FR2840302B1 - Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant - Google Patents

Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant

Info

Publication number: FR2840302B1
Authority: FR; France
Prior art keywords: medicaments; intermediary; preparation; same; pharmaceutical compositions
Prior art date: 2002-06-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

FR0206783A

Other languages

English (en)

Other versions

FR2840302A1 (fr

Inventor

Jean Christophe Carry

Serge Mignani

Antony Bigot

Baptiste Ronan

Heinz Werner Kleemann

Armin Hofmeister

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharma SA

Original Assignee

Aventis Pharma SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-03

Filing date

2002-06-03

Publication date

2004-07-16

2002-06-03 Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA

2002-06-03 Priority to FR0206783A priority Critical patent/FR2840302B1/fr

2003-05-07 Priority to JO200351A priority patent/JO2357B1/en

2003-05-20 Priority to DE2003605042 priority patent/DE60305042T2/de

2003-05-20 Priority to AT03730076T priority patent/ATE324889T1/de

2003-05-20 Priority to BR0311556A priority patent/BR0311556A/pt

2003-05-20 Priority to PCT/EP2003/005279 priority patent/WO2003101450A1/fr

2003-05-20 Priority to PT03730076T priority patent/PT1528923E/pt

2003-05-20 Priority to NZ536953A priority patent/NZ536953A/en

2003-05-20 Priority to MXPA04011931A priority patent/MXPA04011931A/es

2003-05-20 Priority to HRP20041151AA priority patent/HRP20041151B1/hr

2003-05-20 Priority to HK05108389.7A priority patent/HK1076383B/xx

2003-05-20 Priority to MEP27508 priority patent/MEP27508A/xx

2003-05-20 Priority to YUP104804 priority patent/RS51636B/sr

2003-05-20 Priority to SI200330302T priority patent/SI1528923T1/sl

2003-05-20 Priority to AU2003240677A priority patent/AU2003240677B2/en

2003-05-20 Priority to OA1200400323A priority patent/OA12864A/en

2003-05-20 Priority to JP2004508808A priority patent/JP4634793B2/ja

2003-05-20 Priority to CNB038128500A priority patent/CN1290833C/zh

2003-05-20 Priority to EP20030730076 priority patent/EP1528923B1/fr

2003-05-20 Priority to RU2004138789A priority patent/RU2318809C2/ru

2003-05-20 Priority to UA20041211001A priority patent/UA81118C2/uk

2003-05-20 Priority to ES03730076T priority patent/ES2261939T3/es

2003-05-20 Priority to PL37218803A priority patent/PL372188A1/xx

2003-05-20 Priority to KR1020047019619A priority patent/KR101149771B1/ko

2003-05-20 Priority to DK03730076T priority patent/DK1528923T3/da

2003-05-20 Priority to CA 2488373 priority patent/CA2488373C/fr

2003-05-27 Priority to US10/445,618 priority patent/US7078428B2/en

2003-05-29 Priority to PE2003000523A priority patent/PE20040531A1/es

2003-05-30 Priority to TW92114642A priority patent/TWI286545B/zh

2003-05-30 Priority to HN2003000162A priority patent/HN2003000162A/es

2003-05-30 Priority to ARP030101923 priority patent/AR039927A1/es

2003-06-01 Priority to EG2003060521A priority patent/EG24784A/xx

2003-06-02 Priority to MYPI20032036 priority patent/MY142502A/en

2003-06-02 Priority to PA8574701A priority patent/PA8574701A1/es

2003-06-03 Priority to UY27835A priority patent/UY27835A1/es

2003-12-05 Publication of FR2840302A1 publication Critical patent/FR2840302A1/fr

2004-07-16 Publication of FR2840302B1 publication Critical patent/FR2840302B1/fr

2004-07-16 Application granted granted Critical

2004-11-10 Priority to ZA2004/09094A priority patent/ZA200409094B/en

2004-11-16 Priority to MA27951A priority patent/MA27308A1/fr

2004-11-30 Priority to TNP2004000237A priority patent/TNSN04237A1/en

2004-12-02 Priority to IL165520A priority patent/IL165520A/en

2004-12-02 Priority to ECSP045472 priority patent/ECSP045472A/es

2004-12-27 Priority to NO20045660A priority patent/NO329224B1/no

2006-03-01 Priority to US11/365,319 priority patent/US7589117B2/en

2006-07-28 Priority to CY20061101057T priority patent/CY1105115T1/el

2022-06-03 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Tropical Medicine & Parasitology (AREA)
Immunology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FR0206783A 2002-06-03 2002-06-03 Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant Expired - Fee Related FR2840302B1 (fr)

