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ES2723753T3 - Una composición que comprende noradrenalina y un inhibidor de NET para su administración a un posible donante de órganos en estado de muerte encefálica y con ritmo cardíaco - Google Patents

Una composición que comprende noradrenalina y un inhibidor de NET para su administración a un posible donante de órganos en estado de muerte encefálica y con ritmo cardíaco Download PDF

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Publication number
ES2723753T3
ES2723753T3 ES09836460T ES09836460T ES2723753T3 ES 2723753 T3 ES2723753 T3 ES 2723753T3 ES 09836460 T ES09836460 T ES 09836460T ES 09836460 T ES09836460 T ES 09836460T ES 2723753 T3 ES2723753 T3 ES 2723753T3
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methyl
azabicyclo
octane
carboxylate
tropane
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Stig Steen
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XVIVO Perfusion AB
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XVIVO Perfusion AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Uso de una solucion de infusion para su infusion intravascular en el tratamiento de un posible donante de organos con respiracion artificial, en estado de muerte encefalica y con ritmo cardiaco para el mantenimiento de la estabilidad hemodinamica, en donde la solucion de infusion comprende adrenalina, noradrenalina y un inhibidor de NET seleccionado de cocaina o un analogo de la cocaina, en donde la administracion de la noradrenalina es de entre 0,08 μg/kg/h y 0,8 μg/kg/h y en donde el analogo de la cocaina se selecciona de dimetocaina o larocaina (DMC) ((3- dietilamino-2,2-dimetilpropil)-4-aminobenzoato); 3-(p-fluorobenzoil)tropano ((1R,5S)-(8-metil-8-azabiciclo[3.2.1]octan- 3-il)-4-fluorobenzoato; β-CIT (metil (1R,2S,3S,5S)-3-(4-yodofenil)-8-metil-8-azabiciclo[3.2.1]octano-2-carboxilato); β- CPPIT (3β-(4'-clorofenil)-2β-(3'-fenilisoxazol-5'-il)tropano); FE-β-CPPIT (N-(2'-fluoroetil)-3β-(4'-clorofenil)-2β-(3'- fenilisoxazol-5'-il)nortropano); FP-β-CPPIT (N-(3'-fluoropropil)-3β-(4'-clorofenil)-2β-(3'-fenilisoxazol-5'-il)nortropano); altropano (metil (1R,2S,3S,5S)-3-(4-fluorofenil)-8-[(E)-3-yodoprop-2-enil]-8-azabiciclo[3.2.1]octano-2-carboxilato); brasofensina ((E)-1-[(1R,2R,3S,5S)-3-(3,4-diclorofenil)-8-metil-8-azabiciclo[3.2.1]oct-2-il]-N-metoximetanimina); CFT (metil (1R,2S,3S,5S)-3-(4-fluorofenil)-8-metil-8-azabiciclo[3.2.1]octano-2-carboxilato); dicloropano (metil (1R,2S,3S,5S)-3-(3,4-diclorofenil)-8-azabiciclo[3.2.1]octano-2-carboxilato); difluoropina (metil (1S,2S,3S,5R)-3-[bis(4- fluorofenil)metoxi]-8-metil-8-azabiciclo[3.2.1]octano-2-carboxilato); yoflupano (123I) (metil (1R,2S,3S,5S)-3-(4- yodofenil)-8-(3-fluoropropil)-8-azabiciclo[3.2.1]octano-2-carboxilato); nocaina (metil (3R,4S)-4-(4-clorofenil)-1- metilpiperidina-3-carboxilato); tesofensina ((1R,2R,3S,5S)-3-(3,4-diclorofenil)-2-(etoximetil)-8-metil-8- azabiciclo[3.2.1]octano); troparil (metil (1R,2S,3S,5S)-8-metil-3-fenil-8-azabiciclo[3.2.1]octano-2-carboxilato); tropoxano (metil (1R,2S,3S,5S)-3-(3,4-diclorofenil)-8-oxabiciclo[3.2.1]octano-2-carboxilato); (-)-metil-1-metil-4β-(2- naftil)piperidina-3β-carboxilato (metil (3S,4S)-1-metil-4-naftalen-2-ilpiperidina-3-carboxilato); PIT (2-propanoil-3-(4- isopropilfenil)-tropano); PTT (2β-propanoil-3β-(4-tolil)-tropano); RTI-121, IPCIT (propan-2-il (1R,2S,3S)-3-(4- yodofenil)-8-metil-8-azabiciclo[3.2.1]octano-2-carboxilato); RTI-126 ((1R,2S,3S,5S)-8-metil-2-(1,2,4-oxadiazol-5- metil)-3-fenil-8-azabiciclo[3.2.1]octano); RTI-150 (ciclobutil (1R,2S,3S,5S)-8-metil-3-(4-metilfenil)-8- azabiciclo[3.2.1]octano-2-carboxilato); RTI-336 ((1R,2S,3S,5S)-8-metil-2-(3-(4-metilfenil)isoxazol-5-il)-3-(4-clorofenil)- 8-azabiciclo[3.2.1]octano); WF-23 (2β-propanoil-3β-(2-naftil)-tropano); o WF-33 (2αpropanoil)-3β-(2-(6- metoxinaftil))-tropano).
ES09836460T 2008-12-30 2009-12-30 Una composición que comprende noradrenalina y un inhibidor de NET para su administración a un posible donante de órganos en estado de muerte encefálica y con ritmo cardíaco Active ES2723753T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0802678A SE533552C2 (sv) 2008-12-30 2008-12-30 Förfarande och lösning för behandling av en potentiell organdonator
US21044409P 2009-03-19 2009-03-19
PCT/SE2009/000541 WO2010077200A1 (en) 2008-12-30 2009-12-30 A composition comprising nor-adrenaline and a net inhibitor for administering to a brain-dead, heart-beating potential organ donor.

