[go: up one dir, main page]

SI1294358T1 - Wet milling process - Google Patents

Wet milling process

Info

Publication number
SI1294358T1
SI1294358T1 SI200130212T SI200130212T SI1294358T1 SI 1294358 T1 SI1294358 T1 SI 1294358T1 SI 200130212 T SI200130212 T SI 200130212T SI 200130212 T SI200130212 T SI 200130212T SI 1294358 T1 SI1294358 T1 SI 1294358T1
Authority
SI
Slovenia
Prior art keywords
milling process
wet milling
wet
milling
Prior art date
Application number
SI200130212T
Other languages
English (en)
Slovenian (sl)
Inventor
Simon Joseph GlaxoSmithKline HOLLAND
Wendy Anne GlaxoSmithKline KNIGHT
Graham Stanley GlaxoSmithKline LEONARD
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0015856A external-priority patent/GB0015856D0/en
Priority claimed from GB0112496A external-priority patent/GB0112496D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of SI1294358T1 publication Critical patent/SI1294358T1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/02Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/16Mills in which a fixed container houses stirring means tumbling the charge
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/16Mills in which a fixed container houses stirring means tumbling the charge
    • B02C17/163Stirring means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/18Details
    • B02C17/22Lining for containers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catching Or Destruction (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Grinding-Machine Dressing And Accessory Apparatuses (AREA)
  • Disintegrating Or Milling (AREA)
SI200130212T 2000-06-28 2001-06-22 Wet milling process SI1294358T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0015856A GB0015856D0 (en) 2000-06-28 2000-06-28 Wet milling process
GB0112496A GB0112496D0 (en) 2001-05-22 2001-05-22 Wet milling process
PCT/EP2001/007085 WO2002000196A2 (fr) 2000-06-28 2001-06-22 Procede de broyage par voie humide

Publications (1)

Publication Number Publication Date
SI1294358T1 true SI1294358T1 (en) 2004-12-31

Family

ID=26244560

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130212T SI1294358T1 (en) 2000-06-28 2001-06-22 Wet milling process

Country Status (24)

Country Link
US (2) US20040089753A1 (fr)
EP (1) EP1294358B1 (fr)
JP (1) JP4188078B2 (fr)
KR (1) KR100786927B1 (fr)
CN (1) CN1321628C (fr)
AR (1) AR029284A1 (fr)
AT (1) ATE273695T1 (fr)
AU (2) AU2002215608B2 (fr)
BR (1) BR0111747A (fr)
CA (1) CA2413330A1 (fr)
CZ (1) CZ303572B6 (fr)
DE (1) DE60105023T2 (fr)
ES (1) ES2225624T3 (fr)
HU (1) HU230396B1 (fr)
IL (2) IL153231A0 (fr)
MX (1) MXPA03000051A (fr)
MY (1) MY128806A (fr)
NO (1) NO333747B1 (fr)
NZ (1) NZ522783A (fr)
PL (1) PL202623B1 (fr)
PT (1) PT1294358E (fr)
SI (1) SI1294358T1 (fr)
TW (1) TWI290836B (fr)
WO (1) WO2002000196A2 (fr)

