR DE 400 NM, METODOS PARA LA PREPARACION DE DICHAS PARTICULAS Y DISPERSIONES QUE CONTIENEN LAS PARTICULAS. LOS COMPUESTOS FARMACEUTICOS QUE CONTIENEN DICHAS PARTICULAS EXHIBEN UNA BIODISPONIBILIDAD INESPERADA Y SE UTILIZAN EN LOS METODOS DE TRATAMIENTO DE LOS MAMIFEROS.
ES92200153T 1991-01-25 1992-01-20 Nanoparticulas de farmacos de superficie modificada. Expired - Lifetime ES2149164T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/647,105 US5145684A (en) 1991-01-25 1991-01-25 Surface modified drug nanoparticles

Publications (1)

Publication Number Publication Date
ES2149164T3 true ES2149164T3 (es) 2000-11-01

Family

ID=24595721

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92200153T Expired - Lifetime ES2149164T3 (es) 1991-01-25 1992-01-20 Nanoparticulas de farmacos de superficie modificada.

Country Status (22)

Country Link
US (1) US5145684A (es)
EP (1) EP0499299B1 (es)
JP (1) JP3602546B2 (es)
KR (1) KR100200061B1 (es)
AT (1) ATE195416T1 (es)
CA (1) CA2059432C (es)
DE (1) DE69231345T2 (es)
DK (1) DK0499299T3 (es)
ES (1) ES2149164T3 (es)
FI (1) FI108333B (es)
GR (1) GR3034759T3 (es)
HU (1) HU221586B (es)
IE (1) IE920217A1 (es)
IL (1) IL100754A (es)
MX (1) MX9200291A (es)
MY (1) MY108134A (es)
NO (1) NO303668B1 (es)
NZ (1) NZ241362A (es)
PT (1) PT499299E (es)
RU (1) RU2066553C1 (es)
SG (1) SG55104A1 (es)
TW (1) TW247275B (es)

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DK0499299T3 (da) 2001-01-02
MY108134A (en) 1996-08-15
IL100754A (en) 1996-10-16
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HUT62462A (en) 1993-05-28
GR3034759T3 (en) 2001-02-28
TW247275B (es) 1995-05-11
AU1014792A (en) 1992-07-30
JP3602546B2 (ja) 2004-12-15
FI920321L (fi) 1992-07-26
IE920217A1 (en) 1992-07-29
CA2059432A1 (en) 1992-07-26
EP0499299B1 (en) 2000-08-16
CA2059432C (en) 2003-03-18
DE69231345T2 (de) 2001-04-26
MX9200291A (es) 1992-10-01
HU9200226D0 (en) 1992-04-28
EP0499299A2 (en) 1992-08-19
RU2066553C1 (ru) 1996-09-20
ATE195416T1 (de) 2000-09-15
EP0499299A3 (en) 1993-03-03
NZ241362A (en) 1993-06-25
AU654836B2 (en) 1994-11-24
FI920321A0 (fi) 1992-01-24
KR100200061B1 (ko) 1999-06-15
DE69231345D1 (de) 2000-09-21
IL100754A0 (en) 1992-09-06
US5145684A (en) 1992-09-08
HU221586B (hu) 2002-11-28
SG55104A1 (en) 1998-12-21
PT499299E (pt) 2001-01-31
FI108333B (fi) 2002-01-15
NO303668B1 (no) 1998-08-17
KR920014468A (ko) 1992-08-25
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