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PE20081837A1 - Derivados de quinuclinidol como antagonistas de los receptores muscarinicos - Google Patents

Derivados de quinuclinidol como antagonistas de los receptores muscarinicos

Info

Publication number
PE20081837A1
PE20081837A1 PE2008000007A PE2008000007A PE20081837A1 PE 20081837 A1 PE20081837 A1 PE 20081837A1 PE 2008000007 A PE2008000007 A PE 2008000007A PE 2008000007 A PE2008000007 A PE 2008000007A PE 20081837 A1 PE20081837 A1 PE 20081837A1
Authority
PE
Peru
Prior art keywords
quinuclinidol
antagonists
ilpropanoil
azoniabiciclo
oxi
Prior art date
Application number
PE2008000007A
Other languages
English (en)
Inventor
Rhonan Ford
Antonio Mete
Ian Millichip
Barry Teobald
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39166793&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081837(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20081837A1 publication Critical patent/PE20081837A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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  • Gynecology & Obstetrics (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE QUINUCLINIDOL DE FORMULA (I), EN DONDE R1 ES ALQUILO(C1-C6); R2 ES FENILO, HETEROARILODE 5 A 6 MIEMBROS OPCIONALMENTE SUSTITUIDOS; R3 Y R4 JUNTO AL N AL CUAL ESTAN UNIDOS FORMAN UN HETEROCICLO ALIFATICO DE 4 A 8 MIEMBROS; R5 ES DE FORMULA (II) O (III), R6 ES -(R7)w-(Q)y-R8, ENTRE OTROS. SON SELECCIONADOS: (3R)-1-(FENOXIPROPIL)-3-[(2-FENIL-2-PIPERIDIN-1-ILPROPANOIL)OXI]-1-AZONIABICICLO[2,2,2]OCTANO X, (3R)-1-[2-(ISOXAZOL-3-ILAMINO)-2-OXOETIL]-3-{[(2S)-2-FENIL-2-PIPERIDIN-1-ILPROPANOIL]OXI}-1-AZONIABICICLO[2,2,2]OCTANO X, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS TIENEN ACCION ANTICOLINERGICA, YA QUE ACTUAN COMO ANTAGONISTAS DE RECEPTORES MUSCARINICOS Y EN PARTICULAR DEL RECEPTOR DE M3, SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES DEL TRACTO RESPIRATORIO EN ESPECIAL DE LA ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA
PE2008000007A 2006-12-19 2008-01-02 Derivados de quinuclinidol como antagonistas de los receptores muscarinicos PE20081837A1 (es)

