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PE20161372A1 - Inhibidores de dihidropirrolopiridina de ror-gamma - Google Patents

Inhibidores de dihidropirrolopiridina de ror-gamma

Info

Publication number
PE20161372A1
PE20161372A1 PE2016001302A PE2016001302A PE20161372A1 PE 20161372 A1 PE20161372 A1 PE 20161372A1 PE 2016001302 A PE2016001302 A PE 2016001302A PE 2016001302 A PE2016001302 A PE 2016001302A PE 20161372 A1 PE20161372 A1 PE 20161372A1
Authority
PE
Peru
Prior art keywords
absent
hydrogen
ror
gamma
compounds
Prior art date
Application number
PE2016001302A
Other languages
English (en)
Inventor
Linghang Zhuang
Yajun Zheng
Wei Zhao
Jing Yuan
Colin M Tice
Suresh B Singh
David A Claremon
Stephen D Lotesta
Zhijie Liu
Lanqi Jia
Yi Fan
Chengguo Dong
Lawrence Wayne Dillard
Andrew Marcus
Original Assignee
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52544571&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20161372(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vitae Pharmaceuticals Inc filed Critical Vitae Pharmaceuticals Inc
Publication of PE20161372A1 publication Critical patent/PE20161372A1/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

Se refiere a compuestos derivados de dihidropirrolopiridina de formula I o sales farmaceuticamente aceptables de los mismos, donde: R2 y R3 son hidrogeno, hidroxi, entre otros; R4es hidrogeno, alquilo C1-C3 o C=O; X es –C(O)NH- o –NHC(O)-; m es 0, 1 o 2; n es 0, 1, 2 o 3; L1 esta asuente o es SO2 o CR7R8; Cy1 esta ausente o es alquilo C1-C3, haloalquilo C1-C3, entre otros; Cy2 esta ausente o es alcoxicarbonilo C1-C6, arilo, heteroarilo, entre otros; R7 y R8 son hidrogeno, hidroxi, entre otros, o R7 y R8 junto con el atomo de carbono al cual se unen forman un cicloalquilo o heterociclilo de 3 a 6 miembros. Son compuestos preferidos: (S)-N-(4-(etilsulfonil)bencil)-7-isopropil-6-(4-(trifluorometil)bencil)-6,7-dihidro-5H-pirrolo[3,4-b]piridin-3-carboxamida; (S)-N-((5-(etilsulfonil)piridin-2-il)metil)-7-isopropil-6-((trans-4-(trifluorometil)ciclohexil)metil)-6,7-dihidro-5H-pirrolo[3,4-b]piridin-3-carboxamida; entre otros. Tambien se refiere a una composicion farmaceutica y a un metodo de tratamiento. Dichos compuestos son inhibidores del receptor ROR-gamma, siendo utiles en el tratamiento de enfermedades inflamatorias, metabolicas, autoinmunes, entre otras
PE2016001302A 2014-02-03 2015-01-30 Inhibidores de dihidropirrolopiridina de ror-gamma PE20161372A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461935162P 2014-02-03 2014-02-03
US201461970637P 2014-03-26 2014-03-26

Publications (1)

Publication Number Publication Date
PE20161372A1 true PE20161372A1 (es) 2017-01-08

Family

ID=52544571

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016001302A PE20161372A1 (es) 2014-02-03 2015-01-30 Inhibidores de dihidropirrolopiridina de ror-gamma

Country Status (26)

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US (6) US9266886B2 (es)
EP (2) EP3102576B8 (es)
JP (1) JP6466461B2 (es)
KR (1) KR102408261B1 (es)
CN (1) CN105940002B (es)
AU (1) AU2015210833B2 (es)
CA (1) CA2938311C (es)
CL (1) CL2016001947A1 (es)
DK (1) DK3102576T3 (es)
EA (1) EA031804B1 (es)
EC (1) ECSP16071151A (es)
ES (1) ES2735099T3 (es)
HU (1) HUE045511T2 (es)
IL (1) IL246902B (es)
LT (1) LT3102576T (es)
MX (1) MX371017B (es)
PE (1) PE20161372A1 (es)
PH (1) PH12016501457A1 (es)
PL (1) PL3102576T3 (es)
PT (1) PT3102576T (es)
RS (1) RS59007B1 (es)
SG (1) SG11201606080SA (es)
SI (1) SI3102576T1 (es)
TW (1) TWI658041B (es)
UA (1) UA121309C2 (es)
WO (1) WO2015116904A1 (es)

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LT3102576T (lt) 2014-02-03 2019-08-12 Vitae Pharmaceuticals, Llc Ror-gama dihidropirolopiridino inhibitoriai
WO2016023082A1 (en) 2014-08-12 2016-02-18 Monash University Lymph directing prodrugs
EA031967B1 (ru) * 2014-10-14 2019-03-29 Вайтаи Фармасьютиклз, Инк. ДИГИДРОПИРРОЛОПИРИДИНОВЫЕ ИНГИБИТОРЫ ROR-γ
WO2016067035A1 (en) 2014-10-29 2016-05-06 Bicycle Therapeutics Limited Bicyclic peptide ligands specific for mt1-mmp
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) * 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
EP3268087A4 (en) 2015-03-12 2018-08-29 The Regents of the University of California METHODS FOR TREATING CANCER WITH RORgamma INHIBITORS
SMT202100286T1 (it) * 2015-05-15 2021-07-12 Aurigene Discovery Tech Ltd Composti di tetraidrochinolinone sostituito come modulatori ror-gamma
UA120651C2 (uk) 2015-06-09 2020-01-10 Еббві Інк. Модулятори ядерних рецепторів
WO2017010399A1 (ja) * 2015-07-10 2017-01-19 塩野義製薬株式会社 ＲＯＲγｔ阻害作用を有する化合物およびそれらを含有する医薬組成物
DK3331876T3 (da) 2015-08-05 2021-01-11 Vitae Pharmaceuticals Llc Modulators of ror-gamma
CN108137482B (zh) 2015-09-08 2024-03-15 莫纳什大学 定向淋巴的前药
EP3356366B1 (en) * 2015-10-01 2019-08-28 Boehringer Ingelheim International GmbH Pteridine derivatives as modulators of ror gamma
MX385332B (es) * 2015-11-20 2025-03-18 Vitae Pharmaceuticals Llc Moduladores de ror-gamma.
JP6448867B2 (ja) 2015-12-15 2019-01-09 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ イソインドール化合物
TW202220968A (zh) * 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
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WO2018042342A1 (en) * 2016-08-30 2018-03-08 Glenmark Pharmaceuticals S.A. 1,2,3-benzotriazole derivatives as ror gamma t modulators
TWI705958B (zh) 2016-12-05 2020-10-01 荷蘭商領導醫藥控股責任有限公司 ＲＯＲγ調節子
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