PT2511262T - Processo para a produção de cloridrato de 2-amino-2-[2-[4-(3- benziloxi-feniltio)-2-clorofenil[etil]-1,3-propanodiol - Google Patents
Processo para a produção de cloridrato de 2-amino-2-[2-[4-(3- benziloxi-feniltio)-2-clorofenil[etil]-1,3-propanodiolInfo
- Publication number
- PT2511262T PT2511262T PT121671754T PT12167175T PT2511262T PT 2511262 T PT2511262 T PT 2511262T PT 121671754 T PT121671754 T PT 121671754T PT 12167175 T PT12167175 T PT 12167175T PT 2511262 T PT2511262 T PT 2511262T
- Authority
- PT
- Portugal
- Prior art keywords
- benzyloxyâ
- phenylthio
- chlorophenyl
- ethyl
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
- C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/07—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004297651 | 2004-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2511262T true PT2511262T (pt) | 2017-03-30 |
Family
ID=36148313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT121671754T PT2511262T (pt) | 2004-10-12 | 2005-10-07 | Processo para a produção de cloridrato de 2-amino-2-[2-[4-(3- benziloxi-feniltio)-2-clorofenil[etil]-1,3-propanodiol |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7795472B2 (pt) |
| EP (2) | EP1806338B1 (pt) |
| JP (1) | JP4792400B2 (pt) |
| KR (1) | KR101181090B1 (pt) |
| CN (2) | CN101880250B (pt) |
| AU (1) | AU2005292984B2 (pt) |
| BR (1) | BRPI0516337A (pt) |
| CA (1) | CA2583846C (pt) |
| ES (2) | ES2615498T3 (pt) |
| MX (1) | MX2007004319A (pt) |
| PL (2) | PL2511262T3 (pt) |
| PT (1) | PT2511262T (pt) |
| RU (1) | RU2376285C2 (pt) |
| WO (1) | WO2006041019A1 (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1772145B1 (en) | 2004-07-16 | 2011-03-23 | Kyorin Pharmaceutical Co., Ltd. | Method of effectively using medicine and method concerning prevention of side effect |
| ES2615498T3 (es) | 2004-10-12 | 2017-06-07 | Kyorin Pharmaceutical Co., Ltd. | Procedimiento para producir hidrocloruro de 2-amino-2-[2-[4-(3-benciloxifeniltio)-2-clorofenil]etil]-1,3-propanodiol |
| KR101297302B1 (ko) * | 2005-10-07 | 2013-08-19 | 교린 세이야꾸 가부시키 가이샤 | 2-아미노-1,3-프로판디올 유도체를 유효성분으로 하는간장질환 치료제 및 간장질환 치료방법 |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| PL2058317T3 (pl) * | 2006-08-08 | 2014-03-31 | Kyorin Seiyaku Kk | Aminowa pochodna estru kwasu fosforowego i modulator receptora S1P zawierający ją jako składnik aktywny |
| WO2008018447A1 (en) * | 2006-08-08 | 2008-02-14 | Kyorin Pharmaceutical Co., Ltd. | Aminoalcohol derivative and immunosuppressant containing the same as active ingredient |
| JP5153648B2 (ja) * | 2006-12-22 | 2013-02-27 | 住友精化株式会社 | ３−ベンジルオキシベンゼンチオールの製造方法 |
| JP5452237B2 (ja) | 2008-02-07 | 2014-03-26 | 杏林製薬株式会社 | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
| WO2009119395A1 (ja) | 2008-03-24 | 2009-10-01 | 杏林製薬株式会社 | ２－アミノ－２－［２－［４－（３－ベンジルオキシフェニルチオ）－２－クロロフェニル］エチル］－１，３－プロパンジオール塩酸塩の結晶化方法 |
| CA2724450A1 (en) * | 2008-05-19 | 2009-11-26 | Takeshi Tsubuki | Method for producing optically active aminoalcohol derivative |
| JP5330066B2 (ja) * | 2009-04-13 | 2013-10-30 | 富士フイルム株式会社 | トリアリールアミン化合物の製造方法 |
| WO2012073249A1 (en) | 2010-12-01 | 2012-06-07 | Arch Pharmalabs Limited | A novel process for the preparation of 3-(benzyloxy)- benzenethiol, a key intermediate for the preparation of pharmaceutical drugs. |
| RU2014146161A (ru) * | 2012-04-18 | 2016-06-10 | Керин Фармасьютикал Ко., Лтд. | Кристаллический 4-(3-бензилоксифенилтио)-2-хлор-1-(3-нитропропил) бензол |
| CN102718662A (zh) * | 2012-07-12 | 2012-10-10 | 杭州新博思生物医药有限公司 | 一种制备盐酸西那卡塞的方法 |
