[go: up one dir, main page]

UY27835A1 - Derivados de isoindolona, proceso de preparacion y compuestos intermedios de este proceso, su uso como medicamentos, y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de isoindolona, proceso de preparacion y compuestos intermedios de este proceso, su uso como medicamentos, y composiciones farmaceuticas que los contienen.

Info

Publication number
UY27835A1
UY27835A1 UY27835A UY27835A UY27835A1 UY 27835 A1 UY27835 A1 UY 27835A1 UY 27835 A UY27835 A UY 27835A UY 27835 A UY27835 A UY 27835A UY 27835 A1 UY27835 A1 UY 27835A1
Authority
UY
Uruguay
Prior art keywords
derivatives
isoindolona
medications
pharmaceutical compositions
compositions containing
Prior art date
Application number
UY27835A
Other languages
English (en)
Inventor
Dr Heinz-Werner Kleemann
Dr Armin Hofmeister
Jean-Christophe Carry
Serge Mignani
Dr Antony Bigot
Baptiste Ronan
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of UY27835A1 publication Critical patent/UY27835A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención se refiere a los nuevos derivados de isoindolona de la fórmula I en la cual R1 a R6 tienen los significados indicados en las reivindicaciones. Los compuestos de la invención son adecuados como medicamentos antiarrítmicos con un componente cardioprotector para la profilaxis del infarto y el tratamiento del infarto y para el tratamiento de la angina de pecho. Dichos derivados inhiben también de manera preventiva los procesos patofisiológicos asociados con el desarrollo del dano inducido por isquemia, en particular en el desencadenamiento de arritmias cardíacas inducidas por isquemia y de la insuficiencia cardiaca.
UY27835A 2002-06-03 2003-06-03 Derivados de isoindolona, proceso de preparacion y compuestos intermedios de este proceso, su uso como medicamentos, y composiciones farmaceuticas que los contienen. UY27835A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0206783A FR2840302B1 (fr) 2002-06-03 2002-06-03 Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
UY27835A1 true UY27835A1 (es) 2003-12-31

Family

ID=29558914

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27835A UY27835A1 (es) 2002-06-03 2003-06-03 Derivados de isoindolona, proceso de preparacion y compuestos intermedios de este proceso, su uso como medicamentos, y composiciones farmaceuticas que los contienen.

Country Status (41)

