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PE20120005A1 - Derivados de (2s,3r)-n-2-((3-piridinil)metil)-1-azabiciclo[2.2.2]oct-3-il)-3,5-difluorobenzamida - Google Patents

Derivados de (2s,3r)-n-2-((3-piridinil)metil)-1-azabiciclo[2.2.2]oct-3-il)-3,5-difluorobenzamida

Info

Publication number
PE20120005A1
PE20120005A1 PE2011001372A PE2011001372A PE20120005A1 PE 20120005 A1 PE20120005 A1 PE 20120005A1 PE 2011001372 A PE2011001372 A PE 2011001372A PE 2011001372 A PE2011001372 A PE 2011001372A PE 20120005 A1 PE20120005 A1 PE 20120005A1
Authority
PE
Peru
Prior art keywords
pyridinyl
oct
difluorobenzamide
methyl
azabicyclo
Prior art date
Application number
PE2011001372A
Other languages
English (en)
Inventor
Merouane Bencherif
Nikolai Fedorov
Terry Hauser
Kristen Jordan
Sharon Rae Letchworth
Anatoly A Mazurov
Julio A Munoz
Jason Speake
Daniel Yohannes
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41719329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120005(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of PE20120005A1 publication Critical patent/PE20120005A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

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  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)

Abstract

SE REFIERE AL COMPUESTO (2S,3R)-N-2-((3-PIRIDINIL)METIL)-1-AZABICICLO[2.2.2]OCT-3-IL)-3,5-DIFLUOROBENZAMIDA DE FORMULA (I) ASI COMO SALES DE ADICION ACIDA COMO EL ACIDO CLORHIDRICO, ACIDO MALEICO, ACIDO FOSFORICO, ACIDO FUMARICO, ENTRE OTROS; SIENDO COMPUESTOS PREFERIDOS: MONO-CLORHIDRATO DE (2S,3R)-N-2-((3-PIRIDINIL)METIL)-1-AZABICICLO[2.2.2]OCT-3-IL)-3,5-DIFLUOROBENZAMIDA, MONO-FOSFATO DE (2S,3R)-N-2-((3-PIRIDINIL)METIL)-1-AZABICICLO[2.2.2]OCT-3-IL)-3,5-DIFLUOROBENZAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA FORMA POLIMORFICA DEL CLORHIDRATO DE (2S,3R)-N-2-((3-PIRIDINIL)METIL)-1-AZABICICLO[2.2.2]OCT-3-IL)-3,5-DIFLUOROBENZAMIDA CUYO PATRON DE DIFRACCION DE RAYOS X EXPRESADO EN GRADOS 2? PRESENTA LOS PICOS: 8,4; 8,8; 11,9; 13,2; 15,2; 16,0; 17,6; 18,4; ENTRE OTROS. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES DE ACETILCOLINA NICOTINICA NEURONAL SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR, SINDROME METABOLICO, DEMENCIA PRESENIL
PE2011001372A 2009-01-26 2010-01-25 Derivados de (2s,3r)-n-2-((3-piridinil)metil)-1-azabiciclo[2.2.2]oct-3-il)-3,5-difluorobenzamida PE20120005A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14726009P 2009-01-26 2009-01-26

Publications (1)

Publication Number Publication Date
PE20120005A1 true PE20120005A1 (es) 2012-01-29

Family

ID=41719329

Family Applications (1)

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PE2011001372A PE20120005A1 (es) 2009-01-26 2010-01-25 Derivados de (2s,3r)-n-2-((3-piridinil)metil)-1-azabiciclo[2.2.2]oct-3-il)-3,5-difluorobenzamida

Country Status (31)

Country Link
US (4) US8476296B2 (es)
EP (1) EP2389378B1 (es)
JP (1) JP5600122B2 (es)
KR (1) KR101737924B1 (es)
CN (1) CN102292335B (es)
AR (1) AR075152A1 (es)
AU (1) AU2010206638B2 (es)
BR (1) BRPI1006053A2 (es)
CA (1) CA2749123C (es)
CL (1) CL2010000059A1 (es)
CO (1) CO6501143A2 (es)
DK (1) DK2389378T3 (es)
EA (1) EA201170976A1 (es)
EC (1) ECSP11011220A (es)
ES (1) ES2503465T3 (es)
HR (1) HRP20140756T1 (es)
IL (1) IL213620A0 (es)
MX (1) MX2011007791A (es)
MY (1) MY152387A (es)
NZ (1) NZ593484A (es)
PE (1) PE20120005A1 (es)
PL (1) PL2389378T3 (es)
PT (1) PT2389378E (es)
RS (1) RS53521B1 (es)
SG (1) SG172156A1 (es)
SI (1) SI2389378T1 (es)
SM (1) SMT201400152B (es)
TW (1) TW201031664A (es)
UA (1) UA105204C2 (es)
WO (1) WO2010085724A1 (es)
ZA (1) ZA201105126B (es)

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