Families Citing this family (356)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2422717A1 (fr) * 2000-10-20 2002-04-25 Biovitrum Ab N1-(benzensulfonyl)indoles substitues en 2, 3, 4 ou 5 et leur utilisation a des fins de traitement
GB0112497D0 (en) * 2001-05-22 2001-07-11 Smithkline Beecham Plc Formulation
GB0206200D0 (en) * 2002-03-15 2002-05-01 Glaxo Group Ltd Pharmaceutical compositions
GB0209022D0 (en) 2002-04-19 2002-05-29 Imp College Innovations Ltd Compounds
UY27939A1 (es) 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
US7140567B1 (en) * 2003-03-11 2006-11-28 Primet Precision Materials, Inc. Multi-carbide material manufacture and use as grinding media
PL1651401T3 (pl) 2003-06-17 2009-12-31 Koppers Performance Chemicals Inc Środki konserwujące do drewna oraz sposób ich wytwarzania
GB0320522D0 (en) 2003-09-02 2003-10-01 Glaxo Group Ltd Formulation
US7875630B2 (en) 2003-09-03 2011-01-25 Glaxo Group Limited Process salts compositions and use
US20050252408A1 (en) * 2004-05-17 2005-11-17 Richardson H W Particulate wood preservative and method for producing same
US7578455B2 (en) * 2004-08-09 2009-08-25 General Motors Corporation Method of grinding particulate material
BRPI0518154A (pt) 2004-10-14 2008-11-04 Osmose Inc composição conservante de madeira, e, método para conservar um produto de madeira
EP1839502A4 (fr) * 2004-12-07 2010-03-24 Ajinomoto Kk Poudre fine d'acide amine et suspension la contenant
WO2006091885A2 (fr) 2005-02-24 2006-08-31 Dr Pharma Nova, Llc Procede d'enregistrement et systeme de controle pour medicaments des listes ii-v de la drug enforcement agency (dea)
JP2008540503A (ja) 2005-05-10 2008-11-20 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 細菌感染症の処置に有用なエーテル結合マクロライド
ES2401482T3 (es) 2005-05-10 2013-04-22 Incyte Corporation Moduladores de la indolamina 2,3-dioxigenasa y métodos de uso de los mismos
JP5119154B2 (ja) 2005-09-22 2013-01-16 インサイト・コーポレイション Janusキナーゼの四環系阻害剤
SI2426129T1 (sl) 2005-12-13 2017-02-28 Incyte Holdings Corporation Heteroarilno substituirani pirolo(2,3-b)piridini in pirolo(2,3-b)pirimidini kot zaviralci janusove kinaze
TWI382974B (zh) 2005-12-20 2013-01-21 英塞特公司 作為吲哚胺2,3-二氧化酶調節劑之n-羥基甲脒基雜環化物
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
DE102006028590A1 (de) * 2006-06-22 2007-12-27 Forschungszentrum Karlsruhe Gmbh Vorrichtung und Verfahren zur Herstellung keramischer Granulate
KR20090025262A (ko) 2006-06-23 2009-03-10 인사이트 코포레이션 Hm74a 아고니스트로서 푸리논 유도체
WO2007150025A2 (fr) 2006-06-23 2007-12-27 Incyte Corporation Dérivés de purinone en tant qu'agonistes du hm74a
US7828543B2 (en) * 2006-07-27 2010-11-09 Casa Herrera, Inc. Dough sheeter cutter roller
CA2660836A1 (fr) 2006-08-07 2008-02-21 Incyte Corporation Utilisation de triazolotriazines en tant qu'inhibiteurs des kinases
WO2008024914A2 (fr) 2006-08-23 2008-02-28 Intellect Neurosciences Inc. Sel de calcium de l'acide 3-(3-indolyl)propionique et méthode de fabrication de l'acide libre de l'acide 3-(3-indolyl)propionique à partir dudit sel
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
EP2064207B1 (fr) 2006-09-19 2013-11-06 Incyte Corporation N-hydroxyamidinohétérocycles en tant que modulateurs d'indoléamine 2,3-dioxygénase
ES2415863T3 (es) 2006-12-22 2013-07-29 Incyte Corporation Heterociclos sustituidos como inhibidores de Janus Quinasas
US7883039B2 (en) * 2007-02-27 2011-02-08 Collette Nv Continuous granulating and drying apparatus including measurement units
JP2008235481A (ja) * 2007-03-19 2008-10-02 Nippon Chem Ind Co Ltd 半導体ウエハ研磨用組成物、その製造方法、及び研磨加工方法
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
MX342814B (es) 2007-06-13 2016-10-13 Incyte Holdings Corp Sales de inhibidor de janus cinasa (r)-3-(4-7h-pirrolo[2,3-d]pirim idin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo.
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
GB0714029D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
GB0714030D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
KR20100052507A (ko) 2007-08-02 2010-05-19 레코르다티 아일랜드 리미티드 mGlu5 길항제로서의 신규 헤테로 고리 화합물
AU2008321046B2 (en) 2007-11-16 2013-10-24 Incyte Holdings Corporation 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as janus kinase inhibitors
SI2288610T1 (sl) 2008-03-11 2016-11-30 Incyte Holdings Corporation Derivati azetidina in ciklobutana kot inhibitorji jak
JP2011518836A (ja) 2008-04-24 2011-06-30 インサイト・コーポレイション 大環状化合物およびそれらのキナーゼ阻害剤としての使用
CN103936743B (zh) 2008-05-21 2018-04-24 因西特控股公司 2-氟-N-甲基-4-[7-(喹啉-6-基甲基)咪唑并[1,2-b][1,2,4]三嗪-2-基]苯甲酰胺的盐及与其相关的制备方法
HRP20141094T1 (hr) 2008-07-08 2015-01-16 Incyte Corporation 1,2,5-oksadiazoli kao inhibitori indolamin 2,3-dioksigenaze
WO2010077839A1 (fr) 2008-12-15 2010-07-08 Wyeth Llc (Formerly Known As Wyeth) Agonistes de cb2 de type oxindole substitué pour le traitement de la douleur
WO2010090680A1 (fr) 2008-12-15 2010-08-12 Wyeth Llc Agonistes de cb2 de type oxindole substitué
US8436008B2 (en) 2008-12-22 2013-05-07 Incyte Corporation Substituted heterocyclic compounds
GB0900599D0 (en) 2009-01-14 2009-02-18 Novacta Biosystems Ltd Treatment
AU2010205472B2 (en) 2009-01-14 2013-03-14 Novacta Biosystems Limited Deoxyactagardine derivatives
WO2010085597A1 (fr) 2009-01-23 2010-07-29 Incyte Corporation Composés macrocycliques et leur utilisation en tant qu'inhibiteurs des kinases
CN102365098A (zh) * 2009-01-30 2012-02-29 明治制果药业株式会社 细粉状药物组合物
CN102388060B (zh) 2009-02-04 2014-09-10 诺瓦克塔生物系统有限公司 阿肽加定衍生物
US20100317630A1 (en) 2009-02-04 2010-12-16 Recordati Ireland Limited Novel heterocyclic compounds as mglu5 antagonists
WO2010093808A1 (fr) 2009-02-11 2010-08-19 Reaction Biology Corp. Inhibiteurs de kinase sélectifs
WO2010100477A2 (fr) 2009-03-03 2010-09-10 Shire Llc Promédicaments de carbamate d'acide aminé et de peptide de tapentadol et leurs utilisations
AR076052A1 (es) 2009-03-20 2011-05-18 Incyte Corp Derivados de pirimidinas sustituidas, composiciones farmaceuticas que los contienen y uso de los mismos en trastornos asociados con receptores de histamina h4, tales como trastornos inflamatorios, prurito y dolor.
EP2413937A1 (fr) 2009-04-02 2012-02-08 Shire LLC Nouveaux promédicaments d'opioïdes à base d'acide aminé et de peptide liés à l'acide dicarboxylique et leurs utilisations
HUE046493T2 (hu) 2009-05-22 2020-03-30 Incyte Holdings Corp 3-[4-(7H-Pirrolo[2,3-d]pirimidin-4-il)-lH-pirazol-l-il]oktán- vagy heptán-nitril JAK inhibitorokként
