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PL2389378T3 - Wytwarzanie i zastosowanie lecznicze (2s,3r)-n-2-((3-pirydynylo)metylo)-1-azabicyklo[2.2.2]okt-3-ylo)-3,5-difluorobenzamidu - Google Patents

Wytwarzanie i zastosowanie lecznicze (2s,3r)-n-2-((3-pirydynylo)metylo)-1-azabicyklo[2.2.2]okt-3-ylo)-3,5-difluorobenzamidu

Info

Publication number
PL2389378T3
PL2389378T3 PL10701307T PL10701307T PL2389378T3 PL 2389378 T3 PL2389378 T3 PL 2389378T3 PL 10701307 T PL10701307 T PL 10701307T PL 10701307 T PL10701307 T PL 10701307T PL 2389378 T3 PL2389378 T3 PL 2389378T3
Authority
PL
Poland
Prior art keywords
difluorobenzamide
azabicyclo
pyridinyl
oct
methyl
Prior art date
Application number
PL10701307T
Other languages
English (en)
Inventor
Merouane Bencherif
Nikolai Fedorov
Terry Hauser
Kristen Jordan
Sharon Rae Letchworth
Anatoly Mazurov
Julio A Munoz
Jason Speake
Daniel Yohannes
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41719329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2389378(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of PL2389378T3 publication Critical patent/PL2389378T3/pl

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

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PL10701307T 2009-01-26 2010-01-25 Wytwarzanie i zastosowanie lecznicze (2s,3r)-n-2-((3-pirydynylo)metylo)-1-azabicyklo[2.2.2]okt-3-ylo)-3,5-difluorobenzamidu PL2389378T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14726009P 2009-01-26 2009-01-26
EP20100701307 EP2389378B1 (en) 2009-01-26 2010-01-25 Preparation and therapeutic applications of (2s,3r)-n-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
PCT/US2010/021926 WO2010085724A1 (en) 2009-01-26 2010-01-25 Preparation and therapeutic applications of (2s,3r)-n-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide

Publications (1)

Publication Number Publication Date
PL2389378T3 true PL2389378T3 (pl) 2014-11-28

Family

ID=41719329

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10701307T PL2389378T3 (pl) 2009-01-26 2010-01-25 Wytwarzanie i zastosowanie lecznicze (2s,3r)-n-2-((3-pirydynylo)metylo)-1-azabicyklo[2.2.2]okt-3-ylo)-3,5-difluorobenzamidu

Country Status (31)

Country Link
US (4) US8476296B2 (pl)
EP (1) EP2389378B1 (pl)
JP (1) JP5600122B2 (pl)
KR (1) KR101737924B1 (pl)
CN (1) CN102292335B (pl)
AR (1) AR075152A1 (pl)
AU (1) AU2010206638B2 (pl)
BR (1) BRPI1006053A2 (pl)
CA (1) CA2749123C (pl)
CL (1) CL2010000059A1 (pl)
CO (1) CO6501143A2 (pl)
DK (1) DK2389378T3 (pl)
EA (1) EA201170976A1 (pl)
EC (1) ECSP11011220A (pl)
ES (1) ES2503465T3 (pl)
HR (1) HRP20140756T1 (pl)
IL (1) IL213620A0 (pl)
MX (1) MX2011007791A (pl)
MY (1) MY152387A (pl)
NZ (1) NZ593484A (pl)
PE (1) PE20120005A1 (pl)
PL (1) PL2389378T3 (pl)
PT (1) PT2389378E (pl)
RS (1) RS53521B1 (pl)
SG (1) SG172156A1 (pl)
SI (1) SI2389378T1 (pl)
SM (1) SMT201400152B (pl)
TW (1) TW201031664A (pl)
UA (1) UA105204C2 (pl)
WO (1) WO2010085724A1 (pl)
ZA (1) ZA201105126B (pl)

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WO2012068553A2 (en) * 2010-11-18 2012-05-24 Dignity Health Methods of diagnosing and treating neurodegenerative diseases
MX2013008704A (es) 2011-01-27 2013-08-21 Novartis Ag Uso de activadores del receptor de acetil-colina nicotinico alfa-7.
MX2013010698A (es) 2011-03-18 2014-02-17 Novartis Ag Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson.
CA3083244C (en) * 2011-10-20 2023-01-03 Novartis Ag Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
JP6114951B2 (ja) 2012-12-11 2017-04-19 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アクチベーターによる処置に対する応答性を予測するバイオマーカー
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WO2014111751A1 (en) 2013-01-15 2014-07-24 Novartis Ag Use of alpha 7 nicotinic receptor agonists for the treatment of narcolepsy
ES2883232T3 (es) 2013-01-15 2021-12-07 Novartis Ag Uso de agonistas del receptor nicotínico de acetilcolina alfa 7
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