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PE20060292A1 - Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos - Google Patents

Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos

Info

Publication number
PE20060292A1
PE20060292A1 PE2005000613A PE2005000613A PE20060292A1 PE 20060292 A1 PE20060292 A1 PE 20060292A1 PE 2005000613 A PE2005000613 A PE 2005000613A PE 2005000613 A PE2005000613 A PE 2005000613A PE 20060292 A1 PE20060292 A1 PE 20060292A1
Authority
PE
Peru
Prior art keywords
beta
combination
antimuscarinal
agents
adrenergic agonists
Prior art date
Application number
PE2005000613A
Other languages
English (en)
Inventor
Escardo Jordi Gras
Calvo Jesus Llenas
Diaz Pio Orviz
Hamish Ryder
Original Assignee
Almirall Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34956036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060292(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall Lab filed Critical Almirall Lab
Publication of PE20060292A1 publication Critical patent/PE20060292A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
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    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
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    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/007—Pulmonary tract; Aromatherapy
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    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Wrappers (AREA)

Abstract

REFERIDA A UNA COMBINACION QUE COMPRENDE UN AGONISTA BETA 2 Y UN ANTAGONISTA DE LOS RECEPTORES MUSCARINICOS M3 QUE ES 3(R)-(2-HIDROXI-2,2-DITIEN-2-ILACETOXI)-1-(3-FENOXIPROPIL)-1-AZONIABICICLO[2,2,2]OCTANO, EN FORMA DE UNA SAL QUE TIENE UN ANION X, QUE ES UN ANION FARMACEUTICAMENTE ACEPTABLE DE UN ACIDO MONO O POLIVALENTE. EL AGONISTA BETA 2 ES ARFORMOTEROL, BAMBUTEROL, BITOLTEROL, IBUTEROL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN ENVASE Y UN KIT QUE CONTIENE DICHA COMBINACION. DICHA COMBINACION ES UTIL EN EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS QUE RESPONDEN AL ANTAGONISMO DE LOS RECEPTORES M3 MUSCARINICOS, PRODUCIENDO MENORES EFECTOS SECUNDARIOS TALES COMO TAQUICARDIA
PE2005000613A 2004-05-31 2005-05-31 Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos PE20060292A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200401312A ES2257152B1 (es) 2004-05-31 2004-05-31 Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.

Publications (1)

Publication Number Publication Date
PE20060292A1 true PE20060292A1 (es) 2006-04-14

Family

ID=34956036

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2008000713A PE20081650A1 (es) 2004-05-31 2005-05-31 Combinaciones que comprenden formoterol y salmeterol y sales de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo[2,2,2]octano
PE2008000712A PE20081649A1 (es) 2004-05-31 2005-05-31 Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos
PE2005000613A PE20060292A1 (es) 2004-05-31 2005-05-31 Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PE2008000713A PE20081650A1 (es) 2004-05-31 2005-05-31 Combinaciones que comprenden formoterol y salmeterol y sales de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo[2,2,2]octano
PE2008000712A PE20081649A1 (es) 2004-05-31 2005-05-31 Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos

Country Status (45)

Country Link
US (41) US20080051378A1 (es)
EP (14) EP1763368B2 (es)
JP (8) JP5049120B2 (es)
KR (3) KR101174677B1 (es)
CN (8) CN1972716A (es)
AR (1) AR049066A1 (es)
AT (3) ATE474600T1 (es)
AU (3) AU2005247103B2 (es)
BE (1) BE1016608A5 (es)
BR (6) BRPI0511667A (es)
CA (3) CA2533061C (es)
CH (1) CH696962A5 (es)
CL (1) CL2011000607A1 (es)
CY (7) CY1108885T1 (es)
DE (3) DE602005022497D1 (es)
DK (5) DK1891973T3 (es)
EC (6) ECSP067038A (es)
ES (7) ES2257152B1 (es)
FR (2) FR2870744B1 (es)
GB (1) GB2419819B (es)
GR (1) GR1006045B (es)
HR (4) HRP20090215T4 (es)
HU (2) HUP0600139A3 (es)
IL (3) IL179689A (es)
IT (1) ITMI20051021A1 (es)
LT (1) LTC1763368I2 (es)
LU (1) LU91214B1 (es)
MC (1) MC200083A1 (es)
ME (4) ME02779B (es)
MX (3) MXPA06013847A (es)
MY (1) MY142095A (es)
NL (2) NL1029151C2 (es)
NO (7) NO338621B1 (es)
NZ (3) NZ544539A (es)
PE (3) PE20081650A1 (es)
PL (6) PL1763369T3 (es)
PT (4) PT1891973E (es)
RS (4) RS53529B1 (es)
RU (4) RU2373935C2 (es)
SI (5) SI1763369T1 (es)
TW (1) TWI404530B (es)
UA (6) UA89185C2 (es)
UY (1) UY28933A1 (es)
WO (3) WO2005115467A1 (es)
ZA (6) ZA200600261B (es)

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ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US20050026948A1 (en) * 2003-07-29 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
CN1829520A (zh) * 2003-07-29 2006-09-06 贝林格尔·英格海姆国际有限公司 抗胆碱能药和类固醇的联用药物及其在通过吸入治疗呼吸疾病中的用途
AU2005247106B2 (en) * 2004-05-31 2010-11-11 Laboratorios Almirall, S.A. Combinations comprising antimuscarinic agents and PDE4 inhibitors
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
US20100150884A1 (en) * 2005-02-10 2010-06-17 Oncolys Biopharma Inc. Anticancer Agent to Be Combined with Telomelysin
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EP1996179A2 (en) * 2006-02-22 2008-12-03 Valorisation-Recherche, Limited Partnership Compositions for disorders associated with metachromatic cell activation
US8007790B2 (en) 2006-04-03 2011-08-30 Stowers Institute For Medical Research Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases
TW200815054A (en) * 2006-06-19 2008-04-01 Otsuka Pharma Co Ltd Methods of using a thiazole derivative
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US20070167489A1 (en) 2007-07-19
US20050267078A1 (en) 2005-12-01
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