SI1326862T1 - Kristalinični monohidrat tiotropijevega bromida, postopek za njegovo pripravo in njegova uporaba za pripravo zdravila - Google Patents

Kristalinični monohidrat tiotropijevega bromida, postopek za njegovo pripravo in njegova uporaba za pripravo zdravila

Info

Publication number: SI1326862T1
Authority: SI; Slovenia
Prior art keywords: preparation; medicament; bromide monohydrate; thiotropium bromide; crystalline
Prior art date: 2000-10-12

Application number

SI200130219T

Other languages

English (en)

Inventor

Rolf Banholzer

Peter Sieger

Christian Kulinna

Michael Trunk

Manfred Ludwig August Graulich

Peter Specht

Helmut Meissner

Andreas Mathes

Original Assignee

Boehringer Ingelheim Pharma Gmbh & Co. Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-12

Filing date

2001-09-28

Publication date

2005-02-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1326862(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-09-28 Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg

2005-02-28 Publication of SI1326862T1 publication Critical patent/SI1326862T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SI200130219T 2000-10-12 2001-09-28 Kristalinični monohidrat tiotropijevega bromida, postopek za njegovo pripravo in njegova uporaba za pripravo zdravila SI1326862T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10050621		2000-10-12
PCT/EP2001/011225 WO2002030928A1 (de)	2000-10-12	2001-09-28	Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels
EP01983510A EP1326862B1 (de)	2000-10-12	2001-09-28	Kristallines monohydrat von tiotropiumbromid, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels

Publications (1)

Publication Number	Publication Date
SI1326862T1 true SI1326862T1 (sl)	2005-02-28

Family

ID=7659568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200130219T SI1326862T1 (sl)	2000-10-12	2001-09-28	Kristalinični monohidrat tiotropijevega bromida, postopek za njegovo pripravo in njegova uporaba za pripravo zdravila

Country Status (46)

Country	Link
EP (2)	EP1326862B1 (sl)
JP (1)	JP3764422B2 (sl)
KR (1)	KR100823860B1 (sl)
CN (2)	CN100519558C (sl)
AP (1)	AP1572A (sl)
AR (2)	AR034389A1 (sl)
AT (1)	ATE276253T1 (sl)
AU (2)	AU2002214996B2 (sl)
BG (1)	BG66161B1 (sl)
BR (1)	BR0114584A (sl)
CA (1)	CA2425539C (sl)
CR (1)	CR6938A (sl)
CZ (1)	CZ301841B6 (sl)
DE (1)	DE50103666D1 (sl)
DK (1)	DK1326862T3 (sl)
DZ (1)	DZ3478A1 (sl)
EA (1)	EA004381B1 (sl)
EC (1)	ECSP034540A (sl)
EE (1)	EE04567B1 (sl)
EG (1)	EG24142A (sl)
ES (1)	ES2228965T3 (sl)
GE (1)	GEP20063905B (sl)
HR (1)	HRP20030276B1 (sl)
HU (1)	HU226830B1 (sl)
IL (2)	IL155335A0 (sl)
IS (1)	IS2339B (sl)
MA (1)	MA25842A1 (sl)
ME (2)	ME00243B (sl)
MX (1)	MXPA03003221A (sl)
MY (1)	MY126931A (sl)
NO (1)	NO328465B1 (sl)
NZ (1)	NZ525733A (sl)
OA (1)	OA12403A (sl)
PE (1)	PE20020422A1 (sl)
PL (1)	PL207870B1 (sl)
PT (1)	PT1326862E (sl)
RS (1)	RS50218B (sl)
SA (1)	SA01220412B1 (sl)
SI (1)	SI1326862T1 (sl)
SK (1)	SK287009B6 (sl)
TR (1)	TR200402579T4 (sl)
TW (1)	TW589313B (sl)
UA (1)	UA74215C2 (sl)
UY (2)	UY26962A1 (sl)
WO (1)	WO2002030928A1 (sl)
ZA (1)	ZA200302500B (sl)

