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DK1385823T3 - Guanidinoforbindelser som melanocortin-4-receptor- (MC4-R) -agonister - Google Patents

Guanidinoforbindelser som melanocortin-4-receptor- (MC4-R) -agonister

Info

Publication number
DK1385823T3
DK1385823T3 DK02719463T DK02719463T DK1385823T3 DK 1385823 T3 DK1385823 T3 DK 1385823T3 DK 02719463 T DK02719463 T DK 02719463T DK 02719463 T DK02719463 T DK 02719463T DK 1385823 T3 DK1385823 T3 DK 1385823T3
Authority
DK
Denmark
Prior art keywords
melanocortin
agonists
receptor
group
compounds
Prior art date
Application number
DK02719463T
Other languages
English (en)
Inventor
Rustum S Boyce
Bryan Chang
Daniel Chu
David Duhl
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Application granted granted Critical
Publication of DK1385823T3 publication Critical patent/DK1385823T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK02719463T 2001-04-09 2002-04-08 Guanidinoforbindelser som melanocortin-4-receptor- (MC4-R) -agonister DK1385823T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28284701P 2001-04-09 2001-04-09
PCT/US2002/010965 WO2002081443A1 (en) 2001-04-09 2002-04-08 Novel guanidino compounds

Publications (1)

Publication Number Publication Date
DK1385823T3 true DK1385823T3 (da) 2007-03-26

Family

ID=23083379

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02719463T DK1385823T3 (da) 2001-04-09 2002-04-08 Guanidinoforbindelser som melanocortin-4-receptor- (MC4-R) -agonister

Country Status (10)

Country Link
US (4) US7456183B2 (da)
EP (2) EP1767525A1 (da)
JP (1) JP4172541B2 (da)
AT (1) ATE348097T1 (da)
CY (1) CY1107442T1 (da)
DE (1) DE60216747T2 (da)
DK (1) DK1385823T3 (da)
ES (1) ES2278016T3 (da)
PT (1) PT1385823E (da)
WO (1) WO2002081443A1 (da)

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US20050038027A1 (en) 2005-02-17
EP1385823B1 (en) 2006-12-13
EP1767525A1 (en) 2007-03-28
JP4172541B2 (ja) 2008-10-29
US20040248895A1 (en) 2004-12-09
ATE348097T1 (de) 2007-01-15
US6960582B2 (en) 2005-11-01
DE60216747D1 (de) 2007-01-25
ES2278016T3 (es) 2007-08-01
JP2004535378A (ja) 2004-11-25
WO2002081443A1 (en) 2002-10-17
EP1385823A1 (en) 2004-02-04
EP1385823A4 (en) 2005-02-16
CY1107442T1 (el) 2012-12-19
US7189727B2 (en) 2007-03-13
PT1385823E (pt) 2007-01-31
DE60216747T2 (de) 2007-10-04
US20040024211A1 (en) 2004-02-05
US6716840B2 (en) 2004-04-06
US7456183B2 (en) 2008-11-25

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