| CN103113270A (zh) * | 2012-11-26 | 2013-05-22 | 盛世泰科生物医药技术(苏州)有限公司 | 一种4-（3-苄氧基-苯基硫烷基）-2-氯-1-乙烯基苯的合成方法 |
| CN108017928A (zh) * | 2017-12-15 | 2018-05-11 | 淮海工学院 | 一种用于生物分子标记的聚乙二醇化吲哚菁染料及其制备方法 |
| US20210283073A1 (en) | 2018-07-27 | 2021-09-16 | Priothera Limited | Agent for inhibiting recurrence of hematological malignancy in patients who have undergone hematopoietic stem cell transplantation |
| EP4248958A3 (en) | 2021-01-28 | 2024-01-03 | Priothera SAS | Methods of treatment with s1p receptor modulators |
| AU2021424131A1 (en) | 2021-01-28 | 2023-07-27 | Priothera Limited | Methods of treatment with s1p receptor modulators |
| US20250170176A1 (en) | 2022-02-16 | 2025-05-29 | Priothera Sas | Methods of treatment with car cells in combination with s1p receptor modulators |
| EP4282407A1 (en) | 2022-05-27 | 2023-11-29 | Priothera SAS | Treatment of cancer with s1p receptor agonists |
| WO2025109119A1 (en) | 2023-11-22 | 2025-05-30 | Priothera Sas | Methods of treatment with multispecific antigen-binding proteins in combination with s1p receptor modulators |
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-
2005
- 2005-10-07 ES ES12167175.4T patent/ES2615498T3/es not_active Expired - Lifetime
- 2005-10-07 KR KR1020077010572A patent/KR101181090B1/ko not_active Expired - Fee Related
- 2005-10-07 AU AU2005292984A patent/AU2005292984B2/en not_active Ceased
- 2005-10-07 JP JP2006540913A patent/JP4792400B2/ja not_active Expired - Fee Related
- 2005-10-07 MX MX2007004319A patent/MX2007004319A/es active IP Right Grant
- 2005-10-07 EP EP05790615.8A patent/EP1806338B1/en not_active Expired - Lifetime
- 2005-10-07 RU RU2007117372/04A patent/RU2376285C2/ru not_active IP Right Cessation
- 2005-10-07 BR BRPI0516337-4A patent/BRPI0516337A/pt not_active IP Right Cessation
- 2005-10-07 PL PL12167175T patent/PL2511262T3/pl unknown
- 2005-10-07 CN CN2010101975227A patent/CN101880250B/zh not_active Expired - Fee Related
- 2005-10-07 EP EP12167175.4A patent/EP2511262B1/en not_active Expired - Lifetime
- 2005-10-07 CN CN2005800417574A patent/CN101072752B/zh not_active Expired - Fee Related
- 2005-10-07 ES ES05790615.8T patent/ES2563034T3/es not_active Expired - Lifetime
- 2005-10-07 PT PT121671754T patent/PT2511262T/pt unknown
- 2005-10-07 WO PCT/JP2005/018602 patent/WO2006041019A1/ja not_active Ceased
- 2005-10-07 PL PL05790615T patent/PL1806338T3/pl unknown
- 2005-10-07 CA CA2583846A patent/CA2583846C/en not_active Expired - Lifetime
- 2005-10-07 US US11/665,058 patent/US7795472B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2511262A1 (en) | 2012-10-17 |
| JPWO2006041019A1 (ja) | 2008-05-15 |
| EP1806338A1 (en) | 2007-07-11 |
| CN101880250A (zh) | 2010-11-10 |
| AU2005292984A1 (en) | 2006-04-20 |
| PL2511262T3 (pl) | 2017-08-31 |
| ES2563034T3 (es) | 2016-03-10 |
| WO2006041019A1 (ja) | 2006-04-20 |
| CN101880250B (zh) | 2013-04-03 |
| EP2511262B1 (en) | 2017-02-01 |
| AU2005292984B2 (en) | 2011-01-20 |
| CA2583846C (en) | 2013-10-01 |
| CN101072752B (zh) | 2010-12-08 |
| ES2615498T3 (es) | 2017-06-07 |
| PL1806338T3 (pl) | 2016-07-29 |
| RU2007117372A (ru) | 2008-11-20 |
| BRPI0516337A (pt) | 2008-04-29 |
| EP1806338A4 (en) | 2009-12-16 |
| US7795472B2 (en) | 2010-09-14 |
| CA2583846A1 (en) | 2006-04-20 |
| MX2007004319A (es) | 2007-06-15 |
| KR101181090B1 (ko) | 2012-09-07 |
| KR20070073895A (ko) | 2007-07-10 |
| RU2376285C2 (ru) | 2009-12-20 |
| US20080207941A1 (en) | 2008-08-28 |
| JP4792400B2 (ja) | 2011-10-12 |
| CN101072752A (zh) | 2007-11-14 |
| EP1806338B1 (en) | 2016-01-20 |
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