Priority Applications (43)

Application Number	Priority Date	Filing Date	Title
FR0206783A FR2840302B1 (fr)	2002-06-03	2002-06-03	Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
JO200351A JO2357B1 (en)	2002-06-03	2003-05-07	Derivatives of isoandolone, method of preparation and intermediate compounds of this method, use as pharmaceutical compositions
DK03730076T DK1528923T3 (da)	2002-06-03	2003-05-20	N-((3-oxo-2,3-dihydro-1H-isoindol-1-yl)-acetyl)guanidinderivater som NHE1-inhibitorer til behandling af infarkt og angina pectoris
BR0311556A BR0311556A (pt)	2002-06-03	2003-05-20	Derivados de n-((3-oxo-2,3-diidro-1h-isoindol-1-il)acetil)guanidina como inibidores de nhe-1 para o tratamento de enfarte e angina pectoris
PCT/EP2003/005279 WO2003101450A1 (fr)	2002-06-03	2003-05-20	Derives de guanidine n- ((3-oxo-2, 3-dihydro-1h-isoindole-1-yle) acetyle) comme inhibiteurs de nhe-1 pour traiter l'infarctus et l'angine pectorale
PT03730076T PT1528923E (pt)	2002-06-03	2003-05-20	Derivados de n-((3-oxo-2,3-di-hidro-1h-isoindol-1-il)acetil)guanidina como inibidores de nhe-1 para o tratamento de enfarte e angina de peito
NZ536953A NZ536953A (en)	2002-06-03	2003-05-20	N-((3-oxo2,3-dihydro-1H-isoindol-1-yl) acetyl) guanidine derivatives as nhe-1 inhibitors for the treatment of infarction and angina pectoris
MXPA04011931A MXPA04011931A (es)	2002-06-03	2003-05-20	Derivados de n-((3-oxo-2, 3-dihidro-1h-isoindol-1-il)acetil)guanidina en calidad de inhibidores de nhe-1 para el tratamiento del infarto y la angina de pecho.
HRP20041151AA HRP20041151B1 (hr)	2002-06-03	2003-05-20	Derivati n-((3-okso-2,3-dihidro-1h-izoindol-1-il)-acetil)gvanidina kao nhe-1 inhibitori za lijeäśenje infarkta i angine pektoris
HK05108389.7A HK1076383B (en)	2002-06-03	2003-05-20	N-((3-oxo2,3-dihydro-1h-isoindol-1-yl) acetyl) guanidine derivatives as nhe-1 inhibitors for the treatment of infarction and angina pectoris
MEP27508 MEP27508A (en)	2002-06-03	2003-05-20	N- ((3-oxo2, 3-dihydro-1h-isoindol-1-yl) acetyl) guanidine derivatives as nhe-1 inhibitors for the treatment of infarction and angina pectoris
YUP104804 RS51636B (sr)	2002-06-03	2003-05-20	Derivati n-((3-okso- 2,3-dihidro-1h-izoindol-1-il) acetil) gvanidina kao inhibitori nhe-1 za lečenje infarkta i angine pektoris
SI200330302T SI1528923T1 (sl)	2002-06-03	2003-05-20	N-((3-okso-2,3-dihidro-1H-izoindol-1-il)acetil)gvanidinski derivati NHE1 za zdravljenje infarkta inangine pektoris
AU2003240677A AU2003240677B2 (en)	2002-06-03	2003-05-20	N- ((3-oxo2, 3-dihydro-1H-isoindol-1-yl) acetyl) guanidine derivatives as NHE-1 inhibitors for the treatment of infarction and angina pectoris
