CO5700782A2 - Derivados de quinuckidina que se enlazan con los receptores muscarinicos m3 - Google Patents
Derivados de quinuckidina que se enlazan con los receptores muscarinicos m3Info
- Publication number
- CO5700782A2 CO5700782A2 CO05112195A CO05112195A CO5700782A2 CO 5700782 A2 CO5700782 A2 CO 5700782A2 CO 05112195 A CO05112195 A CO 05112195A CO 05112195 A CO05112195 A CO 05112195A CO 5700782 A2 CO5700782 A2 CO 5700782A2
- Authority
- CO
- Colombia
- Prior art keywords
- carbon atoms
- alkyl
- group
- nitrogen
- optionally substituted
- Prior art date
Links
- 230000003551 muscarinic effect Effects 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000002837 carbocyclic group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Un compuesto de la fórmula I: en forma de sal o zwiteriónica, en donde:R1 y R2 son cada uno independientemente un grupo carbocíclico de 3 a 15 átomos de carbono, o un grupo heterocícIico de 4 a 12 miembros que tiene cuando menos un heteroátomo del anillo seleccionado a partir de nitrógeno, oxígeno, y azufre,o -CR1R2R3 forman juntos un grupo de la fórmula: en donde R es un enlace, -O-, -S-, -CH2-, -CH=CH-, -CH2-CH2-, ó - N(CH3)-; R2 es hidrógeno, halógeno, hidroxilo, alcoxilo de 1 a 8 átomos de carbono, o alquilo de 1 a 8 átomos de carbono opcionalmente sustituido por hidroxilo; R4 es alquilo de 1 a 8 átomos de carbono sustituido por -NHR5, -NR5-CO-R6 , -NR5-CO-NH-R7, -NR5-SO2-R8, -CO-NR9R10, -OR11, -O-CO-NHR12, -O-CO-R13, ó -CO-O-R14, o R4 es alquinilo de 3 a 10 átomos de carbono opcionalmente sustituido por un grupo carbocíclico de 3 a 15 átomos de carbono, o un grupo heterocíclico de 4 a 12 miembros que tiene cuando menos un heteroátomo del anillo seleccionado a partir de nitrógeno, oxígeno, y azufre; R5 es hidrógeno o alquilo de 1 a 8 átomos de carbono; R6 es alquilo de 1 a 8 átomos de carbono, alquenilo de 2 a 8 átomos de carbono, alquinilo de 2 a 10 átomos de carbono, o alcoxilo de 1 a 8 átomos de carbono, en cada caso opcionalmente sustituidos por un grupo carbocíclico de 3 a 15 átomos de carbono, o un grupo heterocíclico de 4 a 12 miembros que tiene cuando menos un heteroátomo del anillo seleccionado a partir de nitrógeno, ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0310232 | 2003-05-02 | ||
| GB0324887A GB0324887D0 (en) | 2003-10-24 | 2003-10-24 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5700782A2 true CO5700782A2 (es) | 2006-11-30 |
Family
ID=33420896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05112195A CO5700782A2 (es) | 2003-05-02 | 2005-11-03 | Derivados de quinuckidina que se enlazan con los receptores muscarinicos m3 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US20070060563A1 (es) |
| EP (1) | EP1631569B1 (es) |
| JP (1) | JP4416786B2 (es) |
| KR (1) | KR100896544B1 (es) |
| AR (1) | AR044134A1 (es) |
| AT (1) | ATE440840T1 (es) |
| AU (1) | AU2004234069B2 (es) |
| BR (1) | BRPI0410238A (es) |
| CA (1) | CA2523436C (es) |
| CL (1) | CL2004000918A1 (es) |
| CO (1) | CO5700782A2 (es) |
| CY (1) | CY1109655T1 (es) |
| DE (1) | DE602004022805D1 (es) |
| DK (1) | DK1631569T3 (es) |
| EC (1) | ECSP056134A (es) |
| ES (1) | ES2331185T3 (es) |
| HR (1) | HRP20050933A2 (es) |
| IL (1) | IL171591A (es) |
| IS (1) | IS2746B (es) |
| MA (1) | MA27775A1 (es) |
| MX (1) | MXPA05011739A (es) |
| MY (1) | MY142652A (es) |
| NO (1) | NO20055688L (es) |
| NZ (1) | NZ542995A (es) |
| PE (1) | PE20050465A1 (es) |
| PL (1) | PL1631569T3 (es) |
| PT (1) | PT1631569E (es) |