CN102458581B (zh) 2009-05-22 2016-03-30 因塞特控股公司 作为JANUS激酶抑制剂的吡唑-4-基-吡咯并[2,3-d]嘧啶和吡咯-3-基-吡咯并[2,3-d]嘧啶的N-(杂)芳基-吡咯烷衍生物
CN102596896A (zh) 2009-06-24 2012-07-18 夏尔有限责任公司 美西律氨基酸和肽前药以及它们的用途
CN104945420A (zh) 2009-06-29 2015-09-30 因塞特公司 作为pi3k抑制剂的嘧啶酮类
US20110015182A1 (en) 2009-07-17 2011-01-20 Richard Franklin Novel carbamate amino acid and peptide prodrugs of opioids and uses thereof
KR20120046268A (ko) 2009-07-23 2012-05-09 샤이어 엘엘씨 갈란타민 아미노산과 펩티드 프로드러그 및 이들의 용도
US9126938B2 (en) 2009-08-17 2015-09-08 The Brigham And Women's Hospital, Inc. Phosphatidylcholine transfer protein inhibitors
WO2011028685A1 (fr) 2009-09-01 2011-03-10 Incyte Corporation Dérivés hétérocycliques de pyrazol-4-yl-pyrrolo[2,3-d] pyrimidines en tant qu'inhibiteurs de janus kinase
US20120028931A1 (en) 2009-09-14 2012-02-02 Recordati Ireland Limited Heterocyclic m-glu5 antagonists
GB0916163D0 (en) 2009-09-15 2009-10-28 Shire Llc Prodrugs of guanfacine
JP5946768B2 (ja) 2009-10-09 2016-07-06 インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation 3−(4−(7H−ピロロ[2,3−d]ピリミジン−4−イル)−1H−ピラゾール−1−イル)−3−シクロペンチルプロパンニトリルのヒドロキシル、ケト及びグルクロニド誘導体
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
US8680108B2 (en) 2009-12-18 2014-03-25 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
WO2011083304A1 (fr) 2010-01-05 2011-07-14 Shire Llc Promédicaments d'opioïdes et leurs utilisations
TW201138800A (en) 2010-02-02 2011-11-16 Novacta Biosystems Ltd Salts
GB201001688D0 (en) 2010-02-02 2010-03-17 Novacta Biosystems Ltd Compounds
MX2012009541A (es) 2010-02-18 2012-10-01 Incyte Corp Derivados de ciclobutano y metilciclobutano como inhibidores de janus cinasa.
RS57219B1 (sr) 2010-03-10 2018-07-31 Incyte Holdings Corp Piperidin-4-il azetidin derivati kao inhibitori jak1
JP5816678B2 (ja) 2010-04-14 2015-11-18 インサイト・コーポレイションIncyte Corporation PI3Kδ阻害剤としての縮合誘導体
EP3087972A1 (fr) 2010-05-21 2016-11-02 Incyte Holdings Corporation Formulation topique pour un inhibiteur jak
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
JP2013529673A (ja) 2010-07-09 2013-07-22 レコルダーティ アイルランド リミテッド Mglu5アンタゴニストとしての新規スピロ複素環化合物
GB201013509D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013507D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013508D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013513D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
WO2012025744A1 (fr) 2010-08-24 2012-03-01 Imperial Innovations Limited Glycodendrimères de polypropylétherimine
WO2012028629A1 (fr) 2010-09-02 2012-03-08 Glaxo Group Limited 2-(benzyloxy) benzamides en tant qu'inhibiteurs de la lrrk2 kinase
CA2812029A1 (fr) 2010-09-15 2012-03-22 Shire Llc Promedicaments de guanfacine
WO2012046062A1 (fr) 2010-10-05 2012-04-12 Shire, Llc Utilisation de promédicaments pour éviter les événements indésirables à médiation gi
US20150093440A1 (en) * 2010-10-15 2015-04-02 Glaxo Group Limited Aggregate nanoparticulate medicament formulations, manufacture and use thereof
SG190839A1 (en) 2010-11-19 2013-07-31 Incyte Corp Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
ES2536415T3 (es) 2010-11-19 2015-05-25 Incyte Corporation Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK
CA2822070C (fr) 2010-12-20 2019-09-17 Incyte Corporation N-(1-(phenyl substitue)ethyl)-9h-purin-6-amines en tant qu'inhibiteurs de pi3k
WO2012085586A1 (fr) 2010-12-23 2012-06-28 Shire, Llc Promédicaments de méxilétine
RU2013135224A (ru) 2011-01-20 2015-03-10 Бионевиа Фармасьютикалс Инк. Композиции с модифицированным высвобождением эпалрестата или его производных и способы их использования
US9499462B2 (en) 2011-02-02 2016-11-22 Cognition Therapeutics, Inc. Isolated compounds from turmeric oil and methods of use
US9181375B2 (en) 2011-02-14 2015-11-10 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Fluorescent potassium ion sensors
WO2012112922A1 (fr) 2011-02-18 2012-08-23 Alexion Pharmaceuticals, Inc. Procédés de synthèse de dérivés z de précurseur de molybdoptérine
EA026317B1 (ru) 2011-02-18 2017-03-31 Новартис Фарма Аг КОМБИНИРОВАННОЕ ЛЕЧЕНИЕ С ПРИМЕНЕНИЕМ ИНГИБИТОРОВ mTOR/JAK
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (fr) 2011-03-25 2012-10-04 Incyte Corporation Dérivés de pyrimidine-4,6-diamine en tant qu'inhibiteurs de pi3k
PH12013502612A1 (en) 2011-06-20 2014-04-28 Incyte Holdings Corp Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
TW201315470A (zh) * 2011-07-07 2013-04-16 Arqule Inc 吡咯並喹啉基-吡咯啶-2,5-二酮調製劑類及製備和使用彼等之方法
US9358229B2 (en) 2011-08-10 2016-06-07 Novartis Pharma Ag JAK PI3K/mTOR combination therapy
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為jak抑制劑之環己基氮雜環丁烷衍生物
ES2873001T3 (es) 2011-09-02 2021-11-03 Incyte Holdings Corp Heterociclaminas como inhibidores de PI3K
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
JP6073545B2 (ja) * 2011-10-04 2017-02-01 横浜油脂工業株式会社 リグナン類含有微粒子及び組成物
US8895571B2 (en) 2011-10-14 2014-11-25 Incyte Corporation Isoindolinone and pyrrolopyridinone derivatives as Akt inhibitors
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
RU2666963C2 (ru) 2012-04-13 2018-09-13 Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Агрегированные частицы
WO2013173720A1 (fr) 2012-05-18 2013-11-21 Incyte Corporation Dérivés de pyrrolopyridine et de pyrrolopyrimidine substitués par un pipéridinylcyclobutyle à titre d'inhibiteurs jak
UA125503C2 (uk) 2012-06-13 2022-04-13 Інсайт Холдинґс Корпорейшн Заміщені трициклічні сполуки як інгібітори fgfr
WO2014036242A2 (fr) 2012-08-29 2014-03-06 Mount Sinai School Of Medicine Composés de benzothiazole ou de benzoxazole en tant qu'activateurs de la protéine sumo
EP2906564B1 (fr) 2012-10-12 2018-08-22 Mayo Foundation For Medical Education And Research Traitement du cancer du cerveau à l'aide d'agélastatine a (aa) et d'analogues de celle-ci
TWI646099B (zh) 2012-11-01 2019-01-01 英塞特控股公司 作爲jak抑制劑之三環稠合噻吩衍生物
TW202228704A (zh) 2012-11-15 2022-08-01 美商英塞特控股公司 盧梭利替尼之緩釋性劑型
US9504691B2 (en) * 2012-12-06 2016-11-29 Alcon Research, Ltd. Finafloxacin suspension compositions
ES2649156T3 (es) 2013-01-14 2018-01-10 Incyte Holdings Corporation Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim
EA035929B1 (ru) 2013-01-15 2020-09-02 Инсайт Холдингс Корпорейшн ТИАЗОЛКАРБОКСАМИДЫ И ПИРИДИНКАРБОКСАМИДЫ, ИСПОЛЬЗУЕМЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Pim-КИНАЗЫ
EP2961533B1 (fr) * 2013-02-28 2021-10-13 Sun Chemical Corporation Procede continu de broyage avec microparticules contenues
