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WO2001092279A3 - Haplotypes of the aldh5 gene - Google Patents

Haplotypes of the aldh5 gene Download PDF

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Publication number
WO2001092279A3
WO2001092279A3 PCT/US2001/017253 US0117253W WO0192279A3 WO 2001092279 A3 WO2001092279 A3 WO 2001092279A3 US 0117253 W US0117253 W US 0117253W WO 0192279 A3 WO0192279 A3 WO 0192279A3
Authority
WO
WIPO (PCT)
Prior art keywords
aldh5
gene
haplotypes
disclosed
haplotyping
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/017253
Other languages
French (fr)
Other versions
WO2001092279A2 (en
Inventor
Amy Duda
Kevin Finkel
Amir Kazemi
Chad Messer
Angela Sanchis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2001269715A priority Critical patent/AU2001269715A1/en
Publication of WO2001092279A2 publication Critical patent/WO2001092279A2/en
Anticipated expiration legal-status Critical
Publication of WO2001092279A3 publication Critical patent/WO2001092279A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Novel genetic variants of the Aldehyde Dehydrogenase 5 (ALDH5) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the ALDH5 gene. Compositions and methods for haplotyping and/or genotyping the ALDH5 gene in an individual are also disclosed. Polynucleotides defined by the sequence of the haplotypes disclosed herein are also described.
PCT/US2001/017253 2000-05-26 2001-05-29 Haplotypes of the aldh5 gene Ceased WO2001092279A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001269715A AU2001269715A1 (en) 2000-05-26 2001-05-29 Haplotypes of the aldh5 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20750800P 2000-05-26 2000-05-26
US60/207,508 2000-05-26

Publications (2)

Publication Number Publication Date
WO2001092279A2 WO2001092279A2 (en) 2001-12-06
WO2001092279A3 true WO2001092279A3 (en) 2003-09-18

Family

ID=22770874

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/017253 Ceased WO2001092279A2 (en) 2000-05-26 2001-05-29 Haplotypes of the aldh5 gene

Country Status (2)

Country Link
AU (1) AU2001269715A1 (en)
WO (1) WO2001092279A2 (en)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHAMBLISS K.L. ET AL.: "Two exon-skipping mutations as the molecular basis of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutryric aciduria)", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 63, no. 2, 1998, pages 399 - 408, XP002963885 *
HSU L.C. ET AL.: "Cloning and characterization of a new functional human aldehyde dehydrogenase gene", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 19, July 1991 (1991-07-01), pages 12257 - 12265, XP002963884 *

Also Published As

Publication number Publication date
WO2001092279A2 (en) 2001-12-06
AU2001269715A1 (en) 2001-12-11

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