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ES2126693T3 - Derivado de triazina, su produccion y su uso. - Google Patents

Derivado de triazina, su produccion y su uso.

Info

Publication number
ES2126693T3
ES2126693T3 ES94116173T ES94116173T ES2126693T3 ES 2126693 T3 ES2126693 T3 ES 2126693T3 ES 94116173 T ES94116173 T ES 94116173T ES 94116173 T ES94116173 T ES 94116173T ES 2126693 T3 ES2126693 T3 ES 2126693T3
Authority
ES
Spain
Prior art keywords
atom
oxygen
group
bound
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94116173T
Other languages
English (en)
Inventor
Hideki Miki
Koichi Iwanaga
Toshimi Matsuno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2126693T3 publication Critical patent/ES2126693T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fodder In General (AREA)

Abstract

EN LA PRESENTE INVENCION SE PRESENTA UN NUEVO DERIVADO DE TRIAZINA DE LA FORMULA EN LA QUE EL ANILLO A ES UN GRUPO AROMATICO QUE PUEDE SER OPCIONALMENTE SUSTITUIDO; X ES UN ATOMO DE OXIGENO O DE AZUFRE; R1 Y R6 SON CADA UNO UN ATOMO DE HIDROGENO O UN RESIDUO DE HIDROCARBURO OPCIONALMENTE SUSTITUIDO O UN GRUPO HETEROCICLICO ENLAZADO A TRAVES DE UN HETEROATOMO; R2 Y R3 SON CADA UNO, INDEPENDIENTEMENTE, UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO O UN GRUPO ENLAZADO A TRAVES DE UN ATOMO DE CARBONO, OXIGENO O AZUFRE Y JUNTOS REPRESENTAN =S; R4 Y R5 SON CADA UNO, INDEPENDIENTEMENTE, UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO O UN GRUPO ENLAZADO A TRAVES DE UN ATOMO DE CARBONO, OXIGENO, NITROGENO O AZUFRE; R1 Y R2, Y R5 Y R6, SE PUEDEN ENLAZAR CADA UNO ENTRE SI PARA FORMAR UN ENLACE QUIMICO; CON LA CONDICION DE QUE CUANDO EL ANILLO A SEA UN GRUPO FENILO CON AL MENOS UN ATOMO DE HALOGENO EN LA POSICION 2 O 4 Y X SEA UN ATOMO DE OXIGENO, R4 Y R5 NO REPRESENTEN DE FORMA CONJUNTA UN ENLACE QUIMICO YUNA COMPOSICION ANTIPROTOZOARIA QUE LO CONTIENE O UNA SAL DEL MISMO.
ES94116173T 1993-10-15 1994-10-13 Derivado de triazina, su produccion y su uso. Expired - Lifetime ES2126693T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25865493 1993-10-15
JP22376194 1994-09-19

Publications (1)

Publication Number Publication Date
ES2126693T3 true ES2126693T3 (es) 1999-04-01

Family

ID=26525666

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94116173T Expired - Lifetime ES2126693T3 (es) 1993-10-15 1994-10-13 Derivado de triazina, su produccion y su uso.

Country Status (13)

