[go: up one dir, main page]

TR200402579T4 - Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı - Google Patents

Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı

Info

Publication number
TR200402579T4
TR200402579T4 TR2004/02579T TR200402579T TR200402579T4 TR 200402579 T4 TR200402579 T4 TR 200402579T4 TR 2004/02579 T TR2004/02579 T TR 2004/02579T TR 200402579 T TR200402579 T TR 200402579T TR 200402579 T4 TR200402579 T4 TR 200402579T4
Authority
TR
Turkey
Prior art keywords
manufacture
drug substance
crystalline monohydrate
same
monohydrate
Prior art date
Application number
TR2004/02579T
Other languages
English (en)
Inventor
Banholzer Rolf
Sieger Peter
Kulinna Christian
Trunk Michael
Ludwig Manfred Graulich August
Specht Peter
Meissner Helmut
Mathes Andreas
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200402579(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of TR200402579T4 publication Critical patent/TR200402579T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Bulus (1alfa,2 ,4 ,5alfa,7 )-7- [(hidroksidi-2-tienilasetil)oksi]-9 ,9-dimetil-3-oksa-9-azoniatrisiklo [3.3.1.0ÜS(2,4)]nonan-bromid'in bir kristalin monohidrati, aynisinin imalati, ve ayrica aynisinin bir ilaç maddesinin, özellikle de antikolinerjik etkili bir ilaç maddesinin imalati için kullanimi ile ilgilidir.
TR2004/02579T 2000-10-12 2001-09-28 Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı TR200402579T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12

Publications (1)

Publication Number Publication Date
TR200402579T4 true TR200402579T4 (tr) 2004-12-21

Family

ID=7659568

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/02579T TR200402579T4 (tr) 2000-10-12 2001-09-28 Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı

Country Status (46)