OA1200400323A OA12864A (en)	2002-06-03	2003-05-20	N-(3-0X02,3-DIHYDRO-1H-ISOINDOL-1-YL)ACETYL) guanidine derivatives as NHE-1 inhibitors for the treatment of infarction and angina pectoris.
JP2004508808A JP4634793B2 (ja)	2002-06-03	2003-05-20	梗塞および狭心症の治療のためのｎｈｅ−１抑制剤としてのｎ−（（３−オキソ−２，３−ジヒドロ−１ｈ−イソインドール−１−イル）アセチル）グアニジン誘導体
AT03730076T ATE324889T1 (de)	2002-06-03	2003-05-20	N-((3-oxo-2,3-dihydro-1h-isoindol-1- yl)acetyl)guanidin derivate als nhe1-inhibitoren zur behandlung von infarkten und angina pectoris
EP20030730076 EP1528923B1 (fr)	2002-06-03	2003-05-20	Derives de guanidine n- ((3-oxo-2, 3-dihydro-1h-isoindole-1-yle) acetyle) comme inhibiteurs de nhe-1 pour traiter l'infarctus et l'angine pectorale
RU2004138789A RU2318809C2 (ru)	2002-06-03	2003-05-20	Производные n-((3-оксо-2,3-дигидро-1h-изоиндол-1-ил)ацетил)гуанидина в качестве ингибиторов nhe-1 для лечения инфаркта и стенокардии
UA20041211001A UA81118C2 (en)	2002-06-03	2003-05-20	N-((3-oxo-2, 3-dihydro-1h-isoindol-1-yl) acetyl) guanidine derivatives as nhe-1 inhibitors for the treatment of infarction and angina pectoris
ES03730076T ES2261939T3 (es)	2002-06-03	2003-05-20	Derivados de n-((3-oxo-2,3-dihidro-1h-isoindol-1-il)acetil)guanidina como inhibidores de nhe1 para el tratamiento del infarto y la angina de pecho.
PL37218803A PL372188A1 (en)	2002-06-03	2003-05-20	N-((3-oxo-2,3-dihydro-1h-isoindol-1-yl)acetyl)guanidine derivatives as nhe1-inhibitors for the treatment of infarction and angina pectoris
DE2003605042 DE60305042T2 (de)	2002-06-03	2003-05-20	N-((3-oxo-2,3-dihydro-1h-isoindol-1-yl)acetyl)guanidin derivate als nhe1-inhibitoren zur behandlung von infarkten und angina pectoris
CA 2488373 CA2488373C (fr)	2002-06-03	2003-05-20	Derives de guanidine n- ((3-oxo-2, 3-dihydro-1h-isoindole-1-yle) acetyle) comme inhibiteurs de nhe-1 pour traiter l'infarctus et l'angine pectorale
CNB038128500A CN1290833C (zh)	2002-06-03	2003-05-20	用于治疗梗塞和心绞痛的nhe－1抑制剂n－((3－氧代－2,3－二氢－1h－异吲哚－1－基)乙酰基)胍衍生物
KR1020047019619A KR101149771B1 (ko)	2002-06-03	2003-05-20	경색 및 협심증의 치료를 위한 ｎｈｅ-1 억제제로서의ｎ-((3-옥소-2,3-디하이드로-1ｈ-이소인돌-1-일)아세틸)구아니딘 유도체
US10/445,618 US7078428B2 (en)	2002-06-03	2003-05-27	Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them
PE2003000523A PE20040531A1 (es)	2002-06-03	2003-05-29	Derivados de isoindolona, proceso de preparacion, compuestos intermedios de este proceso y composiciones farmaceuticas que los contienen
TW92114642A TWI286545B (en)	2002-06-03	2003-05-30	Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them
HN2003000162A HN2003000162A (es)	2002-06-03	2003-05-30	Derivados de isoindolona, proceso de preparacion y compuestos intermedios de este proceso, su uso como medicamentos, y composiciones farmaceuticas que los contienen.
