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PE20180117A1 - Inhibidores de indolamina-2,3-dioxigenasa para el tratamiento de cancer - Google Patents

Inhibidores de indolamina-2,3-dioxigenasa para el tratamiento de cancer

Info

Publication number
PE20180117A1
PE20180117A1 PE2017001828A PE2017001828A PE20180117A1 PE 20180117 A1 PE20180117 A1 PE 20180117A1 PE 2017001828 A PE2017001828 A PE 2017001828A PE 2017001828 A PE2017001828 A PE 2017001828A PE 20180117 A1 PE20180117 A1 PE 20180117A1
Authority
PE
Peru
Prior art keywords
optionally substituted
indolamine
cancer
treatment
compounds
Prior art date
Application number
PE2017001828A
Other languages
English (en)
Inventor
James Aaron Balog
Emily Charlotte Cherney
Audris Huang
Jay A Markwalder
Steven P Seitz
Weifang Shan
David K Williams
Weiwei Guo
Natesan Murugesan
Susheel Jethanand Nara
Saumya Roy
Soodamani Thangavel
Ramesh Kumar Sistla
Srinivas Cheruku
Srinivasan Thangathirupathy
Yadagiri Kanyaboina
Nagalakshmi Pulicharla
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20180117A1 publication Critical patent/PE20180117A1/es

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    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
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    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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Abstract

Referida a compuestos de formula I, en donde: Y es N, CH o CF; V es N, CH o CF; R1 es -COOH, COOC1-C6, entre otros; R2 y R3 son independientemente -H, C1-C10 alquilo opcionalmente sustituido, entre otros; R4 y R5 son independientemente -H, C1-C10 alquilo opcionalmente sustituido, entre otros; R6 es arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, entre otros; RX y RY son cada uno independientemente H, C1-C10 alquilo opcionalmente sustituido, entre otros. Estos compuestos pueden modular o inhibir la actividad enzimatica de la indolamina-2,3-dioxigenasa (IDO). Dichos compuestos son utiles para el tratamiento y/o profilaxis de multiples enfermedades o trastornos asociados a la actividad enzimatica de IDO, tales como trastornos proliferativos como el cancer, infecciones virales y/o trastornos inflamatorios.
PE2017001828A 2015-04-03 2016-04-01 Inhibidores de indolamina-2,3-dioxigenasa para el tratamiento de cancer PE20180117A1 (es)

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TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
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CN107743481A (zh) * 2015-04-03 2018-02-27 百时美施贵宝公司 用于治疗癌症的吲哚胺2,3‑双加氧酶抑制剂
MX389824B (es) 2015-08-12 2025-03-20 Incyte Holdings Corp Sales de un inhibidor de dimetilasa 1 especifica para lisina (lsd1).
KR20180054827A (ko) * 2015-09-24 2018-05-24 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 인돌아민 2,3-디옥시게나제의 조절제
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