PE20160673A1 - Terapias inmuno-oncoliticas - Google Patents
Terapias inmuno-oncoliticasInfo
- Publication number
- PE20160673A1 PE20160673A1 PE2016000287A PE2016000287A PE20160673A1 PE 20160673 A1 PE20160673 A1 PE 20160673A1 PE 2016000287 A PE2016000287 A PE 2016000287A PE 2016000287 A PE2016000287 A PE 2016000287A PE 20160673 A1 PE20160673 A1 PE 20160673A1
- Authority
- PE
- Peru
- Prior art keywords
- modification
- virus
- glycosylation
- deletion
- incorporation
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 230000004048 modification Effects 0.000 abstract 6
- 238000012986 modification Methods 0.000 abstract 6
- 241000700605 Viruses Species 0.000 abstract 4
- 230000013595 glycosylation Effects 0.000 abstract 3
- 238000006206 glycosylation reaction Methods 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 241000700618 Vaccinia virus Species 0.000 abstract 2
- 230000037430 deletion Effects 0.000 abstract 2
- 238000012217 deletion Methods 0.000 abstract 2
- 238000010348 incorporation Methods 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 108010051913 15-hydroxyprostaglandin dehydrogenase Proteins 0.000 abstract 1
- 102100030489 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Human genes 0.000 abstract 1
- 101150023320 B16R gene Proteins 0.000 abstract 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 abstract 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 abstract 1
- 206010062016 Immunosuppression Diseases 0.000 abstract 1
- 230000005867 T cell response Effects 0.000 abstract 1
- 101100316831 Vaccinia virus (strain Copenhagen) B18R gene Proteins 0.000 abstract 1
- 101100004099 Vaccinia virus (strain Western Reserve) VACWR200 gene Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000000174 oncolytic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24171—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Esta invencion proporciona un virus de vaccinia oncolitica que comprende dos o mas de las siguientes modificaciones: (i) una mutacion de columna viral tal como una supresion B8R, una supresion B18R, entre otros; (ii) una modificacion de glicosilacion viral tal como glicosilacion o glicosilacion reducida; (iii) una modificacion que promueve la respuesta de celula T tal como la incorporacion de un acido nucleico codificando un factor estimulador de la colonia macrofago-granulocito; (iv) una modificacion que inhibe la imunosupresion tal como la incorporacion de un acido nucleico codificando 15-PGDH ; y/o (v) una modificacion que mejora la actividad y esparcimiento del virus tal como la modificacion que aumenta la cantidad de envoltura extracelular desde el virus producido. Este virus modificado promueve una inmunidad en contra de tumores y/o reduce la respuesta del anfitrion en contra del virus. Por tanto, la presente invencion proporciona un virus de vaccinia inmunooncoliticos siendo utiles en el tratamiento de canceres
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361868978P | 2013-08-22 | 2013-08-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20160673A1 true PE20160673A1 (es) | 2016-07-21 |
