[go: up one dir, main page]

ECSP056134A - Derivados de quinuclidina que se enlazan con los receptores muscarínicos m3 - Google Patents

Derivados de quinuclidina que se enlazan con los receptores muscarínicos m3

Info

Publication number
ECSP056134A
ECSP056134A EC2005006134A ECSP056134A ECSP056134A EC SP056134 A ECSP056134 A EC SP056134A EC 2005006134 A EC2005006134 A EC 2005006134A EC SP056134 A ECSP056134 A EC SP056134A EC SP056134 A ECSP056134 A EC SP056134A
Authority
EC
Ecuador
Prior art keywords
link
muscarinic receptors
quinuclidine derivatives
compounds
quinuclidine
Prior art date
Application number
EC2005006134A
Other languages
English (en)
Inventor
Stephen Paul Collingwood
Brian Cox
Urs Baettig
Gurdip Bhalay
Nicholas James Devereux
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33420896&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP056134(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0324887A external-priority patent/GB0324887D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP056134A publication Critical patent/ECSP056134A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Los compuestos de la fórmula (I), en forma de sal o zwiteriónica, en donde R1, R2, R3, y R4 tienen los significados indicados en la memoria descriptiva, son útiles para el tratamiento de condiciones que sean mediadas por el receptor muscarínico M3. También se describen composiciones farmacéuticas que contienen a los compuestos, y un proceso para la preparación de los compuestos.
EC2005006134A 2003-05-02 2005-11-01 Derivados de quinuclidina que se enlazan con los receptores muscarínicos m3 ECSP056134A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0310232 2003-05-02
GB0324887A GB0324887D0 (en) 2003-10-24 2003-10-24 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP056134A true ECSP056134A (es) 2006-04-19

Family

ID=33420896

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005006134A ECSP056134A (es) 2003-05-02 2005-11-01 Derivados de quinuclidina que se enlazan con los receptores muscarínicos m3

Country Status (31)

