PE20050327A1 - Derivados de 8-azoniabiciclo[3.2.1]octano como antagonistas de los receptores muscarinicos de la acetilcolina - Google Patents
Derivados de 8-azoniabiciclo[3.2.1]octano como antagonistas de los receptores muscarinicos de la acetilcolinaInfo
- Publication number
- PE20050327A1 PE20050327A1 PE2004000673A PE2004000673A PE20050327A1 PE 20050327 A1 PE20050327 A1 PE 20050327A1 PE 2004000673 A PE2004000673 A PE 2004000673A PE 2004000673 A PE2004000673 A PE 2004000673A PE 20050327 A1 PE20050327 A1 PE 20050327A1
- Authority
- PE
- Peru
- Prior art keywords
- octane
- endo
- dimethyl
- azoniabiciclo
- antagonists
- Prior art date
Links
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 title abstract 3
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 title abstract 2
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- -1 2,2-DI-2-THENYLETHENYL Chemical class 0.000 abstract 3
- 230000002685 pulmonary effect Effects 0.000 abstract 3
- 208000006673 asthma Diseases 0.000 abstract 2
- BDDIUTHMWNWMRJ-UHFFFAOYSA-N octane;hydrobromide Chemical compound Br.CCCCCCCC BDDIUTHMWNWMRJ-UHFFFAOYSA-N 0.000 abstract 2
- 206010006458 Bronchitis chronic Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 abstract 1
- 229960004373 acetylcholine Drugs 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 208000007451 chronic bronchitis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS OLEFINICOS DE 8-AZONIABICICLO[3.2.1]OCTANO DE LA FORMULA I, EN DONDE R2 Y R3 SON ALQUILO C1-C6 DE CADENA LINEAL O RAMIFICADA, CICLOALQUILO C5-C6, CICLOALQUIL-ALQUILO C6-C10, 2-TIENILO, ENTRE OTROS; X- ES UN ANION ASOCIADO CON LA CARGA POSITIVA DEL ATOMO DE N; DE MODO QUE EL COMPUESTO ESTA EN FORMA DE SAL CUATERNARIA. SON COMPUESTOS PREFERIDOS: BROMURO DE (3-ENDO)-3-(2,2-DI-2-TIENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO; BROMURO DE (3-ENDO)-3-(2,2-DIFENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO; 4-METILBENCENOSULFONATO DE (3-ENDO)-3-(2,2-DIFENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO; ENTRE OTROS. TAMBIEN SE REFIERE A UN COMPUESTO FARMACEUTICO. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR MUSCARINICO DE LA ACETILCOLINA Y SON UTILES PARA TRATAR ENFERMEDADES MEDIADAS POR ESTOS RECEPTORES COMO SON LA ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, BRONQUITIS CRONICA, ASMA, OBSTRUCCION RESPIRATORIA CRONICA, FIBROSIS PULMONAR, ENFISEMA PULMONAR Y RINITIS ALERGICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48798103P | 2003-07-17 | 2003-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050327A1 true PE20050327A1 (es) | 2005-06-08 |
Family
ID=34102735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004000673A PE20050327A1 (es) | 2003-07-17 | 2004-07-15 | Derivados de 8-azoniabiciclo[3.2.1]octano como antagonistas de los receptores muscarinicos de la acetilcolina |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20060178395A1 (es) |
| EP (1) | EP1648460A4 (es) |
| JP (1) | JP2007523877A (es) |
| KR (1) | KR20060063890A (es) |
| CN (1) | CN1822838A (es) |
| AP (1) | AP2006003478A0 (es) |
| AR (1) | AR045913A1 (es) |
| AU (1) | AU2004259232A1 (es) |
| BR (1) | BRPI0412716A (es) |