TWI687220B (zh) 2013-03-01 2020-03-11 美商英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
BR122021015061B1 (pt) 2013-03-06 2022-10-18 Incyte Holdings Corporation Processos e intermediários para preparar um inibidor de jak
US9815847B2 (en) 2013-03-14 2017-11-14 Icahn School Of Medicine At Mount Sinai Pyrimidine compounds as kinase inhibitors
ES2755827T3 (es) 2013-03-15 2020-04-23 Incyte Holdings Corp Heterciclos tricíclicos como inhibidores de proteína BET
WO2014172644A2 (fr) 2013-04-19 2014-10-23 Incyte Corporation Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr
CN107698569B (zh) 2013-05-17 2020-11-27 因赛特公司 作为jak抑制剂的联吡唑衍生物
ES2635560T3 (es) 2013-07-08 2017-10-04 Incyte Holdings Corporation Heterociclos tricíclicos como inhibidores de la proteína NET
DK3030227T3 (da) 2013-08-07 2020-04-20 Incyte Corp Vedvarende frigivelses-doseringsformer for en jak1-inhibitor
SG11201601259YA (en) 2013-08-23 2016-03-30 Incyte Corp Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
US9321755B2 (en) 2013-11-08 2016-04-26 Incyte Corporation Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
WO2015071841A1 (fr) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes de dabigatran et ses dérivés, procédé de préparation de ceux-ci et compositions pharmaceutiques contenant ceux-ci
WO2015081246A1 (fr) 2013-11-26 2015-06-04 Incyte Corporation Hétérocycles bicycliques servant d'inhibiteurs de protéines bet
WO2015081203A1 (fr) 2013-11-26 2015-06-04 Incyte Corporation Hétérocycles bicycliques servant d'inhibiteurs des protéines bet
US9315501B2 (en) 2013-11-26 2016-04-19 Incyte Corporation Bicyclic heterocycles as BET protein inhibitors
WO2015095492A1 (fr) 2013-12-19 2015-06-25 Incyte Corporation Hétérocycles tricycliques en tant qu'inhibiteurs des protéines bet
US10758569B2 (en) 2014-01-13 2020-09-01 The General Hospital Corporation Heteroaryl disulfide compounds as allosteric effectors for increasing the oxygen-binding affinity of hemoglobin
MX368755B (es) 2014-01-31 2019-10-15 Cognition Therapeutics Inc Composiciones de isoindolina y métodos para tratar una enfermedad neurodegenerativa.
PH12020552066A1 (en) 2014-02-13 2022-05-11 Incyte Corp Cyclopropylamines as lsd1 inhibitors
RS59534B1 (sr) 2014-02-13 2019-12-31 Incyte Corp Ciklopropilamini kao lsd1 inhibitori
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
ES2672797T3 (es) 2014-02-13 2018-06-18 Incyte Corporation Ciclopropilaminas como inhibidores de LSD1
SMT201800551T1 (it) 2014-02-28 2019-01-11 Incyte Corp Inibitori di jak1 per il trattamento di sindromi mielodisplastiche
EP3129021B1 (fr) 2014-04-08 2020-09-23 Incyte Corporation Traitement d'affections malignes par lymphocytes b par un inhibiteur jak et pi3k combiné
EP3674302B1 (fr) 2014-04-23 2023-03-01 Incyte Holdings Corporation 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones et de pyrazolo[3,4-c]pyridin-7(6h)-ones en tant qu'inhibiteurs de protéines bet
PE20170300A1 (es) 2014-04-30 2017-04-19 Incyte Corp Procesos para preparar un inhibidor de jak 1 y nuevas formas de este
TW201625641A (zh) 2014-05-22 2016-07-16 健臻公司 Nampt抑制劑及方法
US9498467B2 (en) 2014-05-30 2016-11-22 Incyte Corporation Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
WO2015188015A1 (fr) 2014-06-04 2015-12-10 Haro Pharmaceutical Inc. Composés bi-polycycliques de 18 à 20 éléments
WO2015191677A1 (fr) 2014-06-11 2015-12-17 Incyte Corporation Dérivés d'hétéroarylaminoalkylphényle bicycliques à titre d'inhibiteurs de pi3k
RU2562219C1 (ru) * 2014-06-30 2015-09-10 Закрытое акционерное общество "Путь 910" Способ получения активированной суспензии
WO2016007736A1 (fr) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines en tant qu'inhibiteurs de lsd1
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為lsd1抑制劑之咪唑并吡啶及咪唑并吡嗪
WO2016007722A1 (fr) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9527864B2 (en) 2014-09-15 2016-12-27 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
JP6716570B2 (ja) 2014-12-22 2020-07-01 スーダ ファーマシューティカルズ リミテッド 血小板増加性癌患者における転移性疾患の予防及び治療
US9593127B2 (en) 2014-12-29 2017-03-14 Recordati Ireland Ltd. Heterocyclylalkyne derivatives and their use as modulators of mGluR5 receptors
WO2016130501A1 (fr) 2015-02-09 2016-08-18 Incyte Corporation Composés aza-hétéroaryle en tant qu'inhibiteurs de pi3k-gamma
UA121669C2 (uk) 2015-02-20 2020-07-10 Інсайт Корпорейшн Біциклічні гетероцикли як інгібітори fgfr
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
JP6816005B2 (ja) 2015-02-27 2021-01-20 インサイト・コーポレイションIncyte Corporation Pi3k阻害剤の塩及びその調製のためのプロセス
EP3626720A1 (fr) 2015-04-03 2020-03-25 Incyte Corporation Composés hétérocycliques utilisés en tant qu'inhibiteurs de lsd1
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
WO2016183060A1 (fr) 2015-05-11 2016-11-17 Incyte Corporation Procédé de synthèse d'un inhibiteur de phospho-inositide 3-kinases
WO2016183062A1 (fr) 2015-05-11 2016-11-17 Incyte Corporation Sels de (s)-7-(1-(9h-purin-6-ylamino)éthyl)-6-(3-fluorophényl)-3-méthyl-5h-thiazolo[3,2-a]pyrimidin-5-one
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
US20180153835A1 (en) * 2015-06-05 2018-06-07 Lupin Limited Compositions of diclofenac acid
MX389824B (es) 2015-08-12 2025-03-20 Incyte Holdings Corp Sales de un inhibidor de dimetilasa 1 especifica para lisina (lsd1).
WO2017035366A1 (fr) 2015-08-26 2017-03-02 Incyte Corporation Dérivés de type pyrrolo-pyrimidine utilisés comme inhibiteurs des tam
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
JP6887996B2 (ja) 2015-09-23 2021-06-16 ザ ジェネラル ホスピタル コーポレイション Tead転写因子自己パルミトイル化阻害剤
TW201718546A (zh) 2015-10-02 2017-06-01 英塞特公司 適用作pim激酶抑制劑之雜環化合物
TW201718581A (zh) 2015-10-19 2017-06-01 英塞特公司 作為免疫調節劑之雜環化合物
AR106520A1 (es) 2015-10-29 2018-01-24 Incyte Corp Forma sólida amorfa de un inhibidor de proteína bet
ES2915550T3 (es) 2015-11-06 2022-06-23 Incyte Corp Compuestos heterocíclicos como inhibidores de PI3K-gamma
LT3377488T (lt) 2015-11-19 2023-01-10 Incyte Corporation Heterocikliniai junginiai, kaip imunomoduliatoriai
CN108472298B (zh) 2015-11-24 2021-04-20 深圳阿拉丁医疗科技有限公司 选择性激酶抑制剂
MA44075A (fr) 2015-12-17 2021-05-19 Incyte Corp Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1
US20170174679A1 (en) 2015-12-22 2017-06-22 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2017120194A1 (fr) 2016-01-05 2017-07-13 Incyte Corporation Pyridine et utilisation de composés de la pyridimine comme inhibiteurs de pi3k-gamma