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DE10317461A1 (de)	2003-04-16	2004-10-28	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
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CN101163706A (zh)	2005-04-21	2008-04-16	贝林格尔·英格海姆国际有限公司	用于治疗炎性疾病的二氢噻吩并嘧啶
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DK1881980T3 (da)	2005-05-02	2012-10-01	Boehringer Ingelheim Int	Nye krystalline former af tiotropiumbromid
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AU2006259202B2 (en) *	2005-06-15	2012-05-10	Boehringer Ingelheim International Gmbh	Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005030733A1 (de)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
CA2617717C (en) *	2005-08-06	2014-02-11	Boehringer Ingelheim International Gmbh	Use of tiotropium salts in the treatment of severe persistant asthma
WO2007020227A1 (de)	2005-08-15	2007-02-22	Boehringer Ingelheim International Gmbh	Verfahren zur herstellung von betamimetika
TWI396541B (zh)	2005-10-10	2013-05-21	Boehringer Ingelheim Int	用於治療呼吸疾病之新穎藥物組合
US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de)	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Mikronisierung
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JP5086267B2 (ja) *	2005-12-19	2012-11-28	シコールインコーポレイティド	臭化チオトロピウムの新規な形態およびそれを製造する方法
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JP6535022B2 (ja)	2014-03-19	2019-06-26	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ヘテロアリールｓｙｋ阻害剤
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2001
- 2001-09-28 CA CA002425539A patent/CA2425539C/en not_active Expired - Lifetime
- 2001-09-28 EP EP01983510A patent/EP1326862B1/de not_active Expired - Lifetime
- 2001-09-28 KR KR1020037005083A patent/KR100823860B1/ko not_active Expired - Lifetime
- 2001-09-28 RS YU27303A patent/RS50218B/sr unknown
- 2001-09-28 HR HR20030276A patent/HRP20030276B1/xx not_active IP Right Cessation
- 2001-09-28 AU AU2002214996A patent/AU2002214996B2/en not_active Expired
- 2001-09-28 EP EP04016877A patent/EP1468998A1/de not_active Withdrawn
- 2001-09-28 SK SK436-2003A patent/SK287009B6/sk not_active IP Right Cessation
- 2001-09-28 ES ES01983510T patent/ES2228965T3/es not_active Expired - Lifetime
- 2001-09-28 EE EEP200300171A patent/EE04567B1/xx unknown
- 2001-09-28 IL IL15533501A patent/IL155335A0/xx active IP Right Grant
- 2001-09-28 AU AU1499602A patent/AU1499602A/xx active Pending
- 2001-09-28 GE GE5214A patent/GEP20063905B/en unknown
- 2001-09-28 CZ CZ20031025A patent/CZ301841B6/cs not_active IP Right Cessation
- 2001-09-28 DE DE50103666T patent/DE50103666D1/de not_active Expired - Lifetime
- 2001-09-28 DK DK01983510T patent/DK1326862T3/da active
- 2001-09-28 WO PCT/EP2001/011225 patent/WO2002030928A1/de not_active Ceased
- 2001-09-28 CN CNB2005100977370A patent/CN100519558C/zh not_active Ceased
- 2001-09-28 ME MEP-2008-400A patent/ME00243B/me unknown
- 2001-09-28 BR BR0114584-3A patent/BR0114584A/pt not_active Application Discontinuation
- 2001-09-28 OA OA1200300107A patent/OA12403A/fr unknown
- 2001-09-28 AT AT01983510T patent/ATE276253T1/de active
- 2001-09-28 JP JP2002534314A patent/JP3764422B2/ja not_active Expired - Lifetime
- 2001-09-28 DZ DZ013478A patent/DZ3478A1/fr active
- 2001-09-28 HU HU0301022A patent/HU226830B1/hu unknown
- 2001-09-28 UA UA2003054185A patent/UA74215C2/uk unknown
- 2001-09-28 TR TR2004/02579T patent/TR200402579T4/xx unknown
- 2001-09-28 PT PT01983510T patent/PT1326862E/pt unknown
- 2001-09-28 CN CNB018171435A patent/CN1221549C/zh not_active Ceased