| CA (1) | CA2532375A1 (es) |
| EA (1) | EA200600267A1 (es) |
| EC (1) | ECSP056254A (es) |
| IL (1) | IL172822A0 (es) |
| IS (1) | IS8302A (es) |
| MA (1) | MA27900A1 (es) |
| MX (1) | MXPA06000662A (es) |
| NO (1) | NO20060775L (es) |
| PE (1) | PE20050327A1 (es) |
| TW (1) | TW200523261A (es) |
| UY (1) | UY28417A1 (es) |
| WO (1) | WO2005009439A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200519108A (en) * | 2003-07-17 | 2005-06-16 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| KR20080065318A (ko) | 2003-10-14 | 2008-07-11 | 글락소 그룹 리미티드 | 무스카린성 아세틸콜린 수용체 길항제 |
| CN1897947A (zh) * | 2003-10-17 | 2007-01-17 | 葛兰素集团有限公司 | 蕈毒碱乙酰胆碱受体拮抗剂 |
| TW200524577A (en) * | 2003-11-04 | 2005-08-01 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
| JP2007528420A (ja) * | 2004-03-11 | 2007-10-11 | グラクソ グループ リミテッド | 新規ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト |
| JP2007529511A (ja) * | 2004-03-17 | 2007-10-25 | グラクソ グループ リミテッド | Ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト |
| US7384946B2 (en) * | 2004-03-17 | 2008-06-10 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| PE20060259A1 (es) | 2004-04-27 | 2006-03-25 | Glaxo Group Ltd | Compuestos de quinuclidina como antagonistas del receptor de acetilcolina muscarinico |
| US7598267B2 (en) * | 2004-05-13 | 2009-10-06 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| WO2006055553A2 (en) * | 2004-11-15 | 2006-05-26 | Glaxo Group Limited | Novel m3 muscarinic acetylcholine receptor antagonists |
| TWI268704B (en) * | 2005-06-28 | 2006-12-11 | Realtek Semiconductor Corp | Apparatus and method for detecting vertical blanking interval |
| EP1937230A4 (en) * | 2005-08-02 | 2009-08-26 | Glaxo Group Ltd | M3-MUSCARIN ACETYLCHOLIN RECEPTOR ANTAGONISTS |
| UY31635A1 (es) | 2008-02-06 | 2009-08-31 | Farmacóforos duales-antagonistas muscarínicos de pde4 | |
| TW201000476A (en) | 2008-02-06 | 2010-01-01 | Glaxo Group Ltd | Dual pharmacophores-PDE4-muscarinic antagonistics |
| AR070563A1 (es) | 2008-02-06 | 2010-04-21 | Glaxo Group Ltd | Compuesto de un biciclo condensado pirazol-piridin-amina, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento de enfermedades respiratorias. |
| WO2010094643A1 (en) | 2009-02-17 | 2010-08-26 | Glaxo Group Limited | Quinoline derivatives and their uses for rhinitis and urticaria |
| EP2627317A4 (en) * | 2010-10-15 | 2014-08-20 | Glaxo Group Ltd | MEDICINAL FORMULATIONS FROM AGGREGATED NANOPARTICLES AND THEIR PREPARATION AND USE |
| ES2814336T3 (es) | 2012-04-13 | 2021-03-26 | Glaxosmithkline Ip Dev Ltd | Partículas de agregado |
| JP2023519585A (ja) | 2020-03-26 | 2023-05-11 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | ウイルス感染を予防または治療するカテプシン阻害剤 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2800481A (en) * | 1955-07-01 | 1957-07-23 | Smith Kline French Lab | Tertiary alcohol derivatives of 8-alkylnortropanes and the acid and quaternary ammonium salts thereof |
| US2800478A (en) * | 1955-07-01 | 1957-07-23 | Smith Kline French Lab | 3-substituted-8-alkylnortropanes and the acid and quaternary ammonium salts thereof |
| US2800482A (en) * | 1955-07-01 | 1957-07-23 | Smith Kline French Lab | Olefinic derivatives of 8-alkylnortropanes and the acid and quaternary ammonium salts thereof |