Country Link
EP (2) EP1326862B1 (tr)
JP (1) JP3764422B2 (tr)
KR (1) KR100823860B1 (tr)
CN (2) CN100519558C (tr)
AP (1) AP1572A (tr)
AR (2) AR034389A1 (tr)
AT (1) ATE276253T1 (tr)
AU (2) AU1499602A (tr)
BG (1) BG66161B1 (tr)
BR (1) BR0114584A (tr)
CA (1) CA2425539C (tr)
CR (1) CR6938A (tr)
CZ (1) CZ301841B6 (tr)
DE (1) DE50103666D1 (tr)
DK (1) DK1326862T3 (tr)
DZ (1) DZ3478A1 (tr)
EA (1) EA004381B1 (tr)
EC (1) ECSP034540A (tr)
EE (1) EE04567B1 (tr)
EG (1) EG24142A (tr)
ES (1) ES2228965T3 (tr)
GE (1) GEP20063905B (tr)
HR (1) HRP20030276B1 (tr)
HU (1) HU226830B1 (tr)
IL (2) IL155335A0 (tr)
IS (1) IS2339B (tr)
MA (1) MA25842A1 (tr)
ME (2) MEP40008A (tr)
MX (1) MXPA03003221A (tr)
MY (1) MY126931A (tr)
NO (1) NO328465B1 (tr)
NZ (1) NZ525733A (tr)
OA (1) OA12403A (tr)
PE (1) PE20020422A1 (tr)
PL (1) PL207870B1 (tr)
PT (1) PT1326862E (tr)
RS (1) RS50218B (tr)
SA (1) SA01220412B1 (tr)
SI (1) SI1326862T1 (tr)
SK (1) SK287009B6 (tr)
TR (1) TR200402579T4 (tr)
TW (1) TW589313B (tr)
UA (1) UA74215C2 (tr)
UY (2) UY26962A1 (tr)
WO (1) WO2002030928A1 (tr)
ZA (1) ZA200302500B (tr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
PL208137B1 (pl) * 2001-06-22 2011-03-31 Boehringer Ingelheim Pharma Bezwodny krystaliczny bromek tiotropium, sposób jego wytwarzania i zastosowanie krystalicznego monohydratu bromku tiotropium do wytwarzania krystalicznego bezwodnego bromku tiotropium
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (de) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
JP4553902B2 (ja) * 2003-11-03 2010-09-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗コリン作用を有する新規結晶性無水物
US7968717B2 (en) 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
ATE478071T1 (de) * 2003-11-03 2010-09-15 Boehringer Ingelheim Int Verfahren zur herstellung neuer tiotropiumsalze
HRP20100149T1 (hr) 2003-11-03 2010-04-30 Boehringer Ingelheim International Gmbh Postupak priprave tiotropijevih soli
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
DK2422786T3 (da) 2004-04-22 2014-11-17 Boehringer Ingelheim Int Nye lægemiddelkombinationer til behandling af luftvejssygdomme
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
ES2322148T3 (es) 2004-08-11 2009-06-17 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO. KG Medicamentos que contienen anticolinergicos para el tratamiento en las vias urinarias.
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
NZ554930A (en) * 2004-10-21 2010-04-30 Boehringer Ingelheim Int Blister for inhalers
JP2008532973A (ja) * 2005-03-09 2008-08-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗コリン作用薬とｐｄｅ５−阻害剤に基づく新規な医薬組成物
CN101163706A (zh) 2005-04-21 2008-04-16 贝林格尔·英格海姆国际有限公司 用于治疗炎性疾病的二氢噻吩并嘧啶
KR20080007645A (ko) 2005-04-28 2008-01-22 베링거 인겔하임 인터내셔날 게엠베하 염증성 질환 치료용 신규 화합물
RU2007144531A (ru) * 2005-05-02 2009-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Новые кристаллические формы тиотропийбромида
SI1881980T1 (sl) 2005-05-02 2012-12-31 Boehringer Ingelheim International Gmbh Nove kristalinične oblike tiotropijevega bromida
CN101227905A (zh) * 2005-06-15 2008-07-23 贝林格尔·英格海姆国际有限公司 制备噻托铵盐的方法、噻托铵盐及其药物组合物
DE102005030733A1 (de) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
AU2006277968A1 (en) * 2005-08-06 2007-02-15 Boehringer Ingelheim International Gmbh Use of tiotropium salts in the treatment of severe persistant asthma
BRPI0614410A2 (pt) 2005-08-15 2011-03-29 Boehringer Ingelheim Int processo para preparação de betamiméticos
TWI396541B (zh) 2005-10-10 2013-05-21 Boehringer Ingelheim Int 用於治療呼吸疾病之新穎藥物組合
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de) * 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
CN101360744A (zh) * 2005-12-19 2009-02-04 西科尔公司 纯和稳定的噻托溴铵
BRPI0608427A2 (pt) 2005-12-19 2009-12-29 Sicor Inc novas formas de brometo de tiotrópio e processos para seu preparo
SI1971332T1 (sl) * 2006-01-04 2011-05-31 Boehringer Ingelheim Int Uporaba tiotropijevih soli pri zdravljenju zmerne persistentne astme
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
DE502007006951D1 (de) 2006-08-07 2011-05-26 Boehringer Ingelheim Pharma Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
UY30550A1 (es) 2006-08-22 2008-03-31 Boehringer Ingelheim Int Nuevos beta-agonistas enantioméricamente puros, procedimientos para su preparacion y su uso como medicamentos
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
BRPI0818006B8 (pt) 2007-10-19 2021-05-25 Boehringer Ingelheim Int compostos de piperidino-di-hidrotienopirimidinas substituídas, uso dos mesmos e formulações farmacêuticas
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
WO2010011813A1 (en) * 2008-07-23 2010-01-28 Alkermes, Inc. Complex of trospium and pharmaceutical compositions thereof
EA020548B1 (ru) 2008-12-19 2014-12-30 Бёрингер Ингельхайм Интернациональ Гмбх Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл
EP2201934A1 (en) 2008-12-23 2010-06-30 CHIESI FARMACEUTICI S.p.A. Tiotropium aerosol formulation products with improved chemical stability
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
EP2462140A2 (en) 2009-08-07 2012-06-13 Generics [UK] Limited Anhydrate of triotropium bromide
ME01908B (me) 2009-12-17 2014-12-20 Boehringer Ingelheim Int Novi antagonisti ccr2 receptora i njihova primjena
JP5658272B2 (ja) 2009-12-17 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２の新規アンタゴニスト及びこれらの使用
KR20120125267A (ko) 2010-01-29 2012-11-14 베링거 인겔하임 인터내셔날 게엠베하 치환된 나프티리딘 및 ｓｙｋ 키나제 억제제로서의 이의 용도
US8877745B2 (en) 2010-05-12 2014-11-04 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
WO2011141477A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
WO2011147772A1 (en) 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists
EP2576538B1 (en) 2010-06-01 2015-10-28 Boehringer Ingelheim International GmbH New CCR2 antagonists
EP2668177B1 (en) 2011-01-28 2014-10-22 Boehringer Ingelheim International GmbH Substituted pyridinyl-pyrimidines and their use as medicaments
TR201102068A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
JP5786257B2 (ja) 2011-06-16 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の選択的ｃｃｒ２拮抗薬
EP2731941B1 (en) 2011-07-15 2019-05-08 Boehringer Ingelheim International GmbH Novel and selective ccr2 antagonists
KR101986484B1 (ko) 2011-07-26 2019-06-10 베링거 인겔하임 인터내셔날 게엠베하 치환된 퀴놀린 및 이의 약제로서의 용도
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CZ304368B6 (cs) * 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
UA115888C2 (uk) 2012-11-05 2018-01-10 Зентіва, К.С. Стабілізація сольватів тіотропію
EP2913332A1 (en) * 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
KR102431017B1 (ko) 2014-03-19 2022-08-11 베링거 인겔하임 인터내셔날 게엠베하 헤테로아릴 syk 억제제
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
EP3414243A1 (en) 2016-02-11 2018-12-19 Sima Patent Ve Lisanslama Hizmetleri Ltd. STI Crystalline form of tiotropium bromide anhydrate
WO2018084817A2 (en) * 2016-11-04 2018-05-11 Si̇ma Patent Ve Li̇sanslama Hi̇zmetleri̇ Ltd. Şti̇ A new form of active agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
ES2129117T3 (es) * 1992-12-09 1999-06-01 Boehringer Ingelheim Pharma Formulaciones en disolucion en forma de aerosol medicinales estabilizadas.
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
WO2000007567A1 (de) * 1998-08-04 2000-02-17 Jago Research Ag Medizinische aerosolformulierungen