| RU (1) | RU2363700C2 (es) |
| SI (1) | SI1631569T1 (es) |
| TW (1) | TWI340139B (es) |
| WO (1) | WO2004096800A2 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2239546B1 (es) * | 2004-03-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos esteres de quinuclidina cuaternizados. |
| GB0410712D0 (en) | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
| GB0424284D0 (en) * | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| GB0428416D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| EP1900737A1 (en) * | 2006-08-31 | 2008-03-19 | Novartis AG | Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide |
| EP1894568A1 (en) * | 2006-08-31 | 2008-03-05 | Novartis AG | Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases |
| TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
| EP2121137B1 (en) * | 2006-12-19 | 2012-04-25 | AstraZeneca AB | Quinuclidinol derivatives as muscarinic receptor antagonists |
| EP1950196A1 (de) * | 2007-01-29 | 2008-07-30 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von Ammoniumhexafluorophosphaten |
| BRPI0816219B8 (pt) * | 2007-09-07 | 2021-05-25 | Theravance Biopharma R&D Ip Llc | compostos contendo guanidina úteis como antagonistas de receptor muscarínico, composição farmacêutica e uso |
| EP2222637A1 (en) * | 2007-12-14 | 2010-09-01 | Theravance, Inc. | Amidine-containing compounds useful as muscarinic receptor antagonists |
| JP5584138B2 (ja) | 2008-01-11 | 2014-09-03 | ノバルティス アーゲー | キナーゼ阻害剤としてのピリミジン類 |
| US8329729B2 (en) * | 2008-05-13 | 2012-12-11 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic M3 receptor antagonists |
| RU2010147881A (ru) * | 2008-05-13 | 2012-06-20 | Астразенека Аб (Se) | ФАРМАЦЕВТИЧЕСКИЙ ПРОДУКТ, СОДЕРЖАЩИЙ АНТАГОНИСТ МУСКАРИНОВОГО РЕЦЕПТОРА И АГОНИСТ β2-АДРЕНОРЕЦЕПТОРА |
| GB0808709D0 (en) * | 2008-05-13 | 2008-06-18 | Astrazeneca Ab | New combination 295 |
| US20090326004A1 (en) | 2008-06-03 | 2009-12-31 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| WO2009153536A1 (en) * | 2008-06-17 | 2009-12-23 | Argenta Discovery Limited | 1-aza-bicyclo [2.2.2] octane derivatives useful as muscarinic receptor antagonists |
| GB0811100D0 (en) * | 2008-06-17 | 2008-07-23 | Astrazeneca Ab | New combination |
| BR112012032332A2 (pt) * | 2010-06-22 | 2016-11-08 | Chiesi Farma Spa | composto, uso de um composto, composição farmacêutica, combinação de um composto e dispositivo |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| CA2828219A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Pyrazolo [1,5-a] pyridines as trk inhibitors |
| JP2011195593A (ja) * | 2011-06-30 | 2011-10-06 | Astrazeneca Ab | ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体 |
| BR112014013179A2 (pt) * | 2011-12-30 | 2017-06-13 | Chiesi Farm Spa | compostos, combinação de um composto, composição farmacêutica e usos de um composto |
| CA2871926A1 (en) | 2012-05-03 | 2013-11-07 | Saint Louis College Of Pharmacy | Compositions and methods for increasing neurotrophic peptides |
| TWI647227B (zh) * | 2013-02-28 | 2019-01-11 | 日商安斯泰來製藥股份有限公司 | ２－醯胺噻唑衍生物或其鹽 |
| CZ306791B6 (cs) | 2013-10-29 | 2017-07-12 | Zentiva, K.S. | Průmyslově využitelný způsob přípravy aklidinium bromidu o vysoké čistotě |
| PT108370B (pt) * | 2015-03-30 | 2018-10-25 | Hovione Farm S A | Processo de preparação de brometo de aclidínio |
| PL3111978T3 (pl) | 2015-07-03 | 2022-01-24 | Novartis Ag | Inhalator przystosowany do odczytu informacji przechowywanych w środkach przechowywania danych pojemnika |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1219606A (en) * | 1968-07-15 | 1971-01-20 | Rech S Et D Applic Scient Soge | Quinuclidinol derivatives and preparation thereof |
