PE20181074A1 - Compuestos heteroaromaticos como inhibidores de btk - Google Patents
Compuestos heteroaromaticos como inhibidores de btkInfo
- Publication number
- PE20181074A1 PE20181074A1 PE2018001111A PE2018001111A PE20181074A1 PE 20181074 A1 PE20181074 A1 PE 20181074A1 PE 2018001111 A PE2018001111 A PE 2018001111A PE 2018001111 A PE2018001111 A PE 2018001111A PE 20181074 A1 PE20181074 A1 PE 20181074A1
- Authority
- PE
- Peru
- Prior art keywords
- heteroaromatic compounds
- btk inhibitors
- pyridinyl
- halo
- halogen
- Prior art date
Links
- 229940124291 BTK inhibitor Drugs 0.000 title 1
- 150000002390 heteroarenes Chemical class 0.000 title 1
- 208000005777 Lupus Nephritis Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invencion refiere un compuesto de formula (I) donde Cy se selecciona de i, ii, cada R1 es H o metilo; R2 es L-Ar en donde Ar es fenilo o piridinilo, y cada uno se sustituye opcionalmente con uno o mas de halogeno, halo C1-C4, entre otros; L es -(CH2)-; Y es C6-C8 espirociclo que contiene 1 atomo de nitrogeno del anillo. Tambien refiere una composicion farmaceutica y es util para el tratamiento de artritis reumatoide, nefritis lupica, rinitis alergica, entre otros mencionados en la invencion.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562268278P | 2015-12-16 | 2015-12-16 | |
| US201662431008P | 2016-12-07 | 2016-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20181074A1 true PE20181074A1 (es) | 2018-07-04 |
Family
ID=58737849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018001111A PE20181074A1 (es) | 2015-12-16 | 2016-12-15 | Compuestos heteroaromaticos como inhibidores de btk |
Country Status (30)
| Country | Link |
|---|---|
| US (6) | US9975882B2 (es) |
| EP (1) | EP3390390B1 (es) |
| JP (1) | JP6976947B2 (es) |
| KR (1) | KR102691112B1 (es) |
| CN (1) | CN108368086B (es) |
| AU (1) | AU2016370743B2 (es) |
| BR (1) | BR112018011969B1 (es) |
| CA (1) | CA3005268C (es) |
| CL (1) | CL2018001569A1 (es) |
| CO (1) | CO2018005954A2 (es) |
| CY (1) | CY1124749T1 (es) |
| DK (1) | DK3390390T3 (es) |
| EA (1) | EA034561B1 (es) |
| ES (1) | ES2897910T3 (es) |
| HR (1) | HRP20211845T1 (es) |
| HU (1) | HUE056877T2 (es) |
| IL (1) | IL259281B (es) |
| LT (1) | LT3390390T (es) |
| MX (1) | MX375471B (es) |
| MY (1) | MY197440A (es) |
| PE (1) | PE20181074A1 (es) |
| PH (1) | PH12018501248B1 (es) |
| PL (1) | PL3390390T3 (es) |
| PT (1) | PT3390390T (es) |
| RS (1) | RS62525B1 (es) |
| SA (1) | SA518391864B1 (es) |
| SG (1) | SG11201804890TA (es) |
| SI (1) | SI3390390T1 (es) |
| TW (1) | TWI726017B (es) |
| WO (1) | WO2017106429A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140045813A1 (en) | 2012-08-10 | 2014-02-13 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
| SI3390395T1 (sl) | 2015-12-16 | 2020-11-30 | Loxo Oncology, Inc. | Spojine uporabne kot inhibitorji kinaz |
| CA3005268C (en) * | 2015-12-16 | 2024-04-30 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
| US10570118B2 (en) | 2016-01-13 | 2020-02-25 | Boehringer Ingelheim International Gmbh | Isoquinolones as BTK inhibitors |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| JP7166331B2 (ja) * | 2017-08-01 | 2022-11-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 中間体化合物及び方法 |
| EP3829543A1 (en) | 2018-07-31 | 2021-06-09 | Loxo Oncology, Inc. | Spray-dried dispersions and formulations of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoro propan-2-yl)-1h-pyrazole-4-carboxamide |
| ES2928919T3 (es) | 2018-12-03 | 2022-11-23 | Boehringer Ingelheim Int | Compuestos heteroaromáticos como inhibidores de vanina |
| KR20210099093A (ko) * | 2018-12-03 | 2021-08-11 | 베링거 인겔하임 인터내셔날 게엠베하 | 바닌 억제제로서의 헤테로방향족 화합물 |
| BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| SI3972603T1 (sl) * | 2019-05-23 | 2025-02-28 | Novartis Ag | Postopki zdravljenja sjogrenovega sindroma z uporabo zaviralca brutonove tirozin kinaze |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| WO2023110936A1 (en) | 2021-12-14 | 2023-06-22 | Netherlands Translational Research Center Holding B.V | Reversible macrocyclic kinase inhibitors |
| MX2024007328A (es) | 2021-12-14 | 2024-09-30 | Crossfire Oncology Holding B V | Inhibidores macrociclicos de btk. |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9608435D0 (en) | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| EP1196390A2 (en) * | 2000-02-05 | 2002-04-17 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of erk |