ARP030101923 AR039927A1 (es)	2002-06-03	2003-05-30	Derivados de isoindolona, proceso de preparacion y compuestos intermedios de este proceso, su uso como medicamentos, y composiciones farmaceuticas que los contienen
EG2003060521A EG24784A (en)	2002-06-03	2003-06-01	Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments and pharmaceutical comprising them.
MYPI20032036 MY142502A (en)	2002-06-03	2003-06-02	N-((3-oxo-2,3-dihydro-1h-isoindol-1-yl)acetyl)guanidine derivatives as nhe1-inhibitors for the treatment of infarction and angina pectoris
PA8574701A PA8574701A1 (es)	2002-06-03	2003-06-02	Derivados de isoindolona, proceso de preparacion y compuestos intermedios de este proceso, su uso como medicamentos, y composiciones farmaceuticas que los contienen
UY27835A UY27835A1 (es)	2002-06-03	2003-06-03	Derivados de isoindolona, proceso de preparacion y compuestos intermedios de este proceso, su uso como medicamentos, y composiciones farmaceuticas que los contienen.
ZA2004/09094A ZA200409094B (en)	2002-06-03	2004-11-10	N-((3-oxo2,3-dihydro-1h-isoindol-1-yl), acetyl) guanidine derivatives as nhe-1- inhibitor for the treatment of infarction and angina pectoris
MA27951A MA27308A1 (fr)	2002-06-03	2004-11-16	Derives de n-( (3-oxo-2, 3-dihydro- 1h-isoindol-1-yl) acetyl)guanidine en tant qu'inhibiteurs du nhe-1-destines au traitement de l'infractus et de l'angine de poitrine
TNP2004000237A TNSN04237A1 (en)	2002-06-03	2004-11-30	N- ((3-oxo2, 3-dihydro-1h-isoindol-1-yl) acetyl) guanidine derivatives as nhe-1 inhibitors for the treatment of infarction and angina pectoris
IL165520A IL165520A (en)	2002-06-03	2004-12-02	N-((3-oxo-2, 3-dihydro-1h-isoindol-1-yl), acetyl) guanidine derivatives as nhe - 1 - inhibitors, pharmaceutical compositions comprising them, process for their preparation and uses thereof
ECSP045472 ECSP045472A (es)	2002-06-03	2004-12-02	"derivados de n-((3-oxo-2,3-dihidro-1h-isoindol-1-il)acetil)guanidina en calidad de inhibidores de nhe-1 para el tratamiento del infarto y la angina de pecho"
NO20045660A NO329224B1 (no)	2002-06-03	2004-12-27	N-((3okso-2,3-dihydro-IH-isoindol-1-yl)acetyl)guanidinderivater, anvendelse derav, farmasoytisk sammensetning inneholdende en slik forbindelse samt fremgangsmater for fremstilling av forbindelsene
US11/365,319 US7589117B2 (en)	2002-06-03	2006-03-01	Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them
CY20061101057T CY1105115T1 (el)	2002-06-03	2006-07-28	Παραγωγα ν-((3-οξο-2,3-διυδρο-1η-ισοϊνδολ-1-υλ)ακετυλ)γουανιδινης ως nhe1-αναστολεις για την θepαπεια του εμφραγματος και της στηθαγχης

