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RU2007105568A - Эффективный способ использования лекарственных средств и способ предотвращения выраженности побочных эффектов - Google Patents

Эффективный способ использования лекарственных средств и способ предотвращения выраженности побочных эффектов Download PDF

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RU2007105568A
RU2007105568A RU2007105568/15A RU2007105568A RU2007105568A RU 2007105568 A RU2007105568 A RU 2007105568A RU 2007105568/15 A RU2007105568/15 A RU 2007105568/15A RU 2007105568 A RU2007105568 A RU 2007105568A RU 2007105568 A RU2007105568 A RU 2007105568A
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carbon atoms
group containing
drug according
amino
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RU2007105568/15A
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RU2396982C2 (ru
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Шиньи КУДОУ (JP)
Шиньи КУДОУ
Казухико КУРИЯМА (JP)
Казухико КУРИЯМА
Токутароу ЯСУЕ (JP)
Токутароу ЯСУЕ
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Киорин Фармасьютикал Ко., Лтд. (Jp)
Киорин Фармасьютикал Ко., Лтд.
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Claims (8)

1. Лекарственное средство, содержащее соединение диарилсульфида или диарилового эфира, имеющее структуру 2-амино-1,3-пропандиола, обладающее активностью восстанавливать лимфоциты периферического кровообращения, в комбинации с иммунодепрессантом и/или противовоспалительным средством.
2. Лекарственное средство по п.1, отличающееся тем, что указанное соединение диарилсульфида или диарилового эфира, имеющее структуру 2-амино-1,3-пропандиола, обладающее активностью восстанавливать лимфоциты периферического кровообращения, представляет собой соединение, представленное общей формулой (1)
Figure 00000001
в которой R1 представляет собой атом галогена; тригалоидометильную группу; гидрокси-группу; группу низшего алкила, содержащую 1-7 атомов углерода; необязательно замещенную фенильную группу; аралкильную группу; низшую алкоксигруппу, содержащую 1-4 атомов углерода; трифторметилоксигруппу; феноксигруппу; циклогексилметилоксигруппу; необязательно замещенную аралкилоксигруппу; пиридилметилоксигруппу; циннамилоксигруппу; нафтилметилоксигруппу; феноксиметильную группу; гидроксиметильную группу; гидроксиэтильную группу; низшую алкилтиогруппу, содержащую 1-4 атомов углерода; низшую алкилсульфинильную группу, содержащую 1-4 атомов углерода; низшую алкилсульфонильную группу, содержащую 1-4 атомов углерода; бензилтиогруппу; ацетильную группу; нитрогруппу или цианогруппу; R2 представляет собой атом водорода; атом галогена; тригалоидометильную группу; низшую алкоксигруппу, содержащую 1-4 атомов углерода; низшую алкильную группу, содержащую 1-7 атомов углерода; фенетильную группу или бензилоксигруппу; R3 представляет собой атом водорода; атом галогена; трифторметильную группу; низшую алкоксигруппу, содержащую 1-4 атомов углерода; гидроксигруппу; бензилоксигруппу; группу низшего алкила, содержащую 1-7 атомов углерода; фенильную группу; низшую алкоксиметильную группу, содержащую 1-4 атомов углерода, или низшую алкилтиогруппу, содержащую 1-4 атомов углерода; Х представляет собой О, S, SO или SO2, а n представляет собой целое число от 1 до 4, или их фармацевтически приемлемая соль и гидрат.
3. Лекарственное средство по п.2, отличающееся тем, что указанное соединение, представленное общей формулой (1) представляет собой 2-амино-2-[4-(3-бензилоксифенилтио)-2-хлорфенил]этил-1,3-пропандиол.
4. Лекарственное средство по п.2, отличающееся тем, что указанное соединение, представленное общей формулой (1) представляет собой гидрохлорид 2-амино-2-[4-(3-бензилоксифенилтио)-2-хлорфенил]этил-1,3-пропандиола.
5. Лекарственное средство по п.1, отличающееся тем, что указанный иммунодепрессант представляет собой ингибитор кальциневрина.
6. Лекарственное средство по п.5, отличающееся тем, что указанный ингибитор кальциневрина представляет собой циклоспорин А или такролимус.
7. Лекарственное средство по п.1, отличающееся тем, что указанный иммунодепрессант представляет собой метотрексат, или микофенольную кислоту, или микофенолят мофетила.
8. Способ предотвращения выраженности побочных эффектов путем применения лекарственного средства, содержащего соединение диарилсульфида или диарилового эфира, имеющее структуру 2-амино-1,3-пропандиола, обладающее активностью восстанавливать лимфоциты периферического кровообращения, в комбинации с иммунодепрессантом и/или противовоспалительным средством, при этом одновременно увеличивается эффективность указанных средств, а используемые количества снижаются.
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CA2573479A1 (en) 2006-01-26
DE602005027074D1 (de) 2011-05-05
CN101884781A (zh) 2010-11-17
MX2007000564A (es) 2007-03-30
NO20070745L (no) 2007-04-13
CN101905023B (zh) 2012-07-11
BRPI0513110A (pt) 2008-04-29
PT1772145E (pt) 2011-05-27
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