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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
GB0808707D0 (en) * 2008-05-13 2008-06-18 Argenta Discovery Ltd New compounds 275
EA017627B1 (ru) 2008-05-13 2013-01-30 Астразенека Аб Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора
GB0811100D0 (en) * 2008-06-17 2008-07-23 Astrazeneca Ab New combination
WO2009153536A1 (en) * 2008-06-17 2009-12-23 Argenta Discovery Limited 1-aza-bicyclo [2.2.2] octane derivatives useful as muscarinic receptor antagonists
GB0811099D0 (en) * 2008-06-17 2008-07-23 Astrazeneca Ab New combination 376
WO2010008341A1 (en) * 2008-07-16 2010-01-21 Astrazeneca Ab A combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist
EP2206712A1 (en) * 2008-12-23 2010-07-14 CHIESI FARMACEUTICI S.p.A. "Alkaloid aminoester derivatives and medicinal composition thereof"
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
WO2010144043A1 (en) * 2009-06-12 2010-12-16 Astrazeneca Ab A novel 4-methylbenzenesulphonate salt and a process for preparing a pharmaceutical composition comprising the salt
EP2459524A2 (en) 2009-07-31 2012-06-06 Cadila Healthcare Limited Novel compounds as modulators of glucocorticoid receptors
WO2011073662A1 (en) 2009-12-17 2011-06-23 Astrazeneca Ab Combination of a benzoxazinone and a further agent for treating respiratory diseases
EP2585457B1 (en) * 2010-06-22 2015-07-22 Chiesi Farmaceutici S.p.A. Alkaloid aminoester derivatives and medicinal composition thereof
WO2011160919A1 (en) * 2010-06-22 2011-12-29 Chiesi Farmaceutici S.P.A. Alkaloid aminoester derivatives and medicinal composition thereof
KR20140105746A (ko) 2011-12-30 2014-09-02 키에시 파르마슈티시 엣스. 피. 에이. 항무스카린제로서 1-아자헤테로시클릴아세트산의 퀴누클리딘 에스터, 이들의 제조 방법 및 이들의 의약 조성물
US9751875B2 (en) * 2013-07-13 2017-09-05 Beijing Fswelcome Technology Development Co., Ltd. Quinine compounds, and optical isomers, preparation method and medical use thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334494D0 (en) 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
GB8923590D0 (en) * 1989-10-19 1989-12-06 Pfizer Ltd Antimuscarinic bronchodilators
GR1001529B (el) 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
PT880508E (pt) 1996-02-13 2003-07-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
IL125954A (en) 1996-03-05 2003-06-24 Zeneca Ltd Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
WO2001092224A1 (en) 2000-05-31 2001-12-06 Astrazeneca Ab Indole derivatives with vascular damaging activity
GB0015876D0 (en) 2000-06-28 2000-08-23 Novartis Ag Organic compounds
AU6623301A (en) 2000-07-07 2002-01-21 Angiogene Pharm Ltd Colchinol derivatives as vascular damaging agents
HUP0301742A3 (en) 2000-07-07 2005-08-29 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors, process for producing them, pharmaceutical compositions containing them and their use
ES2296923T3 (es) 2001-03-22 2008-05-01 Glaxo Group Limited Derivados formanilidas como agonistas del adrenorreceptor beta2.
PT1383786E (pt) 2001-04-30 2008-12-30 Glaxo Group Ltd Derivados anti-inflamatórios de éster 17.beta-carbotioato de androstano com um grupo éster ciclíco na posição 17.alfa
US20030229058A1 (en) 2001-11-13 2003-12-11 Moran Edmund J. Aryl aniline beta2 adrenergic receptor agonists
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
ATE392206T1 (de) 2002-10-11 2008-05-15 Pfizer Indolderivate als beta-2 agonisten
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
AR044134A1 (es) * 2003-05-02 2005-08-24 Novartis Ag Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas.
CN100445281C (zh) * 2003-05-02 2008-12-24 诺瓦提斯公司 与毒蕈碱性m3受体结合的奎宁环衍生物
EP1684767A1 (en) 2003-11-03 2006-08-02 Norton Healthcare Limited Soft steroid compositions for use in dry powder inhalers
KR20070068432A (ko) 2004-10-29 2007-06-29 아스트라제네카 아베 염증 질환의 치료를 위한 글루코코르티코이드 수용체조절제로서의 신규 술폰아미드 유도체
GB0424284D0 (en) * 2004-11-02 2004-12-01 Novartis Ag Organic compounds
TW200722418A (en) * 2005-04-20 2007-06-16 Astrazeneca Ab Novel compounds

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US20100113510A1 (en) 2010-05-06
IL199015A0 (en) 2010-02-17
WO2008075005A1 (en) 2008-06-26
BRPI0721039A2 (pt) 2014-07-29
AR064414A1 (es) 2009-04-01
AU2007336054A1 (en) 2008-06-26
CL2007003690A1 (es) 2008-08-22
NO20092689L (no) 2009-09-14
CA2672446A1 (en) 2008-06-26
MX2009006018A (es) 2009-06-16
ES2385681T3 (es) 2012-07-30
ATE555111T1 (de) 2012-05-15
UY30803A1 (es) 2008-07-31
RU2009120229A (ru) 2011-01-27
JP4604129B2 (ja) 2010-12-22
ECSP099394A (es) 2009-07-31
CN101610813A (zh) 2009-12-23
EP2121137B1 (en) 2012-04-25
EP2121137A1 (en) 2009-11-25
TW200831507A (en) 2008-08-01
CO6180439A2 (es) 2010-07-19
JP2010513434A (ja) 2010-04-30

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