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0206783A FR2840302B1 (fr)	2002-06-03	2002-06-03	Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant

Publications (2)

Publication Number	Publication Date
FR2840302A1 FR2840302A1 (fr)	2003-12-05
FR2840302B1 true FR2840302B1 (fr)	2004-07-16

Family

ID=29558914

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR0206783A Expired - Fee Related FR2840302B1 (fr)	2002-06-03	2002-06-03	Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant

Country Status (41)

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US (2)	US7078428B2 (fr)
EP (1)	EP1528923B1 (fr)
JP (1)	JP4634793B2 (fr)
KR (1)	KR101149771B1 (fr)
CN (1)	CN1290833C (fr)
AR (1)	AR039927A1 (fr)
AT (1)	ATE324889T1 (fr)
AU (1)	AU2003240677B2 (fr)
BR (1)	BR0311556A (fr)
CA (1)	CA2488373C (fr)
CY (1)	CY1105115T1 (fr)
DE (1)	DE60305042T2 (fr)
DK (1)	DK1528923T3 (fr)
EC (1)	ECSP045472A (fr)
EG (1)	EG24784A (fr)
ES (1)	ES2261939T3 (fr)
FR (1)	FR2840302B1 (fr)
HN (1)	HN2003000162A (fr)
HR (1)	HRP20041151B1 (fr)
IL (1)	IL165520A (fr)
JO (1)	JO2357B1 (fr)
MA (1)	MA27308A1 (fr)
ME (1)	MEP27508A (fr)
MX (1)	MXPA04011931A (fr)
MY (1)	MY142502A (fr)
NO (1)	NO329224B1 (fr)
NZ (1)	NZ536953A (fr)
OA (1)	OA12864A (fr)
PA (1)	PA8574701A1 (fr)
PE (1)	PE20040531A1 (fr)
PL (1)	PL372188A1 (fr)
PT (1)	PT1528923E (fr)
RS (1)	RS51636B (fr)
RU (1)	RU2318809C2 (fr)
SI (1)	SI1528923T1 (fr)
TN (1)	TNSN04237A1 (fr)
TW (1)	TWI286545B (fr)
UA (1)	UA81118C2 (fr)
UY (1)	UY27835A1 (fr)
WO (1)	WO2003101450A1 (fr)
ZA (1)	ZA200409094B (fr)

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KR100518184B1 (ko) *	2003-12-27	2005-10-04	한국화학연구원	퓨란카보닐구아니딘 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물
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TWI417100B (zh)	2007-06-07	2013-12-01	Astrazeneca Ab	二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
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GB0811643D0 (en) *	2008-06-25	2008-07-30	Cancer Rec Tech Ltd	New therapeutic agents
WO2012003147A1 (fr) *	2010-07-01	2012-01-05	Merck Sharp & Dohme Corp.	Modulateurs allostériques positifs du récepteur m1 de l'isoindolone
US8895571B2 (en)	2011-10-14	2014-11-25	Incyte Corporation	Isoindolinone and pyrrolopyridinone derivatives as Akt inhibitors
CN103193794B (zh) *	2013-04-12	2016-04-06	中国药科大学	一种异吲哚酮并异噁唑类稠环化合物及其合成方法
GB201517216D0 (en)	2015-09-29	2015-11-11	Cancer Res Technology Ltd And Astex Therapeutics Ltd	Pharmaceutical compounds
GB201517217D0 (en)	2015-09-29	2015-11-11	Astex Therapeutics Ltd And Cancer Res Technology Ltd	Pharmaceutical compounds
CN106316922B (zh) *	2016-08-17	2019-02-01	华东师范大学	一种含c-3全取代氧化吲哚衍生物及其合成方法和应用
WO2018058109A1 (fr)	2016-09-26	2018-03-29	Nusirt Sciences, Inc.	Compositions et méthodes pour le traitement de troubles métaboliques
GB201704966D0 (en)	2017-03-28	2017-05-10	Astex Therapeutics Ltd	Pharmaceutical compounds
GB201704965D0 (en)	2017-03-28	2017-05-10	Astex Therapeutics Ltd	Pharmaceutical compounds
CN110664803B (zh) *	2019-09-19	2023-08-29	中山大学	异吲哚酮类化合物在制备防治溶骨性疾病药物中的应用