EP3939570A1 (fr) 2016-02-18 2022-01-19 Immune Therapeutics, Inc. Naltrexone pour le traitement des maladies auto-immunes et inflammatoires
UA123785C2 (uk) 2016-03-28 2021-06-02 Інсайт Корпорейшн Сполуки піролотриазину як інгібітори tam
IL262488B (en) 2016-04-22 2022-08-01 Incyte Corp lsdi inhibitor formulations
GB2554333A (en) 2016-04-26 2018-04-04 Big Dna Ltd Combination therapy
MA44860A (fr) 2016-05-06 2019-03-13 Incyte Holdings Corp Composés hétérocycliques utilisés comme immunomodulateurs
WO2017205464A1 (fr) 2016-05-26 2017-11-30 Incyte Corporation Composés hétérocycliques utilisés comme immunomodulateurs
CN114366748A (zh) 2016-06-20 2022-04-19 因赛特公司 Bet抑制剂的结晶固体形式
HUE060256T2 (hu) 2016-06-20 2023-02-28 Incyte Corp Heterociklusos vegyületek mint immunmodulátorok
WO2017223414A1 (fr) 2016-06-24 2017-12-28 Incyte Corporation Composants hétérocycliques utilisés en tant qu'inhibiteurs de pi3k-y
US20180016260A1 (en) 2016-07-14 2018-01-18 Incyte Corporation Heterocyclic compounds as immunomodulators
US20180055835A1 (en) 2016-08-25 2018-03-01 Immune Therapeutics Inc. Method for Treating And Preventing Protozoal Infections
ES2941716T3 (es) 2016-08-29 2023-05-25 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
WO2018049191A1 (fr) 2016-09-09 2018-03-15 Incyte Corporation Dérivés de pyrazolopyridone en tant que modulateurs de hpk1 et leurs utilisations pour le traitement du cancer
US20180072718A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine compounds and uses thereof
WO2018049152A1 (fr) 2016-09-09 2018-03-15 Incyte Corporation Dérivés de pyrazolopyrimidine en tant que modulateurs de hpk1 et leurs utilisations pour le traitement du cancer
TWI867311B (zh) 2016-09-09 2024-12-21 美商英塞特公司 吡唑并吡啶化合物及其用途
EP3558989B1 (fr) 2016-12-22 2021-04-14 Incyte Corporation Dérivés de triazolo[1,5-a]pyridine en tant qu'immunomodulateurs
WO2018119221A1 (fr) 2016-12-22 2018-06-28 Incyte Corporation Dérivés pyridine utilisés en tant qu'immunomodulateurs
WO2018119266A1 (fr) 2016-12-22 2018-06-28 Incyte Corporation Dérivés de benzooxazole en tant qu'mmunomodulateurs
CN116115764A (zh) 2016-12-22 2023-05-16 因赛特公司 四氢咪唑并[4,5-c]吡啶衍生物作为pd-l1内在化诱导剂
JP7303108B2 (ja) 2016-12-22 2023-07-04 インサイト・コーポレイション 免疫調節剤としての二環式複素芳香環化合物
US20180177784A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
US20180228786A1 (en) 2017-02-15 2018-08-16 Incyte Corporation Pyrazolopyridine compounds and uses thereof
EP3634394A4 (fr) 2017-05-15 2021-04-07 Cognition Therapeutics, Inc. Compositions pour le traitement de maladies neurodégénératives
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
US11440922B2 (en) 2017-06-29 2022-09-13 Recordati Industria Chimica e Farmacentica S.p.A. Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors
WO2019051199A1 (fr) 2017-09-08 2019-03-14 Incyte Corporation Composés de 6-cyano-indazole utilisés en tant que modulateurs de kinase 1 progénitrices hématopoïétiques (hpk1)
JP7447002B2 (ja) 2017-09-11 2024-03-11 クルーゾン・ファーマシューティカルズ・インコーポレイテッド SHP2のオクタヒドロシクロペンタ[c]ピロールのアロステリック阻害剤
PL3687996T3 (pl) 2017-09-27 2022-02-21 Incyte Corporation Sole pochodnych pirolotriazyny użyteczne jako inhibitory tam
SMT202100656T1 (it) 2017-10-18 2022-01-10 Incyte Corp Derivati di imidazolo condensati sostituiti con gruppi ossidrile terziari come inibitori di pi3k-gamma
US11306086B2 (en) 2017-10-26 2022-04-19 Xynomic Pharmaceuticals, Inc. Crystalline salts of a B-RAF kinase inhibitor
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
EP3723760B1 (fr) * 2017-12-14 2025-06-11 SpecGx LLC Procédé de broyage en une étape pour préparer des esters de palipéridone micronisés
US11306079B2 (en) 2017-12-21 2022-04-19 Incyte Corporation 3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as PI3K-gamma kinase inhibitors
SG11202006622VA (en) 2018-01-26 2020-08-28 Recordati Ind Chimica E Farmaceutica S P A TRIAZOLE, IMIDAZOLE AND PYRROLE CONDENSED PIPERAZINE DERIVATIVES AND THEIR USE AS MODULATORS OF mGlu5 RECEPTORS
CA3089832A1 (fr) 2018-01-30 2019-08-08 Incyte Corporation Procedes de preparation de (1-(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
KR20240157777A (ko) 2018-02-16 2024-11-01 인사이트 코포레이션 사이토카인-관련 장애의 치료를 위한 jak1 경로 억제제
US10752635B2 (en) 2018-02-20 2020-08-25 Incyte Corporation Indazole compounds and uses thereof
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
PE20210397A1 (es) 2018-02-20 2021-03-02 Incyte Corp Derivados de n-(fenil)-2-(fenil)pirimidina-4-carboxamida y compuestos relacionados como inhibidores hpki para tratar el cancer
CR20200441A (es) 2018-02-27 2021-03-15 Incyte Corp Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b
SMT202200134T1 (it) 2018-03-08 2022-05-12 Incyte Corp Composti di amminopirazindiolo come inibitori di pi3k-y
ES3030010T3 (en) 2018-03-30 2025-06-26 Incyte Corp Heterocyclic compounds as immunomodulators
IL318069A (en) 2018-03-30 2025-02-01 Incyte Corp Using JAK inhibitors to treat hidradenitis suppurativa
US11220510B2 (en) 2018-04-09 2022-01-11 Incyte Corporation Pyrrole tricyclic compounds as A2A / A2B inhibitors
US11299473B2 (en) 2018-04-13 2022-04-12 Incyte Corporation Benzimidazole and indole compounds and uses thereof
SI3788047T1 (sl) 2018-05-04 2024-11-29 Incyte Corporation Trdne oblike inhibitorja fgfr in postopki priprave le-teh
CN112566912A (zh) 2018-05-04 2021-03-26 因赛特公司 Fgfr抑制剂的盐
BR112020022936A2 (pt) 2018-05-11 2021-02-02 Incyte Corporation derivados de tetra-hidro-imidazo[4,5-c]piridina como imunomoduladores de pd-l1
MX2020012376A (es) 2018-05-18 2021-03-09 Incyte Corp Derivados de pirimidina fusionados como inhibidores de los receptores de adenosina a2a/a2b.
MA52754A (fr) 2018-05-25 2021-04-14 Incyte Corp Composés hétérocycliques tricycliques en tant qu'activateurs de sting
MA52761A (fr) 2018-06-01 2021-04-14 Incyte Corp Schéma posologique destiné au traitement de troubles liés à la pi3k
EP4606432A3 (fr) 2018-06-29 2025-10-29 Incyte Corporation Formulations d'un inhibiteur axl/mer
WO2020010003A1 (fr) 2018-07-02 2020-01-09 Incyte Corporation DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ
IL279829B2 (en) 2018-07-05 2025-05-01 Incyte Holdings Corp Fused pyrazine derivatives as A2A/A2B inhibitors
GB2575490A (en) 2018-07-12 2020-01-15 Recordati Ind Chimica E Farmaceutica Spa P2X3 receptor antagonists
US10875872B2 (en) 2018-07-31 2020-12-29 Incyte Corporation Heteroaryl amide compounds as sting activators