Also Published As

Publication number Publication date
DK1326862T3 (da) 2004-11-22
AU2002214996B2 (en) 2007-03-15
EP1326862B1 (de) 2004-09-15
UY34901A (es) 2015-02-27
AP1572A (en) 2006-02-13
JP3764422B2 (ja) 2006-04-05
WO2002030928A1 (de) 2002-04-18
CN100519558C (zh) 2009-07-29
DE50103666D1 (de) 2004-10-21
YU27303A (sh) 2006-05-25
HK1086557A1 (zh) 2006-09-22
UY26962A1 (es) 2002-06-20
CA2425539A1 (en) 2003-04-11
BG66161B1 (bg) 2011-09-30
CN1733761A (zh) 2006-02-15
CA2425539C (en) 2007-04-03
SA01220412B1 (ar) 2006-11-05
IS6772A (is) 2003-04-09
JP2004526668A (ja) 2004-09-02
EE04567B1 (et) 2005-12-15
TW589313B (en) 2004-06-01
KR20030042008A (ko) 2003-05-27
IL155335A (en) 2009-02-11
ECSP034540A (es) 2003-07-25
SK287009B6 (sk) 2009-09-07
AR068527A2 (es) 2009-11-18
BR0114584A (pt) 2003-08-26
DZ3478A1 (fr) 2002-04-18
EA004381B1 (ru) 2004-04-29
IS2339B (is) 2008-02-15
EP1468998A1 (de) 2004-10-20
HUP0301022A2 (hu) 2003-10-28
EA200300457A1 (ru) 2003-10-30
UA74215C2 (uk) 2005-11-15
PT1326862E (pt) 2004-11-30
HK1060567A1 (en) 2004-08-13
EG24142A (en) 2008-08-06
CZ301841B6 (cs) 2010-07-07
MEP40008A (en) 2011-02-10
SK4362003A3 (en) 2003-08-05
MA25842A1 (fr) 2003-07-01
OA12403A (en) 2006-04-18
HUP0301022A3 (en) 2005-12-28
CR6938A (es) 2004-10-28
KR100823860B1 (ko) 2008-04-21
ZA200302500B (en) 2004-04-22
NO328465B1 (no) 2010-02-22
NO20031694L (no) 2003-04-11
SI1326862T1 (sl) 2005-02-28
PE20020422A1 (es) 2002-06-28
AP2003002775A0 (en) 2003-03-31
NZ525733A (en) 2005-01-28
CN1469877A (zh) 2004-01-21
PL366041A1 (en) 2005-01-24
AU1499602A (en) 2002-04-22
RS50218B (sr) 2009-07-15
GEP20063905B (en) 2006-08-25
HRP20030276B1 (en) 2006-02-28
HRP20030276A2 (en) 2005-02-28
AR034389A1 (es) 2004-02-25
MXPA03003221A (es) 2004-12-03
PL207870B1 (pl) 2011-02-28
MY126931A (en) 2006-10-31
ME00243B (me) 2011-05-10
NO20031694D0 (no) 2003-04-11
ES2228965T3 (es) 2005-04-16
BG107687A (bg) 2003-09-30
CN1221549C (zh) 2005-10-05
EE200300171A (et) 2003-06-16
HU226830B1 (en) 2009-11-30
IL155335A0 (en) 2003-11-23
EP1326862A1 (de) 2003-07-16
ATE276253T1 (de) 2004-10-15