| AU5790598A (en) * | 1996-12-02 | 1998-06-29 | Georgetown University | Tropane derivatives and method for their synthesis |
| US6248752B1 (en) * | 1998-02-27 | 2001-06-19 | Charles Duane Smith | Azabicyclooctane compositions and methods for enhancing chemotherapy |
| US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| CA2365258A1 (en) * | 1999-05-04 | 2000-11-09 | Neurosearch A/S | Heteroaryl diazabicycloalkanes, their preparation and use |
| ES2165768B1 (es) * | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| CA2415468A1 (en) * | 2000-07-11 | 2003-01-10 | Yoshio Ogino | Ester derivatives |
| JP2005512974A (ja) * | 2001-10-17 | 2005-05-12 | ユ セ ベ ソシエテ アノニム | キヌクリジン誘導体、その調製方法、及びｍ２及び／又はｍ３ムスカリン受容体阻害剤としてのその使用 |
| ES2329586T3 (es) * | 2003-11-21 | 2009-11-27 | Theravance, Inc. | Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino. |
-
2004
- 2004-07-15 UY UY28417A patent/UY28417A1/es not_active Application Discontinuation
- 2004-07-15 AR ARP040102498A patent/AR045913A1/es unknown
- 2004-07-15 TW TW093121062A patent/TW200523261A/zh unknown
- 2004-07-15 PE PE2004000673A patent/PE20050327A1/es not_active Application Discontinuation
- 2004-07-16 EA EA200600267A patent/EA200600267A1/ru unknown
- 2004-07-16 AP AP2006003478A patent/AP2006003478A0/xx unknown
- 2004-07-16 CN CNA2004800206494A patent/CN1822838A/zh active Pending
- 2004-07-16 CA CA002532375A patent/CA2532375A1/en not_active Abandoned
- 2004-07-16 AU AU2004259232A patent/AU2004259232A1/en not_active Abandoned
- 2004-07-16 BR BRPI0412716-1A patent/BRPI0412716A/pt not_active IP Right Cessation
- 2004-07-16 WO PCT/US2004/022947 patent/WO2005009439A1/en not_active Ceased
- 2004-07-16 MX MXPA06000662A patent/MXPA06000662A/es unknown
- 2004-07-16 KR KR1020067001000A patent/KR20060063890A/ko not_active Withdrawn
- 2004-07-16 JP JP2006520377A patent/JP2007523877A/ja not_active Withdrawn
- 2004-07-16 US US10/565,046 patent/US20060178395A1/en not_active Abandoned
- 2004-07-16 EP EP04778451A patent/EP1648460A4/en not_active Withdrawn
-
2005
- 2005-12-26 IL IL172822A patent/IL172822A0/en unknown
- 2005-12-27 EC EC2005006254A patent/ECSP056254A/es unknown
-
2006
- 2006-01-06 MA MA28704A patent/MA27900A1/fr unknown
- 2006-02-14 IS IS8302A patent/IS8302A/is unknown
- 2006-02-17 NO NO20060775A patent/NO20060775L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1648460A1 (en) | 2006-04-26 |
| AU2004259232A1 (en) | 2005-02-03 |
| UY28417A1 (es) | 2005-02-28 |
| EA200600267A1 (ru) | 2006-06-30 |
| TW200523261A (en) | 2005-07-16 |
| EP1648460A4 (en) | 2009-04-01 |
| WO2005009439A1 (en) | 2005-02-03 |
| JP2007523877A (ja) | 2007-08-23 |
| IS8302A (is) | 2006-02-14 |
| US20060178395A1 (en) | 2006-08-10 |
| NO20060775L (no) | 2006-04-11 |
| BRPI0412716A (pt) | 2006-09-26 |
| AR045913A1 (es) | 2005-11-16 |
| IL172822A0 (en) | 2006-06-11 |
| MXPA06000662A (es) | 2006-03-30 |
| CN1822838A (zh) | 2006-08-23 |
| KR20060063890A (ko) | 2006-06-12 |
| MA27900A1 (fr) | 2006-05-02 |
| CA2532375A1 (en) | 2005-02-03 |
| ECSP056254A (es) | 2006-04-19 |
| AP2006003478A0 (en) | 2006-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |