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ES2145264T3 - (2,4-disulfofenil)-n-tert-butilnitrona, sus sales y su utilizacion como agentes captadores de radicales farmaceuticos. - Google Patents

(2,4-disulfofenil)-n-tert-butilnitrona, sus sales y su utilizacion como agentes captadores de radicales farmaceuticos.

Info

Publication number
ES2145264T3
ES2145264T3 ES95907224T ES95907224T ES2145264T3 ES 2145264 T3 ES2145264 T3 ES 2145264T3 ES 95907224 T ES95907224 T ES 95907224T ES 95907224 T ES95907224 T ES 95907224T ES 2145264 T3 ES2145264 T3 ES 2145264T3
Authority
ES
Spain
Prior art keywords
tert
salts
disulfofenil
butylnitrone
radicals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95907224T
Other languages
English (en)
Inventor
John M Carney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oklahoma Medical Research Foundation
University of Kentucky Research Foundation
Original Assignee
Oklahoma Medical Research Foundation
University of Kentucky Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Medical Research Foundation, University of Kentucky Research Foundation filed Critical Oklahoma Medical Research Foundation
Application granted granted Critical
Publication of ES2145264T3 publication Critical patent/ES2145264T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBE LA 2,4-DISULFONIL AL -FENIL-TERT-BUTIL-NITRONA Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. ESTOS COMPUESTO SON UTILES COMO MEDICAMENTOS PARA LA ADMINISTRACION ORAL O PARENTERAL, P. E. ADMINISTRACION INTRAVENOSA EN PACIENTES QUE SUFREN DE OXIDACION AGUDA DEL SISTEMA NERVIOSO CENTRAL COMO SUCEDE EN TRASTORNOS CEREBRO-VASCULARES O EN LA OXIDACION GRADUAL DEL SISTEMA NERVIOSO CENTRAL QUE SE MUESTRA COMO UNA PERDIDA PROGRESIVA DE LA FUNCION DEL SISTEMA NERVIOSO CENTRAL. LOS COMPUESTOS TAMBIEN SE UTILIZAN PARA MEJORAR LOS EFECTOS SECUNDARIOS DEL DAÑO OXIDATIVO QUE CAUSAN LOS TRATAMIENTOS ANTINEOPLASICOS.
ES95907224T 1993-12-23 1994-12-22 (2,4-disulfofenil)-n-tert-butilnitrona, sus sales y su utilizacion como agentes captadores de radicales farmaceuticos. Expired - Lifetime ES2145264T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/173,579 US5488145A (en) 1993-12-23 1993-12-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Publications (1)

Publication Number Publication Date
ES2145264T3 true ES2145264T3 (es) 2000-07-01

Family

ID=22632663

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95907224T Expired - Lifetime ES2145264T3 (es) 1993-12-23 1994-12-22 (2,4-disulfofenil)-n-tert-butilnitrona, sus sales y su utilizacion como agentes captadores de radicales farmaceuticos.

Country Status (28)

Country Link
US (4) US5488145A (es)
EP (1) EP0736004B1 (es)
JP (3) JP3412821B2 (es)
KR (1) KR100370522B1 (es)
CN (1) CN1070176C (es)
AT (1) ATE192736T1 (es)
AU (1) AU679835B2 (es)
BR (2) BR9408378A (es)
CA (1) CA2179521C (es)
CZ (1) CZ289629B6 (es)
DE (1) DE69424441T2 (es)
DK (1) DK0736004T3 (es)
ES (1) ES2145264T3 (es)
FI (1) FI111718B (es)
GR (1) GR3034134T3 (es)
HR (1) HRP950358B1 (es)
HU (1) HU221167B1 (es)
MY (1) MY114178A (es)
NO (1) NO306457B1 (es)
NZ (1) NZ279025A (es)
PL (1) PL185189B1 (es)
PT (1) PT736004E (es)
RU (1) RU2159231C2 (es)
SG (1) SG64903A1 (es)
SK (1) SK282403B6 (es)
TW (1) TW299315B (es)
UA (1) UA45964C2 (es)
WO (1) WO1995017876A2 (es)