Family
ID=52484194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2016000287A PE20160673A1 (es) | 2013-08-22 | 2014-08-22 | Terapias inmuno-oncoliticas |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US11478518B2 (es) |
| EP (3) | EP4324918A3 (es) |
| JP (3) | JP6912199B2 (es) |
| KR (1) | KR102389240B1 (es) |
| CN (1) | CN105658795B (es) |
| AU (1) | AU2014308648B2 (es) |
| CA (3) | CA3213683A1 (es) |
| DK (2) | DK3778897T3 (es) |
| EA (1) | EA037582B1 (es) |
| ES (2) | ES2847305T3 (es) |
| FI (1) | FI3778897T3 (es) |
| HR (1) | HRP20240078T1 (es) |
| HU (1) | HUE066593T2 (es) |
| IL (1) | IL243996A0 (es) |
| LT (1) | LT3778897T (es) |
| MD (2) | MD4748C1 (es) |
| MX (1) | MX2016002257A (es) |
| NZ (1) | NZ716825A (es) |
| PE (1) | PE20160673A1 (es) |
| PH (1) | PH12016500329A1 (es) |
| PL (1) | PL3778897T3 (es) |
| PT (1) | PT3778897T (es) |
| RS (1) | RS65104B1 (es) |
| SG (1) | SG11201600960PA (es) |
| SI (1) | SI3778897T1 (es) |
| SM (1) | SMT202400047T1 (es) |
| WO (1) | WO2015027163A1 (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4748C1 (ro) * | 2013-08-22 | 2021-09-30 | Питтсбургский Университет Содружества Системы Высшего Образования | Terapii imunooncolitice |
| EP3261669B1 (en) | 2015-02-25 | 2022-08-03 | Memorial Sloan Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
| WO2016168862A1 (en) | 2015-04-17 | 2016-10-20 | Memorial Sloan-Kettering Cancer Center | Use of mva or mvadeltae3l as immunotherapeutic agents against solid tumors |
| EP3327137B1 (en) * | 2015-07-22 | 2020-12-09 | National University Corporation Tottori University | Host regulation factor for enhancing proliferation and propagation of vaccinia virus |
| HK1255192A1 (zh) * | 2015-09-08 | 2019-08-09 | Sillajen, Inc. | 表达细胞因子和羧酸酯酶的修饰的溶瘤痘苗病毒及其使用方法 |
| EP3371221A2 (en) | 2015-11-07 | 2018-09-12 | MultiVir Inc. | Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer |
| KR20180130500A (ko) | 2016-02-25 | 2018-12-07 | 메모리얼 슬로안 케터링 캔서 센터 | 인간 flt3l을 발현하는 재조합 mva 또는 mvaδe3l 및 고형 종양에 대한 면역요법제로서 그의 용도 |
| MX2018010204A (es) | 2016-02-25 | 2019-05-06 | Memorial Sloan Kettering Cancer Center | Virus de la vaccinia atenuada competentes para replicacion con la supresion de timidina quinasa con y sin la expresion del flt3l o gm-csf humanos para inmunoterapia del cancer. |
| CN109152736A (zh) * | 2016-03-25 | 2019-01-04 | 联邦高等教育系统匹兹堡大学 | 合成包封病毒 |
| EP3254692A1 (en) * | 2016-06-10 | 2017-12-13 | Ceva Sante Animale | Multivalent recombinant spv |
| KR102546501B1 (ko) | 2016-07-19 | 2023-06-21 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | Stat3를 타겟으로 하는 종양용해성 바이러스 |
| US11065286B2 (en) * | 2016-09-21 | 2021-07-20 | Stephen H. Thorne | High mobility group box I mutant |
| GB201616365D0 (en) | 2016-09-27 | 2016-11-09 | Helsingin Yliopisto | Non-genetic modification of enveloped viruses |
| CA3046961A1 (en) | 2016-12-12 | 2018-06-21 | Multivir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
| US12350303B2 (en) | 2017-02-03 | 2025-07-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Oncolytic virus therapy |