| DK534178A (da) * | 1977-12-16 | 1979-06-17 | Interx Research Corp | Anticholinerge midler med sektrtionshaemmende virkning |
| IT1230881B (it) * | 1989-06-20 | 1991-11-08 | Angeli Inst Spa | Derivati del r(-) 3-chinuclidinolo |
| ES2165768B1 (es) * | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| CA2415468A1 (en) * | 2000-07-11 | 2003-01-10 | Yoshio Ogino | Ester derivatives |
| KR100869721B1 (ko) * | 2000-12-28 | 2008-11-21 | 알미랄 에이쥐 | 신규한 퀴누클리딘 유도체 및 그를 함유한 의약 조성물 |
| US7452904B2 (en) * | 2001-12-20 | 2008-11-18 | Chiesi Farmaceutici S.P.A. | 1-alkyl-1-azoniabicyclo' 2.2.2 octane carbamate derivatives and their use as muscarinic receptor antagonists |
| GB0424284D0 (en) * | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| EP1900737A1 (en) * | 2006-08-31 | 2008-03-19 | Novartis AG | Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide |
-
2004
- 2004-04-29 AR ARP040101468A patent/AR044134A1/es not_active Application Discontinuation
- 2004-04-30 DE DE602004022805T patent/DE602004022805D1/de not_active Expired - Lifetime
- 2004-04-30 CA CA2523436A patent/CA2523436C/en not_active Expired - Fee Related
- 2004-04-30 DK DK04730519T patent/DK1631569T3/da active
- 2004-04-30 MY MYPI20041637A patent/MY142652A/en unknown
- 2004-04-30 PT PT04730519T patent/PT1631569E/pt unknown
- 2004-04-30 RU RU2005137360/04A patent/RU2363700C2/ru not_active IP Right Cessation
- 2004-04-30 SI SI200431277T patent/SI1631569T1/sl unknown
- 2004-04-30 MX MXPA05011739A patent/MXPA05011739A/es active IP Right Grant
- 2004-04-30 KR KR1020057020776A patent/KR100896544B1/ko not_active Expired - Fee Related
- 2004-04-30 CL CL200400918A patent/CL2004000918A1/es unknown
- 2004-04-30 JP JP2006505341A patent/JP4416786B2/ja not_active Expired - Fee Related
- 2004-04-30 US US10/554,558 patent/US20070060563A1/en not_active Abandoned
- 2004-04-30 WO PCT/EP2004/004605 patent/WO2004096800A2/en not_active Ceased
- 2004-04-30 EP EP04730519A patent/EP1631569B1/en not_active Expired - Lifetime
- 2004-04-30 ES ES04730519T patent/ES2331185T3/es not_active Expired - Lifetime
- 2004-04-30 NZ NZ542995A patent/NZ542995A/en not_active IP Right Cessation
- 2004-04-30 BR BRPI0410238-0A patent/BRPI0410238A/pt not_active IP Right Cessation
- 2004-04-30 PE PE2004000435A patent/PE20050465A1/es not_active Application Discontinuation
- 2004-04-30 PL PL04730519T patent/PL1631569T3/pl unknown
- 2004-04-30 HR HR20050933A patent/HRP20050933A2/xx not_active Application Discontinuation
- 2004-04-30 AU AU2004234069A patent/AU2004234069B2/en not_active Ceased
- 2004-04-30 AT AT04730519T patent/ATE440840T1/de active
- 2004-04-30 TW TW093112339A patent/TWI340139B/zh not_active IP Right Cessation
-
2005
- 2005-10-27 IL IL171591A patent/IL171591A/en not_active IP Right Cessation
- 2005-11-01 EC EC2005006134A patent/ECSP056134A/es unknown
- 2005-11-03 CO CO05112195A patent/CO5700782A2/es not_active Application Discontinuation
- 2005-11-08 MA MA28583A patent/MA27775A1/fr unknown
- 2005-11-30 IS IS8158A patent/IS2746B/is unknown
- 2005-12-01 NO NO20055688A patent/NO20055688L/no not_active Application Discontinuation
-
2009
- 2009-10-20 US US12/582,291 patent/US8168654B2/en not_active Expired - Fee Related
- 2009-11-25 CY CY20091101230T patent/CY1109655T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted | ||
| FD | Application lapsed |