PL3778897T3 - Terapie immunoonkolityczne - Google Patents

Terapie immunoonkolityczne

Info

Publication number: PL3778897T3
Authority: PL; Poland
Prior art keywords: immuno; oncolytic therapies; oncolytic; therapies
Prior art date: 2013-08-22

Application number

PL20189155.3T

Other languages

English (en)

Inventor

Stephen Howard Thorne

Original Assignee

University Of Pittsburgh - Of The Commonwealth System Of Higher Education

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-08-22

Filing date

2014-08-22

Publication date

2024-04-02

2014-08-22 Application filed by University Of Pittsburgh - Of The Commonwealth System Of Higher Education filed Critical University Of Pittsburgh - Of The Commonwealth System Of Higher Education

2024-04-02 Publication of PL3778897T3 publication Critical patent/PL3778897T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24171—Demonstrated in vivo effect

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Virology (AREA)
Organic Chemistry (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Mycology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

PL20189155.3T 2013-08-22 2014-08-22 Terapie immunoonkolityczne PL3778897T3 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201361868978P	2013-08-22	2013-08-22

Publications (1)

Publication Number	Publication Date
PL3778897T3 true PL3778897T3 (pl)	2024-04-02

Family

ID=52484194

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL20189155.3T PL3778897T3 (pl)	2013-08-22	2014-08-22	Terapie immunoonkolityczne

Country Status (27)

Country	Link
US (2)	US11478518B2 (pl)
EP (3)	EP3778897B1 (pl)
JP (3)	JP6912199B2 (pl)
KR (1)	KR102389240B1 (pl)
CN (1)	CN105658795B (pl)
AU (1)	AU2014308648B2 (pl)
CA (3)	CA2921041C (pl)
DK (2)	DK3036329T3 (pl)
EA (1)	EA037582B1 (pl)
ES (2)	ES2847305T3 (pl)
FI (1)	FI3778897T3 (pl)
HR (1)	HRP20240078T1 (pl)
HU (1)	HUE066593T2 (pl)
IL (1)	IL243996A0 (pl)
LT (1)	LT3778897T (pl)
MD (2)	MD4624C1 (pl)
MX (1)	MX2016002257A (pl)
NZ (1)	NZ716825A (pl)
PE (1)	PE20160673A1 (pl)
PH (1)	PH12016500329A1 (pl)
PL (1)	PL3778897T3 (pl)
PT (1)	PT3778897T (pl)
RS (1)	RS65104B1 (pl)
SG (1)	SG11201600960PA (pl)
SI (1)	SI3778897T1 (pl)
SM (1)	SMT202400047T1 (pl)
WO (1)	WO2015027163A1 (pl)