Country Link
US (2) US7078428B2 (es)
EP (1) EP1528923B1 (es)
JP (1) JP4634793B2 (es)
KR (1) KR101149771B1 (es)
CN (1) CN1290833C (es)
AR (1) AR039927A1 (es)
AT (1) ATE324889T1 (es)
AU (1) AU2003240677B2 (es)
BR (1) BR0311556A (es)
CA (1) CA2488373C (es)
CY (1) CY1105115T1 (es)
DE (1) DE60305042T2 (es)
DK (1) DK1528923T3 (es)
EC (1) ECSP045472A (es)
EG (1) EG24784A (es)
ES (1) ES2261939T3 (es)
FR (1) FR2840302B1 (es)
HN (1) HN2003000162A (es)
HR (1) HRP20041151B1 (es)
IL (1) IL165520A (es)
JO (1) JO2357B1 (es)
MA (1) MA27308A1 (es)
ME (1) MEP27508A (es)
MX (1) MXPA04011931A (es)
MY (1) MY142502A (es)
NO (1) NO329224B1 (es)
NZ (1) NZ536953A (es)
OA (1) OA12864A (es)
PA (1) PA8574701A1 (es)
PE (1) PE20040531A1 (es)
PL (1) PL372188A1 (es)
PT (1) PT1528923E (es)
RS (1) RS51636B (es)
RU (1) RU2318809C2 (es)
SI (1) SI1528923T1 (es)
TN (1) TNSN04237A1 (es)
TW (1) TWI286545B (es)
UA (1) UA81118C2 (es)
UY (1) UY27835A1 (es)
WO (1) WO2003101450A1 (es)
ZA (1) ZA200409094B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10356717A1 (de) * 2003-12-02 2005-07-07 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von (3-Oxo-2,3-dihydro-1H-isoindol-1-yl)-acetylguanidin-Derivaten
US7531569B2 (en) 2003-12-02 2009-05-12 Sanofi-Aventis Deutschland Gmbh Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives
KR100518184B1 (ko) * 2003-12-27 2005-10-04 한국화학연구원 퓨란카보닐구아니딘 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물
TW200613272A (en) 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
US7807706B2 (en) 2005-08-12 2010-10-05 Astrazeneca Ab Metabotropic glutamate-receptor-potentiating isoindolones
US20070161648A1 (en) * 2005-10-14 2007-07-12 Hughes Terry V Substituted dihydro-isoindolones useful in treating kinase disorders
TW200812962A (en) * 2006-07-12 2008-03-16 Astrazeneca Ab New compounds I/418
TWI417100B (zh) 2007-06-07 2013-12-01 Astrazeneca Ab 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
SA109300358B1 (ar) 2008-06-06 2012-11-03 استرازينيكا ايه بي مقويات مستقبل جلوتامات ذي انتحاء أيضي من أيزو إندولون
GB0811643D0 (en) * 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
WO2012003147A1 (en) * 2010-07-01 2012-01-05 Merck Sharp & Dohme Corp. Isoindolone m1 receptor positive allosteric modulators
US8895571B2 (en) 2011-10-14 2014-11-25 Incyte Corporation Isoindolinone and pyrrolopyridinone derivatives as Akt inhibitors
CN103193794B (zh) * 2013-04-12 2016-04-06 中国药科大学 一种异吲哚酮并异噁唑类稠环化合物及其合成方法
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
CN106316922B (zh) * 2016-08-17 2019-02-01 华东师范大学 一种含c-3全取代氧化吲哚衍生物及其合成方法和应用
WO2018058109A1 (en) 2016-09-26 2018-03-29 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
CN110664803B (zh) * 2019-09-19 2023-08-29 中山大学 异吲哚酮类化合物在制备防治溶骨性疾病药物中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2708605A1 (fr) * 1993-07-30 1995-02-10 Sanofi Sa Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
EP0612723B1 (de) * 1993-02-20 1997-08-27 Hoechst Aktiengesellschaft Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament
FR2735166B1 (fr) * 1995-06-08 1997-08-29 Aerospatiale Procede de fabrication d'un panneau ou analogue a proprietes structurale et acoustique et panneau ainsi obtenu
DE19737224A1 (de) * 1997-08-27 1999-03-18 Hoechst Marion Roussel De Gmbh Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen
DE19737463A1 (de) * 1997-08-28 1999-03-04 Hoechst Marion Roussel De Gmbh Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden
DE19738604A1 (de) * 1997-09-04 1999-03-11 Hoechst Marion Roussel De Gmbh Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe
TR200002480T2 (tr) * 1998-02-27 2000-12-21 Pfizer Products Inc. İzaşemi tedavisi için guanidin türevleri
DE19859727A1 (de) * 1998-12-23 2000-06-29 Aventis Pharma Gmbh Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung
US6534651B2 (en) * 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
OA12256A (en) * 2000-04-28 2003-11-06 Pfizer Prod Inc Sodium-hydrogen exchanger type 1 inhibitor (NHE-1).
DE10046993A1 (de) * 2000-09-22 2002-04-11 Aventis Pharma Gmbh Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
DK1385823T3 (da) * 2001-04-09 2007-03-26 Novartis Vaccines & Diagnostic Guanidinoforbindelser som melanocortin-4-receptor- (MC4-R) -agonister

Also Published As

Publication number Publication date
US7078428B2 (en) 2006-07-18
RS51636B (sr) 2011-08-31
CN1658869A (zh) 2005-08-24
DK1528923T3 (da) 2006-09-04
NZ536953A (en) 2007-10-26
FR2840302B1 (fr) 2004-07-16
JP2005533034A (ja) 2005-11-04
AR039927A1 (es) 2005-03-09
CA2488373C (en) 2012-07-17
SI1528923T1 (sl) 2006-08-31
WO2003101450A1 (en) 2003-12-11
DE60305042T2 (de) 2007-05-24
MXPA04011931A (es) 2005-03-31
MY142502A (en) 2010-11-30
TWI286545B (en) 2007-09-11
ES2261939T3 (es) 2006-11-16
EG24784A (en) 2010-09-01
US7589117B2 (en) 2009-09-15
UA81118C2 (en) 2007-12-10
PL372188A1 (en) 2005-07-11
IL165520A0 (en) 2006-01-15
HK1076383A1 (en) 2006-01-20
EP1528923A1 (en) 2005-05-11
DE60305042D1 (de) 2006-06-08
BR0311556A (pt) 2005-04-12
MEP27508A (en) 2010-06-10
PT1528923E (pt) 2006-08-31
RU2004138789A (ru) 2005-06-27
CA2488373A1 (en) 2003-12-11
NO329224B1 (no) 2010-09-20
ECSP045472A (es) 2005-01-28
IL165520A (en) 2009-12-24
NO20045660L (no) 2004-12-27
HN2003000162A (es) 2004-05-05
AU2003240677A1 (en) 2003-12-19
JO2357B1 (en) 2006-12-12
JP4634793B2 (ja) 2011-02-16
US20040048916A1 (en) 2004-03-11
TNSN04237A1 (en) 2007-03-12
PA8574701A1 (es) 2004-05-07
TW200404780A (en) 2004-04-01
RS104804A (sr) 2006-12-15
HRP20041151A2 (en) 2005-06-30
HRP20041151B1 (hr) 2013-06-30
EP1528923B1 (en) 2006-05-03
RU2318809C2 (ru) 2008-03-10
ATE324889T1 (de) 2006-06-15
ZA200409094B (en) 2005-08-31
CN1290833C (zh) 2006-12-20
KR101149771B1 (ko) 2012-06-08
PE20040531A1 (es) 2004-09-27
MA27308A1 (fr) 2005-05-02
US20060148880A1 (en) 2006-07-06
AU2003240677B2 (en) 2008-07-17
KR20050010855A (ko) 2005-01-28
CY1105115T1 (el) 2010-03-03
OA12864A (en) 2006-09-15
FR2840302A1 (fr) 2003-12-05