Country Link
US (2) US20070060563A1 (es)
EP (1) EP1631569B1 (es)
JP (1) JP4416786B2 (es)
KR (1) KR100896544B1 (es)
AR (1) AR044134A1 (es)
AT (1) ATE440840T1 (es)
AU (1) AU2004234069B2 (es)
BR (1) BRPI0410238A (es)
CA (1) CA2523436C (es)
CL (1) CL2004000918A1 (es)
CO (1) CO5700782A2 (es)
CY (1) CY1109655T1 (es)
DE (1) DE602004022805D1 (es)
DK (1) DK1631569T3 (es)
EC (1) ECSP056134A (es)
ES (1) ES2331185T3 (es)
HR (1) HRP20050933A2 (es)
IL (1) IL171591A (es)
IS (1) IS2746B (es)
MA (1) MA27775A1 (es)
MX (1) MXPA05011739A (es)
MY (1) MY142652A (es)
NO (1) NO20055688L (es)
NZ (1) NZ542995A (es)
PE (1) PE20050465A1 (es)
PL (1) PL1631569T3 (es)
PT (1) PT1631569E (es)
RU (1) RU2363700C2 (es)
SI (1) SI1631569T1 (es)
TW (1) TWI340139B (es)
WO (1) WO2004096800A2 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2239546B1 (es) * 2004-03-15 2006-12-01 Almirall Prodesfarma, S.A. Nuevos esteres de quinuclidina cuaternizados.
GB0410712D0 (en) 2004-05-13 2004-06-16 Novartis Ag Organic compounds
GB0424284D0 (en) * 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0428416D0 (en) 2004-12-24 2005-02-02 Novartis Ag Organic compounds
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
EP1900737A1 (en) * 2006-08-31 2008-03-19 Novartis AG Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide
EP1894568A1 (en) * 2006-08-31 2008-03-05 Novartis AG Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases
TW200825084A (en) * 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
BRPI0721039A2 (pt) * 2006-12-19 2014-07-29 Astrazeneca Ab " derivados de quinuclidinol como antagonistas de receptores muscarínicos ".
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
WO2009035542A2 (en) 2007-09-07 2009-03-19 Theravance, Inc. Guanidine-containing compounds useful as muscarinic receptor antagonists
US8017617B2 (en) 2007-12-14 2011-09-13 Theravance, Inc. Amidine-containing compounds useful as muscarinic receptor antagonists
WO2009087224A1 (en) 2008-01-11 2009-07-16 Novartis Ag Pyrimidines as kinase inhibitors
CN102089304A (zh) * 2008-05-13 2011-06-08 阿斯利康(瑞典)有限公司 作为m3毒蕈碱性受体拮抗剂的奎宁环衍生物
BRPI0912657A2 (pt) * 2008-05-13 2016-01-26 Astrazeneca Ab produto farmacêutico compreendendo um antagonista de receptor muscarínico e um agonista beta2-adrenorreceptor
GB0808709D0 (en) * 2008-05-13 2008-06-18 Astrazeneca Ab New combination 295
US20090326004A1 (en) 2008-06-03 2009-12-31 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
GB0811100D0 (en) * 2008-06-17 2008-07-23 Astrazeneca Ab New combination
WO2009153536A1 (en) * 2008-06-17 2009-12-23 Argenta Discovery Limited 1-aza-bicyclo [2.2.2] octane derivatives useful as muscarinic receptor antagonists
KR20130087405A (ko) * 2010-06-22 2013-08-06 키에시 파르마슈티시 엣스. 피. 에이. 알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
JP5959541B2 (ja) 2011-02-25 2016-08-02 ノバルティス アーゲー Ｔｒｋ阻害剤としてのピラゾロ［１，５−ａ］ピリジン
JP2011195593A (ja) * 2011-06-30 2011-10-06 Astrazeneca Ab ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体
BR112014013179A2 (pt) * 2011-12-30 2017-06-13 Chiesi Farm Spa compostos, combinação de um composto, composição farmacêutica e usos de um composto
CA2871926A1 (en) * 2012-05-03 2013-11-07 Saint Louis College Of Pharmacy Compositions and methods for increasing neurotrophic peptides
TWI647227B (zh) * 2013-02-28 2019-01-11 日商安斯泰來製藥股份有限公司 ２－醯胺噻唑衍生物或其鹽
CZ306791B6 (cs) 2013-10-29 2017-07-12 Zentiva, K.S. Průmyslově využitelný způsob přípravy aklidinium bromidu o vysoké čistotě
PT108370B (pt) * 2015-03-30 2018-10-25 Hovione Farm S A Processo de preparação de brometo de aclidínio
EP3111978B1 (en) 2015-07-03 2021-09-01 Novartis AG Inhaler adapted to read information stored in a data storage means of a container

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
DK534178A (da) * 1977-12-16 1979-06-17 Interx Research Corp Anticholinerge midler med sektrtionshaemmende virkning
IT1230881B (it) * 1989-06-20 1991-11-08 Angeli Inst Spa Derivati del r(-) 3-chinuclidinolo
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
AU2001271027B2 (en) * 2000-07-11 2005-07-07 Msd K.K. Ester derivatives
CA2433128C (en) * 2000-12-28 2010-05-25 Almirall Prodesfarma Ag Novel quinuclidine derivatives and medicinal compositions containing the same
EA006505B1 (ru) * 2001-12-20 2005-12-29 Лабораториос С.А.Л.В.А.Т.,С.А. Производные карбамата 1-алкил-1-азониабицикло[2.2.2]октана и их применение в качестве антагонистов мускаринового рецептора
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
EP1900737A1 (en) * 2006-08-31 2008-03-19 Novartis AG Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide

