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CL2016001947A1 - Compuestos derivados de dihidropirrolopiridina, inhibidores de ror-gamma (ror); composición farmacéutica; y uso en el tratamiento de asma, enfermedad pulmonar obstructiva crónica, artritis reumatoide, fibrosis quística, psoriasis, epilepsia, alzheimer, entre otras. - Google Patents

Compuestos derivados de dihidropirrolopiridina, inhibidores de ror-gamma (ror); composición farmacéutica; y uso en el tratamiento de asma, enfermedad pulmonar obstructiva crónica, artritis reumatoide, fibrosis quística, psoriasis, epilepsia, alzheimer, entre otras.

Info

Publication number
CL2016001947A1
CL2016001947A1 CL2016001947A CL2016001947A CL2016001947A1 CL 2016001947 A1 CL2016001947 A1 CL 2016001947A1 CL 2016001947 A CL2016001947 A CL 2016001947A CL 2016001947 A CL2016001947 A CL 2016001947A CL 2016001947 A1 CL2016001947 A1 CL 2016001947A1
Authority
CL
Chile
Prior art keywords
ror
treatment
pharmaceutical composition
asthma
pulmonary disease
Prior art date
Application number
CL2016001947A
Other languages
English (en)
Inventor
Yi Fan
Suresh B Singh
Jing Yuan
Yajun Zheng
Lawrence Wayne Dillard
Lanqi Jia
David A Claremon
Chengguo Dong
Zhijie Liu
Stephen D Lotesta
Andrew Marcus
Colin M Tice
Wei Zhao
Linghang Zhuang
Original Assignee
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52544571&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016001947(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vitae Pharmaceuticals Inc filed Critical Vitae Pharmaceuticals Inc
Publication of CL2016001947A1 publication Critical patent/CL2016001947A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

EL PROBLEMA TÉCNICO PLANTEADO POR LA SOLICITUD SE REFIERE A COMPUESTOS QUE ACTÚAN COMO INHIBIDORES DE ROR-GAMMA, COMPOSICIÓN FARMACÉUTICA Y USO EN EL TRATAMIENTO DE ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRÓNICA, ARTRITIS REUMATOIDE, FIBROSIS QUÍSTICA, PSORIASIS, EPILEPSIA, ALZHEIMER, ENTRE OTROS. LA SOLUCIÓN AL PROBLEMA TÉCNICO PLANTEADO CONSISTE EN PROPORCIONAR COMPUESTOS DERIVADOS DE DIHIDROPIRROLOPIRIDINA DE FÓRMULA (IV), QUE ACTÚAN COMO INHIBIDORES DE ROR-GAMMA, PROPORCIONAR UNA COMPOSICIÓN FARMACÉUTICA Y USO EN EL TRATAMIENTO DE ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRÓNICA, ARTRITIS REUMATOIDE, ENTRE OTRAS.
CL2016001947A 2014-02-03 2016-08-02 Compuestos derivados de dihidropirrolopiridina, inhibidores de ror-gamma (ror); composición farmacéutica; y uso en el tratamiento de asma, enfermedad pulmonar obstructiva crónica, artritis reumatoide, fibrosis quística, psoriasis, epilepsia, alzheimer, entre otras. CL2016001947A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461935162P 2014-02-03 2014-02-03
US201461970637P 2014-03-26 2014-03-26

Publications (1)

Publication Number Publication Date
CL2016001947A1 true CL2016001947A1 (es) 2017-04-07

Family

ID=52544571

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016001947A CL2016001947A1 (es) 2014-02-03 2016-08-02 Compuestos derivados de dihidropirrolopiridina, inhibidores de ror-gamma (ror); composición farmacéutica; y uso en el tratamiento de asma, enfermedad pulmonar obstructiva crónica, artritis reumatoide, fibrosis quística, psoriasis, epilepsia, alzheimer, entre otras.

Country Status (26)

Country Link
US (6) US9266886B2 (es)
EP (2) EP3102576B8 (es)
JP (1) JP6466461B2 (es)
KR (1) KR102408261B1 (es)
CN (1) CN105940002B (es)
AU (1) AU2015210833B2 (es)
CA (1) CA2938311C (es)
CL (1) CL2016001947A1 (es)
DK (1) DK3102576T3 (es)
EA (1) EA031804B1 (es)
EC (1) ECSP16071151A (es)
ES (1) ES2735099T3 (es)
HU (1) HUE045511T2 (es)
IL (1) IL246902B (es)
LT (1) LT3102576T (es)
MX (1) MX371017B (es)
PE (1) PE20161372A1 (es)
PH (1) PH12016501457A1 (es)
PL (1) PL3102576T3 (es)
PT (1) PT3102576T (es)
RS (1) RS59007B1 (es)
SG (1) SG11201606080SA (es)
SI (1) SI3102576T1 (es)
TW (1) TWI658041B (es)
UA (1) UA121309C2 (es)
WO (1) WO2015116904A1 (es)

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WO2015017335A1 (en) * 2013-07-30 2015-02-05 Boehringer Ingelheim International Gmbh Azaindole compounds as modulators of rorc
KR102408261B1 (ko) 2014-02-03 2022-06-10 비타이 파마슈티컬즈, 엘엘씨 Ror-감마의 디하이드로피롤로피리딘 저해제
AU2015303835B2 (en) 2014-08-12 2020-04-09 Monash University Lymph directing prodrugs
DK3207043T6 (da) * 2014-10-14 2020-01-20 Vitae Pharmaceuticals Llc Dihydropyrrolopyridin-inhibitorer af ror-gamma
US10532106B2 (en) 2014-10-29 2020-01-14 Bicyclerd Limited Bicyclic peptide ligands specific for MT1-MMP
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
CN107614062A (zh) 2015-03-12 2018-01-19 加利福尼亚大学董事会 用RORγ抑制剂治疗癌症的方法
CN108026045B (zh) 2015-05-15 2021-04-27 奥瑞基尼探索技术有限公司 用作RORγ调节剂的经过取代的四氢喹啉酮化合物
PT3307734T (pt) 2015-06-09 2020-02-25 Abbvie Inc Moduladores de recetores nucleares (ror) para o tratamento de doenças inflamatórias e autoimunes
WO2017010399A1 (ja) * 2015-07-10 2017-01-19 塩野義製薬株式会社 ＲＯＲγｔ阻害作用を有する化合物およびそれらを含有する医薬組成物
US10301261B2 (en) 2015-08-05 2019-05-28 Vitae Pharmaceuticals, Llc Substituted indoles as modulators of ROR-gamma
CA2997106C (en) 2015-09-08 2024-06-04 Monash University Lymph directing prodrugs
WO2017058831A1 (en) * 2015-10-01 2017-04-06 Boehringer Ingelheim International Gmbh Pteridine derivatives as modulators of ror gamma
EP3868750A1 (en) 2015-11-20 2021-08-25 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
JP6448867B2 (ja) 2015-12-15 2019-01-09 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ イソインドール化合物
TWI757266B (zh) * 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
CN106632313B (zh) * 2016-03-04 2021-04-09 上海贤鼎生物科技有限公司 一种抗癌药帕博昔布重要中间体及合成工艺
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TW201815388A (zh) 2016-07-14 2018-05-01 印度商卡迪拉保健有限公司 作為ＲＯＲγ調節劑之新穎化合物
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