- 2001-09-28 PL PL366041A patent/PL207870B1/pl unknown
- 2001-09-28 AP APAP/P/2003/002775A patent/AP1572A/en active
- 2001-09-28 SI SI200130219T patent/SI1326862T1/sl unknown
- 2001-09-28 NZ NZ525733A patent/NZ525733A/en not_active IP Right Cessation
- 2001-09-28 ME MEP-400/08A patent/MEP40008A/xx unknown
- 2001-09-28 EA EA200300457A patent/EA004381B1/ru not_active IP Right Cessation
- 2001-09-28 MX MXPA03003221A patent/MXPA03003221A/es active IP Right Grant
- 2001-10-02 SA SA01220412A patent/SA01220412B1/ar unknown
- 2001-10-09 EG EG20011058A patent/EG24142A/xx active
- 2001-10-09 TW TW090124963A patent/TW589313B/zh active
- 2001-10-10 PE PE2001001000A patent/PE20020422A1/es active IP Right Grant
- 2001-10-10 MY MYPI20014705A patent/MY126931A/en unknown
- 2001-10-10 UY UY26962A patent/UY26962A1/es not_active Application Discontinuation
- 2001-10-12 AR ARP010104782A patent/AR034389A1/es active IP Right Grant
2003
- 2003-03-26 CR CR6938A patent/CR6938A/es unknown
- 2003-03-28 BG BG107687A patent/BG66161B1/bg unknown
- 2003-03-31 ZA ZA200302500A patent/ZA200302500B/en unknown
- 2003-04-07 EC EC2003004540A patent/ECSP034540A/es unknown
- 2003-04-08 MA MA27102A patent/MA25842A1/fr unknown
- 2003-04-09 IS IS6772A patent/IS2339B/is unknown
- 2003-04-10 IL IL155335A patent/IL155335A/en unknown
- 2003-04-11 NO NO20031694A patent/NO328465B1/no not_active IP Right Cessation
2008
- 2008-09-19 AR ARP080104109A patent/AR068527A2/es unknown
2013
- 2013-07-11 UY UY34901A patent/UY34901A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2004526668A (ja)	2004-09-02
HK1060567A1 (en)	2004-08-13
EA200300457A1 (ru)	2003-10-30
SK4362003A3 (en)	2003-08-05
JP3764422B2 (ja)	2006-04-05
YU27303A (sh)	2006-05-25
HRP20030276A2 (en)	2005-02-28
RS50218B (sr)	2009-07-15
EP1326862A1 (de)	2003-07-16
CZ301841B6 (cs)	2010-07-07
KR20030042008A (ko)	2003-05-27
MY126931A (en)	2006-10-31
CA2425539C (en)	2007-04-03
NO328465B1 (no)	2010-02-22
AP1572A (en)	2006-02-13
OA12403A (en)	2006-04-18
CR6938A (es)	2004-10-28
AU1499602A (en)	2002-04-22
AR068527A2 (es)	2009-11-18
KR100823860B1 (ko)	2008-04-21
EG24142A (en)	2008-08-06
CN1221549C (zh)	2005-10-05
EE200300171A (et)	2003-06-16
ES2228965T3 (es)	2005-04-16
EE04567B1 (et)	2005-12-15
DE50103666D1 (de)	2004-10-21
MEP40008A (en)	2011-02-10
NO20031694L (no)	2003-04-11
PE20020422A1 (es)	2002-06-28
SK287009B6 (sk)	2009-09-07
SA01220412B1 (ar)	2006-11-05
HUP0301022A2 (hu)	2003-10-28
DK1326862T3 (da)	2004-11-22
PL366041A1 (en)	2005-01-24
MA25842A1 (fr)	2003-07-01
CN100519558C (zh)	2009-07-29
UY34901A (es)	2015-02-27
NZ525733A (en)	2005-01-28
AP2003002775A0 (en)	2003-03-31
ZA200302500B (en)	2004-04-22
IS6772A (is)	2003-04-09
HU226830B1 (en)	2009-11-30
ME00243B (me)	2011-05-10
BG107687A (bg)	2003-09-30
TW589313B (en)	2004-06-01
EP1468998A1 (de)	2004-10-20
CN1469877A (zh)	2004-01-21
TR200402579T4 (tr)	2004-12-21
UA74215C2 (uk)	2005-11-15
AU2002214996B2 (en)	2007-03-15
BR0114584A (pt)	2003-08-26
WO2002030928A1 (de)	2002-04-18
PL207870B1 (pl)	2011-02-28
EP1326862B1 (de)	2004-09-15
CA2425539A1 (en)	2003-04-11
HK1086557A1 (zh)	2006-09-22
NO20031694D0 (no)	2003-04-11
IL155335A (en)	2009-02-11
DZ3478A1 (fr)	2002-04-18
IL155335A0 (en)	2003-11-23
ATE276253T1 (de)	2004-10-15
CN1733761A (zh)	2006-02-15
AR034389A1 (es)	2004-02-25
GEP20063905B (en)	2006-08-25
EA004381B1 (ru)	2004-04-29
UY26962A1 (es)	2002-06-20
IS2339B (is)	2008-02-15
PT1326862E (pt)	2004-11-30
BG66161B1 (bg)	2011-09-30
HUP0301022A3 (en)	2005-12-28
MXPA03003221A (es)	2004-12-03
ECSP034540A (es)	2003-07-25
HRP20030276B1 (en)	2006-02-28