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CA3004530A1 (en)	2015-11-07	2017-05-11	Multivir Inc.	Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
SG11201807022XA (en)	2016-02-25	2018-09-27	Memorial Sloan Kettering Cancer Center	Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors
CN116440176A (zh)	2016-02-25	2023-07-18	纪念斯隆凯特琳癌症中心	具有胸苷激酶缺失和具有或不具有人flt3l或gm-csf表达的复制型减毒痘苗病毒
CA3057579A1 (en) *	2016-03-25	2017-09-28	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Synthetically enveloped virus
EP3254692A1 (en) *	2016-06-10	2017-12-13	Ceva Sante Animale	Multivalent recombinant spv
JP7312695B2 (ja) *	2016-07-19	2023-07-21	ユニバーシティオブピッツバーグ－オブザコモンウェルスシステムオブハイヤーエデュケイション	Ｓｔａｔ３を標的とする腫瘍溶解性ウイルス
AU2017332367B2 (en) *	2016-09-21	2021-12-23	Stephen H. Thorne	High mobility group box i mutant
GB201616365D0 (en) *	2016-09-27	2016-11-09	Helsingin Yliopisto	Non-genetic modification of enveloped viruses
CN110381997A (zh)	2016-12-12	2019-10-25	茂体外尔公司	用于治疗和预防癌症和感染性疾病的包含病毒基因治疗和免疫检查点抑制剂的方法和组合物
CN118662538A (zh)	2017-02-03	2024-09-20	匹兹堡大学联邦系统高等教育	溶瘤病毒疗法
CA3055754A1 (en) *	2017-03-06	2018-09-13	Talaris Therapeutics, Inc.	Methods and compositions for determining the potency of a therapeutic cellular composition
JP7718815B2 (ja) *	2017-04-21	2025-08-05	シルラゼン，インコーポレイテッド	腫瘍溶解性ワクシニアウイルスおよびチェックポイント阻害剤の併用療法
CN111107872A (zh)	2017-05-12	2020-05-05	纪念斯隆-凯特林癌症中心	有用于癌症免疫疗法的牛痘病毒突变体
CA3081436A1 (en)	2017-10-31	2019-05-09	Western Oncolytics Ltd.	Platform oncolytic vector for systemic delivery
US11633441B2 (en)	2017-12-01	2023-04-25	Gerd Sutter	Immuno-modulated replication-efficient vaccinia virus strain
SG11202006457YA (en) *	2018-01-05	2020-08-28	Ottawa Hospital Res Inst	Modified orthopoxvirus vectors
AU2019322487B2 (en)	2018-03-19	2024-04-18	Multivir Inc.	Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer
WO2020018996A2 (en) *	2018-07-20	2020-01-23	Ansun Biopharma, Inc.	Delivery of sialidase to cancer cells, immune cells and the tumor microenvironment
WO2020056424A1 (en)	2018-09-15	2020-03-19	Memorial Sloan Kettering Cancer Center	Recombinant poxviruses for cancer immunotherapy
KR20210132002A (ko) *	2018-12-21	2021-11-03	오타와 하스피털 리서치 인스티튜트	변형된 오르토폭스 바이러스 벡터
SG11202107017TA (en) *	2019-01-07	2021-07-29	Kalivir Immunotherapeutics Inc	Methods of treating cancer
WO2020148612A1 (en) *	2019-01-14	2020-07-23	Ignite Immunotherapy, Inc.	Recombinant vaccinia virus and methods of use thereof
WO2020165730A1 (en)	2019-02-14	2020-08-20	Ignite Immunotherapy, Inc.	Recombinant vaccinia virus and methods of use thereof
AU2019463579B2 (en) *	2019-08-26	2024-08-08	Bionoxx Inc.	Pharmaceutical composition comprising vaccinia virus and hydroxyurea as active ingredient for treatment of cancer
AU2020366456A1 (en) *	2019-10-16	2022-03-24	Kalivir Immunotherapeutics, Inc.	Modified extracellular enveloped virus
US20230002465A1 (en) *	2019-11-20	2023-01-05	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Vaccinia viruses and methods for using vaccinia viruses
WO2021113644A1 (en)	2019-12-05	2021-06-10	Multivir Inc.	Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
EP4073088A1 (en) *	2019-12-12	2022-10-19	Ignite Immunotherapy, Inc.	Variant oncolytic vaccinia virus and methods of use thereof
US20230201283A1 (en) *	2020-01-09	2023-06-29	Pfizer Inc.	Recombinant vaccinia virus
CN115243714A (zh) *	2020-03-06	2022-10-25	匹兹堡大学联邦系统高等教育	用于治疗癌症的表达irf调节剂的溶瘤病毒
TW202227621A (zh)	2020-11-19	2022-07-16	美商凱立凡爾免疫治療股份有限公司	重塑腫瘤微環境的溶瘤免疫療法
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FI3778897T3 (fi)	2013-08-22	2024-01-25	Univ Pittsburgh Commonwealth Sys Higher Education	Immuno-onkolyyttisiä hoitoja