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US20040208875A1 (en) * 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
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AU7739796A (en) 1995-11-17 1997-06-11 Florida International University Azulenyl nitrone spin trapping agents, methods of making and using same
WO1997038683A1 (en) * 1996-04-17 1997-10-23 Oklahoma Medical Research Foundation Nitrone free radical trap treatment of dementia associated with aids virus (hiv-1) infection
CA2260825A1 (en) * 1996-07-19 1998-01-29 Centaur Pharmaceuticals, Inc. Furan nitrone compounds
TW429241B (en) 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
DE69904018D1 (en) * 1998-01-16 2003-01-02 Centaur Pharmaceuticals Inc Thiophennitronderivate
ZA99252B (en) * 1998-01-16 1999-07-14 Centaur Pharmaceuticals Inc Thioether furan nitrone compounds.
US6255353B1 (en) * 1998-03-13 2001-07-03 Centaur Pharmaceuticals, Inc. Inhibition of angiogenesis
EP1077696A1 (en) * 1998-05-19 2001-02-28 Centaur Pharmaceuticals, Inc. Furan nitrone therapeutics for the treatment of inflammatory bowel disease
US6083989A (en) * 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
US6730700B2 (en) 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
CA2359116C (en) 1999-01-25 2009-03-17 National Jewish Medical And Research Center Substituted porphyrins
DK1276483T3 (da) * 1999-04-28 2009-12-14 Bellus Health International Ltd Sammensætninger og fremgangsmåder til at behandle amyloidose ved anvendelse af sulfonatderivater
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
US6815425B1 (en) 1999-10-22 2004-11-09 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
WO2001028578A2 (en) * 1999-10-22 2001-04-26 Wrair A PHARMACEUTICAL COMPOSITION CONTAINING pGLU-GLU-PRO-NH2 AND METHOD FOR TREATING DISEASES AND INJURIES TO THE BRAIN, SPINAL CORD AND RETINA USING SAME
US20020022743A1 (en) * 2000-01-10 2002-02-21 Sergei Pouhov Method for the purification of aryl sulfonic acids and salts
SE0000056D0 (sv) 2000-01-10 2000-01-10 Astrazeneca Ab Novel process
SE0000055D0 (sv) 2000-01-10 2000-01-10 Centaur Pharmaceuticals Inc Novel process
SE0001916D0 (sv) * 2000-05-23 2000-05-23 Astrazeneca Ab Novel formulation
US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
AU2002253857A1 (en) 2001-01-08 2002-09-04 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
US20030045461A1 (en) * 2001-09-06 2003-03-06 Jen-Chang Hsia Composition and methods of esterified nitroxides gated with carboxylic acids
FR2846968B1 (fr) * 2002-11-08 2005-02-04 Salles Jean Pierre Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone
US7414076B2 (en) * 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) * 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
AU2005310986A1 (en) * 2004-11-12 2006-06-08 Bellus Health (International) Limited Methods and fluorinated compositions for treating amyloid-related diseases
WO2006059245A2 (en) * 2004-11-16 2006-06-08 Neurochem (International) Limited Compounds for the treatment of cns and amyloid associated diseases
JP5145537B2 (ja) * 2004-12-22 2013-02-20 ビーエイチアイ リミテッド パートナーシップ アミロイド関連疾患を治療するための方法および組成物
US20060235370A1 (en) * 2005-04-04 2006-10-19 Oblong John E Method of regulating mammalian keratinous tissue
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WO2007013842A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimino)methyl) benzene-1,3-disulfonate n-oxide against maemorrhagic changes in the brain
WO2007013844A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea
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ES2967330T3 (es) 2006-10-12 2024-04-29 Bellus Health Inc Métodos, compuestos, composiciones y vehículos para suministrar ácido 3-amino-1-propanosulfónico
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DE3914650A1 (de) * 1989-05-03 1990-11-08 Basf Ag Neue phenylendiamine sowie ein verfahren zur herstellung von phenylendiaminen
US5025032A (en) * 1989-10-17 1991-06-18 Oklahoma Medical Research Foundation Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
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CA2069961C (en) * 1989-10-17 2000-05-02 John M. Carney Method and compositions for inhibition of disorders associated with oxidative damage
DE3937342A1 (de) * 1989-11-09 1991-05-16 Bayer Ag Verfahren zur herstellung von 2-aminobenzol-disulfonsaeuren-(1,4) und die neue verbindung 6-chlor-2-aminobenzol-disulfonsaeure-(1,4)
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US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Also Published As

Publication number Publication date
NO962637L (no) 1996-08-13
NO962637D0 (no) 1996-06-20
UA45964C2 (uk) 2002-05-15
DE69424441D1 (de) 2000-06-15
CZ289629B6 (cs) 2002-03-13
BR1100626A (pt) 1999-11-23
US5780510A (en) 1998-07-14
EP0736004B1 (en) 2000-05-10
PL185189B1 (pl) 2003-03-31
BR9408378A (pt) 1997-08-19
AU1552795A (en) 1995-07-17
CA2179521C (en) 2002-03-19
CN1156447A (zh) 1997-08-06
KR100370522B1 (ko) 2003-05-16
HRP950358A2 (en) 1997-08-31
HK1008294A1 (en) 1999-05-07
PL315154A1 (en) 1996-10-14
SK78896A3 (en) 1997-09-10
FI111718B (fi) 2003-09-15
JPH09507232A (ja) 1997-07-22
US5488145A (en) 1996-01-30
JP2004075696A (ja) 2004-03-11
HU221167B1 (en) 2002-08-28
MY114178A (en) 2002-08-30
CN1070176C (zh) 2001-08-29
JP2001010953A (ja) 2001-01-16
DK0736004T3 (da) 2000-10-09
DE69424441T2 (de) 2000-10-12
SK282403B6 (sk) 2002-01-07
CA2179521A1 (en) 1995-07-06
WO1995017876A2 (en) 1995-07-06
SG64903A1 (en) 1999-05-25
GR3034134T3 (en) 2000-11-30
JP3412821B2 (ja) 2003-06-03
RU2159231C2 (ru) 2000-11-20
FI962589L (fi) 1996-08-20
ATE192736T1 (de) 2000-05-15
NZ279025A (en) 1998-02-26
NO306457B1 (no) 1999-11-08
HU9601739D0 (en) 1996-08-28
TW299315B (es) 1997-03-01
WO1995017876A3 (en) 1995-08-10
PT736004E (pt) 2000-09-29
US5475032A (en) 1995-12-12
HK1001768A1 (en) 1998-07-10
AU679835B2 (en) 1997-07-10
HUT76788A (en) 1997-11-28
CZ177596A3 (en) 1996-12-11
US5508305A (en) 1996-04-16
FI962589A0 (fi) 1996-06-20
EP0736004A1 (en) 1996-10-09
HRP950358B1 (en) 2001-04-30

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