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PE20091724A1 - Derivados de indol como moduladores del receptor nicotinico de acetilcolina alfa 7 - Google Patents

Derivados de indol como moduladores del receptor nicotinico de acetilcolina alfa 7

Info

Publication number
PE20091724A1
PE20091724A1 PE2009000537A PE2009000537A PE20091724A1 PE 20091724 A1 PE20091724 A1 PE 20091724A1 PE 2009000537 A PE2009000537 A PE 2009000537A PE 2009000537 A PE2009000537 A PE 2009000537A PE 20091724 A1 PE20091724 A1 PE 20091724A1
Authority
PE
Peru
Prior art keywords
modulators
alpha
trifluoromethyl
methyl
nicotine receptor
Prior art date
Application number
PE2009000537A
Other languages
English (en)
Inventor
Kevin Dinnell
Andrew Plightfoot
Howard Robert Marshall
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0807050A external-priority patent/GB0807050D0/en
Priority claimed from GB0810229A external-priority patent/GB0810229D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20091724A1 publication Critical patent/PE20091724A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN DERIVADO DE INDOL DE FORMULA (I), DONDE R1 ES H O ALQUILO C1-C3; R2 ES H, HALO O CIANO; R3 ES PIRIDINA SUSTITUIDA CON Ra; Ra ES HALO, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[(2-TRIFLUOROMETIL-1H-INDOL-5-IL)METIL]-5-(TRIFLUOROMETIL)-2-PIRIDINACARBOXAMIDA, 6-BROMO-N-{[2-(TRIFLUOROMETIL)-1H-INDOL-5-IL]METIL}-3-PIRIDINACARBOXAMIDA, N-[(1-METIL-2-TRIFLUOROMETILINDOL-5-IL)METIL]-5-(TRIFLUOROMETIL)-2-PIRIDINACARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR NICOTINICO DE ACETILCOLINA ALFA 7 (nAChR)ALFA7 Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS PSICOTICOS, DETERIORO COGNITIVO, DEPRESION, ENTRE OTROS
PE2009000537A 2008-04-17 2009-04-16 Derivados de indol como moduladores del receptor nicotinico de acetilcolina alfa 7 PE20091724A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0807050A GB0807050D0 (en) 2008-04-17 2008-04-17 Novel compounds
GB0810229A GB0810229D0 (en) 2008-06-04 2008-06-04 Novel compounds

Publications (1)

Publication Number Publication Date
PE20091724A1 true PE20091724A1 (es) 2009-12-06

Family

ID=40791353

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000537A PE20091724A1 (es) 2008-04-17 2009-04-16 Derivados de indol como moduladores del receptor nicotinico de acetilcolina alfa 7

Country Status (19)

Country Link
US (2) US8377941B2 (es)
EP (2) EP2279184B1 (es)
JP (2) JP2011516599A (es)
KR (2) KR20100133016A (es)
CN (2) CN102066357B (es)
AR (1) AR071203A1 (es)
AU (2) AU2009237649B2 (es)
BR (2) BRPI0910585A2 (es)
CA (2) CA2725441C (es)
CL (1) CL2009000916A1 (es)
EA (2) EA017726B1 (es)
ES (2) ES2392796T3 (es)
IL (2) IL208575A (es)
MX (2) MX2010011359A (es)
PE (1) PE20091724A1 (es)
TW (1) TW201004939A (es)
UY (1) UY31769A1 (es)
WO (2) WO2009127679A1 (es)
ZA (2) ZA201006856B (es)