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2002
- 2002-06-03 FR FR0206783A patent/FR2840302B1/fr not_active Expired - Fee Related
2003
- 2003-05-07 JO JO200351A patent/JO2357B1/en active
- 2003-05-20 JP JP2004508808A patent/JP4634793B2/ja not_active Expired - Fee Related
- 2003-05-20 DE DE2003605042 patent/DE60305042T2/de not_active Expired - Lifetime
- 2003-05-20 CA CA 2488373 patent/CA2488373C/fr not_active Expired - Fee Related
- 2003-05-20 OA OA1200400323A patent/OA12864A/en unknown
- 2003-05-20 ME MEP27508 patent/MEP27508A/xx unknown
- 2003-05-20 PT PT03730076T patent/PT1528923E/pt unknown
- 2003-05-20 EP EP20030730076 patent/EP1528923B1/fr not_active Expired - Lifetime
- 2003-05-20 KR KR1020047019619A patent/KR101149771B1/ko not_active Expired - Fee Related
- 2003-05-20 DK DK03730076T patent/DK1528923T3/da active
- 2003-05-20 WO PCT/EP2003/005279 patent/WO2003101450A1/fr not_active Ceased
- 2003-05-20 PL PL37218803A patent/PL372188A1/xx unknown
- 2003-05-20 SI SI200330302T patent/SI1528923T1/sl unknown
- 2003-05-20 CN CNB038128500A patent/CN1290833C/zh not_active Expired - Fee Related
- 2003-05-20 UA UA20041211001A patent/UA81118C2/uk unknown
- 2003-05-20 RU RU2004138789A patent/RU2318809C2/ru not_active IP Right Cessation
- 2003-05-20 BR BR0311556A patent/BR0311556A/pt not_active IP Right Cessation
- 2003-05-20 AU AU2003240677A patent/AU2003240677B2/en not_active Ceased
- 2003-05-20 RS YUP104804 patent/RS51636B/sr unknown
- 2003-05-20 AT AT03730076T patent/ATE324889T1/de active
- 2003-05-20 NZ NZ536953A patent/NZ536953A/en not_active IP Right Cessation
- 2003-05-20 ES ES03730076T patent/ES2261939T3/es not_active Expired - Lifetime
- 2003-05-20 MX MXPA04011931A patent/MXPA04011931A/es active IP Right Grant
- 2003-05-20 HR HRP20041151AA patent/HRP20041151B1/hr not_active IP Right Cessation
- 2003-05-27 US US10/445,618 patent/US7078428B2/en not_active Expired - Lifetime
- 2003-05-29 PE PE2003000523A patent/PE20040531A1/es not_active Application Discontinuation
- 2003-05-30 TW TW92114642A patent/TWI286545B/zh not_active IP Right Cessation
- 2003-05-30 HN HN2003000162A patent/HN2003000162A/es unknown
- 2003-05-30 AR ARP030101923 patent/AR039927A1/es active IP Right Grant
- 2003-06-01 EG EG2003060521A patent/EG24784A/xx active
- 2003-06-02 PA PA8574701A patent/PA8574701A1/es unknown
- 2003-06-02 MY MYPI20032036 patent/MY142502A/en unknown
- 2003-06-03 UY UY27835A patent/UY27835A1/es unknown
2004
- 2004-11-10 ZA ZA2004/09094A patent/ZA200409094B/en unknown
- 2004-11-16 MA MA27951A patent/MA27308A1/fr unknown
- 2004-11-30 TN TNP2004000237A patent/TNSN04237A1/en unknown
- 2004-12-02 EC ECSP045472 patent/ECSP045472A/es unknown
- 2004-12-02 IL IL165520A patent/IL165520A/en not_active IP Right Cessation
- 2004-12-27 NO NO20045660A patent/NO329224B1/no not_active IP Right Cessation
2006
- 2006-03-01 US US11/365,319 patent/US7589117B2/en not_active Expired - Fee Related
- 2006-07-28 CY CY20061101057T patent/CY1105115T1/el unknown