Similar Documents

Publication Publication Date Title
TR200402579T4 (tr) Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı
BR0014818A (pt) Imidazo-3-il-aminas bicìclicas procedimento de preparação e medicamentos que contém como substância ativa pelo menos uma imidazo-3-il-amina bicìclica
TR200103302T2 (tr) Diamorfin etkin maddeli farmasötik preparat
MY122779A (en) Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition.
EE200000532A (et) Pürimidiini derivaatide kasutamine ravimi valmistamiseks, mis on ette nähtud HIV nakkuse raviks, ühend, seda sisaldav farmatseutiline kompositsioon, meetod ühendi ja kompositsiooni valmistamiseks ningkombineeritud preparaat kasutamiseks HIV nakkusera
BR0014320A (pt) Composições de substâncias terapêuticas solúveis em tocol
BR9912975A (pt) Composto e composições para liberação de agentes ativos, método para sua obtenção e seu uso
NO894887D0 (no) Farmakologisk aktive pyrimidinforbindelser og fremgangsmaate for deres fremstilling.
WO2001019829A3 (en) Pyrazolopyrimidines as therapeutic agents
FI962948A7 (fi) Menetelmä vaikealiukoisten farmaseuttisesti aktiivisten aineiden liuot tamiseksi
EE04431B1 (et) Bensamidiini derivaadid ja nende kasutamine LTB-4antagonistliku mõjuga ravimitena
ES2195638T3 (es) Preparaciones de combinaciones farmaceuticas en forma solida de dosificacion que contienen cardevilol e hidroclorotiazida.
HUP0101597A3 (en) Oral medicinal preparations with reproducible release of the active ingredient gatifloxacin or its pharmaceutically suitable salts or hydrates
NO994165L (no) Anvendelse av deskarboetoksyloratadin for fremstilling av et medikament for behandling av urininkontinens, reisesyke og svimmelhet
EE05054B1 (et) 5-HT4 agonisti v?i antagonisti peroraalne ravimkoostis ja selle kasutamine meditsiinis
MX9708394A (es) Composicion farmaceutica que contiene clorhidrato de tiagabina y el proceso para su preparacion.
AU7788500A (en) Use of substance p antagonists for influencing the circadian timing system
EE04914B1 (et) Eletriptaanvesinikbromiidi monohüdraat, selle kasutamine ja protsess selle valmistamiseks ning eletriptaanvesinikbromiidi monohüdraati sisaldav farmatseutiline kompositsioon
EE9400296A (et) Piperidinüültioindooli derivaadid, ravimvormid, aktiivne valuvaigisti, nende valmistamise meetodid
IS5390A (is) Bensoxazín og bensóþíazín afleiður og notkun þeirra í lyf
UA32598C2 (uk) Спосіб одержання лікарської форми карбамазепіну
AP2000001937A0 (en) Method for identifying chemical active agents and active agents for inhibiting the 1-desoxy-d-xylulose-5-phosphate biosynthetic pathway.
MX9709453A (es) Composicion farmaceutica oral de compuestos de piperidinoalcanol en forma de solucion.
ATE280575T1 (de) Transdermales therapeutisches system zur anwendung von candesartan
TR199900480T2 (tr) Kristalin farmasötik ürün.