2014
- 2014-08-22 FI FIEP20189155.3T patent/FI3778897T3/fi active
- 2014-08-22 MD MD20160027A patent/MD4624C1/ro active IP Right Grant
- 2014-08-22 HU HUE20189155A patent/HUE066593T2/hu unknown
- 2014-08-22 ES ES14837931T patent/ES2847305T3/es active Active
- 2014-08-22 EP EP20189155.3A patent/EP3778897B1/en active Active
- 2014-08-22 DK DK14837931.6T patent/DK3036329T3/da active
- 2014-08-22 PL PL20189155.3T patent/PL3778897T3/pl unknown
- 2014-08-22 PE PE2016000287A patent/PE20160673A1/es unknown
- 2014-08-22 WO PCT/US2014/052308 patent/WO2015027163A1/en not_active Ceased
- 2014-08-22 SI SI201432060T patent/SI3778897T1/sl unknown
- 2014-08-22 SG SG11201600960PA patent/SG11201600960PA/en unknown
- 2014-08-22 JP JP2016536482A patent/JP6912199B2/ja active Active
- 2014-08-22 ES ES20189155T patent/ES2971528T3/es active Active
- 2014-08-22 CN CN201480058401.0A patent/CN105658795B/zh active Active
- 2014-08-22 RS RS20240082A patent/RS65104B1/sr unknown
- 2014-08-22 EP EP23215391.6A patent/EP4324918A3/en not_active Withdrawn
- 2014-08-22 KR KR1020167006785A patent/KR102389240B1/ko active Active
- 2014-08-22 LT LTEP20189155.3T patent/LT3778897T/lt unknown
- 2014-08-22 NZ NZ716825A patent/NZ716825A/en unknown
- 2014-08-22 DK DK20189155.3T patent/DK3778897T3/da active
- 2014-08-22 MX MX2016002257A patent/MX2016002257A/es unknown
- 2014-08-22 EP EP14837931.6A patent/EP3036329B1/en active Active
- 2014-08-22 HR HRP20240078TT patent/HRP20240078T1/hr unknown
- 2014-08-22 CA CA2921041A patent/CA2921041C/en active Active
- 2014-08-22 CA CA3213683A patent/CA3213683A1/en active Pending
- 2014-08-22 CA CA3213715A patent/CA3213715A1/en active Pending
- 2014-08-22 EA EA201690444A patent/EA037582B1/ru unknown
- 2014-08-22 SM SM20240047T patent/SMT202400047T1/it unknown
- 2014-08-22 PT PT201891553T patent/PT3778897T/pt unknown
- 2014-08-22 MD MDA20180086A patent/MD4748C1/ro active IP Right Grant
- 2014-08-22 AU AU2014308648A patent/AU2014308648B2/en active Active
2016
- 2016-02-07 IL IL243996A patent/IL243996A0/en unknown
- 2016-02-18 PH PH12016500329A patent/PH12016500329A1/en unknown
- 2016-02-19 US US15/048,698 patent/US11478518B2/en active Active
2019
- 2019-07-19 JP JP2019133264A patent/JP7021154B2/ja active Active
2022
- 2022-02-03 JP JP2022015459A patent/JP7333431B2/ja active Active
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CA2921041A1 (en)	2015-02-26
MD4748C1 (ro)	2021-09-30
DK3036329T3 (da)	2021-01-11
SMT202400047T1 (it)	2024-03-13
EP4324918A2 (en)	2024-02-21
JP7021154B2 (ja)	2022-02-16
JP7333431B2 (ja)	2023-08-24
IL243996A0 (en)	2016-04-21
FI3778897T3 (fi)	2024-01-25
ES2847305T3 (es)	2021-08-02
CA3213683A1 (en)	2015-02-26
MD4748B1 (ro)	2021-02-28
CA2921041C (en)	2023-10-31
US20230008089A1 (en)	2023-01-12
HK1223402A1 (zh)	2017-07-28
EP3036329B1 (en)	2020-10-07
EP4324918A3 (en)	2024-04-24
CA3213715A1 (en)	2015-02-26
MD20160027A2 (ro)	2016-08-31
MD20180086A2 (ro)	2019-03-31
WO2015027163A1 (en)	2015-02-26
HRP20240078T1 (hr)	2024-03-29
US11478518B2 (en)	2022-10-25
US20160235793A1 (en)	2016-08-18
JP2019205451A (ja)	2019-12-05
JP2016527920A (ja)	2016-09-15
EP3036329A1 (en)	2016-06-29
DK3778897T3 (da)	2024-01-29
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HUE066593T2 (hu)	2024-08-28
AU2014308648B2 (en)	2020-11-12
MD4624C1 (ro)	2019-10-31
CN105658795A (zh)	2016-06-08
RS65104B1 (sr)	2024-02-29
EP3778897A1 (en)	2021-02-17
SG11201600960PA (en)	2016-03-30
WO2015027163A9 (en)	2016-04-14
PT3778897T (pt)	2024-02-01
EA037582B1 (ru)	2021-04-16
CN105658795B (zh)	2020-07-03
KR102389240B1 (ko)	2022-04-20
EA201690444A1 (ru)	2016-08-31
EP3036329A4 (en)	2017-08-02
MX2016002257A (es)	2016-11-08
EP3778897B1 (en)	2023-12-20
KR20160044529A (ko)	2016-04-25
JP6912199B2 (ja)	2021-08-04
AU2014308648A1 (en)	2016-03-03
PE20160673A1 (es)	2016-07-21
LT3778897T (lt)	2024-02-12
NZ716825A (en)	2022-02-25
MD4624B1 (ro)	2019-03-31
PH12016500329A1 (en)	2016-05-02
SI3778897T1 (sl)	2024-03-29
JP2022062171A (ja)	2022-04-19

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IL243996A0 (en)	2016-04-21	Immuno-oncolytic treatments
DK3689865T3 (en)	2023-06-19	Hidtil ukendte aminopyrimidinderivater
DK3088517T3 (en)	2023-12-04	Humant anti-il-33-neutraliserende monoklonalt antistof
DK3736291T3 (en)	2023-09-25	Anti-FCRH5-antistoffer
DK3077519T3 (en)	2021-06-14	Cmv-vacciner
DK3470074T3 (en)	2020-12-14	Probiotika
AU353576S (en)	2014-02-07	Stamphousing
GB201301329D0 (en)	2013-03-06	Fluidfoil
DK2979701T3 (en)	2020-10-26	Antitumormiddel indbefattende irinotecanhydrochloridhydrat
GB201301891D0 (en)	2013-03-20	Holo-scare
GB201301617D0 (en)	2013-03-13	T-Monitor
DK2989854T3 (en)	2022-08-08	Strømstyret opvarmningssystem
AU4899P (en)	2014-08-15	Herbie53 Iresine herbstii
AU4977P (en)	2015-03-16	Harrosy Gaura lindheimeri
AU353327S (en)	2014-01-21	Kettlebell
AU353328S (en)	2014-01-21	Kettlebell
AU353329S (en)	2014-01-21	Kettlebell
AU353326S (en)	2014-01-21	Kettlebell
AU353330S (en)	2014-01-21	Kettlebell
AP00812S1 (en)	2016-04-13	Stumbelbloc
AU2013231V (en)	2014-06-11	Bonsca7200 Scaevola aemula
GB201313320D0 (en)	2013-09-11	Hand-eze
AP2013000703S (en)	2016-10-11	Adwura wura
AP2013000704S (en)	2016-10-11	Gramoquat
AU2013099V (en)	2013-12-02	Little Lorey Chamelaucium floriferum