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TW200526658A - Heterocyclic inhibitors of MEK and methods of use thereof - Google Patents

Heterocyclic inhibitors of MEK and methods of use thereof

Info

Publication number
TW200526658A
TW200526658A TW093135618A TW93135618A TW200526658A TW 200526658 A TW200526658 A TW 200526658A TW 093135618 A TW093135618 A TW 093135618A TW 93135618 A TW93135618 A TW 93135618A TW 200526658 A TW200526658 A TW 200526658A
Authority
TW
Taiwan
Prior art keywords
compounds
methods
mek
heterocyclic inhibitors
mammals
Prior art date
Application number
TW093135618A
Other languages
English (en)
Inventor
Eli Wallace
Jeongbob Seo
Joseph P Lyssikatos
Allison Marlow
Hong-Woon Yang
Jim Blake
T Brian Hurley
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of TW200526658A publication Critical patent/TW200526658A/zh

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    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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