Also Published As

Publication number Publication date
EP1631569A2 (en) 2006-03-08
BRPI0410238A (pt) 2006-05-16
CL2004000918A1 (es) 2005-02-11
CO5700782A2 (es) 2006-11-30
JP2006525267A (ja) 2006-11-09
PL1631569T3 (pl) 2010-02-26
HK1087704A1 (en) 2006-10-20
KR100896544B1 (ko) 2009-05-07
WO2004096800A3 (en) 2005-01-06
TWI340139B (en) 2011-04-11
IS2746B (is) 2011-08-15
NO20055688L (no) 2006-01-09
SI1631569T1 (sl) 2010-01-29
DK1631569T3 (da) 2009-11-23
CA2523436C (en) 2011-11-01
MA27775A1 (fr) 2006-02-01
DE602004022805D1 (de) 2009-10-08
US20100041887A1 (en) 2010-02-18
EP1631569B1 (en) 2009-08-26
ES2331185T3 (es) 2009-12-23
CA2523436A1 (en) 2004-11-11
MXPA05011739A (es) 2006-01-26
AR044134A1 (es) 2005-08-24
ATE440840T1 (de) 2009-09-15
RU2363700C2 (ru) 2009-08-10
PE20050465A1 (es) 2005-07-18
NZ542995A (en) 2009-02-28
JP4416786B2 (ja) 2010-02-17
TW200505920A (en) 2005-02-16
MY142652A (en) 2010-12-15
NO20055688D0 (no) 2005-12-01
KR20060015572A (ko) 2006-02-17
PT1631569E (pt) 2009-11-26
IS8158A (is) 2005-11-30
RU2005137360A (ru) 2006-07-27
WO2004096800A2 (en) 2004-11-11
IL171591A (en) 2010-11-30
AU2004234069A1 (en) 2004-11-11
US8168654B2 (en) 2012-05-01
HRP20050933A2 (en) 2006-12-31
US20070060563A1 (en) 2007-03-15
AU2004234069B2 (en) 2008-02-21
CY1109655T1 (el) 2014-08-13

Similar Documents

Publication Publication Date Title
ECSP056134A (es) Derivados de quinuclidina que se enlazan con los receptores muscarínicos m3
ECSP088871A (es) Derivados de triazolopirazina
CR11554A (es) Pirrolo-Pirimidinas y Pirrolo-Piridinas
PA8591701A1 (es) Derivados de pirrolopirimidina
IL189191A0 (en) Thiazolyl piperidine derivatives useful as h3 receptor modulators
MY148429A (en) Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with benzyl groups, method for producing drugs containing said compounds and use thereof
UY29710A1 (es) Benzimidazoles tricíclicos y su uso como moduladores de receptores metabotrópicos de glutamato
CY1108880T1 (el) Παραγωγα καρβοξαμιδιου ως ανταγωνιστες μουσκαρινικου υποδοχεα
ATE556074T1 (de) Neue imidazoä1,5-aüpyridinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
DE602004008959D1 (de) Benzoäbüä1,4üdioxepinderivate
BRPI0519292A2 (pt) compostos orgÂnicos
TW200626158A (en) Naphthaline derivatives
UY29370A1 (es) Derivados de tiazol, composiciones que lo contienen, procedimientos de preparación y aplicaciones
ATE466842T1 (de) 3-substituierte pyridinderivate als h3- antagonisten
ATE541839T1 (de) Pyrrolidiniumderivate als m3-muskarinische rezeptoren
PL1732902T3 (pl) Pochodne nukleozydów i ich terapeutyczne zastosowanie
TNSN05279A1 (en) Quinuclidine derivatives binding to mucarinic m3 receptors
DOP2007000096A (es) Derivados de triazolopirazina
DOP2003000784A (es) Derivados de pirrrolopirimidina
CR7881A (es) Derivados de pirrolopirimida
EA200601842A1 (ru) D-гомо-17-хлор-16(17)-ен-стероиды
CU20080204A7 (es) Derivados de triazolopirazina
CU20100147A7 (es) Pirrolo-pirimidinas y pirrolo-piridinas
UY29566A1 (es) "derivados de piperidina, composiciones farmaccuticas que los contienen, procedimientos de preparacinn y su uso"