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EP2212309B1 (en) 2007-10-18 2013-06-19 Janssen Pharmaceutica N.V. Trisubstituted 1,2,4-triazoles
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
ES2479440T3 (es) 2008-01-30 2014-07-24 Cephalon, Inc. Derivados de piridazina sustituidos que tienen actividad antagonista de histamina H3
CA2714662C (en) 2008-03-19 2016-05-10 Janssen Pharmaceutica Nv Trisubstituted 1,2,4-triazoles as nicotinic acetylcholine receptor modulators
EA018187B1 (ru) 2008-05-09 2013-06-28 Янссен Фармацевтика Нв Тризамещенные пиразолы в качестве модуляторов рецепторов ацетилхолина
SG175084A1 (en) * 2009-04-16 2011-11-28 Proximagen Ltd Indole derivative modulators of the alpha 7 nachr
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
GB201012686D0 (en) * 2010-07-28 2010-09-15 Glaxo Group Ltd Novel compounds
JO3078B1 (ar) * 2009-11-27 2017-03-15 Janssen Pharmaceutica Nv مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
CN103443092B (zh) 2011-02-03 2015-11-25 鲁平有限公司 用作α7胆碱受体调节剂的吡咯衍生物
HRP20161481T1 (hr) 2011-02-23 2016-12-30 Lupin Limited Derivati heteroarila kao modulatori nachr alfa7
CA2830458A1 (en) * 2011-03-18 2012-09-27 Novartis Ag Combinations of alpha 7 nicotinic acetylcholine receptor activators and mglur5 antagonists for use in dopamine induced dyskinesia in parkinson's disease
MX344696B (es) 2011-03-31 2017-01-03 Lupin Ltd Derivados de pirrol como moduladores de los receptores de acetilcolina nicotinicos para su uso en el tratamiento de enfermedades neurodegenerativas como el alzheimer y la enfermedad de parkinson.
TW201245185A (en) 2011-04-01 2012-11-16 Lundbeck & Co As H New positive allosteric modulators of nicotinic acetylcholine receptor
US8946432B2 (en) 2011-07-05 2015-02-03 Lupin Limited Biaryl derivatives as nAChR modulators
SG11201405239WA (en) 2012-03-06 2014-09-26 Lupin Ltd Thiazole derivatives as alpha 7 nachr modulators
EA201491857A1 (ru) * 2012-05-08 2015-04-30 АНВИЛ ЭлЭлСи АЛЛОСТЕРИЧЕСКИЕ МОДУЛЯТОРЫ α7 НИКОТИНОВОГО ХОЛИНОРЕЦЕПТОРА, ИХ ПРОИЗВОДНЫЕ И ИХ ПРИМЕНЕНИЕ
CN104837820A (zh) * 2012-10-02 2015-08-12 大日本住友制药株式会社 咪唑衍生物
WO2014072957A1 (en) 2012-11-12 2014-05-15 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
CN103006642B (zh) * 2013-01-04 2014-10-22 中国药科大学 一类炔亚甲基吲哚-2-酮类衍生物的用途
EP2945941B1 (en) 2013-01-16 2016-12-07 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
US10058310B2 (en) 2013-03-13 2018-08-28 Ethicon Llc Electrosurgical device with drum-driven articulation
CN105051024A (zh) 2013-03-13 2015-11-11 鲁平有限公司 作为α7烟碱型乙酰胆碱受体的调节剂的吡咯衍生物
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
AU2014282886A1 (en) 2013-06-17 2015-12-17 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators
WO2015148480A1 (en) * 2014-03-25 2015-10-01 Emicipi Llc Treatment of rett syndrome
JP6870304B2 (ja) * 2016-12-05 2021-05-12 住友電気工業株式会社 半導体装置の製造方法
JP7120549B2 (ja) * 2016-12-15 2022-08-17 小野薬品工業株式会社 Ｔｒｅｋ（ｔｗｉｋ関連ｋチャネル）チャネルのアクチベータ
HU231333B1 (hu) 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok
HU231478B1 (hu) 2018-07-13 2024-02-28 Richter Gedeon Nyrt. Szubsztituált (aza)indol származékok
HU231414B1 (hu) 2018-07-13 2023-08-28 Richter Gedeon Nyrt. Tiadiazin származékok
IL293340A (en) * 2019-12-02 2022-07-01 Storm Therapeutics Ltd Polyheterocyclic compounds as mettl3 inhibitors
CN111285792B (zh) * 2020-03-23 2023-05-02 三峡大学 2-取代吲哚化合物及其制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903997D0 (sv) * 1999-11-03 1999-11-03 Astra Ab New compounds
GB0403155D0 (en) * 2004-02-12 2004-03-17 Vernalis Res Ltd Chemical compounds
JP2011511800A (ja) * 2008-02-07 2011-04-14 アボット・ラボラトリーズ 正のアロステリックな修飾物質としてのアミド誘導体およびこれらの使用方法

Also Published As

Publication number Publication date
EP2279184A1 (en) 2011-02-02
EP2279183B1 (en) 2012-08-08
ES2392795T3 (es) 2012-12-13
EA017726B1 (ru) 2013-02-28
EP2279183A1 (en) 2011-02-02
MX2010011358A (es) 2010-11-10
ZA201006855B (en) 2011-06-29
CL2009000916A1 (es) 2010-12-31
IL208574A0 (en) 2010-12-30
AU2009237650A1 (en) 2009-10-22
TW201004939A (en) 2010-02-01
IL208574A (en) 2014-04-30
CN102066357A (zh) 2011-05-18
EA018113B1 (ru) 2013-05-30
BRPI0911682A2 (pt) 2015-10-13
IL208575A (en) 2014-04-30
AU2009237649A1 (en) 2009-10-22
US8377941B2 (en) 2013-02-19
EA201071202A1 (ru) 2011-06-30
JP2011516599A (ja) 2011-05-26
WO2009127679A1 (en) 2009-10-22
AU2009237650B2 (en) 2012-05-31
ES2392796T3 (es) 2012-12-13
JP2011516598A (ja) 2011-05-26
IL208575A0 (en) 2010-12-30
CA2725441A1 (en) 2009-10-22
AU2009237649B2 (en) 2012-07-26
KR20100135911A (ko) 2010-12-27
CN102066356A (zh) 2011-05-18
BRPI0910585A2 (pt) 2015-09-22
CN102066356B (zh) 2014-06-11
MX2010011359A (es) 2010-11-12
EA201071201A1 (ru) 2011-04-29
AR071203A1 (es) 2010-06-02
CA2721630A1 (en) 2009-10-22
US20110034515A1 (en) 2011-02-10
UY31769A1 (es) 2009-09-30
CA2725441C (en) 2014-05-27
US8283365B2 (en) 2012-10-09
US20110028486A1 (en) 2011-02-03
ZA201006856B (en) 2011-06-29
KR20100133016A (ko) 2010-12-20
EP2279184B1 (en) 2012-08-08
CN102066357B (zh) 2014-04-09
WO2009127678A1 (en) 2009-10-22

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Legal Events

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FD Application declared void or lapsed