Also Published As

Publication number	Publication date
US7078428B2 (en)	2006-07-18
RS51636B (sr)	2011-08-31
CN1658869A (zh)	2005-08-24
DK1528923T3 (da)	2006-09-04
NZ536953A (en)	2007-10-26
JP2005533034A (ja)	2005-11-04
AR039927A1 (es)	2005-03-09
CA2488373C (fr)	2012-07-17
SI1528923T1 (sl)	2006-08-31
WO2003101450A1 (fr)	2003-12-11
DE60305042T2 (de)	2007-05-24
MXPA04011931A (es)	2005-03-31
MY142502A (en)	2010-11-30
TWI286545B (en)	2007-09-11
ES2261939T3 (es)	2006-11-16
EG24784A (en)	2010-09-01
US7589117B2 (en)	2009-09-15
UY27835A1 (es)	2003-12-31
UA81118C2 (en)	2007-12-10
PL372188A1 (en)	2005-07-11
IL165520A0 (en)	2006-01-15
HK1076383A1 (en)	2006-01-20
EP1528923A1 (fr)	2005-05-11
DE60305042D1 (de)	2006-06-08
BR0311556A (pt)	2005-04-12
MEP27508A (en)	2010-06-10
PT1528923E (pt)	2006-08-31
RU2004138789A (ru)	2005-06-27
CA2488373A1 (fr)	2003-12-11
NO329224B1 (no)	2010-09-20
ECSP045472A (es)	2005-01-28
IL165520A (en)	2009-12-24
NO20045660L (no)	2004-12-27
HN2003000162A (es)	2004-05-05
AU2003240677A1 (en)	2003-12-19
JO2357B1 (en)	2006-12-12
JP4634793B2 (ja)	2011-02-16
US20040048916A1 (en)	2004-03-11
TNSN04237A1 (en)	2007-03-12
PA8574701A1 (es)	2004-05-07
TW200404780A (en)	2004-04-01
RS104804A (sr)	2006-12-15
HRP20041151A2 (en)	2005-06-30
HRP20041151B1 (hr)	2013-06-30
EP1528923B1 (fr)	2006-05-03
RU2318809C2 (ru)	2008-03-10
ATE324889T1 (de)	2006-06-15
ZA200409094B (en)	2005-08-31
CN1290833C (zh)	2006-12-20
KR101149771B1 (ko)	2012-06-08
PE20040531A1 (es)	2004-09-27
MA27308A1 (fr)	2005-05-02
US20060148880A1 (en)	2006-07-06
AU2003240677B2 (en)	2008-07-17
KR20050010855A (ko)	2005-01-28
CY1105115T1 (el)	2010-03-03
OA12864A (en)	2006-09-15
FR2840302A1 (fr)	2003-12-05

Publication	Publication Date	Title
FR2840302B1 (fr)	2004-07-16	Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
FR2836915B1 (fr)	2008-01-11	Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
MA27392A1 (fr)	2005-06-01	Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant
FR2824825B1 (fr)	2005-05-06	Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2816938B1 (fr)	2003-01-03	Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant
EE200200409A (et)	2003-12-15	1,3-dihüdro-2H-indool-2-ooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
EE200100431A (et)	2002-12-16	16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine
EE04464B1 (et)	2005-04-15	Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
FR2827604B1 (fr)	2003-09-19	Nouveaux derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2- one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
EE05104B1 (et)	2008-12-15	Asetidiini derivaadid, nende valmistamise meetodid ja farmatseutiline kompositsioon
FR2862647B1 (fr)	2008-07-04	Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant
FR2822826B1 (fr)	2003-05-09	Nouveaux derives sulfonyles d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2789079B3 (fr)	2001-03-02	Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
FR2846656B1 (fr)	2004-12-24	Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2793794B1 (fr)	2001-07-27	Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
FR2852954B1 (fr)	2006-07-14	Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
FR2804429B1 (fr)	2003-05-09	Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2854159B1 (fr)	2008-01-11	Nouveaux derives de l'indole, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de kdr
FR2842525B1 (fr)	2005-05-13	Derives de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments et compositions pharmaceutiques les renfermant
FR2858619B1 (fr)	2006-12-22	Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
FR2805538B1 (fr)	2006-08-04	Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
EE200300553A (et)	2004-02-16	Piperidiinkarboksamiidi derivaadid, nende valmistamise meetod ja neid sisaldavad farmatseutilised kompositsioonid
FR2854634B1 (fr)	2005-07-08	Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2883876B1 (fr)	2007-05-04	Derives d'indanyl-piperazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2833956B1 (fr)	2004-01-30	Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

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