Publication	Publication Date	Title
SI1326862T1 (sl)	2005-02-28	Kristalinični monohidrat tiotropijevega bromida, postopek za njegovo pripravo in njegova uporaba za pripravo zdravila
NO2020007I1 (no)	2020-03-19	Sitagliptin, eventuelt i form av et farmasøytisk akseptabelt salt
NO20025227L (no)	2002-10-31	Tropanderivater nyttige i terapi
HUP0302943A3 (en)	2007-08-28	New heterocyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents
EE05316B1 (et)	2010-08-16	Kristalliline antikolinergikum, meetod selle valmistamiseks ja selle kasutamine ravimi valmistamiseks
PT1296974E (pt)	2009-11-03	Derivados 2-cianopirrolidina e sua utilização como medicamentos
EE05109B1 (et)	2008-12-15	Sulfoonamiidi derivaadid, nende kasutamine meditsiinis ning meetod nende valmistamiseks
EE04565B1 (et)	2005-12-15	Adamantaani derivaadid, nende saamine ja kasutamine
EE200300151A (et)	2003-06-16	Ravimitena kasutatavad antikolinergikumid ning meetodid nende valmistamiseks
NO20032909L (no)	2003-08-27	Glukopyranosyloksypyrazolderivater samt medikamentell anvendelse derav
AU2001279905A1 (en)	2002-05-09	Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents
AU2001279905A2 (en)	2003-05-01	Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents
EE200300048A (et)	2004-12-15	Bensimidasooli derivaadid, nende valmistamine ja terapeutiline kasutamine
HUP0400988A3 (en)	2006-07-28	Use of compounds with combined nep/mp-inhibitory activity in the preparation of medicaments
EE04497B1 (et)	2005-06-15	Püridopüranoasepiini derivaadid, nende valmistamine ja terapeutiline kasutamine
EE04490B1 (et)	2005-06-15	Ühend, selle valmistamise meetod ning kasutamine meditsiinis
EE200300255A (et)	2003-08-15	Asitromütsiin monohüdraadina, selle valmistamismeetod ja selle kasutamine ravimkoostises
NO20032614D0 (no)	2003-06-10	Farmasöytisk sammensetning med forbedret absorbabilitet
DE50112350D1 (de)	2007-05-24	Arzneimittel enthaltend aktiviertes antithrombin iii
SI1333819T1 (sl)	2007-12-31	Inhalacijska formulacija v raztopini s tiotropijevo soljo
NO20023517D0 (no)	2002-07-24	Stol
DZ3364A1 (fr)	2002-02-07	Agent therapeutique cristallin
EE200300466A (et)	2003-12-15	Püridoindolooni derivaatide kasutamine ravimite valmistamiseks
BR8003087Y1 (pt)	2009-01-13	aperfeiÇoamento em artigo absorvente descartÁvel.
FIU20000364U0 (fi)	2000-09-20	Levyrunkoinen tuoli