Country Link
EP (1) EP0648760B1 (es)
KR (1) KR100346128B1 (es)
CN (1) CN1062861C (es)
AT (1) ATE176231T1 (es)
BR (1) BR9404113A (es)
CA (1) CA2118193A1 (es)
DE (1) DE69416235T2 (es)
DK (1) DK0648760T3 (es)
ES (1) ES2126693T3 (es)
GR (1) GR3029856T3 (es)
MY (1) MY111486A (es)
RU (1) RU2146674C1 (es)
TW (1) TW403741B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994355A (en) * 1993-10-15 1999-11-30 Takeda Chemical Industries, Ltd. 1, 2, 4-Triazin-3-one derivatives, production and use thereof
DE69615601T2 (de) * 1995-04-14 2002-07-11 Takeda Schering-Plough Animal Health K.K., Osaka Verfahren zur Herstellung von Triazinderivate
DE69717380T2 (de) * 1996-08-30 2003-03-20 Takeda Schering-Plough Animal Health K.K., Osaka 1,2,4-Triazin-3,5-Dionderivate als Anticoccidiosemittel
US6867207B2 (en) 1997-07-10 2005-03-15 Janssen Pharmaceutica N.V. IL-5 inhibiting 6-azauracil derivatives
SK183999A3 (en) * 1997-07-10 2000-08-14 Janssen Pharmaceutica Nv Il-5 inhibiting 6-azauracil derivatives
WO1999011634A1 (en) 1997-08-29 1999-03-11 Takeda Chemical Industries, Ltd. Triazine derivatives, their production and use
NZ512748A (en) 1998-12-18 2004-05-28 Janssen Pharmaceutica Nv IL-5 inhibiting 6-azauracil derivatives
CA2427134A1 (en) * 2000-10-27 2002-07-25 Dow Agrosciences Llc Substituted 4,5-dihydro-1,2,4-triazin-3-ones, 1,2,4-triazin-3-ones, and their use as fungicides and insecticides
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
HRP20141053T1 (hr) 2005-05-10 2014-12-19 Intermune, Inc. Derivati piridona za moduliranje stresom aktiviranog sustava protein kinaze
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN103497193B (zh) * 2013-09-25 2015-09-02 武汉大学 具有1,2,4-三嗪骨架结构的衍生物及其合成方法
JP6525437B2 (ja) 2014-04-02 2019-06-05 インターミューン， インコーポレイテッド 抗線維性ピリジノン
EP3860982A1 (en) * 2018-10-01 2021-08-11 PI Industries Ltd. Oxadiazoles as fungicides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2532363A1 (de) * 1975-07-19 1977-02-03 Bayer Ag Substituierte 2-phenyl-1,2,4- triazin-3,5(2h,4h)-dione, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2606850A1 (de) * 1976-02-20 1977-09-15 Hoechst Ag Substituierte p-aminophenyl-as- triazindione und ihre herstellung
CH628349A5 (en) * 1977-10-21 1982-02-26 Pfizer Thiazol derivatives and anthelmintic medicament containing them
DE3408924A1 (de) * 1984-03-12 1985-09-26 Hoechst Ag, 6230 Frankfurt Substituierte 2-phenyl-hexahydro-1,2,4-triazin-3,5-dione, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
BR8602556A (pt) * 1984-06-12 1987-02-03 Fmc Corp Composto herbicida;composicao herbicida e processo para controlar o crescimento de plantas indesejadas
US4631278A (en) * 1984-08-01 1986-12-23 Janssen Pharmaceutica N.V. Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
CN1044905A (zh) * 1989-02-16 1990-08-29 赫彻斯特股份公司 鱼和昆虫寄生虫对抗剂
DE4030042A1 (de) * 1990-05-17 1991-11-21 Bayer Ag Verwendung von substituierten 1,2,4-triazindionen
EP0476439A1 (de) * 1990-09-18 1992-03-25 Bayer Ag Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung

Also Published As

Publication number Publication date
CA2118193A1 (en) 1995-04-16
DE69416235D1 (de) 1999-03-11
DK0648760T3 (da) 1999-09-13
TW403741B (en) 2000-09-01
EP0648760A3 (en) 1995-06-28
KR950011420A (ko) 1995-05-15
EP0648760A2 (en) 1995-04-19
RU94036760A (ru) 1996-08-10
DE69416235T2 (de) 1999-09-30
CN1062861C (zh) 2001-03-07
RU2146674C1 (ru) 2000-03-20
CN1106394A (zh) 1995-08-09
EP0648760B1 (en) 1999-01-27
KR100346128B1 (ko) 2002-11-23
ATE176231T1 (de) 1999-02-15
GR3029856T3 (en) 1999-07-30
MY111486A (en) 2000-06-30
BR9404113A (pt) 1995-06-27

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