| HRP20040098B1 (en) | 2001-08-13 | 2012-08-31 | Janssen Pharmaceutica N.V. | 2,4,5-TRlSUBSTITUTED THIAZOLYL DERIVATIVES AND THEIR ANTIINFLAMMATORY ACTIVITY |
| EP1436265A4 (en) * | 2001-09-27 | 2004-12-15 | Smithkline Beecham Corp | CHEMICALS |
| FR2881426B1 (fr) | 2005-02-03 | 2007-03-30 | Aventis Pharma Sa | Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation |
| AU2007235237B2 (en) | 2006-04-11 | 2011-08-18 | Vertex Pharmaceuticals Incorporated | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
| PL2529622T3 (pl) | 2006-09-22 | 2018-07-31 | Pharmacyclics Llc | Inhibitory kinazy tyrozynowej brutona |
| CA2681756C (en) | 2007-03-28 | 2015-02-24 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| AU2009275988B2 (en) | 2008-07-29 | 2014-03-27 | Universite De Liege | A genetic marker test for Brachyspina and fertility in cattle |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| CN102395585A (zh) | 2009-01-30 | 2012-03-28 | 米伦纽姆医药公司 | 杂芳基化合物和其作为pi3k抑制剂的用途 |
| KR20120096076A (ko) | 2009-12-17 | 2012-08-29 | 메르크 파텐트 게엠베하 | 스핑고신 키나아제 저해제 |
| KR101537148B1 (ko) | 2010-05-31 | 2015-07-15 | 오노 야꾸힝 고교 가부시키가이샤 | 푸리논 유도체 |
| JP2013533318A (ja) | 2010-08-11 | 2013-08-22 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | ヘテロアリールおよびその使用 |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| WO2013113097A1 (en) | 2012-01-31 | 2013-08-08 | Beta Pharma Canada Inc. | Cyclic molecules as bruton's tyrosine kinase inhibitors |
| US20140045813A1 (en) | 2012-08-10 | 2014-02-13 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
| HK1211293A1 (en) | 2012-11-02 | 2016-05-20 | 辉瑞公司 | Bruton's tyrosine kinase inhibitors |
| CN103848810A (zh) * | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| EP2970163B1 (en) * | 2013-03-14 | 2018-02-28 | Boehringer Ingelheim International GmbH | 5-thiazolecarboxamide dervatives and their use as btk inhibitors |
| WO2015116485A1 (en) * | 2014-01-29 | 2015-08-06 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as btk inhibitors |
| CA3005268C (en) * | 2015-12-16 | 2024-04-30 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
-
2016
- 2016-12-15 CA CA3005268A patent/CA3005268C/en active Active
- 2016-12-15 CN CN201680072250.3A patent/CN108368086B/zh active Active
- 2016-12-15 US US15/379,745 patent/US9975882B2/en active Active
- 2016-12-15 MY MYPI2018000892A patent/MY197440A/en unknown
- 2016-12-15 BR BR112018011969-5A patent/BR112018011969B1/pt active IP Right Grant
- 2016-12-15 PE PE2018001111A patent/PE20181074A1/es unknown
- 2016-12-15 HU HUE16867378A patent/HUE056877T2/hu unknown
- 2016-12-15 LT LTEPPCT/US2016/066799T patent/LT3390390T/lt unknown
- 2016-12-15 RS RS20211356A patent/RS62525B1/sr unknown
- 2016-12-15 ES ES16867378T patent/ES2897910T3/es active Active
- 2016-12-15 PL PL16867378T patent/PL3390390T3/pl unknown
- 2016-12-15 WO PCT/US2016/066799 patent/WO2017106429A2/en not_active Ceased
- 2016-12-15 AU AU2016370743A patent/AU2016370743B2/en active Active
- 2016-12-15 HR HRP20211845TT patent/HRP20211845T1/hr unknown
- 2016-12-15 SI SI201631382T patent/SI3390390T1/sl unknown
- 2016-12-15 DK DK16867378.8T patent/DK3390390T3/da active
- 2016-12-15 EA EA201891399A patent/EA034561B1/ru not_active IP Right Cessation
- 2016-12-15 PH PH1/2018/501248A patent/PH12018501248B1/en unknown
- 2016-12-15 KR KR1020187020450A patent/KR102691112B1/ko active Active
- 2016-12-15 PT PT168673788T patent/PT3390390T/pt unknown
- 2016-12-15 EP EP16867378.8A patent/EP3390390B1/en active Active
- 2016-12-15 SG SG11201804890TA patent/SG11201804890TA/en unknown
- 2016-12-15 TW TW105141510A patent/TWI726017B/zh active
- 2016-12-15 MX MX2018007333A patent/MX375471B/es active IP Right Grant
- 2016-12-15 JP JP2018531127A patent/JP6976947B2/ja active Active
-
2017
- 2017-10-12 US US15/782,214 patent/US20180030037A1/en not_active Abandoned
-
2018
- 2018-04-09 US US15/947,978 patent/US20180222893A1/en not_active Abandoned
- 2018-05-10 IL IL259281A patent/IL259281B/en active IP Right Grant
- 2018-06-12 CO CONC2018/0005954A patent/CO2018005954A2/es unknown
- 2018-06-13 CL CL2018001569A patent/CL2018001569A1/es unknown
- 2018-06-23 SA SA518391864A patent/SA518391864B1/ar unknown
- 2018-09-21 US US16/137,790 patent/US20190092759A1/en not_active Abandoned
-
2019
- 2019-08-29 US US16/555,205 patent/US20200055843A1/en not_active Abandoned
-
2020
- 2020-07-23 US US16/936,821 patent/US20210009567A1/en not_active Abandoned
-
2021
- 2021-11-24 CY CY20211101015T patent/CY1124749T1/el unknown
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