Publications (1)

Publication Number Publication Date
ES2723753T3 true ES2723753T3 (es) 2019-08-30

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ES09836460T Active ES2723753T3 (es) 2008-12-30 2009-12-30 Una composición que comprende noradrenalina y un inhibidor de NET para su administración a un posible donante de órganos en estado de muerte encefálica y con ritmo cardíaco

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US (3) US20110281794A1 (es)
EP (2) EP2384113A4 (es)
JP (1) JP2012513992A (es)
CN (2) CN104887653A (es)
AU (1) AU2009333947B2 (es)
CA (1) CA2748233A1 (es)
ES (1) ES2723753T3 (es)
IL (1) IL213753A0 (es)
SE (1) SE533552C2 (es)
WO (2) WO2010077201A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE534862C2 (sv) * 2010-05-14 2012-01-24 Vivoline Medical Ab Användning av en medicinsk vätska för behandling av ett uttaget organ
US20140255905A1 (en) * 2011-10-03 2014-09-11 Vivoline Medical Ab Medical fluid comprising globulin and its use for preservation of harvested organs
EP2903607B1 (en) * 2012-10-03 2017-08-16 Bioprojet A combination of adrenalin with an antidepressant for use in the treatment of shocks
US10091986B2 (en) 2016-05-09 2018-10-09 Xor-Labs Toronto Inc. Organ perfusion device and method
PL3544420T3 (pl) * 2016-11-24 2022-11-21 Sigmadrugs Kutató Korlátolt Felelösségü Társaság Zastosowanie kompozycji do konserwowania narządów/tkanek
CN113384522B (zh) * 2020-03-12 2023-03-21 中国科学院上海高等研究院 一种改善去甲肾上腺素溶解度的方法
EP3900611A1 (en) * 2020-04-24 2021-10-27 Elmedix NV Monitoring fluid balance

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AU2001259848B2 (en) * 2000-05-12 2005-10-13 Septodont Holding Sas Local anesthetic methods and kits
US7238171B2 (en) * 2001-03-12 2007-07-03 Medical Solutions, Inc. Method and apparatus for controlling pressurized infusion and temperature of infused liquids
WO2005056763A2 (en) * 2003-12-04 2005-06-23 University Of Utah Research Foundation Process and formulation to improve viability of stored cells and tissue

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Publication number Publication date
IL213753A0 (en) 2011-07-31
AU2009333947A1 (en) 2011-07-07
CN102271499A (zh) 2011-12-07
EP2384113A1 (en) 2011-11-09
JP2012513992A (ja) 2012-06-21
CN104887653A (zh) 2015-09-09
CN102271499B (zh) 2015-05-13
SE0802678A1 (sv) 2010-07-01
EP2384113A4 (en) 2012-07-11
WO2010077200A1 (en) 2010-07-08
EP2384112A4 (en) 2012-07-11
EP2384112A1 (en) 2011-11-09
EP2384112B1 (en) 2019-02-27
US20160354359A1 (en) 2016-12-08
CA2748233A1 (en) 2010-07-08
WO2010077201A1 (en) 2010-07-08
AU2009333947B2 (en) 2015-02-12
US20110270215A1 (en) 2011-11-03
US20110281794A1 (en) 2011-11-17
SE533552C2 (sv) 2010-10-26

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