| EP3593136A1 (en) * | 2017-03-06 | 2020-01-15 | Talaris Therapeutics, Inc. | Methods and compositions for determining the potency of a therapeutic cellular composition |
| EP3612201B1 (en) * | 2017-04-21 | 2023-10-25 | Sillajen, Inc. | Oncolytic vaccinia virus and checkpoint inhibitor combination therapy |
| WO2018209315A1 (en) | 2017-05-12 | 2018-11-15 | Memorial Sloan Kettering Cancer Center | Vaccinia virus mutants useful for cancer immunotherapy |
| JP7551496B2 (ja) | 2017-10-31 | 2024-09-17 | カリヴィル イムノセラピューティクス， インコーポレイテッド | 全身送達のためのプラットフォーム腫瘍溶解性ベクター |
| CN119530172A (zh) | 2017-12-01 | 2025-02-28 | 玛丽恩·克里斯汀-苏特 | 免疫调节的复制高效的痘苗病毒株 |
| SG11202006457YA (en) * | 2018-01-05 | 2020-08-28 | Ottawa Hospital Res Inst | Modified orthopoxvirus vectors |
| US12454561B2 (en) | 2018-03-19 | 2025-10-28 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer |
| CA3106983A1 (en) * | 2018-07-20 | 2020-01-23 | Ansun Biopharma, Inc. | Delivery of sialidase to cancer cells, immune cells and the tumor microenvironment |
| JP7480126B2 (ja) | 2018-09-15 | 2024-05-09 | メモリアル スローン ケタリング キャンサー センター | がん免疫療法のための、組換えポックスウイルス |
| MX2021007439A (es) * | 2018-12-21 | 2021-08-05 | Ottawa Hospital Res Inst | Vectores de orthopoxvirus modificados. |
| EP3908650A4 (en) * | 2019-01-07 | 2022-10-19 | KaliVir Immunotherapeutics, Inc. | METHODS OF TREATMENT OF CANCER |
| US11529402B2 (en) * | 2019-01-14 | 2022-12-20 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
| CA3129883A1 (en) | 2019-02-14 | 2020-08-20 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
| AU2019463579B2 (en) * | 2019-08-26 | 2024-08-08 | Bionoxx Inc. | Pharmaceutical composition comprising vaccinia virus and hydroxyurea as active ingredient for treatment of cancer |
| AU2020366456A1 (en) * | 2019-10-16 | 2022-03-24 | Kalivir Immunotherapeutics, Inc. | Modified extracellular enveloped virus |
| EP4061417A4 (en) * | 2019-11-20 | 2023-10-11 | University of Pittsburgh - of the Commonwealth System of Higher Education | VACCINIA VIRUSES AND METHOD FOR USING VACCINIA VIRUSES |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| KR20220113467A (ko) * | 2019-12-12 | 2022-08-12 | 이그나이트 이뮤노테라피, 인크. | 변이체 종양용해성 백시니아 바이러스 및 그의 사용 방법 |
| MX2022008547A (es) * | 2020-01-09 | 2022-08-10 | Pfizer | Virus de vacuna recombinante. |
| JP2023517183A (ja) * | 2020-03-06 | 2023-04-24 | ユニバーシティ オブ ピッツバーグ －オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | がんを治療するためのｉｒｆモジュレーター発現腫瘍溶解性ウィルス |
| WO2022109133A1 (en) | 2020-11-19 | 2022-05-27 | Kalivir Immunotherapeutics, Inc. | Oncolytic immunotherapy by tumor micro-environment remodeling |
| KR20240004764A (ko) | 2021-04-30 | 2024-01-11 | 칼리버 임뮤노쎄라퓨틱스, 인크. | 변형된 mhc 발현을 위한 종양용해성 바이러스 |
| US20240316104A1 (en) * | 2021-06-29 | 2024-09-26 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| WO2023106839A1 (ko) * | 2021-12-07 | 2023-06-15 | 재단법인 아산사회복지재단 | Il-12를 발현하는 재조합 백시니아 바이러스 및 이의 용도 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1578396A4 (en) * | 2002-08-12 | 2007-01-17 | David Kirn | METHODS AND COMPOSITIONS RELATING TO POXVIRUS AND CANCER |
| WO2007023725A1 (ja) * | 2005-08-25 | 2007-03-01 | Yokohama City University | 遺伝子ワクチン |