Similar Documents

Publication Publication Date Title
UY27835A1 (es) Derivados de isoindolona, proceso de preparacion y compuestos intermedios de este proceso, su uso como medicamentos, y composiciones farmaceuticas que los contienen.
BR0312134A (pt) Benzoilguanidinas derivadas de cicloalquilas fluoradas e seu emprego como medicamento
UY29300A1 (es) Compuestos quimicos
AR066184A1 (es) Compuesto heterociclico de carboxamida, composicion farmacutica que lo comprende, proceso para prepararla y uso de dicho compuesto solo o en combinacion con un agente antineoplastico para la preparacion de un medicamento util como inhibidor de la akt y dicha combinacion farmaceutica
AR056291A1 (es) Composiciones farmaceuticas para el tratamiento de la trombosis
MX390044B (es) Derivados de naftiridinona y su uso en el tratamiento de la arritmia.
HRP20041078B1 (hr) Pentafluorsulfanil-benzoilgvanidini, postupak za njihovu pripravu, njihova upotreba kao lijeka ili dijagnostika, kao i lijek koji ih sadrži
BR0312701A (pt) Derivados de 3-guanidinocarbonil-1-hete-roaril-indol, processo de preparação, seu uso como medicamentos e composições farmacêuticas os compreendendo
BR0312702A (pt) Derivados de 3-guanidinocarbonil-1-heteroaril-pirrol, processo de preparação e intermediários desse processo, seu uso como medicamentos e composições farmacêuticas compreendendo os mesmos
CL2022000320A1 (es) Compuestos adecuados para el tratamiento y la profilaxis del desgaste muscular y otras afecciones
ES2142895T3 (es) Guanidinas sustituidas con diacilo, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.
UY28358A1 (es) Derivados de 3-(guanidinocarbonil)heterociclos, procedimiento de preparación y compuestos intermedios de este procedimiento, su uso como medicamentos, y composiciones farmaceuticas que los incluyen.
UY31118A1 (es) Derivados de di(hetero)arilciclohexano, su preparacion, su uso y composiciones farmaceuticas que los comprenden
UY28616A1 (es) Pentafluorosulfanilbenzoilguanidinas, procedimiento para su preparación, su uso como medicamento o coadyuvante de diagnostico, y medicamento que las comprende.
AR008761A1 (es) Benzoil-guanidinas sustituidas en orto, procedimiento para su preparacion, su utilizacion como medicamento, asi como medicamento que las contiene
BR0313188A (pt) Derivados de 3-guanidocarbonil-1-heteroaril-indol, processo de preparação, seu uso como medicamentos e composições farmacêuticas compreendendo os mesmos
UY28487A1 (es) Benzoilguanidinas sustituidas con pentafluorosulfanilfenilo, procedimientos para su preparación, su uso como medicamento o coadyuvante de diagnóstico y el medicamento que las comprende.
UY29113A1 (es) Benzoilguanidinas sustituidas con pentfluorosulfanilfenilo, procedimientos para su preparacion, su uso como medicamento o agente de diagnostico, y medicamento que las comprende.
AR045384A1 (es) Benzoilguanidinas sustituidas con pentafluorosulfanilfenilo, procedimientos para su preparacion, composiciones farmaceuticas que las comprende y su uso
BRPI0516704A (pt) composto, processo para a preparação de um composto, processo para produzir uma composição farmacêutica, composição farmacêutica, uso de um composto e uso de uma composição farmacêutica
AR006051A1 (es) Benzoilguanidinas sustituidas en posicion orto, su utilizacion para la preparacion de un medicamento para la profilaxis y tratamiento de infarto,angina de pecho, estados isquemicos y de proliferacion celular.
AR027237A1 (es) Benzoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento o medio de diagnostico como tambien medicamento que lascontiene.
PA8617501A1 (es) Pentafluorosulfanilbenzoilguanidinas, procedimiento para su preparacion, su uso como medicamento o coadyuvante de diagnostico, y medicamento que las comprende.