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PE20160122A1 - Compuestos nobles y composiciones para la inhibicion de fasn - Google Patents

Compuestos nobles y composiciones para la inhibicion de fasn

Info

Publication number
PE20160122A1
PE20160122A1 PE2015001983A PE2015001983A PE20160122A1 PE 20160122 A1 PE20160122 A1 PE 20160122A1 PE 2015001983 A PE2015001983 A PE 2015001983A PE 2015001983 A PE2015001983 A PE 2015001983A PE 20160122 A1 PE20160122 A1 PE 20160122A1
Authority
PE
Peru
Prior art keywords
compounds
fasn
inhibition
compositions
heterocycloalkyl
Prior art date
Application number
PE2015001983A
Other languages
English (en)
Inventor
Kenneth W Bair
David R Lancia
Hongbin Li
James Loch
Mark J Tebbe
Matthew W Martin
David S Millan
Shawn E R Schiller
Wei Lu
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of PE20160122A1 publication Critical patent/PE20160122A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invencion esta referida a compuestos de Formula I, en donde R1 es alquilo hidroxilo C1-C3, entre otras opciones; A y B son O o S; Ar1 es un arilo, heteroarilo o heterocicloalquilo; R2 es H, arilo, heteroarilo, cicloalquilo o heterocicloalquilo, etc., y L es un anillo monociclo de 5 a 10, etc. Estos compuestos inhiben selectivamente las actividades de FASN y modulan el crecimiento y la proliferacion de lineas celulares de cancer
PE2015001983A 2013-03-13 2014-03-11 Compuestos nobles y composiciones para la inhibicion de fasn PE20160122A1 (es)

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ME03564B (me) 2020-07-20
MX2015012470A (es) 2016-06-28
RS59411B1 (sr) 2019-11-29
US10995078B2 (en) 2021-05-04
CU20150120A7 (es) 2016-04-25
US10457655B2 (en) 2019-10-29
RU2019111684A3 (es) 2019-11-28
US20190241532A1 (en) 2019-08-08

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