| AU2012244210B2 (en) * | 2005-09-07 | 2014-10-02 | Sillajen Biotherapeutics, Inc. | Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses |
| US8980246B2 (en) * | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
| KR101772375B1 (ko) * | 2005-09-07 | 2017-08-29 | 신라젠(주) | Ｇｍ-ｃｓｆ를 발현하는 폭스바이러스를 사용한 전이성 및/또는 전신 파종성 암의 전신 치료법 |
| KR20080084528A (ko) | 2007-03-15 | 2008-09-19 | 제네렉스 바이오테라퓨틱스 인크. | 종양살상형 백시니아 바이러스 암 치료 |
| WO2009124044A2 (en) * | 2008-03-31 | 2009-10-08 | University Of Florida Research Foundation, Inc. | Tumor growth inhibition via conditioning of tumor microenvironment |
| CN107303302A (zh) | 2009-09-14 | 2017-10-31 | 希拉金股份有限公司 | 溶瘤牛痘病毒组合癌症疗法 |
| WO2011119925A2 (en) * | 2010-03-25 | 2011-09-29 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthetic herpes simplex viruses for treatment of cancers |
| JP6415977B2 (ja) * | 2011-04-15 | 2018-10-31 | ジェネラックス・コーポレイションＧｅｎｅｌｕｘ Ｃｏｒｐｏｒａｔｉｏｎ | 弱毒化ワクシニアウイルスのクローン株およびその使用方法 |
| US20150250837A1 (en) * | 2012-09-20 | 2015-09-10 | Morningside Technology Ventures Ltd. | Oncolytic virus encoding pd-1 binding agents and uses of the same |
| MD4748C1 (ro) | 2013-08-22 | 2021-09-30 | Питтсбургский Университет Содружества Системы Высшего Образования | Terapii imunooncolitice |
-
2014
- 2014-08-22 MD MDA20180086A patent/MD4748C1/ro active IP Right Grant
- 2014-08-22 EP EP23215391.6A patent/EP4324918A3/en not_active Withdrawn
- 2014-08-22 EP EP20189155.3A patent/EP3778897B1/en active Active
- 2014-08-22 MD MD20160027A patent/MD4624C1/ro active IP Right Grant
- 2014-08-22 JP JP2016536482A patent/JP6912199B2/ja active Active
- 2014-08-22 WO PCT/US2014/052308 patent/WO2015027163A1/en not_active Ceased
- 2014-08-22 CA CA3213683A patent/CA3213683A1/en active Pending
- 2014-08-22 FI FIEP20189155.3T patent/FI3778897T3/fi active
- 2014-08-22 EP EP14837931.6A patent/EP3036329B1/en active Active
- 2014-08-22 CA CA3213715A patent/CA3213715A1/en active Pending
- 2014-08-22 HU HUE20189155A patent/HUE066593T2/hu unknown
- 2014-08-22 HR HRP20240078TT patent/HRP20240078T1/hr unknown
- 2014-08-22 ES ES14837931T patent/ES2847305T3/es active Active
- 2014-08-22 PT PT201891553T patent/PT3778897T/pt unknown
- 2014-08-22 KR KR1020167006785A patent/KR102389240B1/ko active Active
- 2014-08-22 PE PE2016000287A patent/PE20160673A1/es unknown
- 2014-08-22 DK DK20189155.3T patent/DK3778897T3/da active
- 2014-08-22 DK DK14837931.6T patent/DK3036329T3/da active
- 2014-08-22 SG SG11201600960PA patent/SG11201600960PA/en unknown
- 2014-08-22 SI SI201432060T patent/SI3778897T1/sl unknown
- 2014-08-22 PL PL20189155.3T patent/PL3778897T3/pl unknown
- 2014-08-22 LT LTEP20189155.3T patent/LT3778897T/lt unknown
- 2014-08-22 ES ES20189155T patent/ES2971528T3/es active Active
- 2014-08-22 CN CN201480058401.0A patent/CN105658795B/zh active Active
- 2014-08-22 NZ NZ716825A patent/NZ716825A/en unknown
- 2014-08-22 MX MX2016002257A patent/MX2016002257A/es unknown
- 2014-08-22 CA CA2921041A patent/CA2921041C/en active Active
- 2014-08-22 EA EA201690444A patent/EA037582B1/ru unknown
- 2014-08-22 SM SM20240047T patent/SMT202400047T1/it unknown
