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PE20080407A1 - Derivados de quinuclidina como antagonistas de m3 - Google Patents

Derivados de quinuclidina como antagonistas de m3

Info

Publication number
PE20080407A1
PE20080407A1 PE2007000959A PE2007000959A PE20080407A1 PE 20080407 A1 PE20080407 A1 PE 20080407A1 PE 2007000959 A PE2007000959 A PE 2007000959A PE 2007000959 A PE2007000959 A PE 2007000959A PE 20080407 A1 PE20080407 A1 PE 20080407A1
Authority
PE
Peru
Prior art keywords
antagonists
azoniabiciclo
trifluorbenzyl
fluorphenyl
carbamoyloxy
Prior art date
Application number
PE2007000959A
Other languages
English (en)
Inventor
Gabriele Amari
Andrea Rizzi
Ricardo Patacchini
Valentina Cenacchi
Gino Villetti
Ruiz Juan Lorenzo Catena
Masip Isabel Masip
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of PE20080407A1 publication Critical patent/PE20080407A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA Ic DONDE R1 ES F, Cl, Br, ENTRE OTROS; R2 ES 3,4,5-TRIFLUORFENILO; 3,4-DIFLUORFENILO, ENTRE OTROS; X ES UN ANION. SON COMPUESTOS PREFERIDOS: (3R)-3-[(3-FLUOROFENIL)-(3,4,5-TRIFLUORBENCIL)-CARBAMOILOXI]-1-(2-OXO-2-FENILETIL)-1-AZONIABICICLO[2.2.2]OCTANO, BROMURO; (3R)-3-[(3-FLUORFENIL) -(3,4,5-TRIFLUORBENCIL)-CARBAMOILOXI]-1-(2-OXO-2-(4-FLUORFENIL)ETIL)-1-AZONIABICICLO[2.2.2]OCTANO-BROMURO; ENTRE OTROS. SE REFIERE TAMBIEN UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS SON MODULADORES DEL RECEPTOR MUSCARINICO M3, UTILES EN EL TRATAMIETO Y PREVENCION DE ENFERMEDADES RESPIRATORIAS TALES COMO ASMA, BRONQUITIS CRONICA, ENFISEMA Y DEMAS RELACIONADAS
PE2007000959A 2006-07-26 2007-07-24 Derivados de quinuclidina como antagonistas de m3 PE20080407A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06117883A EP1882691A1 (en) 2006-07-26 2006-07-26 Quinuclidine derivatives as M3 antagonists

Publications (1)

Publication Number Publication Date
PE20080407A1 true PE20080407A1 (es) 2008-06-17

Family

ID=37890216

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000959A PE20080407A1 (es) 2006-07-26 2007-07-24 Derivados de quinuclidina como antagonistas de m3

Country Status (16)

Country Link
US (1) US7838534B2 (es)
EP (2) EP1882691A1 (es)
JP (1) JP5331688B2 (es)
KR (1) KR20090033443A (es)
CN (1) CN101490049A (es)
AR (1) AR062104A1 (es)
AU (1) AU2007278231B2 (es)
BR (1) BRPI0713826A2 (es)
CA (1) CA2658649A1 (es)
CL (1) CL2007002159A1 (es)
EA (1) EA017698B1 (es)
MX (1) MX2009000999A (es)
PE (1) PE20080407A1 (es)
TW (1) TW200817398A (es)
WO (1) WO2008012290A2 (es)
ZA (1) ZA200901124B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100869722B1 (ko) 2000-12-22 2008-11-21 알미랄 에이쥐 퀴누클리딘 카르바메이트 유도체 및 ｍ3 길항제로서 그의사용
ES2246170B1 (es) * 2004-07-29 2007-04-01 Almirall Prodesfarma, S.A. Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.
EP2080507A1 (en) * 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Pharmaceutical formulations comprising an anticholinergic drug
EP2080523A1 (en) 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Compositions comprising an antimuscarinic and a long-acting beta-agonist
EP2080508A1 (en) 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Dry powder formulation comprising an anticholinergic drug
EP2154136A1 (en) * 2008-08-08 2010-02-17 CHIESI FARMACEUTICI S.p.A. Quinuclidine carbonate derivatives and medicinal compositions thereof
EP2206712A1 (en) * 2008-12-23 2010-07-14 CHIESI FARMACEUTICI S.p.A. "Alkaloid aminoester derivatives and medicinal composition thereof"
CN102947300B (zh) 2010-06-22 2016-09-21 奇斯药制品公司 生物碱氨基酯衍生物及其药物组合物
EP2585457B1 (en) * 2010-06-22 2015-07-22 Chiesi Farmaceutici S.p.A. Alkaloid aminoester derivatives and medicinal composition thereof
EP2585047A1 (en) * 2010-06-22 2013-05-01 Chiesi Farmaceutici S.p.A. Dry powder formulation comprising an antimuscarinic drug
WO2011160919A1 (en) 2010-06-22 2011-12-29 Chiesi Farmaceutici S.P.A. Alkaloid aminoester derivatives and medicinal composition thereof
BR112013012160A2 (pt) 2010-11-26 2019-09-24 Chiesi Farm Spa compostos, composição farmacêutica, uso de um composto e dispositivo
US20120220557A1 (en) 2011-02-17 2012-08-30 Chiesi Farmaceutici S.P.A. Liquid propellant-free formulation comprising an antimuscarinic drug
CA2834467A1 (en) 2011-04-29 2012-11-01 Chiesi Farmaceutici S.P.A. Alkaloid ester and carbamate derivatives and medicinal compositions thereof
KR20140105746A (ko) 2011-12-30 2014-09-02 키에시 파르마슈티시 엣스. 피. 에이. 항무스카린제로서 1-아자헤테로시클릴아세트산의 퀴누클리딘 에스터, 이들의 제조 방법 및 이들의 의약 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72632C2 (uk) * 2000-06-27 2005-03-15 Лабораторіос С.А.Л.В.А.Т., С.А. Карбамати, похідні від арилалкіламінів
KR100869722B1 (ko) * 2000-12-22 2008-11-21 알미랄 에이쥐 퀴누클리딘 카르바메이트 유도체 및 ｍ3 길항제로서 그의사용
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
UA76571C2 (en) * 2001-12-20 2006-08-15 Derivatives of 1-alkyl-1-azoniabicyclo [2.2.2.]octanecarbamate and use thereof as antagonists of muscarin receptor
ES2203327B1 (es) * 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
KR20090033443A (ko) 2009-04-03
AU2007278231A1 (en) 2008-01-31
AU2007278231B2 (en) 2012-08-16
EP2049533A2 (en) 2009-04-22
AR062104A1 (es) 2008-10-15
CA2658649A1 (en) 2008-01-31
CL2007002159A1 (es) 2008-01-04
TW200817398A (en) 2008-04-16
EP1882691A1 (en) 2008-01-30
EA200970158A1 (ru) 2009-06-30
US20080039493A1 (en) 2008-02-14
MX2009000999A (es) 2009-04-15
CN101490049A (zh) 2009-07-22
WO2008012290A2 (en) 2008-01-31
US7838534B2 (en) 2010-11-23
JP2009544659A (ja) 2009-12-17
BRPI0713826A2 (pt) 2015-05-12
WO2008012290A3 (en) 2008-03-13
ZA200901124B (en) 2010-05-26
JP5331688B2 (ja) 2013-10-30
EA017698B1 (ru) 2013-02-28

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