WO2020028565A1 (fr) 2018-07-31 2020-02-06 Incyte Corporation Composés hétéroaryles tricycliques en tant qu'activateurs de sting
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
CR20250050A (es) 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
ES2973117T3 (es) 2018-09-25 2024-06-18 Incyte Corp Compuestos de pirazolo[4,3-d]pirimidina como moduladores de ALK2 y/o FGFR
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
EA202191170A1 (ru) 2018-10-31 2021-07-27 Инсайт Корпорейшн Комбинированная терапия для лечения гематологических заболеваний
US11078204B2 (en) 2018-11-13 2021-08-03 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
US11161838B2 (en) 2018-11-13 2021-11-02 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
US11396502B2 (en) 2018-11-13 2022-07-26 Incyte Corporation Substituted heterocyclic derivatives as PI3K inhibitors
US11596692B1 (en) 2018-11-21 2023-03-07 Incyte Corporation PD-L1/STING conjugates and methods of use
PH12021551455A1 (en) 2018-12-19 2022-04-18 Incyte Corp Jak1 pathway inhibitors for the treatment of gastrointestinal disease
BR112021011948A2 (pt) 2018-12-20 2021-09-08 Incyte Corporation Compostos de imidazopiridazina e imidazopiridina e usos dos mesmos
WO2020146237A1 (fr) 2019-01-07 2020-07-16 Incyte Corporation Composés d'amide d'hétéroaryle en tant qu'activateurs de sting
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
WO2020168197A1 (fr) 2019-02-15 2020-08-20 Incyte Corporation Composés de pyrrolo[2,3-d]pyrimidinone en tant qu'inhibiteurs de cdk2
WO2020180959A1 (fr) 2019-03-05 2020-09-10 Incyte Corporation Composés de pyrazolyl pyrimidinylamine en tant qu'inhibiteurs de cdk2
PH12021552130A1 (en) 2019-03-05 2022-08-31 Incyte Corp Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
WO2020185532A1 (fr) 2019-03-08 2020-09-17 Incyte Corporation Méthodes de traitement du cancer au moyen d'un inhibiteur de fgfr
US12187722B2 (en) 2019-03-15 2025-01-07 The General Hospital Corporation Small molecule inhibitors of TEAD transcription factors
WO2020205560A1 (fr) 2019-03-29 2020-10-08 Incyte Corporation Composés sulfonylamides utilisés comme inhibiteurs de la cdk2
WO2020223235A1 (fr) 2019-04-29 2020-11-05 Incyte Corporation Formes pharmaceutiques de ponatinib du type mini-comprimés
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2020223469A1 (fr) 2019-05-01 2020-11-05 Incyte Corporation Dérivés de n-(1-(méthylsulfonyl)pipéridin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine et composés apparentés utilisés en tant qu'inhibiteurs de kinase 2 dépendante des cyclines (cdk2) pour le traitement du cancer
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
TWI865579B (zh) 2019-08-06 2024-12-11 美商英塞特公司 Hpk1抑制劑之固體形式
KR20220047589A (ko) 2019-08-08 2022-04-18 래크나 리미티드 암 치료 방법
CA3150434A1 (fr) 2019-08-09 2021-02-18 Incyte Corporation Sels d'un inhibiteur de pd-1/pd-l1
CA3150681A1 (fr) 2019-08-14 2021-02-18 Incyte Corporation Composes imidazolyl-pyrimidinylamines utilises comme inhibiteurs de la cdk2
CR20220124A (es) 2019-08-26 2022-06-15 Incyte Corp Triazolopirimidinas como inhibidores de a2a/a2b
IL291471B2 (en) 2019-09-30 2025-04-01 Incyte Corp Pyrimido[3,2–D]pyrimidine compounds as immunomodulators
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CR20220170A (es) 2019-10-11 2022-10-10 Incyte Corp Aminas bicíclicas como inhibidoras de la cdk2
EP4045151A1 (fr) 2019-10-14 2022-08-24 Incyte Corporation Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr
WO2021076124A1 (fr) 2019-10-16 2021-04-22 Incyte Corporation Utilisation d'inhibiteurs de jak1 pour le traitement du lupus érythémateux cutané et du lichen plan (l.p.)
US11992490B2 (en) 2019-10-16 2024-05-28 Incyte Corporation Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP2023500395A (ja) 2019-11-11 2023-01-05 インサイト・コーポレイション Pd-1/pd-l1阻害剤の塩及び結晶形態
EP4069695A1 (fr) 2019-12-04 2022-10-12 Incyte Corporation Dérivés d'un inhibiteur de fgfr
CA3163875A1 (fr) 2019-12-04 2021-06-10 Incyte Corporation Heterocycles tricycliques en tant qu'inhibiteurs de fgfr
CN115279766B (zh) 2020-01-03 2025-05-02 因赛特公司 包含a2a/a2b和pd-1/pd-l1抑制剂的组合疗法
IL294526B1 (en) 2020-01-10 2025-10-01 Incyte Corp Tricyclic compounds as KRAS inhibitors
WO2021146424A1 (fr) 2020-01-15 2021-07-22 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
US11530218B2 (en) 2020-01-20 2022-12-20 Incyte Corporation Spiro compounds as inhibitors of KRAS
US20210253582A1 (en) 2020-02-06 2021-08-19 Incyte Corporation Salts and solid forms and processes of preparing a pi3k inhibitor
AU2021230385A1 (en) 2020-03-06 2022-09-22 Incyte Corporation Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors
WO2021198962A1 (fr) 2020-04-01 2021-10-07 Cytocom Inc. Procédé de traitement de maladies virales
PE20230825A1 (es) 2020-04-16 2023-05-19 Incyte Corp Inhibidores de kras triciclicos fusionados
US11739102B2 (en) 2020-05-13 2023-08-29 Incyte Corporation Fused pyrimidine compounds as KRAS inhibitors
GB202008135D0 (en) 2020-05-29 2020-07-15 Neolife Int Llc Dietary supplements
BR112022024632A2 (pt) 2020-06-02 2023-02-28 Incyte Corp Processos para preparar um inibidor de jak1
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
CA3184633A1 (fr) 2020-06-03 2021-12-09 Incyte Corporation Polytherapie pour le traitement des neoplasies myeloproliferatives
MX2022015493A (es) 2020-06-12 2023-03-21 Incyte Corp Compuestos de imidazopiridazina y usos de los mismos.
US11753413B2 (en) 2020-06-19 2023-09-12 Incyte Corporation Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
WO2022006456A1 (fr) 2020-07-02 2022-01-06 Incyte Corporation Composés de pyridone tricyclique en tant qu'inhibiteurs de v617f de jak2
IL299612A (en) 2020-07-02 2023-03-01 Incyte Corp Tricyclic urea compounds as JAK2 V617F inhibitors
WO2022046989A1 (fr) 2020-08-27 2022-03-03 Incyte Corporation Composés d'urée tricycliques en tant qu'inhibiteurs de v617f de jak2
US11999752B2 (en) 2020-08-28 2024-06-04 Incyte Corporation Vinyl imidazole compounds as inhibitors of KRAS
WO2022072783A1 (fr) 2020-10-02 2022-04-07 Incyte Corporation Composés diones bicycliques en tant qu'inhibiteurs de kras
KR102271247B1 (ko) * 2020-11-04 2021-06-30 삼천당제약주식회사 안과용 현탁액 조성물의 제조방법
US11760756B2 (en) 2020-11-06 2023-09-19 Incyte Corporation Crystalline form of a PD-1/PD-L1 inhibitor
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
TW202233616A (zh) 2020-11-06 2022-09-01 美商英塞特公司 用於製備pd-1/pd-l1抑制劑以及其鹽及結晶形式之方法