- 2014-08-22 RS RS20240082A patent/RS65104B1/sr unknown
- 2014-08-22 AU AU2014308648A patent/AU2014308648B2/en active Active
-
2016
- 2016-02-07 IL IL243996A patent/IL243996A0/en unknown
- 2016-02-18 PH PH12016500329A patent/PH12016500329A1/en unknown
- 2016-02-19 US US15/048,698 patent/US11478518B2/en active Active
-
2019
- 2019-07-19 JP JP2019133264A patent/JP7021154B2/ja active Active
-
2022
- 2022-02-03 JP JP2022015459A patent/JP7333431B2/ja active Active
- 2022-09-07 US US17/939,707 patent/US20230008089A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20160673A1 (es) | Terapias inmuno-oncoliticas | |
| SG10201803081TA (en) | Oncolytic adenovirus encoding a b7 protein | |
| CO2018005377A2 (es) | Vectores virales que codifican variantes de fviii recombinantes con mayor expresión para la terapia génica de hemofilia a | |
| CY1126074T1 (el) | Περιοχες gla ως παραγοντες στοχευσης | |
| CO2019011450A2 (es) | Expresión transgénica selectiva de tejidos | |
| CO2018005215A2 (es) | Construcciones específicas del hígado para expresión del factor viii | |
| BR112015021884A8 (pt) | vetores de plasmídeo recombinantes, partícula viral avv ou pluralidade de partículas virais, seus métodos de produção e seus usos, e composição farmacêutica | |
| MX2019010735A (es) | Sistemas y metodos para la produccion dirigida de una proteina terapeutica dentro de una celula objetivo. | |
| EA201792663A1 (ru) | Способы скрининга бактерий, архей, водорослей и дрожжей с использованием нуклеиновых кислот crispr | |
| CO2017009104A2 (es) | Derivados dinucleotidos de purina bis-2’-fluoro-bis-3’-5’-cíclico | |
| AR090470A1 (es) | Vacuna contra el virus sincicial respiratorio (rsv) | |
| CL2015002556A1 (es) | Inhibidores de la ruta de quinurenina | |
| BR112016013387A2 (pt) | composições e métodos para controle de vírus em ácaros varroa e abelhas | |
| AR091512A1 (es) | Control biologico de plagas de coleopteros | |
| PE20170895A1 (es) | Proteinas quimericas insecticidas novedosas toxicas o inhibidoras de plagas de lepidopteros | |
| BR112014018179A2 (pt) | vacinas baseadas no vírus da paragripe 5 | |
| MX2017004814A (es) | Polipeptidos insecticidas que tienen un espectro de actividad mejorado y sus usos. | |
| BR112022016992A2 (pt) | Vacina com base em poxvírus recombinante contra ví-rus sars-cov-2 | |
| PH12017501993A1 (en) | Methods of treating epstein-barr-virus-associated lymphoproliferative disorders by t cell therapy | |
| DOP2010000251A (es) | Paramyxovirus eficaz como antitumoral | |
| CY1123793T1 (el) | Γονιδιακη θεραπεια rpgr για μελαγχρωστικη αμφιβληστροειδοπαθεια | |
| BR112019009131A2 (pt) | vacina contra o parvovírus suíno, o vírus da síndrome respiratória e reprodutiva dos suínos e métodos de produção das mesmas | |
| CO2018005380A2 (es) | Vectores virales que codifican variantes de fviii recombinantes con mayor expresión para la terapia génica de hemofilia a | |
| BR112019004496A2 (pt) | estabilizantes de mastócitos para tratamento de hipercitocinemia e infecção viral | |
| AU2017256910A1 (en) | Optogenetic visual restoration using Chrimson |