WO2022115762A1 (fr) 2020-11-30 2022-06-02 Incyte Corporation Polythérapie faisant appel à un anticorps anti-cd19 et à du parsaclisib
WO2022115120A1 (fr) 2020-11-30 2022-06-02 Incyte Corporation Polythérapie comprenant un anticorps anti-cd19 et le parsaclisib
MX2023006542A (es) 2020-12-08 2023-08-25 Incyte Corp Inhibidores de la vía cinasa jano 1 (jak1) para el tratamiento del vitiligo.
TW202241420A (zh) 2020-12-18 2022-11-01 美商英塞特公司 Pd-l1抑制劑之口服調配物
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
MX2023007850A (es) 2020-12-29 2023-09-11 Incyte Corp Terapia combinada que comprende inhibidores de adora2a/adora2b (a2a/a2b), inhibidores de muerte programada/ligando 1 de muerte programada (pd-1/pd-l1) y anticuerpos de cumulo de diferenciacion 73 (anti-cd73).
MX2023008141A (es) 2021-01-11 2023-10-20 Incyte Corp Terapia combinada que comprende el inhibidor de la vía de proteínas tirosina cinasas de janus cinasas (jak) y el inhibidor de la proteína cinasa asociada a rho (rock).
AR125273A1 (es) 2021-02-25 2023-07-05 Incyte Corp Lactamas espirocíclicas como inhibidores de jak2 v617f
GB202103100D0 (en) 2021-03-05 2021-04-21 Suda Pharmaceuticals Ltd Mitigating the off-target pharmacology of anagrelide in the treatment of thrombocytosis in various diseases
WO2022204112A1 (fr) 2021-03-22 2022-09-29 Incyte Corporation Inhibiteurs d'imidazole et triazole kras
US12065494B2 (en) 2021-04-12 2024-08-20 Incyte Corporation Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent
DK4333840T3 (da) 2021-05-03 2025-11-24 Incyte Corp Jak1-vejinhibitorer til behandling af prurigo nodularis
TW202308639A (zh) 2021-05-03 2023-03-01 美商英塞特公司 用於治療結節性癢疹之鲁索替尼
CA3220155A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Heterocycles tricycliques utiles en tant qu'inhibiteurs de fgfr
WO2022261160A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
WO2023272720A1 (fr) 2021-07-02 2023-01-05 Ascletis BioScience Co., Ltd Composés hétérocycliques utiles comme immunomodulateurs d'interactions de pd-l1
PE20241127A1 (es) 2021-07-07 2024-05-24 Incyte Corp Compuestos triciclicos como inhibidores de kras
US20230114765A1 (en) 2021-07-14 2023-04-13 Incyte Corporation Tricyclic compounds as inhibitors of kras
CN117813309A (zh) 2021-08-17 2024-04-02 歌礼生物科技(杭州)有限公司 作为pd-l1相互作用的免疫调节剂的化合物
EP4396187A1 (fr) 2021-08-31 2024-07-10 Incyte Corporation Composés de naphtyridine en tant qu'inhibiteurs de kras
WO2023049697A1 (fr) 2021-09-21 2023-03-30 Incyte Corporation Composés hétéro-tricycliques utilisés en tant qu'inhibiteurs de kras
CN113908932A (zh) * 2021-09-22 2022-01-11 浙江工业大学 一种磁性粉体连续细化及级分的方法与装置
EP4408536A1 (fr) 2021-10-01 2024-08-07 Incyte Corporation Inhibiteurs de kras tels que la pyrazoloquinoline
WO2023064857A1 (fr) 2021-10-14 2023-04-20 Incyte Corporation Composés de quinoléine utiles en tant qu'inhibiteurs de kras
US20230203010A1 (en) 2021-12-03 2023-06-29 Incyte Corporation Bicyclic amine cdk12 inhibitors
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
EP4452982A1 (fr) 2021-12-22 2024-10-30 Incyte Corporation Sels et formes solides d'un inhibiteur de fgfr et leurs méthodes de préparation
CN114289159B (zh) * 2021-12-29 2023-06-06 湖北华世通生物医药科技有限公司 碳酸司维拉姆的后处理方法及其制备方法
CA3240970A1 (fr) * 2022-01-06 2023-07-27 Sunil Mehta Systeme a usage unique et procede pour lyse ou homogeneisation continue
AR128717A1 (es) 2022-03-07 2024-06-05 Incyte Corp Formas sólidas, sales y procesos de preparación de un inhibidor de cdk2
EP4493189A1 (fr) 2022-03-14 2025-01-22 Laekna Limited Traitement combiné pour le cancer
CR20240447A (es) 2022-03-17 2025-01-29 Incyte Corp Compuestos de urea tricíclica como inhibidores de v617f de jak2.
CR20250008A (es) 2022-06-08 2025-05-05 Incyte Corp Compuestos tricíclicos de triazolo como inhibidores de dgk
US20250353842A1 (en) 2022-06-22 2025-11-20 Incyte Corporation Bicyclic amine cdk12 inhibitors
US20240101557A1 (en) 2022-07-11 2024-03-28 Incyte Corporation Fused tricyclic compounds as inhibitors of kras g12v mutants
KR20250044437A (ko) 2022-08-05 2025-03-31 인사이트 코포레이션 Jak 억제제를 사용한 두드러기의 치료
WO2024086273A1 (fr) 2022-10-21 2024-04-25 Incyte Corporation Composés d'urée tricycliques en tant qu'inhibiteurs de v617f de jak2
TW202428272A (zh) 2022-11-18 2024-07-16 美商英塞特公司 作為dgk抑制劑之雜芳基氟烯烴
EP4389746A3 (fr) 2022-12-21 2024-07-03 Recordati Industria Chimica E Farmaceutica SPA Antagonistes des récepteurs p2x3
AR131101A1 (es) 2023-01-12 2025-02-19 Incyte Corp Heteroarilfluoroalquenos como inhibidores de dgk
WO2024191996A1 (fr) 2023-03-13 2024-09-19 Incyte Corporation Urées bicycliques utilisées en tant qu'inhibiteurs de kinase
WO2024192350A1 (fr) 2023-03-16 2024-09-19 Incyte Corporation Inhibiteurs de la voie jak1 pour le traitement de l'asthme
WO2024220532A1 (fr) 2023-04-18 2024-10-24 Incyte Corporation Composés pyrrolidines inhibiteurs de kras
TW202446371A (zh) 2023-04-18 2024-12-01 美商英塞特公司 2-氮雜雙環[2.2.1]庚烷kras抑制劑
WO2024254245A1 (fr) 2023-06-09 2024-12-12 Incyte Corporation Amines bicycliques utilisées en tant qu'inhibiteurs de cdk2
TW202515858A (zh) 2023-08-18 2025-04-16 美商英塞特公司 作為mrgprx2拮抗劑之雙環雜環化合物
TW202517247A (zh) 2023-08-24 2025-05-01 美商英塞特公司 雙環dgk抑制劑
WO2025096738A1 (fr) 2023-11-01 2025-05-08 Incyte Corporation Inhibiteurs de kras
WO2025096373A1 (fr) 2023-11-02 2025-05-08 Incyte Corporation Ruxolitinib destiné à être utilisé dans le traitement du prurigo nodulaire
TW202523667A (zh) 2023-12-05 2025-06-16 美商英塞特公司 作為dgk抑制劑之三環三唑并化合物
US20250186450A1 (en) 2023-12-06 2025-06-12 Incyte Corporation COMBINATION THERAPY COMPRISING DGK INHIBITORS and PD-1/PD-L1 INHIBITORS
US20250195536A1 (en) 2023-12-13 2025-06-19 Incyte Corporation Bicyclooctane kras inhibitors
US20250243208A1 (en) 2024-01-25 2025-07-31 Incyte Corporation Bicyclic heterocycles as mrgprx2 antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4076347A (en) * 1976-07-21 1978-02-28 Dayco Corporation Antifriction nylon member
US4547534A (en) * 1983-03-18 1985-10-15 Memorex Corporation Method to disperse fine solids without size reduction
US4768366A (en) * 1987-04-30 1988-09-06 Tadeusz Sendzimir Wide strip mill using pressure elements
NZ248813A (en) * 1992-11-25 1995-06-27 Eastman Kodak Co Polymeric grinding media used in grinding pharmaceutical substances
GB9726543D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel compositions
JP4156807B2 (ja) * 1999-06-01 2008-09-24 エラン ファーマ インターナショナル,リミティド 小型ミル及びその方法
GB9920148D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel composition

Also Published As

Publication number Publication date
WO2002000196A2 (fr) 2002-01-03
ATE273695T1 (de) 2004-09-15
CN1438876A (zh) 2003-08-27
MY128806A (en) 2007-02-28
TWI290836B (en) 2007-12-11
DE60105023D1 (de) 2004-09-23
US20060214037A1 (en) 2006-09-28
HU230396B1 (hu) 2016-04-28
KR100786927B1 (ko) 2007-12-17
PL359065A1 (pl) 2004-08-23
CN1321628C (zh) 2007-06-20
KR20030018013A (ko) 2003-03-04
JP2004501182A (ja) 2004-01-15
PT1294358E (pt) 2004-12-31
JP4188078B2 (ja) 2008-11-26
CZ303572B6 (cs) 2012-12-12
BR0111747A (pt) 2003-07-08
EP1294358B1 (fr) 2004-08-18
MXPA03000051A (es) 2003-08-19
WO2002000196A3 (fr) 2002-06-27
AU1560802A (en) 2002-01-08
HUP0301583A2 (en) 2003-08-28
NO333747B1 (no) 2013-09-09
EP1294358A2 (fr) 2003-03-26
CA2413330A1 (fr) 2002-01-03
IL153231A (en) 2008-06-05
US20040089753A1 (en) 2004-05-13
AR029284A1 (es) 2003-06-18
NO20026120L (no) 2003-01-27
DE60105023T2 (de) 2005-08-18
NZ522783A (en) 2004-07-30
HK1055242A1 (en) 2004-01-02
IL153231A0 (en) 2003-07-06
CZ20024263A3 (cs) 2003-06-18
ES2225624T3 (es) 2005-03-16
PL202623B1 (pl) 2009-07-31
NO20026120D0 (no) 2002-12-19
AU2002215608B2 (en) 2004-12-09

Similar Documents

Publication Publication Date Title
IL153231A0 (en) Wet milling process
GB0011120D0 (en) Process
GB0023781D0 (en) Process
GB0020523D0 (en) Process
GB0013793D0 (en) Process
GB0010437D0 (en) Process
GB0002201D0 (en) Process
GB0020021D0 (en) Process
GB0014583D0 (en) Process
GB0021488D0 (en) Process
GB0013791D0 (en) Process
GB0028523D0 (en) Process
GB0015856D0 (en) Wet milling process
GB0021342D0 (en) Improved Process
GB0001564D0 (en) Process
GB0112496D0 (en) Wet milling process
GB0020738D0 (en) Process
GB0016972D0 (en) Process
GB0024716D0 (en) Process
GB0027116D0 (en) Process
GB0011520D0 (en) Process
GB0011519D0 (en) Process
GB0017128D0 (en) Process
GB0019753D0 (en) Process
GB0010691D0 (en) Process